JPS6340131B2 - - Google Patents

Info

Publication number: JPS6340131B2
Authority: JP; Japan
Prior art keywords: coating; tablets; minutes; coated; sprinkle
Prior art date: 1981-04-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP56055232A

Other languages

English (en)

Japanese (ja)

Other versions

JPS57171428A (en

Inventor

Yoshihiko Ikegami

Kozo Kurihara

Motoo Ichikawa

Hisanori Nakane

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-13

Filing date

1981-04-13

Publication date

1988-08-09

1981-04-13 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

1981-04-13 Priority to JP56055232A priority Critical patent/JPS57171428A/ja

1982-04-01 Priority to DE8282301744T priority patent/DE3265352D1/de

1982-04-01 Priority to EP82301744A priority patent/EP0063014B1/en

1982-04-13 Priority to ES511401A priority patent/ES8306019A1/es

1982-10-22 Publication of JPS57171428A publication Critical patent/JPS57171428A/ja

1984-04-19 Priority to US06/601,736 priority patent/US4533562A/en

1988-08-09 Publication of JPS6340131B2 publication Critical patent/JPS6340131B2/ja

Status Granted legal-status Critical Current

Links

239000007788 liquid Substances 0.000 claims description 41
229920000642 polymer Polymers 0.000 claims description 19
239000004014 plasticizer Substances 0.000 claims description 18
239000007787 solid Substances 0.000 claims description 15
229920001688 coating polymer Polymers 0.000 claims description 11
238000002360 preparation method Methods 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 10
229940079593 drug Drugs 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 2
239000003826 tablet Substances 0.000 description 86
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 56
238000000576 coating method Methods 0.000 description 55
239000011248 coating agent Substances 0.000 description 53
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 35
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 35
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 30
239000001087 glyceryl triacetate Substances 0.000 description 28
235000013773 glyceryl triacetate Nutrition 0.000 description 28
229960002622 triacetin Drugs 0.000 description 28
-1 carboxymethyl ethyl Chemical group 0.000 description 26
239000002245 particle Substances 0.000 description 25
238000000034 method Methods 0.000 description 23
239000000843 powder Substances 0.000 description 20
238000009423 ventilation Methods 0.000 description 19
238000005507 spraying Methods 0.000 description 17
239000007921 spray Substances 0.000 description 16
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 15
239000000126 substance Substances 0.000 description 15
229920002554 vinyl polymer Polymers 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
239000000243 solution Substances 0.000 description 13
239000000454 talc Substances 0.000 description 13
229910052623 talc Inorganic materials 0.000 description 13
238000007664 blowing Methods 0.000 description 12
239000001856 Ethyl cellulose Substances 0.000 description 11
235000019325 ethyl cellulose Nutrition 0.000 description 11
229920001249 ethyl cellulose Polymers 0.000 description 11
239000008187 granular material Substances 0.000 description 11
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 10
238000002156 mixing Methods 0.000 description 10
229940057838 polyethylene glycol 4000 Drugs 0.000 description 10
229920001577 copolymer Polymers 0.000 description 9
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 8
235000010980 cellulose Nutrition 0.000 description 8
229920002678 cellulose Polymers 0.000 description 8
239000001913 cellulose Substances 0.000 description 8
239000006185 dispersion Substances 0.000 description 8
239000000203 mixture Substances 0.000 description 8
230000003287 optical effect Effects 0.000 description 8
BTNNPSLJPBRMLZ-LGMDPLHJSA-N benfotiamine Chemical compound C=1C=CC=CC=1C(=O)SC(/CCOP(O)(O)=O)=C(/C)N(C=O)CC1=CN=C(C)N=C1N BTNNPSLJPBRMLZ-LGMDPLHJSA-N 0.000 description 7
229960002873 benfotiamine Drugs 0.000 description 7
239000000463 material Substances 0.000 description 7
SQABAALQCGKFFO-UHFFFAOYSA-N octanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC(O)=O SQABAALQCGKFFO-UHFFFAOYSA-N 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
238000010828 elution Methods 0.000 description 6
239000011812 mixed powder Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 6
238000010998 test method Methods 0.000 description 6
235000013339 cereals Nutrition 0.000 description 5
239000010419 fine particle Substances 0.000 description 5
239000003960 organic solvent Substances 0.000 description 5
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
229920000053 polysorbate 80 Polymers 0.000 description 5
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
229940081735 acetylcellulose Drugs 0.000 description 4
239000003125 aqueous solvent Substances 0.000 description 4
229920002301 cellulose acetate Polymers 0.000 description 4
239000007931 coated granule Substances 0.000 description 4
239000002662 enteric coated tablet Substances 0.000 description 4
239000012530 fluid Substances 0.000 description 4
239000001530 fumaric acid Substances 0.000 description 4
238000002844 melting Methods 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
229940068918 polyethylene glycol 400 Drugs 0.000 description 4
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
235000008429 bread Nutrition 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
239000001863 hydroxypropyl cellulose Substances 0.000 description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
229940093429 polyethylene glycol 6000 Drugs 0.000 description 3
239000012085 test solution Substances 0.000 description 3
239000001993 wax Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
239000004372 Polyvinyl alcohol Substances 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
235000010724 Wisteria floribunda Nutrition 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000002775 capsule Substances 0.000 description 2
229940084030 carboxymethylcellulose calcium Drugs 0.000 description 2
239000003086 colorant Substances 0.000 description 2
SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 2
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
239000008101 lactose Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000006187 pill Substances 0.000 description 2
229920002451 polyvinyl alcohol Polymers 0.000 description 2
239000008213 purified water Substances 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
229920003176 water-insoluble polymer Polymers 0.000 description 2
229920003169 water-soluble polymer Polymers 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
WQZGKKKJIJFFOK-CBPJZXOFSA-N D-Gulose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-CBPJZXOFSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 description 1
SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
150000001241 acetals Chemical class 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
VEHZBMGMMPZMRJ-UHFFFAOYSA-N acetic acid;2-(diethylamino)acetic acid Chemical compound CC(O)=O.CCN(CC)CC(O)=O VEHZBMGMMPZMRJ-UHFFFAOYSA-N 0.000 description 1
IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000005345 coagulation Methods 0.000 description 1
230000015271 coagulation Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
CRVGKGJPQYZRPT-UHFFFAOYSA-N diethylamino acetate Chemical compound CCN(CC)OC(C)=O CRVGKGJPQYZRPT-UHFFFAOYSA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
238000007720 emulsion polymerization reaction Methods 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
238000000227 grinding Methods 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229940063559 methacrylic acid Drugs 0.000 description 1
229920003145 methacrylic acid copolymer Polymers 0.000 description 1
229940117841 methacrylic acid copolymer Drugs 0.000 description 1
IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
229940102838 methylmethacrylate Drugs 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
239000000178 monomer Substances 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
229940079938 nitrocellulose Drugs 0.000 description 1
239000003973 paint Substances 0.000 description 1
239000008016 pharmaceutical coating Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
239000000049 pigment Substances 0.000 description 1
238000005498 polishing Methods 0.000 description 1
239000003505 polymerization initiator Substances 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229940075065 polyvinyl acetate Drugs 0.000 description 1
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
238000009495 sugar coating Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
239000012815 thermoplastic material Substances 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Glanulating (AREA)

