JPS63500539A - イオン選択電極をもつセンサ− - Google Patents

イオン選択電極をもつセンサ−

Info

Publication number: JPS63500539A
Authority: JP; Japan
Prior art keywords: ion; selective; membrane; electrode; sensor
Prior art date: 1985-06-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP61503624A

Other languages

English (en)

Japanese (ja)

Inventor

コノヴァー，ギルバート

ミニアー，タッデウス

ウィリス，ジョン・ビー

Original Assignee

イーオーエス・テクノロジー・コーポレーション

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-27

Filing date

1986-06-25

Publication date

1988-02-25

1986-06-25 Application filed by イーオーエス・テクノロジー・コーポレーション filed Critical イーオーエス・テクノロジー・コーポレーション

1988-02-25 Publication of JPS63500539A publication Critical patent/JPS63500539A/ja

Status Pending legal-status Critical Current

Links

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239000000546 pharmaceutical excipient Substances 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
125000005498 phthalate group Chemical class 0.000 description 1
210000004508 polar body Anatomy 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
229920000056 polyoxyethylene ether Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001343 polytetrafluoroethylene Polymers 0.000 description 1
239000004810 polytetrafluoroethylene Substances 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229920002981 polyvinylidene fluoride Polymers 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
238000004313 potentiometry Methods 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
SCUZVMOVTVSBLE-UHFFFAOYSA-N prop-2-enenitrile;styrene Chemical compound C=CC#N.C=CC1=CC=CC=C1 SCUZVMOVTVSBLE-UHFFFAOYSA-N 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
235000021067 refined food Nutrition 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
230000035440 response to pH Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical class OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
OGFYIDCVDSATDC-UHFFFAOYSA-N silver silver Chemical compound [Ag].[Ag] OGFYIDCVDSATDC-UHFFFAOYSA-N 0.000 description 1
RDZTWEVXRGYCFV-UHFFFAOYSA-M sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate Chemical compound [Na+].OCCN1CCN(CCS([O-])(=O)=O)CC1 RDZTWEVXRGYCFV-UHFFFAOYSA-M 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
XOIQMTLWECTKJL-FBZUZRIGSA-M sodium;(2s,3r,4s)-4-[(2s,5r,7s,8r,9s)-2-[(2r,5s)-5-ethyl-5-[(2r,3s,5r)-5-[(2s,3s,5r,6r)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate Chemical compound [Na+].C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O2 XOIQMTLWECTKJL-FBZUZRIGSA-M 0.000 description 1
239000008279 sol Substances 0.000 description 1
239000004071 soot Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
229920000638 styrene acrylonitrile Polymers 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
239000012085 test solution Substances 0.000 description 1
YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000012546 transfer Methods 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
WTLBZVNBAKMVDP-UHFFFAOYSA-N tris(2-butoxyethyl) phosphate Chemical compound CCCCOCCOP(=O)(OCCOCCCC)OCCOCCCC WTLBZVNBAKMVDP-UHFFFAOYSA-N 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000003260 vortexing Methods 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Ecology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

JP61503624A 1985-06-27 1986-06-25 イオン選択電極をもつセンサ− Pending JPS63500539A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75052585A	1985-06-27	1985-06-27
US750525		1985-06-27

Publications (1)

Publication Number	Publication Date
JPS63500539A true JPS63500539A (ja)	1988-02-25

Family

ID=25018222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61503624A Pending JPS63500539A (ja)	1985-06-27	1986-06-25	イオン選択電極をもつセンサ−

Country Status (7)

Country	Link
EP (1)	EP0230449A1 (fr)
JP (1)	JPS63500539A (fr)
AU (1)	AU602868B2 (fr)
CA (1)	CA1257331A (fr)
DK (1)	DK98987A (fr)
IL (1)	IL79230A0 (fr)
WO (1)	WO1987000286A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2020516884A (ja) *	2017-04-12	2020-06-11	メディツィーニシェ・ウニヴェルジテート・インスブルックＭｅｄｉｚｉｎｉｓｃｈｅＵｎｉｖｅｒｓｉｔａｅｔＩｎｎｓｂｒｕｃｋ	ナトリウム濃度およびクレアチニン濃度の定量的決定のための手段
JP2022098478A (ja) *	2020-12-21	2022-07-01	エフホフマン－ラロッシュアクチェンゲゼルシャフト	センサアセンブリ

