JPS6284014A - Hair tonic - Google Patents

Abstract

PURPOSE:A hair tonic having synergistic effects, containing 4-estrene-3,17- dione-17-cyclic ethylene ketal and a telangiectatic agent for the skin. CONSTITUTION:A safe hair tonic containing 0.0001-2wt%, preferably 0.0001-0.2wt% 4-estrene-3,17-dione-17-cyclic ethylene ketal and 0.0001-5wt%, especially preferably 0.01-3.0wt% telangiectatic agent for the skin (e.g., carpronium chloride, minoxidil, spironolactone, vitamin B6 hydrochloride, etc.,), free from side effects. Solution, milky lotion, ointment, etc., may be used as the form. EFFECT:The former active ingredient and the telangiectatic agent for the skin for dilating peripheral blood vessels of the scalp and for promoting increase in amount of blood stream act effectively and show synergistic hair nourishing effects.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a hair nourishing agent having excellent hair nourishing effects.

[Prior Art] Physiological symptoms such as male-pattern baldness and seborrhea are said to be due to increased stimulation of male hormones due to excessive accumulation of male hormones. The main body of this male hormone activity is 5α-dihydrotestosterone (hereinafter referred to as 5α-DHT), which is produced by reducing testosterone (male hormone) in these target organs by an enzyme called testosterone-5α-reductase (hereinafter referred to as reductase). ) is becoming well known. In other words, testosterone produced by the adrenal glands and adrenal glands travels through the bloodstream to the sebaceous glands, where it is converted into 5α-DHT, a more powerful male hormone, by reductase in the sebaceous gland cells. This 5α-
DHT binds to intracellular receptors, acts on the nucleus, and promotes the proliferation of sebaceous gland cells, while DHT itself exits the sebaceous gland cells and enters the bloodstream, acting on hair matrix cells and stimulating the growth of hair in the hair bulb. It is said to suppress the division of mother cells, impede hair growth, and promote hair pulling and hair loss.

[Problems to be Solved by the Invention] Therefore, symptoms such as male pattern baldness and hair loss can be reduced or prevented by inhibiting the activity of reductase and the binding of 5α-DHT to receptor proteins. Based on this viewpoint, substances such as chlormadinone acetate, oleic acid, and linoleic acid have been discovered so far. However, even though these substances have a high inhibition rate of reductase activity, they have undesirable side effects, and their inhibition rate of binding between 5α-DHT and receptor protein is very low, so they are inferior to the actual hair growth effect. There was a drawback.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have developed a method that does not have undesirable side effects such as hormonal effects, is safe, inhibits reductase activity, and inhibits 5α-D HT and receptor protein. As a result of intensive research in search of a substance that has both the effect of inhibiting the binding of 4-estrene-3,17-dione- It has been found that the above object can be achieved by blending 17-cyclic ethylene ketal (Japanese Patent Application Laid-Open No. 60-67411). This time, as a result of further research,
The present invention has been completed by discovering that by combining 4-estrene-3,17-dione-17-cyclic ethylene ketal with one or more skin peripheral vasodilators, the effects can be synergistically increased. I ended up doing it.

That is, the present invention is a hair nourishing material containing 4-estrene-3,17-dione-17-cyclic ethylene ketal and one or more skin peripheral vasodilators.

Hereinafter, the configuration of the present invention will be explained in detail.

The blending amount of 4-yenistrene-3,17-dione-17-cyclic ethylene ketal is 0 in the hair nourishing material of the present invention.
．． 0001 to 2% by weight is preferred. Particularly preferably, 0
．． 0001 to 0.2% by weight. 0.0001% by weight
If the amount is less than that, the hair nourishing effect may not be exhibited. The higher the amount, the greater the hair-nourishing effect, but in view of the possibility of unexpected side effects occurring when a large amount is used, the amount is preferably 2% by weight or less.

