JPS6277308A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, obtained by incorporating a mucopolysaccharide with an extract of Sambucus sieboldiana Blume, capable of preventing the drying and roughening of the skin and imparting elasticity and flexibility to the skin and having improved skin protecting effect. CONSTITUTION:A cosmetic, obtained by incorporating 0.001-3.0wt% one or two or more mucopolysaccharides, e.g. hyaluronic acid or chondroitin 4-sulfate, with 0.0001-10wt% extract of Sambucus sieboldiana Blume and capable of exhibiting synergistically increased improving effect on skin roughening by incorporation of the two constituents in combination as compared with that in the case of the independent use thereof. The extract of the Sambucus sieboldiana Blume is obtained by extracting flowers, leaves, roots, stems, etc., of Sambucus sieboldiana Blume or Sambucus buergeriana Blume, etc., with water, a lower monohydric alcohol, liquid polyhydric alcohol, lower ketone, etc. In incorporating the resultant extract in a cosmetic base, it is preferably used in a dried state or state dissolved in water or ethyl alcohol.

Description

[Detailed description of the invention] "Industry" field of application] Undeveloped
The present invention relates to a cosmetic containing one or more mucopolysaccharides and an elderberry extract.

The purpose of the present invention is to prevent skin irritation and dryness of skin IG, improve skin adhesiveness and flexibility, and provide excellent skin protection, moisturizing, and rough skin improvement effects. The goal is to provide financial services.

[Prior art] The stratum corneum of the skin 1a maintains an appropriate wood content through a balance between water supply from inside and outside the body and water release from the skin, and generally has a ratio of 10 to 20. % water separation is said to be optimal. However, in people with dry skin that does not secrete a lot of sebum, or due to changes in '+NJ, this balance is disrupted and the moisture level decreases.
If it's below 0%, it's a condition called rough skin! E, and in extreme cases may cause cracks and chaps.

From this point of view, cosmetics containing moisturizing agents such as glycerin, pyrrolidonecarboxylic acid, sodium lactate, etc. have been used in the past in order to improve rough skin.

Attempts have also been made to incorporate mucopolysaccharides, allantoin, kolaken, and various plant extracts into cosmetics, as they are said to have effects such as preventing rough skin and healing wounds. In this context, elderberry extract has also been used as one of the plant extracts.

[Problems to be Solved by the Invention] However, although moisturizers have the function of supplying moisture to the stratum corneum, they have only a poetic effect, and furthermore, they have the drawback of being easily influenced by environmental conditions. ing.

In addition, mucopolysaccharides, allantoin, collagen, and elderberry plant extracts have useful beauty effects as mentioned above, but there is still no satisfactory effect when combined alone. There wasn't. Furthermore, sufficient consideration has not been given to combining them.

[Means for Solving the Problems] As a result of intensive research in view of the above points, the inventors of the present invention, Nagisa et al., found that by using one or more mucopolysaccharides and elderberry extract in combination, each can be used alone. The present inventors have discovered that the skin roughening effect is synergistically increased compared to the case where the skin is exposed to the skin, and have completed the present invention.

That is, the present invention is characterized by blending one or more types of mucopolysaccharides with elderberry extract, which has excellent skin 161' protective effects, moisturizing effects, and improvement of rough skin. The present invention provides a lotion I with a lot of moisture.

The l-copolysaccharides used in the present invention include hyaluronic acid, chondroitin 4-sulfate, chondroitin-6-sulfur, chondroitin-4,6-disulfur, dermatanii iW&
, Germaqun 4,6 disulfuric acid, Keratan sulfate, Heparan &
j M, chitin, etc., and their m-types and derivatives. Mucopolysaccharides are one of the constituent components of skin products, and can be derived from animals, microorganisms, or synthetic products.

That is, the origin, extraction method, and purification process pressure are not particularly limited.

