JPS628204B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a higher alcohol alkylene oxide adduct-based solubilizer. As is well known, cosmetic solubilizers are widely used in lotions, lotions, hair tonics, hair liquids, and the like, and are used to solubilize fragrances, oil-soluble vitamins, oils and fats, and the like. Functions that such a solubilizer should have include the following. 1 Excellent solubilization performance. 2 Difficult to hydrolyze. 3 There is little foaming. 4 Excellent safety. As a typical solubilizing agent conventionally used,
polyoxyethylene n-hexadecyl ether,
There are polyoxyethylene oleyl ether, polyoxyethylene stearic acid derivatives, polyoxyethylene sorbitan oleate, etc., but these do not sufficiently have the above-mentioned functions. That is, there were particular problems with the stability of the product over time, foaming, etc., and the solubilization ability was also unsatisfactory. The purpose of the present invention is to provide a cosmetic solubilizer that has many excellent characteristics not found in conventional products, that is, a cosmetic solubilizer that has excellent solubilization performance, is difficult to hydrolyze, has low foaming, and is highly safe. It is in. That is, the present invention is based on the general formula (In the formula, R is a branched alkyl group or alkenyl group having 20 or more carbon atoms, l and m are both integers, l is 1 or more and m is 5 or more, and if R is a branched alkyl group, l
is 1 to 10 (however, when combined with the branched alkyl core, the polyoxypropylene alkyl ether partial molecular weight is
It is a solubilizing agent consisting of one or more types of higher alcohol alkylene oxide adducts shown in
It is a solubilizing agent consisting of one or more types of higher alcohol alkylene oxide adducts in the range of ~40. According to the present invention, surfactants with excellent solubilizing ability are structurally required to have a branched or unsaturated bond in the hydrophobic group, have a high molecular weight, and have a hydrophobic group material that is liquid at around room temperature. As a result of research, it was found that an aliphatic branched alkyl group having 20 or more carbon atoms (hereinafter referred to as a branched alkyl group of the raw alcohol of the solubilizing agent of the present invention) By adding propylene oxide and ethylene oxide to a higher alcohol having an aliphatic branched alkyl group or an alkenyl group, it was possible to obtain a product of the present invention that satisfies all the desirable conditions as a solubilizer. Examples of alcohols having an alkyl group having 20 or more carbon atoms include eicosanol, docosanol,
Tetracosanol, octacosanol, triantanol, dotriacontanol, etc. are conceivable, but it is important that all of them have branches, and the state of the branches can be in various positions. In addition, alkenyls having unsaturated bonds are also good raw materials for solubilizing agents. Furthermore, in the present invention, it has been found that there is a preferable molar ratio between the above-mentioned higher alcohol having a branched or unsaturated bond, propylene oxide, and ethylene oxide. In other words, it was found that when the number of moles of propylene oxide added to the aforementioned branched alkyl group or alkenyl group is increased too much, the solubilizing ability decreases, and that the optimal number of moles of propylene oxide added is 4 to 16. . Furthermore, those with an added mole number of 5 moles of ethylene oxide are insoluble in water and are suitable as emulsifiers, but lack hydrophilicity as solubilizers. As a solubilizer, the number of moles of ethylene oxide added is 8.
~40 was optimal, and when the number of moles added was too large, the solubilization ability decreased. Furthermore, in the solubilized system using the solubilizer of the present invention, precipitation of insoluble matter does not occur. In other words, sagging does not occur over time. With conventional solubilizers, water-insoluble substances such as unreacted alcohol and fatty acids precipitate over time, so steps such as filtration with a microfilter have been taken during the production of cosmetics. The solubilizing agent of the present invention is synthesized by adding ethylene oxide to a propylene oxide adduct of liquid higher alcohol having a branched alkyl group or alkenyl group at room temperature, so it has a high solubilizing power. It is excellent, and no deposits of sludge are observed over time, making it possible to significantly improve the manufacturing process of cosmetics. Furthermore, when using cosmetics such as lotion, foaming significantly impairs the feeling of use, so it is very difficult to defoam when preparing a prescription. The solubilizer of the present invention is an epoch-making surfactant that has significantly improved foaming properties compared to conventional products. Table 1 shows the features of the solubilizer of the present invention in comparison with conventional products. As can be seen from Table 1, the solubilizing agent according to the present invention is significantly superior in solubilizing power compared to polyoxyethylene derivatives and polyoxyethylene polyoxypropylene derivatives conventionally used as solubilizing agents. I understand that. Also, lotions used in acidic conditions,
Conventional solubilizers with ester bonds have had the disadvantage of being practically unusable for lotions because they cause hydrolysis, but this problem can be solved by using ether type surfactants such as the solubilizer of the present invention. is resolved. Furthermore, we conducted a patch test for safety.
As a result of evaluation after 24 hours and 48 hours, it was found that the product of the present invention did not cause any reaction and was found to be a safe surfactant with very little skin irritation. Furthermore, the solubilizer of the present invention has excellent emulsifying power and can also be used as a cosmetic emulsifier. The product of the present invention can also be used in combination with conventional solubilizers and emulsifiers. Next, examples of the present invention will be shown, and the performance test results are shown in Table 1.

