JPS6284011A - Hair tonic - Google Patents

Abstract

PURPOSE:The titled cosmetic having improved hair nourishing effects, locally effective, having low side effects and sink irritation, containing 4-androstene-3,17- dione-17-cyclic ethylene ketal and a telangiectatic agent for the skin as active ingredients. CONSTITUTION:Safe 4-androstene-3,17-dione-17-cyclic ethylene ketal having no unfavorable side effects such as hormone action, etc., having both inhibitory action on reductase and inhibitory effects on bonding of 5alpha-dihydrotestosterone (male hormone) and an acceptor protein free from unfavorable side effects such as hormone action, etc., as an active ingredient, is further blended with one or more of telangiectatic agents for the skin such as carpronium chloride, benzyl nicotinate, etc. The amount of the former active ingredient blended is 0.0001-2wt% and the amount of the latter telangiectatic agent for the skin is preferably 0.01-3.0wt%.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a hair nourishing agent having excellent hair nourishing effects.

[Prior art] Physiological symptoms such as male-pattern baldness and seborrhea are said to be caused by increased stimulation of male hormones due to excessive accumulation of male hormones. The main body of this androgen activity in organs is 5α-dihydrotestosterone (hereinafter referred to as 5α- It is becoming well known that testosterone produced in the adrenal glands and the adrenal glands travels through the bloodstream to the sebaceous glands, where it is made more powerful by reductase in the sebaceous gland cells. It is converted to the male hormone 5α-DHT.This 5α
-DHT binds to intracellular receptors and acts on the nucleus to promote the proliferation of sebaceous gland cells, while DHT itself exits the sebaceous gland cells and enters the bloodstream, acting on hair matrix cells and acting on the hair at the hair bulb. It is said to suppress the division of mother cells, impede hair growth, and promote hair pulling and hair loss.

[Problems to be Solved by the Invention] Therefore, symptoms such as male pattern baldness and hair loss can be reduced or prevented by inhibiting the activity of reductase and the binding of 5α-DHT to receptor proteins. Based on this viewpoint, substances such as chlormadinone acetate, oleic acid, and linoleic acid have been discovered so far. However, even though these substances have a high inhibition rate of reductase activity, they have undesirable side effects, and their inhibition rate of binding between 5α-DHT and receptor protein is very low, so they are inferior to the actual hair growth effect. There was a drawback.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have developed a method that does not have undesirable side effects such as hormonal effects, is safe, inhibits reductase activity, and inhibits 5α-DHT and receptor protein. As a result of intensive research to find a substance that has both the effect of inhibiting the binding of - It has been discovered that the above object can be achieved by blending cyclic ethylene ketal (Japanese Patent Application Laid-Open No. 6O-136505). As a result of further research, we found that by combining 4-androstene-3,17-dione-17-cyclic ethylene ketal with one or more skin peripheral vasodilators, the effect is synergistic. The present invention was completed based on the discovery that

That is, the present invention is a hair nourishment characterized by containing 4-androstene-3,17-dione-17-cyclic ethylene ketal and one or more skin peripheral vasodilators.

Hereinafter, the configuration of the present invention will be explained in detail.

The blending amount of 4-androstene-3,17-dione-17-cyclic ethylene ketal is preferably 0.0001 to 2% by weight in the hair nourishing material of the present invention. Particularly preferably, it is 0.0001 to 2% by weight. 0.0001% by weight
If the amount is less than that, the hair nourishing effect may not be exhibited. The higher the amount, the greater the hair-nourishing effect, but in view of the possibility of unexpected side effects occurring when a large amount is used, the amount is preferably 2% by weight or less.