In the present invention, the skin peripheral vasodilators, which are substances that synergistically increase the hair-nurturing effect, include carpronium chloride, minoxidil, spironolactone, vitamin B6 hydrochloride, cephalanthine (Tamasa Kidzurafji extract), D-camphor, DL-camphor, DL-α-tocopherol, iodized garlic extract, DL-α-tocopherol lyric acid ester, Jasmine japonica extract, inositol hexanicotinic acid ester, vitamin E1 dextran sodium sulfate, nicotinic acid, DL-α-tocopherol nicotinic acid ester, nicotine Butoxyethyl acid, γ-olipnol, benzyl nicotinate, methyl nicotinate, vanillylamide nonanoate, DL-α-tocopherol succinate,
These include DL-α-tocopherol acetate, capsicum tincture, cantharis tincture, and ginger tincture, as well as cephalanthine (Tamasakidzurafuji extract), DL-α-
Tocopherol, iodized garlic extract, Jasmine japonica extract, DL-α-tocopherol nicotinic acid ester, nicotinic acid pencil, nonanoic acid panillylamide, acetic acid DL
-α-tocopherol, capsicum tincture, cantharis tincture, ginger tincture, etc. are preferred.

The compounding amount of the skin peripheral vasodilator is 0.0001 to 5% by weight.
is preferred, particularly preferably 0.01 to 3.0% by weight. If it is less than 0.0001% by weight, the hair nourishing effect may not be exhibited, and even if it exceeds 5% by weight, no further hair nourishing effect may be expected.

The hair nourishing material according to the present invention includes the above-mentioned 4-estrene-3,1
In addition to 7-dione-17-cyclic ethylene ketal and a skin peripheral vasodilator, additives commonly used in hair care products, such as hinokitiol, hexachlorophene, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, Antibacterial agents such as trichlorocarbanilide and bithionol, cooling agents such as menthol, drugs such as salicylic acid, zinc and its derivatives, lactic acid and its alkyl esters, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, higher alcohols, etc. The oil component, its low surfactant, fragrance, antioxidant, ultraviolet absorber, pigment, ethanol, water, humectant, thickener, etc. can be appropriately blended within the range that does not impair the effects of the present invention.

The hair growth material of the present invention may be in any form as long as it can be applied to the outer skin, such as liquid, emulsion, or ointment.

The hair growth agent according to the present invention has a synergistic effect in which 4-estrene-3,17-dione-17-cyclic ethylene ketal and a skin peripheral vasodilator that dilates peripheral blood vessels in the scalp and promotes an increase in blood flow. It has a hair-nourishing effect.

[Example] Next, the present invention will be explained in more detail by giving examples. The present invention is not limited thereby. The blending amount is in weight%.

The test method will be explained in Examples below.

Judgment was made based on the change in the number of strands of hair removed during hair washing before and after using the Shimanrai Dosu sample. There were 10 subjects in each of the seven groups of Examples 1 to 6 and Comparative Example 1. The measurement period is 4 months, and the first two
The first month was the period when no sample was applied, and the second half of the second month was the period when the sample was applied. During this period, the hair was washed every two days and the pulled hair was collected, and the number of hairs for one week was counted. To display the number of hairs pulled out for each period, data on the number of hairs pulled out 8 times in 2 months without sample application and data on the number of hairs pulled out 8 times in 2 months with hair tonic applied are summarized for each period, and the average is calculated. Value±
The number of hairs pulled per session was expressed in the form of α. The unit is a book. The effectiveness was determined based on the difference between the average values for each period as shown below.

++: The number of hairs pulled was reduced by 70 or more, indicating a significant effect.

+: The number of hairs pulled was reduced by 40 or more, indicating a considerable effect.

±: The number of hairs pulled was reduced by 10 or more, indicating that it was somewhat effective.

-: The reduction in the number of hairs pulled is less than 10, and it cannot be said that there is an effect.

Example 1.2, Comparative Example 1 (blank below) (Production method) 95% ethanol, 4-estrene-3,17-dione-17-cyclic ethylene ketal, benzyl nicotinate, and hydrogenated castor oil EO (40 A transparent liquid hair growth agent of Example 1 was obtained by adding mol) and stirring to dissolve ion-exchanged water and mixing. Example 2 and Comparative Example 1 were also obtained in the same manner as in Example 1.