JP56055232A 1981-04-13 1981-04-13 Preparation of coated solid preparation Granted JPS57171428A (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
JP56055232A JPS57171428A (en)	1981-04-13	1981-04-13	Preparation of coated solid preparation
DE8282301744T DE3265352D1 (en)	1981-04-13	1982-04-01	A method of preparing coated solid preparations
EP82301744A EP0063014B1 (en)	1981-04-13	1982-04-01	A method of preparing coated solid preparations
ES511401A ES8306019A1 (es)	1981-04-13	1982-04-13	Un metodo de revestimiento de un material solido farmaceuti-co
US06/601,736 US4533562A (en)	1981-04-13	1984-04-19	Method of preparing coated solid preparations

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP56055232A JPS57171428A (en)	1981-04-13	1981-04-13	Preparation of coated solid preparation

Publications (2)

Publication Number	Publication Date
JPS57171428A JPS57171428A (en)	1982-10-22
JPS6340131B2 true JPS6340131B2 (2)	1988-08-09

Family

ID=12992853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP56055232A Granted JPS57171428A (en)	1981-04-13	1981-04-13	Preparation of coated solid preparation

Country Status (5)

Country	Link
US (1)	US4533562A (2)
EP (1)	EP0063014B1 (2)
JP (1)	JPS57171428A (2)
DE (1)	DE3265352D1 (2)
ES (1)	ES8306019A1 (2)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58502097A (ja) *	1981-12-18	1983-12-08	キイ・フア−マシユ−テイカルズ・インコ−ポレイテツド	ポリビニルアルコ−ルおよびポリエチレングリコ−ルの拡張性格子
WO1984000004A1 (en) *	1982-06-14	1984-01-05	Key Pharma	Sustained release aspirin
DE3382392D1 (de) *	1982-07-09	1991-10-02	Key Pharma	Dosierungsart zur dauerhaften verabreichung von chinidin.
JPS5973529A (ja) *	1982-10-12	1984-04-25	Sankyo Co Ltd	被覆固形製剤の製造法
JPS59193831A (ja) *	1983-04-18	1984-11-02	Sankyo Co Ltd	腸溶性製剤の製造法
IT1169772B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Composizioni terapeutiche per uso orale contenenti sali stabili della s-adenosil-l-metionina
EP0147780A3 (en) *	1984-01-03	1987-03-11	Merck & Co. Inc.	Drug delivery device
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1982
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- 1982-04-13 ES ES511401A patent/ES8306019A1/es not_active Expired
1984
- 1984-04-19 US US06/601,736 patent/US4533562A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0063014B1 (en)	1985-08-14
DE3265352D1 (en)	1985-09-19
JPS57171428A (en)	1982-10-22
ES511401A0 (es)	1983-05-01
EP0063014A3 (en)	1983-01-19
EP0063014A2 (en)	1982-10-20
ES8306019A1 (es)	1983-05-01
US4533562A (en)	1985-08-06

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