In the present invention, the skin peripheral vasodilators, which are substances that synergistically increase the hair-nurturing effect, include carpronium chloride, minoxidil, spironolactone, vitamin B6 hydrochloride, cephalanthine (Tamasa Kidzurafji extract), D-camphor, DL-camphor, DL-α-tocopherol, iodized garlic extract, DL-α-tocopherol lyric acid ester, Jasmine japonica extract, inositol hexanicotinic acid ester, vitamin E1 dextran sodium sulfate, nicotinic acid, DL-α-tocopherol nicotinic acid ester, nicotine Butoxyethyl acid, γ-oryzanol, benzyl nicotinate, methyl nicotinate, vanillyl nonanoate, DL-α-tocopherol succinate,
DL-α-tocopherol tt acid, capsicum tincture,
Cantharis tincture, ginger tincture, etc., cephalanthine (Tamasakidzurafuji extract), DL-α
-Tocopherol, iodized garlic extract, Jasmine japonica extract, DL-α-tocopherol nicotinic acid ester,
Benzyl nicotinate, nonanoic acid panillylamide, acetic acid D
L-α-tocopherol, capsicum tincture, cantharis tincture, ginger tincture and the like are preferred.

The compounding amount of the skin peripheral vasodilator is 0.0001 to 5% by weight.
is preferred, particularly preferably 0.01 to 3.0% by weight. If the amount is less than 0,001% by weight, the hair-nurturing effect may not be exhibited, and even if it exceeds 5% by weight, no further hair-nurturing effect may be expected.

The hair nourishment according to the present invention includes the above-mentioned 4-androstene-3.
, 17-dione-17-cyclic ethylene ketal and peripheral skin vasodilators, as well as additives commonly used in hair nourishing products, such as hinokitiol, hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, untecilenic acid, Antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and 7-alkyl esters, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols. Other oils such as surfactants, perfumes, antioxidants, ultraviolet absorbers, pigments, ethanol, water, humectants, thickeners, and the like can be suitably blended as long as they do not impair the effects of the present invention.

The hair tonic of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, milky lotion, or ointment.

The hair nourishing material according to the present invention is 4-androstene-3,17-
Dione-17-cyclic ethylene ketal and a skin peripheral vasodilator that dilates peripheral blood vessels in the scalp and promotes an increase in blood flow act effectively to exert a synergistic hair-nourishing effect.

[Example] Next, the present invention will be explained in detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.

The test method will be explained in Examples below.

Judgment was made based on the change in the number of strands of hair removed during hair washing before and after using the main hair sample. There were 10 subjects in each of the seven groups of Examples 1 to 6 and Comparative Example 1. The measurement period is 4 months, and the first two
The first month was the period when no sample was applied, and the second half of the second month was the period when the sample was applied. During this period, the hair was washed every two days and the pulled hair was collected, and the number of hairs for one week was counted. To display the number of hairs pulled out in each period, data on the number of hairs pulled out 8 times in total for 2 months without sample application and data on the number of hairs pulled out 8 times in total for 2 months with hair growth agent applied are summarized for each period, and the average is calculated. Value ±
The number of hairs pulled per session was expressed in the form of α. The unit is a book. The effectiveness was determined based on the difference between the average values for each period as shown below.

++: The number of hairs pulled was reduced by 70 or more, indicating a significant effect.

+: The number of hairs pulled was reduced by 40 or more, and an origami effect was observed.

±: The number of hairs pulled was reduced by more than 1o, and it could be said that there was a slight effect.

-: The reduction in the number of hairs pulled is less than 10, and it cannot be said that there is an effect.

Example 1.2, Comparative Example 1 (blank below) (Production method) 4-androstene-3,17-dione-17-cyclic ethylene ketal, benzyl nicotinate, and hydrogenated castor oil EO ( 40 mol) adduct was added and stirred to dissolve, and then ion-exchanged water was added and mixed to obtain a transparent liquid hair nourishing material of Example 1. Example 2 and Comparative Example 1 were also obtained in the same manner as Example 1.

