JPS63246149A - Method for packing in vivo hydrolyzable medical product - Google Patents
Method for packing in vivo hydrolyzable medical productInfo
- Publication number
- JPS63246149A JPS63246149A JP62081381A JP8138187A JPS63246149A JP S63246149 A JPS63246149 A JP S63246149A JP 62081381 A JP62081381 A JP 62081381A JP 8138187 A JP8138187 A JP 8138187A JP S63246149 A JPS63246149 A JP S63246149A
- Authority
- JP
- Japan
- Prior art keywords
- moisture content
- paper
- moisture
- sealing
- medical product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims description 15
- 229940127554 medical product Drugs 0.000 title claims description 14
- 238000001727 in vivo Methods 0.000 title 1
- 238000012856 packing Methods 0.000 title 1
- 239000000463 material Substances 0.000 claims description 19
- 238000007789 sealing Methods 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 12
- 238000004806 packaging method and process Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920001519 homopolymer Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 229920000954 Polyglycolide Polymers 0.000 description 6
- 239000004633 polyglycolic acid Substances 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- -1 bone plates Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 description 1
- IYBOGQYZTIIPNI-UHFFFAOYSA-N 2-methylhexano-6-lactone Chemical compound CC1CCCCOC1=O IYBOGQYZTIIPNI-UHFFFAOYSA-N 0.000 description 1
- BKHGTYGMRHXKIG-UHFFFAOYSA-N 3,3-dimethyl-1,4-dioxan-2-one Chemical compound CC1(C)OCCOC1=O BKHGTYGMRHXKIG-UHFFFAOYSA-N 0.000 description 1
- REKYPYSUBKSCAT-UHFFFAOYSA-N 3-hydroxypentanoic acid Chemical compound CCC(O)CC(O)=O REKYPYSUBKSCAT-UHFFFAOYSA-N 0.000 description 1
- ZNXIWVKSYUTDTI-UHFFFAOYSA-N 3-methyl-1,4-dioxan-2-one Chemical compound CC1OCCOC1=O ZNXIWVKSYUTDTI-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- RZTOWFMDBDPERY-UHFFFAOYSA-N Delta-Hexanolactone Chemical compound CC1CCCC(=O)O1 RZTOWFMDBDPERY-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
Landscapes
- Surgical Instruments (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、生体分解吸収性材料からなる医療製品の包装
方法に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a method for packaging medical products made of biodegradable and absorbable materials.
［従来の技術］
生体内に留置するとしだいに分解されて吸収される材料
は、使用終了後再手術により取り出す必要がないことか
ら、以前より縫合糸などに使用されており、最近では種
々の用途に使用拡大が検討されつつある。現在使用され
ている生体分解吸収性材料としては、天然物由来のコラ
ーゲンと合成高分子のポリグリコール酸系重合体がある
が、後者は一定し°た品質の製品が得られることから、
急速に需要が増加しつつある。[Prior Art] Materials that are gradually decomposed and absorbed when left in the living body do not require re-surgery to be removed after use, so they have been used for sutures, etc., and have recently been used for various purposes. Expanding its use is being considered. Biodegradable and absorbable materials currently in use include collagen derived from natural products and polyglycolic acid-based polymers, which are synthetic polymers, but the latter produces products of consistent quality.
Demand is rapidly increasing.
ところで、ポリグリコール酸は生体内の水分によって加
水分解されるものであるので、少量の水分が存在しても
徐々に加水分解が進む。したがって、製品は使用直前ま
でほとんど水分が存在しない状態に保持しておく必要が
ある。そこで、特公昭４９−４４７５４号公報において
は、ボリグリコール酸縫合系を完全に乾煙し、これを水
蒸気を通さない材料で真空包装するかあるいは水分のな
い不活性ガスで置換して包装したパッケージが提案され
実用化されている。By the way, since polyglycolic acid is hydrolyzed by moisture in the living body, hydrolysis proceeds gradually even if a small amount of moisture is present. Therefore, the product must be kept in a substantially moisture-free state until immediately before use. Therefore, in Japanese Patent Publication No. 49-44754, a polyglycolic acid suture system is completely dried and smoked, and then it is packaged in a vacuum packaged with a material that does not pass water vapor or replaced with a moisture-free inert gas. has been proposed and put into practical use.