In addition, the elderberry extract used in the present invention is
Sambucus, Sambucus, Sambucus succumb to the genus Sambucus of the family Caprifoliaceae]
It is obtained by extracting from the flowers, leaves, roots, stems, etc. of plants such as Sambucus and Sambucus. The extraction method is not particularly limited, but for example, as an extraction solvent, water, lower-hydric alcohols such as ethyl alcohol, isopropyl alcohol, butyl alcohol, liquid polyhydric alcohols such as propylene glycol, butylene glycol, glycerin, acetone, methyl ethyl ketone, etc. Examples include lower ketones and lower alkyl esters such as ethyl acetate, and one or more of these may be used in combination.

When blending the elderberry extract extracted with the above extraction solvent into a lotion base, it is preferable to use it in a dry state or in a state dissolved in wood or ethyl alcohol. In addition, in the case of extracts using butylene glycol, glycerin, etc. as extraction solvents, they can be blended as they are without drying.

The amount of mucopolysaccharides in cosmetics is 0.0001~
It is 5.0% by weight, and 0.001 to 3.0% by weight is suitable for use. On the other hand, the content of elderberry extract is 0.00
Effects can be expected if both are used in combination within the range of 0.01 to 10% by weight.

The lotion 1 of the present invention is characterized by containing one or more mucopolysaccharides and elderflower extract as described above, but in addition to this, the lotion 1 contains the following ingredients: Surfactants, oils, humectants, ultraviolet absorbers, alcohols, chelating agents, pH1A adjusters, preservatives, thickeners, pigments, fragrances, and the like may be blended as necessary.

Cosmetics as used in the present invention refer to skin acid cosmetics such as emulsions, lotions, grasshoppers, and creams, as well as hair cosmetics intended to protect the scalp, and which have an excellent effect on improving rough skin. It is suitable for the care of cracked, chapped skin, skin after shaving, scalp damaged by perms, etc.

[Example] The effect of improving skin roughness when mucopolysaccharide and elderberry extract are used together will be described below by giving comparative examples.

(Test Method) Six 2.5 to 3 kg EJ Honwhite native rabbits were checked for needle health, their hindquarters were shaved, and used in the test. First, the back skin IG was divided into four parts, and each part was treated with a 2% aqueous solution of thorium lauryl sulfate for 1 week to cause rough skin.

The sample aqueous solutions of ■ to ■ in Table 1 were applied to the skin of patients with rough skin for one week continuously, and after 41 days of application, the effect of improving rough skin was observed.
Comparison with the non-applied area was evaluated using a four-level evaluation of excellent effect, effective, ineffective, and worsening.

The results are shown in Table 2. Note that the numerical values in Table 2 indicate the number of animals judged to be contaminated in the term L1.

Table 1 Table 2 As is clear from Table 2, it has been demonstrated that the combination of mucopolysaccharide and elderberry extract can provide a remarkable aging effect on rough skin.

Next, the present invention will be further explained by giving examples. These do not limit the present invention in any way.

Table 3 shows the formulations of the emulsions of Example [1] and Comparative Examples [1] to [3].

Table 3 (made’v:＞ A(1) to (8) are heated and dissolved.

Mix and dissolve B(9) to (+2).

Add B to CA and emulsify.

Add (13) to 05) to DC and mix to obtain a product.

Example [1] and Comparative Example [1] obtained as above
] to [3] were investigated for their effect on improving rough skin.

The effects of Example [1] and Comparative Examples [1] to [3] were compared using 18 women aged 20 to 40 years old as test subjects, with 6 women in each group forming the 3rd group.

First, 20ml of 1% sodium lauryl sulfate aqueous solution,
After placing the test subject in a glass cup (inner diameter 4 cta, height 1.5 cm) fixed to the left and right forearm flexors for 30 minutes, the same area was washed with running water and air-dried to develop rough skin.

Next, on one side of the flexor side of the forearm where the skin became rough as described above, each group was treated with Example [1] Juishun Example r11Vl±.
Add 5 pieces of [2] to the other side and add 3 pieces of emulsion to the other side.
I applied 71I on my eyes twice, in the morning and at night. The period of use was two weeks during the winter season.

-] After the application period Y, the effects were evaluated using the following two methods.

■ The electrical conductivity of the test site was measured using an impedance meter (1, B, S, manufactured by Co., Ltd., model I, B, 3.55). The smaller the conductivity (fi), the more severe the skin roughness.