[Table] Preparation examples of the solubilizer of the present invention are also shown below. Example 1 Hair tonic (A) solubilizer 2* (invention product) 2.0wt% Pyridoxine dicaprylate 0.4 Menthol 0.1 Camphor 0.1 Fragrance 0.8 Ethanol 50.0 (B) 1,3-butylene glycol 2.0 Preservative Appropriate amount Purified water 44.6 ( After heating and dissolving A) at 40°C, (B) heated and dissolved at 50°C is gradually added to (A) and cooled while stirring. *2-decyltetradecanol adduct with 8 moles of propylene oxide (PO) and 15 moles of ethylene oxide (EO). Example 2 Hair liquid (A) solubilizer (2-decyltetradecanol PO(8)EO(15)) 2.0wt% polypropylene glycol (molecular weight 2000)
15.0 Pyridoxine dicapolylate 0.2 Fragrance 0.5 Ethanol 40.0 (B) Propylene glycol 2.0 Preservative Appropriate amount Purified water 40.3 After heating and dissolving (A) at 40℃, add (B), which was also heated and dissolved at 40℃, to (A). Cool while stirring. Example 3 (A) Solubilizer (2-decyltetradecanol PO(8)
EO (20) 3.0wt% Ethyl dicarboethoxypantothenate (NIKKOL Bifupant) 0.1 Flavor 0.2 Ethanol 15.0 (B) Glycerin 2.0 Preservative Appropriate amount Purified water 79.7 After uniformly dissolving (A) at 40℃, the same amount of 40 Add (B) dissolved by heating to (A) to (A) and cool while stirring. In all of Formulation Examples (1), (2), and (3), even if the conventional solubilizers were able to temporarily solubilize, scum formed after several hours to several days, making them practically unusable. However,
A stable system was obtained using the solubilizer cm ² of the present invention. In addition, good results were obtained with little foaming. Example 4 Pack (A) Carboxymethyl cellulose 5.0wt% Polyvinyl alcohol 5.0 Preservative appropriate amount Purified water 60.0 (B) Solubilizer (2-decyltetradecanol PO(8)EO(20) 0.6 Ethanol 10.0 1,3-butylene Glycol 1.0 Pyrrolidone carboxylic acid sodium salt 1.5 Purified water 16.9 Dissolve (A) uniformly at 50°C, heat at 50°C, and gradually add uniformly dissolved (B) to (A) while stirring. This formulation Conventional solubilizers were often opaque due to lack of solubilizing power, but the product of the present invention provided a pack with excellent transparency and less skin irritation.Example 5 Acidic lotion (A) Solubilizer (2-decyltetradecanol PO(6)
EO (20)) 3.0wt% Pyridoxine dicaprylate 0.1 Fragrance 0.3 Ethanol 10.0 (B) Propylene glycol 3.0 Citric acid 0.2 Preservative Appropriate amount Purified water 83.4 After uniformly dissolving (A) at 40℃, dissolve at 40℃ as well.
(B) dissolved by heating is gradually added to (A) while stirring. Since this formulation example is acidic, it was hydrolyzed and unusable with conventional ester-type solubilizers.
A stable and low foaming lotion was obtained using the product of the present invention. Example 6 Lotion (A) Isoeicosanol PO(6)EO (30) (Isoeicosanol is the product name NJCol-200A) 2.0wt% Squalane 0.2 Fragrance 0.1 Ethanol 5.0 Preservative Appropriate amount (B) Polyethylene glycol 400 1.5 Glycerin 1.0 Preservative, UV absorber Appropriate amount of distilled water 92.7 (A) + (B) Total 100 Dissolve phase (A) at 40℃. (B) also dissolves at 40°C.
Add phase (B) to phase (A) and solubilize. Conventional solubilizers were unable to solubilize squalane in particular, but the product of the present invention can also solubilize squalane. Example 7 (A) Isoeicosanol PO(6)EO (40) (Product name NJCol-200A) 1.5wt% Fragrance 0.1 Ethanol 2.0 (B) Propylene glycol 4.0 Polyethylene glycol 1500 2.0 Purified water 90.4 Dye Appropriate amount Preservative Dissolve an appropriate amount of agent (A) at 40℃ and add (B) at 40℃. A more stable system is obtained than with conventional solubilizers.

Claims (1)

[Claims] 1. General formula (In the formula, R is an aliphatic branched alkyl group or alkenyl group having 20 or more carbon atoms, l and m are both integers, l is 1 or more and m is 5 or more, and R is an aliphatic branched alkyl group A solubilizing agent consisting of one or more types of higher alcohol alkylene oxide adducts, where l is 1 to 10 (provided that the polyoxypropylene alkyl ether partial molecular weight is less than 900 when combined with the aliphatic branched alkyl core) . 2. The solubilizer according to claim 1, wherein l in the general formula is 4-16 and m is 8-40.