［発明が解決しようとする問題点コ
真空包装あるいは不活性ガスによる置換包装は、パッケ
ージ内に水分が侵入しないという点では理想的な方法で
あるが、パッケージの密封作業をすべて密閉された容器
の中で行わなければならないので特別の装置を必要とす
る問題があり、しかも作業性が悪いために生産効率上も
問題があった。[Problems to be solved by the invention] Vacuum packaging or displacement packaging using inert gas is an ideal method in terms of preventing moisture from entering the package, but it is necessary to do all the sealing work of the package in a sealed container. Since the process has to be carried out indoors, there is a problem in that special equipment is required, and furthermore, there is a problem in terms of production efficiency due to poor workability.
そこで本発明者らは、空気中でパッケージを密封する方
法について検討した。縫合糸はパッケージから取り出し
易いように台紙パネルに包装してからパッケージに入れ
るのが普通であるが、台紙に含まれている水分が多いと
縫合糸への水分の移行が起こると考えられるので、でき
るだけ含水率の低い紙を使用して縫合糸を包装し、これ
らを乾燥して縫合系の含水率を一定値以下にし、空気中
でパッケージを密封した。そして一定期間貯蔵後に取り
出して縫合糸の含水率を測定したところ、密封前の含水
率よりもかなり上昇していた。この理由は、パッケージ
内に封入された空気中の水分が、徐々に縫合糸に移行す
るためではないかと考えられるが、台紙パネルより縫合
糸へ水分が移行している可能性もある。したがって、空
気中でのパッケージの密封は、縫合糸の長期保存を目的
とする場合には問題があることがわかった。そして、本
発明者らは空気中でのパッケージの密封についてさらに
種々の検討を続けた結果、本発明に到達したものである
。Therefore, the present inventors investigated a method of sealing a package in air. Normally, sutures are wrapped in a mount panel and then placed in the package so that they can be easily removed from the package, but if the mount contains a lot of moisture, it is thought that moisture will migrate to the sutures. The sutures were packaged using paper with as low a moisture content as possible, dried to bring the moisture content of the suture system below a certain value, and the package was sealed in air. When the suture was taken out after storage for a certain period of time and the moisture content of the suture was measured, it was found to be significantly higher than the moisture content before sealing. The reason for this is thought to be that moisture in the air enclosed within the package gradually migrates to the suture, but it is also possible that moisture migrates from the mount panel to the suture. Therefore, sealing the package in air has been found to be problematic when long-term storage of sutures is intended. The present inventors continued various studies regarding the sealing of packages in air, and as a result, they arrived at the present invention.
すなわち本発明の目的は、空気中でパッケージを密封し
て′も長期保存の可能な包装方法を提供することにある
。That is, an object of the present invention is to provide a packaging method that allows long-term storage even when the package is sealed in air.
［問題点を解決するための手段］
上記の目的は、意外なことに、平衡含水率の高い紙を所
定含水率以下に乾燥して使用することによって達成でき
ることを見出した。[Means for Solving the Problems] It has surprisingly been found that the above object can be achieved by using paper with a high equilibrium moisture content after drying it to a predetermined moisture content or less.
すなわち本発明は、生体内の水分により加水分解されて
生体に吸収され得る材料からなる医療製品を乾燥し、水
蒸気非透過性の材料を用いて密封するに際して、２５℃
、７５％ＲＨにおける平衡含水率が３％以上の紙を、含
水率が２％以下になるように乾燥したものを共存せしめ
て空気中で密封することを特徴とする医療製品の包装方
法である。なお、長期保存のｊこめには医療製品を含水
率が０．５％以下、好ましくは０．２５％以下に乾燥す
るのが適当である。That is, the present invention provides a method for drying a medical product made of a material that can be hydrolyzed by moisture in the body and absorbed by the body, and sealing it with a water vapor impermeable material at 25°C.
, a method for packaging medical products, characterized by coexisting paper with an equilibrium moisture content of 3% or more at 75% RH, dried so that the moisture content is 2% or less, and sealing it in air. . For long-term storage, it is appropriate to dry the medical product to a moisture content of 0.5% or less, preferably 0.25% or less.
