JPS6236130Y2 - - Google Patents

Description

[Detailed description of the invention] This invention is suitable for serological agglutination reaction equipment, especially for agglutination reactions on the surface of slide glasses, and for agglutination reactions in reaction dishes with many wells (recesses for injecting reaction liquid). This invention relates to a tilting device for mixing a test liquid and a reaction reagent during a reaction.

Conventionally, this type of stirring work has generally been done manually, but not only does it require considerable skill, but it usually needs to be continued for about 4 minutes, causing considerable fatigue. Also, mechanical devices were not sufficiently effective due to horizontal vibration.

This device makes it possible to mechanically perform complex movements that were conventionally performed manually, and also allows the reaction device to be held horizontally before starting and after stopping, allowing the test liquid to be removed from the reaction device. This is to prevent the reaction reagent solution from spilling.

In this device, a tilting pedestal for attaching a reaction device supported almost horizontally is provided on the upper surface of the base so as to be freely tiltable, and the tilting pedestal is unevenly distributed from the center of the tilting pedestal when viewed from the plane, and is tilted in a 90° direction. The difference is that a part of the tilting pedestal is provided with an operating link attachment part, and each of the two synchronously rotating drive shafts is provided with a reciprocating mechanism that converts rotational movement into vertical movement. The driven portion of each reciprocating mechanism is connected to the operating link mounting portion directly or by a link, and a coupling with a 90° play in the middle is connected to one of the two drive shafts to connect the reciprocating mechanism. The serum is interposed closer to the driving side, and the position of the play is such that the reciprocating mechanism on which the coupling is present ranges from exactly the same phase as the other reciprocating mechanism to a phase that is 90 degrees behind the other reciprocating mechanism. It is a scientific reaction instrument tilting device.

The invention will now be explained based on the illustrated representative embodiment.

In the figure, reference numeral 10 is a base, in which a motor as a drive source, other transmission mechanisms, and electrical control equipment are housed, and on the front of this base are a power switch 11, a start switch 12, etc. A tilting pedestal 13 is mounted on the upper surface of this base via a universal joint 14. A table 16 for normally mounting a reaction instrument is detachably attached to the tilting pedestal 13 with screws 15, and can be replaced with another table 16 as necessary.

Reference numerals 17 and 18 indicate drive shafts that rotate synchronously and at the same speed, and in the illustrated example, they are meshed with each other by bevel gears 19 and 20 with the same number of teeth fixed to the respective drive shafts 17 and 18. 17 (or 1
8) is directly connected to a reversible rotary motor 21,
These shafts are designed to rotate at 50 to 60 rpm. A cam plate 22b is fixed to the drive shaft 18, an eccentric member 23b is attached to the end face of the cam plate 22b, and an operating link 24b, which is a type of link, is pivotally attached to this eccentric position, and the upper end is attached to the tilting pedestal. 1
3 is connected to the operating link mounting portion 25b located partially off-center. The cam plate 22b, the eccentric member 23b, and the operating link 24b constitute a reciprocating mechanism 26b that converts rotational motion into reciprocating motion.

The drive shaft 17 is divided into two parts on the same line and connected by a coupling ring 28.
8 has a play of 90°, and the driven shaft portion 1 of the drive shaft 17
7a is provided with a reciprocating mechanism 26a that is the same as the reciprocating mechanism 26b, and similarly operates the operating link 2.
4a, it is connected to a part of the operating link mounting portion 25a of the tilting pedestal 13. The operating link mounting portions 25a and 25b of the tilting pedestal 13 are located outside the center of the tilting pedestal 13 and are oriented 90 degrees apart when viewed from the plane.

The outer peripheral surfaces of the cam plates 22a and 22b, which form part of the reciprocating mechanisms 26a and 26b, serve as cams for operating the switches SW ₁ and SW ₂ , respectively, and both act as driven by the reciprocating mechanisms 26a and 26b. When the operating links 24a and 24b reach the middle position between the vertical movement positions, the switches SW ₁ ,
SW ₂ is activated.

I will now explain how this idea works.

First, the table 16 is screwed onto the tilting pedestal 13, and if the drive shaft 17 is rotated in the direction of the arrow in the forward direction as shown in FIG.
In this case, the coupling 28 is set in a phase position in which the rotation is not transmitted from the shaft 17 to the shaft 17a until the shaft 17 rotates 90 degrees from the stopped state, and the coupling 28 is connected to the eccentric members 23a and 23b of the two reciprocating mechanisms 26a and 26b. The links 24a and 24b are both in the intermediate position, the switches SW ₁ and SW ₂ are fitted into the lower parts of the cam plates 22a and 22b, and the table 16 is in a horizontal state. This state is defined as a normal state.