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7785587A (en) *	1986-07-21	1988-02-10	Ilex Corp.	A clinical chemistry analyzer
US4889613A (en) *	1987-09-11	1989-12-26	Beckman Instruments, Inc.	Analytical apparatus, electrode and sample container for use therewith
CA1307825C (fr) *	1987-12-09	1992-09-22	Michael H. Burnam	Methode et appareil pour l'analyse du sang par dosage unique
DK409188D0 (da) *	1988-07-21	1988-07-21	Radiometer As	Fremgangsmaade til maaling af en karakteristik i et fluidum
US5235526A (en) *	1990-11-27	1993-08-10	Solomat Limited	Multi-probed sonde including microprocessor
EP0752098B1 (fr) *	1994-03-22	2002-09-11	Hans Opl	Capteur de controle de l'activite ionique dans les liquides biologiques
JP3595907B2 (ja) *	1996-06-21	2004-12-02	デイド、ベーリング、インコーポレイテッド	イオン選択性電極製造のための組成物および方法
EP1258728B1 (fr)	1996-10-30	2012-05-30	F. Hoffmann-La Roche AG	Système synchronisé de test d'analytes
DE19747875A1 (de) *	1997-10-20	1999-05-06	Meinhard Prof Dr Knoll	Verfahren zum Messen veränderlicher Größen und Vorrichtung zum Durchführen des Verfahrens
DK0992790T3 (da)	1998-10-09	2008-11-24	Asulab Sa	Elektrokemisk föler i form af en tunge, der er let at manipulere
US7810380B2 (en)	2003-03-25	2010-10-12	Tearlab Research, Inc.	Systems and methods for collecting tear film and measuring tear film osmolarity
US7905134B2 (en)	2002-08-06	2011-03-15	The Regents Of The University Of California	Biomarker normalization
AU2005295106B2 (en)	2004-10-12	2012-03-15	Bayer Healthcare Llc	Concentration determination in a diffusion barrier layer
EP2142905B1 (fr) *	2007-04-16	2013-01-16	The Regents of the University of California	Normalisation de biomarqueur
ES2787027T3 (es)	2014-04-18	2020-10-14	Siemens Healthcare Diagnostics Inc	Membrana de detección de magnesio para el electrodo potenciométrico selectivo de iones para la medición de magnesio ionizado y métodos de uso de los mismos
CA2951859C (fr)	2014-06-12	2021-08-10	Siemens Healthcare Diagnostics Inc.	Reactifs pour capteurs a electrode selective a ion magnesium et procedes de production et d'utilisation de ceux-ci
EP3198257B1 (fr)	2014-09-23	2020-08-12	Tearlab Research, Inc.	Système pour intégration de collecte microfluidique de larme et analyse à écoulement latéral d'analytes d'intérêt
US10561405B2 (en)	2015-03-09	2020-02-18	CoreSyte, Inc.	Method for manufacturing a biological fluid sensor
US10327676B2 (en)	2015-03-09	2019-06-25	CoreSyte, Inc.	Device for measuring biological fluids
US9636061B2 (en)	2015-03-09	2017-05-02	CoreSyte, Inc.	System and method for measuring biological fluid biomarkers
US9579024B2 (en)	2015-03-09	2017-02-28	CoreSyte, Inc.	System and method for measuring biological fluid biomarkers
US11998319B2 (en)	2015-03-09	2024-06-04	CoreSyte, Inc.	Device for measuring biological fluids
US9622725B2 (en)	2015-03-09	2017-04-18	CoreSyte, Inc.	Method for manufacturing a biological fluid sensor
US9645133B2 (en)	2015-03-09	2017-05-09	CoreSyte, Inc.	Method for manufacturing a biological fluid sensor
US11389087B2 (en)	2015-03-09	2022-07-19	CoreSyte, Inc.	Device for measuring biological fluids
US9883827B2 (en)	2015-03-09	2018-02-06	CoreSyte, Inc.	System and method for measuring biological fluid biomarkers
WO2016144529A1 (fr) *	2015-03-09	2016-09-15	CoreSyte, Inc.	Procédés de fabrication de dispositifs de type capteurs de fluides biologiques et dispositifs, systèmes, et procédés de mesure de fluides biologiques
US11883011B2 (en)	2015-03-09	2024-01-30	CoreSyte, Inc.	Method for manufacturing a biological fluid sensor
US10925499B2 (en)	2017-03-02	2021-02-23	SP Global, Inc.	System and method for using integrated sensor arrays to measure and analyze multiple biosignatures in real time
US11016074B2 (en)	2018-03-29	2021-05-25	Ecowater Systems, Llc	Apparatus for measuring water hardness using ion selective electrode
CN121410077B (zh) *	2025-12-30	2026-04-07	四川省科源工程技术测试中心有限责任公司	基于电化学控制变量分析法的土壤成分测定装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4053381A (en) *	1976-05-19	1977-10-11	Eastman Kodak Company	Device for determining ionic activity of components of liquid drops
US4214968A (en) *	1978-04-05	1980-07-29	Eastman Kodak Company	Ion-selective electrode
US4225410A (en) *	1978-12-04	1980-09-30	Technicon Instruments Corporation	Integrated array of electrochemical sensors
US4273639A (en) *	1979-06-20	1981-06-16	Eastman Kodak Company	Capillary bridge in apparatus for determining ionic activity
US4413407A (en) *	1980-03-10	1983-11-08	Eastman Kodak Company	Method for forming an electrode-containing device with capillary transport between electrodes
JPS58140635A (ja) *	1982-02-16	1983-08-20	Fuji Photo Film Co Ltd	液体移送分配装置およびイオン活量測定器具