［作 用］
本発明の方法により包装を行うと、医療製品の含水率は
、密封後も変化しないかあるいは密封前よりも低くなる
ので、低含水率に維持することができ空気中で密封して
も長期保存が可能となる。[Function] When packaging is performed by the method of the present invention, the moisture content of the medical product does not change after sealing or becomes lower than before sealing, so the moisture content can be maintained at a low level and the product can be sealed in air. However, long-term storage is possible.
このような現象の起こる理由は明確ではない力（、保存
中に封入された空気及び製品中の水分が紙に移行するた
めと考えられる。しかしながら、紙の含水率が製品の含
水率より高いにもかかわらず起こることは、意外なこと
である。The reason why this phenomenon occurs is not clear, but it is thought that the trapped air and moisture in the product migrate to the paper during storage. However, if the moisture content of the paper is higher than the moisture content of the product, However, what happens is surprising.
［実施例］
本発明を適用し得る医療製品としては、縫合系、人工皮
膚、創傷被覆材、遊着防止材、骨プレート及び徐放性医
薬などを例示することができるが、本発明はこれらに限
定されるものではない。これらの医療製品であってその
一部または全部が加水分解により生体内で分解されて吸
収される材料から形成されたものの包装に本発明が適用
される。[Example] Examples of medical products to which the present invention can be applied include suture systems, artificial skin, wound dressings, adhesion prevention materials, bone plates, and sustained-release drugs. It is not limited to. The present invention is applied to the packaging of these medical products, some or all of which are formed from materials that are hydrolyzed and absorbed in the living body.
生体内の水分により加水分解されて生体に吸収され得る
材料としては、グリコール酸、乳酸、β−ヒドロキシブ
チルカルボン酸、β−プロピオラクトン、Ｔ−ブチロラ
クトン、δ−バレロラクトン、δ−カプロラクトン、ε
−カプロラクトン、メチル−ε−カプロラクトン、ｐ−
ジオキサノン、メチル−ｐ−ジオキサノン及びジメチル
−ｐ−ジオキサノン等から得られるホモ重合体及び共重
合体、β−マロラクトンの開環重合によって得られるポ
リエステルならびにエチレングリコール、プロピレング
リコール、ブチレングリコールなどのアルキレングリコ
ールとフェニレン−ビス−オキシアセテートとを重合し
て得られるポリエステルなどを例示することができる。Materials that can be hydrolyzed by moisture in the body and absorbed into the body include glycolic acid, lactic acid, β-hydroxybutylcarboxylic acid, β-propiolactone, T-butyrolactone, δ-valerolactone, δ-caprolactone, and ε.
-caprolactone, methyl-ε-caprolactone, p-
Homopolymers and copolymers obtained from dioxanone, methyl-p-dioxanone, dimethyl-p-dioxanone, etc., polyesters obtained by ring-opening polymerization of β-malolactone, and alkylene glycols such as ethylene glycol, propylene glycol, and butylene glycol. Examples include polyester obtained by polymerizing phenylene bis-oxyacetate.
これらは単独で使用したものであってもよいし複合して
使用したものであってもよい。These may be used alone or in combination.
本発明においては、２５℃、７５％ＲＨにおける平衡含
水率が３％以上の紙を使用する必要がある。平衡含水率
が３％以上であれば、どのような材質の紙でも使用する
ことができる。また、紙の大きさ、形状、厚さ等は目的
に応じて任意に選ぶことができ、医療製品が縫合系であ
るときは、台紙パネルをこのような紙で作れば便利であ
る。In the present invention, it is necessary to use paper with an equilibrium moisture content of 3% or more at 25° C. and 75% RH. Any paper material can be used as long as the equilibrium moisture content is 3% or more. Further, the size, shape, thickness, etc. of the paper can be arbitrarily selected depending on the purpose, and when the medical product is a suture type, it is convenient to make the mount panel from such paper.
本発明においては、上記の紙を含水率が２％以下になる
ように乾燥して用いる。これによって包装後の製品の含
水率が一定に維持されるか、あるいはさらに゛減少する
。もし紙の含水率が２％よりも大きいと、製品の含水率
は逆に増加するので好ましくない。紙は製品と共存した
状態で乾燥すれば、直ちに密封できるので便利であるが
、場合によっては紙を製品とは別に乾燥することもでき
る。In the present invention, the above-mentioned paper is used after being dried to a moisture content of 2% or less. This keeps the moisture content of the product constant or even reduces it after packaging. If the moisture content of the paper is greater than 2%, the moisture content of the product will increase, which is undesirable. If the paper is dried together with the product, it can be sealed immediately, which is convenient, but in some cases, the paper can also be dried separately from the product.