(Left below) All the results mentioned above are based on 4-androstene-3,17
- The hair nourishing material according to the present invention containing dione-17-cyclic ethylene ketal and a skin peripheral vasodilator is a hair nourishing material containing conventionally known 4-androstene-3,17-dione-17-cyclic ethylene ketal. This shows that it has a synergistically superior hair-nourishing effect compared to other materials.

Example 3 (Phase A) 4-Androsterone-3,17-dione-17-cyclic ethylene 2.0 Ketal assembly extract 3.0 Polyoxyethylene (60 mol) Hydrogenated castor oil 2.0 Glycerin 7.0 Di Propylene glycol 8.41.3-Butylene glycol 5.0 Polyethylene glycol 150
0 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 (Phase C) Carboxyvinyl polymer 1% water soluble if 30.0 Sodium hexametaphosphate 0.03 ion Exchanged water 8.95 (D phase) Ion exchanged water 4.5 (E phase) Caustic potash 0.12 Ion exchanged water 5.0 (manufacturing method) Phase A and phase B are dissolved by heating at 60°C, respectively, and mixed. Treat with a homomixer to make a gel. Phase C is gradually added to this and dispersed using a homomixer.

Next, the dissolved phase C was added thereto, and finally the dissolved phase E was added and emulsified with a homomixer to obtain a 0/W emulsion type hair nourishing material.

When this hair nourishing material was subjected to a practical use test in the same manner as in Example 1.2, it was confirmed that its hair nourishing effect was excellent.

Example 4 (Phase A) 4-androstene-3,17-dione-17-cyclic ethylene ketal 0.2 Cephalanthine 5.0 Liquid paraffin
5.0 Cetostearyl alcohol 5.1 Glyceryl monostearate
3.0 EO (20 mol)-2-octyldodecyl ether 3.0 Propylparaben 0.3 Fragrance
0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate o, oos ion exchange water
45.295 (Production method) Phase A and phase B were respectively heated and dissolved and mixed, and emulsified with a homomixer to obtain an ointment-like hair nourishing material.

When this hair nourishing material was subjected to a practical use test in the same manner as in Example 3, it was confirmed that its hair nourishing effect was excellent.Example 5 Ethanol 55.04-androstene-3,17-dione-17 -Cyclic ethylene ketal 0.0001 DL-α-tocopher nicotinic acid ester 0.01 EO (8 mol) oleyl alcohol ether 2.0 Hinokitiol o, 05 Fragrance
0.1 dye
0.0899 ion exchange water
42.75 (Manufacturing method) EO (8 mol) oleyl alcohol ether and 4-androsesterone-3,17-dione-1 fusai exchange water were added to ethanol to solubilize it to obtain a hair nourishing material.

Example 6 4-androstene-3,17-dione-17-cyclic ethylene ketal 0.2 g 1 tincture 0.0001 g, liquid paraffin 5.0 g, cetostearyl alcohol 5.5 g, vaseline 5.5 g, glyceryl mono Stearate 3.0g, EO (20mol)-2
- 3.0 g of octyl dodecyl ether, 0.2 g of propyl paraben, and 0.1 g of fragrance are heated and dissolved and mixed. To this, 7.0 g of glycerin and 20 g of dipropylene glycol. Og, 5.0g polyethylene glycol 4
000, a hot melt mixture of 0.005 g of sodium hexametaphosphate and 45.4949 g of ion exchange water,
The mixture was emulsified using a homomixer to obtain a creamy hair nourishing agent. The obtained hair nourishing material showed an excellent hair nourishing effect.

[Effect of the Invention 1 The hair nourishing material of the present invention has an excellent hair nourishing effect, is locally effective, has no systemic side effects, has little skin irritation, and is highly safe. The hair nourishing material of the present invention is a highly safe hair nourishing material that has an excellent hair nourishing effect, is locally effective, has no systemic side effects, and has little skin irritation. be.

Claims (1)

[Claims] A hair nourishment containing 4-androstene-3,17-dione-17-cyclic ethylene ketal and one or more skin peripheral vasodilators.