Next, a type of reaction device, such as a slide glass, is fixed with a holder on the table 16, and the test liquid and reagent are dropped onto it, or if the reagent has been applied in advance, only the test liquid is dropped onto it. do.

Then, the drive shaft 17 is rotated manually or by the motor 21.
Rotate in the direction of the arrow in the figure. When driving with the motor 21, a control device as shown in FIG. 4 is used. First, when the power switch 11 is turned on and the start switch 12 is turned on, this signal is self-maintained and also generates a signal to rotate the motor 21 in the forward direction. At the same time, a timer or a separate timer T is activated by the rotation of the motor 21.

While this timer T is operating, the drive shaft 17 continues to rotate in the direction of the arrow, and when it first rotates by 90 degrees, the shaft 18, which is engaged and transmitted by the bevel gears 19 and 20, also rotates by the same angle, and the eccentric member of the reciprocating mechanism 26b 23b
And the operating link 24b is at the highest position, and the tilting pedestal is tilted around the X-X line, and the table 1 above it is tilted.
6 and the slide glass are also tilted in the same way. (Refer to the operating diagram in Figure 3.) When the shaft 17a further rotates, the coupling 28 loses its play, and in the figure, the coupling 28 becomes integral with the shaft 17.
The shaft 1 is attached to the terminal end 30 of the notch of the 1/4 notch disk 28a.
A pin 31 implanted in a disk 28b integrated with 7a engages with the shaft 17a, causing the shaft 17a to also rotate in the same direction as the shaft 17, and the reciprocating mechanism 26a
6b, the movement is started with a phase delay of 90 degrees, and the tilting pedestal 13, table 16, and slide glass are tilted around the YY line (see FIG. 3). Therefore, since the two reciprocating mechanisms 26a and 26b sequentially move up and down with a phase difference of 90 degrees, the tilting pedestal 13 and the like can be rotated in the direction of inclination. However, since the tilting pedestal itself is supported by the base 10 by the universal joint 14, it does not rotate.

This state continues for the time set by the timer T, and a timer T end signal is issued. If this signal is just when the switch SW ₁ fits into the recess of the cam plate 22a, the motor 21 will be reversed immediately, but if the timer T end signal is received by the switch SW ₁ or the cam plate 22a, the motor 21 will be reversed immediately.
If the motor 21 is at a high location a, the motor 21 continues to rotate in the normal direction until the switch SW ₁ falls into the recess of the cam plate 22a. In other words, the timer T end signal and the switch
Motor 2 is controlled by the AND signal with the operating signal of SW ₂ .
1 is rotated in the opposite direction.

When the shaft 17a rotates in the opposite direction, there is a gap between the shaft 17a and the shaft 17a.
Since there is a play of 90 degrees, the shaft 17 rotates in reverse while the shaft 17a is stopped at that position, and the shaft 18, which rotates synchronously with it, also rotates in the opposite direction.When the shaft 17a rotates 90 degrees after the start of reverse rotation, the switch SW ₂ It falls into the recess of the cam plate 22b that rotates together with the cam plate 18, stops the motor 21, and stops the tilting pedestal 13 and the like in a horizontal state.

When manually performing reverse operation, switch SW ₁ ,
This can be done by visually measuring the SW ₂ signal.

As described above, since the device of this invention is constructed and operates, the table 16 and the slide glass mounted on the tilting pedestal 13 sequentially rotate in the direction of inclination, so that the liquid thereon is absorbed by its own weight. The unevenly distributed position rotates to produce a stirring effect on the slide glass, and since the tilt angle does not exceed a predetermined angle, there is no risk of liquid spilling, and it is much more reliable than traditional manual methods. Especially if it is an electric type, the level of fatigue for both the surgeon and the worker will be negligible.

Since the operating phases of the other two reciprocating mechanisms 26a and 26b are set to have a 90° difference, the inclination direction turns when the inclination angle is the largest.
The stirring effect is the most significant.

Further, one of the drive shafts is provided with a coupling 28 with a play of 90 degrees, and the reciprocating mechanism 26a of the one with this coupling 28 is completely in phase with the reciprocating mechanism 26b of the other drive shaft 18, but is delayed by 90 degrees. Since the coupling 28 is configured to be able to freely rotate with respect to the main drive side until the phase is reached, the tilting pedestal 1
3 can be kept horizontal before starting and after stopping, which has the effect of preventing the test liquid or reagent from spilling when the slide glass is attached to or removed from the tilting pedestal via the table 16.

If an electric control device as shown in FIG. 4 is added, the tilting pedestal will always be in a horizontal position before starting and when stopping, making it easy to use.