乾燥は常圧で乾燥気流中で行ってもよいし、減圧乾燥を
行うこともできる。しかし、いずれの乾燥法を採用する
にしても、包装の最終的な密封は空気中で行う。Drying may be carried out in a dry air stream at normal pressure, or may be carried out under reduced pressure. However, whichever drying method is used, the final sealing of the package is performed in air.
本発明において使用する水蒸気非透過性材料として最も
一般的なものは、アルミニウムなどの金属箔を積層した
フィルムである。フィルムは、２枚を合せて端部を熱シ
ールし袋状にして使用する。The most common water vapor impermeable material used in the present invention is a film laminated with metal foils such as aluminum. Two pieces of film are put together and the ends are heat-sealed to form a bag.
紙の乾燥は、このようなフィルムで作成した袋の１端の
みを開いた状態で紙と製品とを入れて実施すると、乾燥
終了後に直ちに開口端をシールして密封できる。If paper is dried by putting the paper and product into a bag made of such a film with only one end open, the open end can be sealed immediately after drying.
ところで、本発明を適用する医療製品は、通常は滅菌処
理を行うが、滅菌方法としてはエチレンオキサイド等に
よるガス滅菌が好ましい。また、放射線によ°る劣化の
少ないものは、放射線滅菌を行うこともできる。ガス滅
菌を行う場合には°、滅菌後に乾燥を実施すべきであり
、乾燥工程で製品の滅菌状態が維持されるようにしなけ
ればならない。そのためには乾燥工程を無菌室内で行う
方法もあるが、水蒸気非透過性材料からなる包装の外側
をさらにガス透過性で細菌非透過性の材料で密閉し、こ
の状態で滅菌、乾燥を行い、乾燥終了後、 に外側より
加熱して水蒸気非透過性材料をシールするようにすれば
、通常の作業環境下で作業を行うことができるので便利
である。By the way, medical products to which the present invention is applied are usually sterilized, and gas sterilization using ethylene oxide or the like is preferred as the sterilization method. Furthermore, if the material is less likely to deteriorate due to radiation, it can also be sterilized by radiation. If gas sterilization is used, drying should be performed after sterilization, and it must be ensured that the product remains sterile during the drying process. For this purpose, there is a method of performing the drying process in a sterile room, but the outside of the packaging made of water vapor impermeable material is further sealed with gas permeable and bacteria impermeable material, and sterilization and drying are carried out in this state. After drying, it is convenient to seal the water vapor impermeable material by heating it from the outside, as this allows work to be carried out under normal working conditions.
実施具体例 １
２５℃、７５％ＲＨにおける平衡含水率が６．０％の上
質紙（１５７ｇ／ｍ”）を９ ｃｍ Ｘ ６ｃｍの大き
さに切り、これでポリグリコール酸縫合糸を包んで種々
の含水率まで乾燥し、アルミニウム積層シートを用いて
空気中で密封した。次いで６０℃で８日間保存し、開封
して縫合糸の含水率を測定した。結果を表１に示す。Practical Example 1 A piece of high-quality paper (157 g/m") with an equilibrium moisture content of 6.0% at 25°C and 75% RH was cut into pieces of 9 cm x 6 cm, and polyglycolic acid sutures were wrapped in the paper and various The suture was dried to a moisture content of , and sealed in air using an aluminum laminated sheet.Then, it was stored at 60°C for 8 days, opened, and the moisture content of the suture was measured.The results are shown in Table 1.
表 １
表１から明らかなように、紙の含水率が２％よりも高い
と縫合糸の含水率は密封後に上昇するのに対して、２％
以下であれば逆に低下しており、長期保存が可能である
。Table 1 As is clear from Table 1, when the moisture content of the paper is higher than 2%, the moisture content of the suture increases after sealing;
If it is below, it is on the contrary decreasing and long-term storage is possible.
