JPS63257543A - 病原性増殖組織の破壊法 - Google Patents
病原性増殖組織の破壊法Info
- Publication number
- JPS63257543A JPS63257543A JP63074265A JP7426588A JPS63257543A JP S63257543 A JPS63257543 A JP S63257543A JP 63074265 A JP63074265 A JP 63074265A JP 7426588 A JP7426588 A JP 7426588A JP S63257543 A JPS63257543 A JP S63257543A
- Authority
- JP
- Japan
- Prior art keywords
- metal particles
- lipid
- ultrasound
- shock wave
- pathogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 31
- 230000001717 pathogenic effect Effects 0.000 title claims 18
- 238000009395 breeding Methods 0.000 title 1
- 230000001488 breeding effect Effects 0.000 title 1
- 239000002923 metal particle Substances 0.000 claims description 63
- 230000035939 shock Effects 0.000 claims description 53
- 150000002632 lipids Chemical class 0.000 claims description 45
- 210000004027 cell Anatomy 0.000 claims description 21
- 239000002502 liposome Substances 0.000 claims description 20
- 238000002604 ultrasonography Methods 0.000 claims description 18
- 238000000926 separation method Methods 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 11
- 230000006378 damage Effects 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 229910000510 noble metal Inorganic materials 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 6
- 230000001575 pathological effect Effects 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 239000000232 Lipid Bilayer Substances 0.000 claims description 5
- 210000000170 cell membrane Anatomy 0.000 claims description 5
- 229910052737 gold Inorganic materials 0.000 claims description 5
- 239000010931 gold Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims description 2
- 238000009217 hyperthermia therapy Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 230000008520 organization Effects 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 230000002062 proliferating effect Effects 0.000 claims 13
- 238000009210 therapy by ultrasound Methods 0.000 claims 5
- 238000002372 labelling Methods 0.000 claims 4
- 230000002950 deficient Effects 0.000 claims 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 230000005389 magnetism Effects 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000010970 precious metal Substances 0.000 description 3
- 238000010322 bone marrow transplantation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000002691 unilamellar liposome Substances 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical group 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000034153 membrane organization Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Laser Surgery Devices (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873710371 DE3710371A1 (de) | 1987-03-28 | 1987-03-28 | Zerstoerung von krankhaft veraenderten gewebezellen |
| DE3710371.7 | 1987-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63257543A true JPS63257543A (ja) | 1988-10-25 |
Family
ID=6324282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63074265A Pending JPS63257543A (ja) | 1987-03-28 | 1988-03-28 | 病原性増殖組織の破壊法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0284802A3 (fr) |
| JP (1) | JPS63257543A (fr) |
| DE (1) | DE3710371A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008039692A (ja) * | 2006-08-09 | 2008-02-21 | Canon Inc | 標的物質検出材料、及びその製造方法 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3741201A1 (de) | 1987-12-02 | 1989-06-15 | Schering Ag | Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung |
| DE3900433A1 (de) * | 1989-01-10 | 1990-07-12 | Schubert Werner | Verfahren und vorrichtung fuer die behandlung von erkrankungen mit ultraschallwellen |
| DE3921808A1 (de) * | 1989-07-03 | 1991-01-17 | Schubert Werner | Vorrichtung zur fokussierten stosswellenbehandlung von tumoren |
| US6645464B1 (en) * | 1998-07-30 | 2003-11-11 | James F. Hainfeld | Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy |
| DE102007000800A1 (de) * | 2007-10-01 | 2009-04-02 | Beiersdorf Ag | Vorrichtung und Verfahren zur Reduktion der Hautpigmentierung |
| CN102781350B (zh) | 2010-01-19 | 2016-09-14 | 得克萨斯大学体系董事会 | 产生高频冲击波的装置和系统以及使用方法 |
| AR087170A1 (es) * | 2011-07-15 | 2014-02-26 | Univ Texas | Aparato para generar ondas de choque terapeuticas y sus aplicaciones |
| EP2634246A1 (fr) * | 2012-03-02 | 2013-09-04 | Justus-Liebig-Universität Giessen | Dispositif et procédé d'identification, de séparation et/ou de manipulation spécifique au type de cellule d'au moins une cellule d'un système cellulaire ainsi que de micro-organismes |
| US11229575B2 (en) | 2015-05-12 | 2022-01-25 | Soliton, Inc. | Methods of treating cellulite and subcutaneous adipose tissue |
| EP3432985A4 (fr) | 2016-03-23 | 2019-11-20 | Soliton, Inc. | Système et procédé de nettoyage cutané par ondes acoustiques pulsées |
| TWI742110B (zh) | 2016-07-21 | 2021-10-11 | 美商席利通公司 | 具備改良電極壽命之快速脈波電動液壓脈衝產生裝置及使用該裝置生成壓縮聲波之方法 |
| KR102583380B1 (ko) | 2017-01-17 | 2023-10-04 | 솔리톤, 인코포레이티드 | 개선된 음향 파면을 갖는 급속 펄스 전기유압식（ｅｈ） 충격파 발생기 장치 |