(judgement) Compared with comparative example [3] The results are shown in Table 4.

(Left below) Table 4 Glass cup fixed to the test site (inner diameter 4cm,
height], 5 cm) and 1. ', Fill the ice cube, and after 30 minutes,
The amounts of protein and amino acids eluted in the purified water at Lowry were added to Jilt. Measurement ((The larger i is, the more rough the skin is.

(judgement) Compared to comparative example [3] The results are shown in Table 5.

As is clear from the results in Table 5, the emulsion of Example [1]
It had a remarkable effect on improving rough skin compared to the case where 1, Kotabutsu, or elderberry extract was blended alone.

Example [2] Bag (prescription) (wt%) (1)
Polyvinyl alcohol (43,0cp) 10
．． 0(2:J polyvinyl alcohol (5,3cp)
IO', 0 (3) 1.3-butylene glycol 10.0 (4) Brucine denatured ethanol 5.0 (5) Hyaluronic acid
0.5 (0 elderflower)
0.5(2) Methylparaben
0.1 (8) Purified water
Yousei (manufacturing method) According to the above recipe, the bag is manufactured by a conventional method.

Example [3] Lotion (prescription) (wt%) (1)
Squalane 0.03 (2
) Jojoba oil 0.04 (3
) Polyoxyethylene polyoxypropylene cetyl ether (20E, O,, 8P, O,) 0.4 (4) Monopyroglutamine fused monoisostearate polyoxine ethylene hydrogenated castor oil (40E, O,) 1.3
(5) Chondroitin hexasulfate 0.00
1(6) 1,3-butylene glycol
5.0(2) Elderberry extract 0
．． 001(8) Ethyl alcohol
5.0 (9) No Age 4

0.1(lO) Methylparahen
0.1 (11) Purified water
Remainder;

Example [4] Cream (formulation) (wt%) (1)
N-stearoyl-L-glutamine
1.5 (2)
Setanol 3.0 (3)
Cetyl palmitate 3.0 (4)
Lanolin 3.0 (5)
Liquid paraffin 15.0 (6)
Lipophilic glyceryl monostearate

2
．． 0(2) Polyethylene monostearate u :I
-/l/ (IOE, 0.) 1.
0(8) 1,3-butylene glycol 1
5. .

(9) Sodium hydroxide o, o
i(10) Chondroitin 6ft Msu[Rium 0.1(11) Elderberry extract
0.01 (12) Hyaluronic acid
0,■(13) Kabuki I
O, 1 liter Vj preservative
0.1 (+5) Purified water
Remaining h1 (Production V,) A cream is manufactured by a conventional method according to the recipe described in 2.

All of the skin softening agents of Examples [2] to [4] obtained as described above were excellent in the effect of improving skin roundness.

[Effects of the Invention] As described in detail below, the present invention is characterized in that by blending one or more mucopolysaccharides with elderberry extract, the effects of these components are synergistically enhanced. This is a novel cosmetic product that has been developed.

That is, the present invention has made it possible to provide makeup that has an unprecedented effect on improving rough skin, has excellent skin protection and moisture retention, and is extremely comfortable.

Applicant Kobayashi Corner Co., Ltd. Sleeve termination letter (voluntary) 1st layer phase 1961 7
Month 1st, Out-of-town Indication II/(Japanese Patent Application No. 218308 □0 Name of Invention Cosmetics, person making the amendment outside of the city) Intermediary Patent Applicant Address Hiki Maki, Chuo-ku, Tokyo 3-chome Exit 6-2 Name Kobayashi Corner Co., Ltd. Representative Rei Kobayashi Next Department.

, in the amendment order [1 voluntarily, the subject of the amendment 4+1 divination, "Detailed explanation of the invention" column 6, contents of the amendment (1) "Rough skin effect" on page 3, line 17 of the specification
is corrected to "improving effect on rough skin."

(2) "Comparative example" on page 6, line 17 of the 1-town detailed book is corrected to "test example."

Claims (1)

[Claims] A cosmetic comprising one or more mucopolysaccharides and an elderberry extract.