(Margins below) (Results) All of the above results indicate that the hair nourishing material of the present invention containing 4-estrene-3,17-dione-17-cyclic ethylene ketal and a skin peripheral vasodilator was better than the conventionally known 4-estrene-3,17-dione-17-cyclic ethylene ketal and skin peripheral vasodilator.
This shows that the hair-nurturing effect is synergistically superior to the hair-nurturing material containing estrene-3,17-dione-17-cyclic ethylene ketal.

Example 3 (Phase A) 4-Estrene-3,17-dione-17-cyclic ethylene ketal 2.0 Japonica extract 3.0 Polyoxyethylene (60 L) Hydrogenated castor oil 2.0 Glycerin 7.0 Di Propylene glycol 8.4 1.3-Butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanate 10.0 Squalane 5.0 Vaseline
2.0 Propylparaben
2.0 (C phase) Carboxyvinyl polymer 1χ water soluble? & 30.0 Sodium hexametaphosphate 0.03 Ion exchange water 8.95 (D phase) Ion exchange water 4.5 (E phase) Caustic potash 0.12 Ion exchange water 5.0 (Production method) A phase, B phase P8 was dissolved in each at 60°C, mixed and treated with a homomixer to form a gel. Phase D is gradually added to this and dispersed using a homomixer.

Next, the dissolved phase C was added thereto, and finally the dissolved phase E was added and emulsified with a homomixer to obtain an O/W emulsion type hair nourishing material. - When this hair nourishing material was subjected to a practical use test in the same manner as in Example 1.2, it was confirmed that its hair nourishing effect was excellent.

Example 4 (Phase A) 4-estrene-3,17-dione-17-cyclic ethylene ketal 0.24-
Estren-3-one-17β-carboxylic acid pentyl ester 0.1 Cephalanthine 5.0 Liquid paraffin
5.0 Cetostearyl alcohol 5.1 Glyceryl monostearate
3.0 EO (20 mol)-2-octyldodecyl ether 3.0 Propylparaben 0.3 Fragrance
0.1 (Phase B) Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate
0.005 ion exchange water
45.295 (Manufacturing method) Phase A and phase B were respectively heated and dissolved, mixed, and emulsified with a homomixer to obtain an ointment-like hair nourishing agent.

This hair nourishing agent was tested in the same manner as in Example 3. Example 5: Ethanol 55.04-estrene-3,17-dione-17-cyclic ethylene ketal 0.0001DL-α-tocopherol nicotinic acid ester 0.01 EO (8 moles) Oleyl alcohol ether 2.0 Hinokitiol 0.05 Fragrance
0.1 dye
0.0899 ion exchange water
42゜75 (Production method) Add EO (8 mol) oleyl alcohol ether, 4-estrene-3,17-dione-17-cyclic ethylene ketal, DL-α-tocopherol nicotinic acid ester, and hinokitiol to ethanol; After adding and dissolving perfume and dye, ion-exchanged water was added to solubilize to obtain a hair nourishing agent.

Example 6 0.2 g of 4-estrene-3,17-dione-1 fucylic ethylene ketal, 0.2 g of ginger tincture.
0001 g, liquid paraffin 5.0 g, cetostearyl alcohol 5.5 g, petrolatum 5.5 g, glyceryl monostearate 3.0 g, EO (20 mol)
3.0 g of 2-octyldodecyl ether, 0.2 g of N-propylparaben, and 0.1 g of fragrance are heated and dissolved and mixed. To this, 7.0 g of glycerin and 20 g of dipropylene glycol. A hot melt mixture of Og, 5.0 g of polyethylene glycol 4000, 0.005 g of sodium hexametaphosphate, and 45.4949 g of ion-exchanged water was added and emulsified with a homomixer to obtain a cream-like hair nourishing agent. The obtained hair nourishing agent showed an excellent hair nourishing effect.

[Effects of the Invention] The hair nourishing agent of the present invention has an excellent hair nourishing effect, is locally effective, has no systemic side effects, and has little skin irritation, and is a highly safe hair nourishing agent. be.

Claims (1)

[Claims] A hair nourishment containing 4-estrene-3,17-dione-17-cyclic ethylene ketal and one or more skin peripheral vasodilators.