| AU2018221251B2 (en) | 2017-02-19 | 2023-04-06 | Soliton, Inc. | Selective laser induced optical breakdown in biological medium |
| CA3135847A1 (fr) | 2019-04-03 | 2020-10-08 | Soliton, Inc. | Systemes, dispositifs et procedes de traitement de tissus et de la cellulite par subcision acoustique non invasive |
| CN113925572B (zh) * | 2021-11-10 | 2025-07-29 | 上海益超医疗器械有限公司 | 一种手术器械 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2628234A1 (de) * | 1976-06-24 | 1978-01-05 | Wolfgang Joachim Guettner | Hochfrequenz-apparaturen fuer industrielle sterilisation und fuer medizinische therapie und diagnostik |
| US4315514A (en) * | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
| DE3150512A1 (de) * | 1981-12-21 | 1983-06-30 | Battelle-Institut E.V., 6000 Frankfurt | "vorrichtung zur hyperthermiebehandlung von tumoren bei kleintieren" |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4610241A (en) * | 1984-07-03 | 1986-09-09 | Gordon Robert T | Atherosclerosis treatment method |
| CA1267840A (fr) * | 1984-11-23 | 1990-04-17 | Cary Arnet Presant | Methode de ciblage des tumeurs chez les humains |
| US4652257A (en) * | 1985-03-21 | 1987-03-24 | The United States Of America As Represented By The Secretary Of The Navy | Magnetically-localizable, polymerized lipid vesicles and method of disrupting same |
| DE3517020C1 (de) * | 1985-05-11 | 1986-08-28 | Dornier System Gmbh, 7990 Friedrichshafen | Beruehrungslose Bearbeitung,insbesondere Zerstoerung von kuenstlich hergestellten Werkstoffen,Bauteilen und Strukturteilen |
| US5041581A (en) * | 1985-10-18 | 1991-08-20 | The University Of Texas System Board Of Regents | Hydrophobic cis-platinum complexes efficiently incorporated into liposomes |
| DE3614657A1 (de) * | 1986-04-30 | 1987-11-05 | Dornier Medizintechnik | Pharmaka enthaltende lipidvesikel, verfahren zu ihrer herstellung und einbringung in den koerper eines lebewesens und freisetzung der in den lipidvesikeln enthaltende pharmaka |
-
1987
- 1987-03-28 DE DE19873710371 patent/DE3710371A1/de not_active Withdrawn
-
1988
- 1988-03-02 EP EP88103152A patent/EP0284802A3/fr not_active Withdrawn
- 1988-03-28 JP JP63074265A patent/JPS63257543A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008039692A (ja) * | 2006-08-09 | 2008-02-21 | Canon Inc | 標的物質検出材料、及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0284802A3 (fr) | 1988-12-28 |
| EP0284802A2 (fr) | 1988-10-05 |
| DE3710371A1 (de) | 1988-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS63257543A (ja) | 病原性増殖組織の破壊法 | |
| JPS62258315A (ja) | 薬剤を含有する脂質小胞、それらの製法および生体に導入する方法、および脂質小胞に含有される薬剤の放出法 | |
| Shen et al. | Adaptive control of nanomotor swarms for magnetic-field-programmed cancer cell destruction | |
| US5614502A (en) | High-pressure impulse transient drug delivery for the treatment of proliferative diseases | |
| Podaru et al. | Pulsed magnetic field induced fast drug release from magneto liposomes via ultrasound generation | |
| US6645464B1 (en) | Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy | |
| Reinišová et al. | Micro/nanomachines: what is needed for them to become a real force in cancer therapy? | |
| JP2008519642A (ja) | ナノ粒子を介した超音波治療および診断影像法 | |
| D’Ammando et al. | Sonodynamic therapy for the treatment of intracranial gliomas | |
| Nonaka et al. | Sonodynamic therapy consisting of focused ultrasound and a photosensitizer causes a selective antitumor effect in a rat intracranial glioma model | |
| Li et al. | Biomembrane‐inspired design of medical micro/nanorobots: from cytomembrane stealth cloaks to cellularized Trojan horses | |
| Pichot et al. | Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells | |
| Eisenbrey et al. | Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents | |
| Yao et al. | An experimental study: Treatment of subcutaneous c6 glioma in rats using acoustic droplet vaporization | |
| Salkho et al. | Liposomes as a promising ultrasound-triggered drug delivery system in cancer treatment | |
| Li et al. | Ultrasound meets nanomedicine: towards disease treatment and medical imaging | |
| Wang et al. | Sonodynamically induced apoptosis by protoporphyrin IX on hepatoma-22 cells in vitro | |
| Ou et al. | Tumor-homing bacterium-adsorbed liposomes encapsulating perfluorohexane/doxorubicin enhance pulsed-focused ultrasound for tumor therapy | |
| Nankya | Nanotechnology in Cancer Treatment: Targeted Drug Delivery | |
| CN110227065B (zh) | 叶酸靶向载NaHCO3脂质体及其在增强肿瘤免疫治疗效果方面的应用 | |
| Kajita et al. | Viability variation of T-cells under ultrasound exposure according to adhesion condition with bubbles | |
| Tran et al. | Ultrasound and microbubbles combined with gold nanoparticles enhanced the therapeutic effect of radiotherapy in breast cancer cells | |
| Mahmoud | The effect of ultrasound on the drug delivery of RGD-targeted liposomes | |
| Mohammad | Acoustically activated release of estrone-targeted liposomes used for breast cancer treatment | |
| KR20230064570A (ko) | 마이크로 버블-세포외 소포 복합체 |