That is, the illustrated state is a state in which the power switch is open, and when the power switch 11 is first turned on and the start switch 12 is turned on, the push buttons PB at addresses 58 and 60 are closed, and the relay coil A at address 63 is energized. However, the relay contacts between addresses 57, 59, and 60 are closed, and relay coil A at address 53 is self-held. At the same time, timer T at address 58 and relay coil B at address 59 are excited, the relay contact at address 59 is closed, and timer T and relay coil B are self-held.

52 and 55 by excitation of relay coil A.
Both address relay contacts switch to addresses 53 and 56,
The reversible rotary motor 21 rotates forward.

Next, when the timer T reaches the set time, the timer contact at address 61 opens. At this time, the switch
When SW ₁ is located high on the cam plate 22a, switch SW ₁ at address 62 is placed on the side of address 63, and the relay coil A continues to be excited, and the reversible motor 21 is Continuing to rotate, when switch SW ₁ falls into the recess of cam plate 22a, switch SW ₁ is reversed, relay coil A is demagnetized, and relay contacts at addresses 53 and 56 return to their original states.
And in that case, switch SW ₂ at number 54 is cam plate 2.
Since the relay coil B is located at the high point of 2b and is in the closed state, the relay coil B continues to be energized, and the relay contact at address 51 is closed, so the reversible rotary motor 21
is reversed. At the same time, buzzer 32 connected to address 52 rings.

Next, when the switch SW ₂ falls into the recess of the cam plate 22b, the switch SW ₂ at address 54 opens, the relay coil B is demagnetized, and the timer T is also reset. Also
The relay contacts at addresses 51, 59, and 61 open and return to their original states, the buzzer 29 stops sounding, and the reversible motor 21 also stops.

Therefore, this device can be used when mixing a test solution and reagent on a slide glass, or when tilting a hemagglutination reaction device that has many wells, making the stirring operation uniform, and also useful for comparison of multiple samples. Suitable.

In the other figures, reference numeral 33 is a friction brake which prevents the shaft 17a from rotating with respect to the shaft 17 without engagement of the coupling 28.

Loosen the set screws 34 of the eccentric members 23a, 23b shown in FIG. 6, change the amount of eccentricity with respect to the cam plate 22a (22b), fix the set screws 34 again, and adjust the inclination angle to suit the viscosity of the test liquid or reagent. Adjust to suit.

[Brief explanation of the drawing]

The drawings show typical embodiments of this invention, and FIG. 1 is an external perspective view;
Figure 2 is a perspective view showing the mechanism, Figure 3 is an operating diagram,
Figure 4 is a wiring diagram showing an example of an electrical control device, Figure 5
The figure is an enlarged longitudinal sectional side view of the tilting pedestal section, and FIG. 6 is an enlarged front view of the eccentric member section. In the figure, the symbols 10...Base, 11...Power switch, 12...Start switch, 13...Tilt pedestal, 14...Universal joint, 15...
Screw, 16... Table, 17, 18... Drive shaft, 19, 20... Bevel gear, 21... Reversible rotation motor, 26a, 26b... Reciprocating mechanism, 2
8...Katsupring.

Claims (1)

[Claims for Utility Model Registration] (1) The upper surface of the base is equipped with a tilting pedestal for attaching reaction equipment that is supported almost horizontally and can be tilted freely.
unevenly distributed from the center of the tilting pedestal when viewed from the plane, and
Parts of the tilting pedestal at 90° different directions are provided with operating link attachment parts, and the two synchronously rotating drive shafts each have a reciprocating mechanism that converts rotational motion into vertical motion. The driven part of each reciprocating mechanism is connected to the operating link mounting part directly or by a link, and one of the two drive shafts has a coupling with a 90° play in the middle. The reciprocating mechanism is located closer to the main drive side than the reciprocating mechanism, and the position of the play is determined by the reciprocating mechanism on which the coupling is present.
A serological reaction instrument tilting device characterized by having a phase that is from exactly the same as that of other reciprocating mechanisms to a phase that is delayed by 90 degrees. (2) Claim 1 of the utility model registration claim characterized in that two drive shafts rotating synchronously are mutually transmitted through gears and are connected to one of a reversible motor and a human-powered handle shaft. Serological reaction instrument tilt device. (3) The device for tilting a serological reaction device according to claim 1, wherein the means for freely tilting the base and the tilting pedestal is a universal joint. (4) The serum according to claim 1, wherein the reciprocating mechanism is one of the following: an eccentric shaft and an eccentric ring, a crank and a crank rod, various cams, levers that come into contact with the cams, and links. Scientific reaction instrument tilting device.