比較例 １
２５℃、７５％ＲＨにおける平衡含水率が０．２％の合
成紙（王子油化合成株式会社製、商品名ユボ）とポリグ
リコール酸縫合糸を使用し、実施具体例１と同様にして
乾燥及び保存を行った。含水率の測定結果を表２に示す
。Comparative Example 1 Synthetic paper with an equilibrium moisture content of 0.2% at 25°C and 75% RH (manufactured by Oji Yukasei Co., Ltd., trade name Yubo) and polyglycolic acid suture thread were used. Drying and storage were performed in the same manner. Table 2 shows the measurement results of moisture content.
表２
りも小さい紙を使用すると、密封包装後に縫合糸の含水
率が上昇するので、好ましくない。Table 2 It is undesirable to use paper that is too small because it increases the moisture content of the suture after it is sealed.
実施具体例 ２
２５℃、７５％ＲＨにおける平衡含水率が３．９％の紙
（十條製紙、商品名クリーンホワイト）を種々の含水率
まで乾燥し、別にポリグリコール酸縫合糸を含水率０．
０５２％まで乾燥した。次いで実施具体例１と同様にし
て両者を一緒に密封包装して保存し、縫合系の含水率の
変化を測定した。Practical Example 2 Paper (Jujo Paper Industries, trade name: Clean White) with an equilibrium moisture content of 3.9% at 25°C and 75% RH was dried to various moisture contents, and polyglycolic acid suture threads were separately dried to a moisture content of 0.9%.
It was dried to 0.52%. Then, in the same manner as in Example 1, both were sealed and stored together, and changes in the water content of the suture system were measured.
表３
［発明の効果コ
本発明によれば、加水分解性の医療製品を空気中で密封
するこζができ、しかも密封後の製品ｐ含水率を低く維
持することができる。したがって密封作業が゛簡単でか
つ製品を長期間安定して保存することができる利点があ
る。Table 3 [Effects of the Invention] According to the present invention, it is possible to seal a hydrolyzable medical product in the air, and moreover, it is possible to maintain a low water content of the product after sealing. Therefore, there are advantages in that the sealing operation is simple and the product can be stored stably for a long period of time.
Claims (4)
れ得る材料からなる医療製品を乾燥し水蒸気非透過性の
材料を用いて密封するに際して、２５℃、７５％ＲＨに
おける平衡含水率が３％以上の紙を、含水率が２％以下
になるように乾燥したものを共存せしめて空気中で密封
することを特徴とする医療製品の包装方法。(1) When drying a medical product made of a material that can be hydrolyzed by moisture in the body and absorbed by the body and sealing it with a water vapor impermeable material, the equilibrium moisture content at 25°C and 75% RH is 3. A method for packaging medical products, characterized by making paper with a moisture content of 2% or more coexist with paper that has been dried so that the moisture content is 2% or less, and sealing the paper in air.
る材料が、グリコール酸のホモ重合体である特許請求の
範囲第１項記載の包装方法。(2) The packaging method according to claim 1, wherein the material that is hydrolyzed by moisture in the body and absorbed by the body is a homopolymer of glycolic acid.
る材料が、乳酸のホモ重合体または共重合体である特許
請求の範囲第１項記載の包装方法。(3) The packaging method according to claim 1, wherein the material that is hydrolyzed by moisture in the body and absorbed by the body is a homopolymer or copolymer of lactic acid.
ルとして共存せしめる特許請求の範囲第１項記載の包装
方法。(4) The packaging method according to claim 1, wherein the medical product is a suture thread, and paper is made to coexist as a mount panel for the suture thread.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62081381A JPS63246149A (en) | 1987-04-02 | 1987-04-02 | Method for packing in vivo hydrolyzable medical product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62081381A JPS63246149A (en) | 1987-04-02 | 1987-04-02 | Method for packing in vivo hydrolyzable medical product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63246149A true JPS63246149A (en) | 1988-10-13 |
| JPH0481456B2 JPH0481456B2 (en) | 1992-12-24 |
Family
ID=13744719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62081381A Granted JPS63246149A (en) | 1987-04-02 | 1987-04-02 | Method for packing in vivo hydrolyzable medical product |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63246149A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0210115U (en) * | 1988-07-05 | 1990-01-23 |
-
1987
- 1987-04-02 JP JP62081381A patent/JPS63246149A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0210115U (en) * | 1988-07-05 | 1990-01-23 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0481456B2 (en) | 1992-12-24 |
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