JPS62190196A - １０β−ハロ−アルキニルエストレン誘導体およびそれらの製造法 - Google Patents

１０β−ハロ−アルキニルエストレン誘導体およびそれらの製造法

Info

Publication number
JPS62190196A
JPS62190196A JP61299057A JP29905786A JPS62190196A JP S62190196 A JPS62190196 A JP S62190196A JP 61299057 A JP61299057 A JP 61299057A JP 29905786 A JP29905786 A JP 29905786A JP S62190196 A JPS62190196 A JP S62190196A
Authority
JP
Japan
Prior art keywords
formula
compound
propynyl
dione
estra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP61299057A
Other languages
English (en)
Japanese (ja)
Inventor
フランコ・フアウステイーニ
エンリコ・デイ・サルレ
アキレ・パンツエリ
パオロ・ロンバルデイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of JPS62190196A publication Critical patent/JPS62190196A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP61299057A 1985-12-24 1986-12-17 １０β−ハロ−アルキニルエストレン誘導体およびそれらの製造法 Pending JPS62190196A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858531743A GB8531743D0 (en) 1985-12-24 1985-12-24 10beta-halo-alkynyl-estrene derivatives
GB8531743 1985-12-24

Publications (1)

Publication Number Publication Date
JPS62190196A true JPS62190196A (ja) 1987-08-20

Family

ID=10590248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61299057A Pending JPS62190196A (ja) 1985-12-24 1986-12-17 １０β−ハロ−アルキニルエストレン誘導体およびそれらの製造法

Country Status (4)

Country Link
JP (1) JPS62190196A (it)
DE (1) DE3644301A1 (it)
GB (2) GB8531743D0 (it)
IT (1) IT1213435B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA912235B (en) * 1990-04-02 1991-12-24 Merrell Dow Pharma Haloethyl-substituted steroidal enzyme inhibitors

Also Published As

Publication number Publication date
GB2185258B (en) 1989-10-18
GB2185258A (en) 1987-07-15
GB8630781D0 (en) 1987-02-04
IT8622840A0 (it) 1986-12-23
DE3644301A1 (de) 1987-07-02
IT1213435B (it) 1989-12-20
GB8531743D0 (en) 1986-02-05

Similar Documents

Publication Publication Date Title
CA1319362C (en) 4-substituted androstendione derivatives and process for their preparation
US5494914A (en) Inhibitors for testosterone 5α-reductase activity
JPH03163093A (ja) ５α―環元酵素阻害剤としての１７β―アシル―４―アザ―５α―アンドロスト―１―エン―３―オン
HU198511B (en) Process for producing 17beta-/cyclopropylamino/-androst-5-en-3beta-ol or -3-one and its derivatives
EP0434571B1 (fr) Nouveaux produits stéroides comportant, en position 10, un radical éthyle substitué, leur procédé de préparation, application comme médicament de l'un de ces produits et les compositions pharmaceutiques le renfermant
JP2643943B2 (ja) 新規な６−もしくは７−メチレンアンドロスタ−１，４−ジエン−３，１７−ジオン誘導体およびその製造方法
EP0490816B1 (de) Fluorverbindungen als Aromatase-Inhibitoren
JPS635096A (ja) 新規なアンドロスト−４−エン−３，１７−ジオンおよびその製造方法
JPS62158300A (ja) １０β−アルキニルエストレン誘導体およびそれらの製造法
EP0650495A1 (en) Improved antiandrogens
JPH07506120A (ja) フッ素化４−アミノアンドロスタジエノン誘導体及びその製造方法
JPS62190196A (ja) １０β−ハロ−アルキニルエストレン誘導体およびそれらの製造法
EP1322660B1 (de) 17alpha-fluoralkylsteroide, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
DE102004025966A1 (de) Estradiol-Prodrugs
JPS6355488B2 (it)
EP0193871A2 (en) 2-Oxa- or aza-pregnane compounds
IE60754B1 (en) Steroidic aromatase inhibitors
JPH07500119A (ja) アンドロスト−４−エノ〔４，５−ｂ〕ピロール誘導体およびその製造法
DE3644358A1 (de) 10(beta)-alkynyl-4,9(11)-oestradien-derivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
JPH0149358B2 (it)
FR2600254A1 (fr) Derives methylenes des androstene-4 diones-3, 17, leur procede de preparation, et leur application comme medicaments
DE3622841C2 (de) Substituierte Androsta-1,4-dien-3,17-dione und Verfahren zu deren Herstellung
DE3706647A1 (de) 3-desoxo-10ss-alkynylsteroide, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
JPH08500609A (ja) フッ素化６−メチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法
JPS62298600A (ja) Ｃ−６またはｃ−７置換ステロイドの４−ヒドロキシ誘導体およびそれらの製造方法