1986
- 1986-06-25 AU AU61244/86A patent/AU602868B2/en not_active Expired - Fee Related
- 1986-06-25 JP JP61503624A patent/JPS63500539A/ja active Pending
- 1986-06-25 IL IL79230A patent/IL79230A0/xx unknown
- 1986-06-25 WO PCT/US1986/001370 patent/WO1987000286A1/fr not_active Ceased
- 1986-06-25 EP EP86904582A patent/EP0230449A1/fr not_active Withdrawn
- 1986-06-27 CA CA000512665A patent/CA1257331A/fr not_active Expired
1987
- 1987-02-26 DK DK098987A patent/DK98987A/da not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2020516884A (ja) *	2017-04-12	2020-06-11	メディツィーニシェ・ウニヴェルジテート・インスブルックＭｅｄｉｚｉｎｉｓｃｈｅＵｎｉｖｅｒｓｉｔａｅｔＩｎｎｓｂｒｕｃｋ	ナトリウム濃度およびクレアチニン濃度の定量的決定のための手段
JP2022098478A (ja) *	2020-12-21	2022-07-01	エフホフマン－ラロッシュアクチェンゲゼルシャフト	センサアセンブリ
JP2023085487A (ja) *	2020-12-21	2023-06-20	エフホフマン－ラロッシュアクチェンゲゼルシャフト	センサアセンブリ

Also Published As

Publication number	Publication date
IL79230A0 (en)	1986-09-30
EP0230449A1 (fr)	1987-08-05
AU602868B2 (en)	1990-11-01
DK98987D0 (da)	1987-02-26
CA1257331A (fr)	1989-07-11
WO1987000286A1 (fr)	1987-01-15
AU6124486A (en)	1987-01-30
DK98987A (da)	1987-04-27

Publication	Publication Date	Title
US4713165A (en)	1987-12-15	Sensor having ion-selective electrodes
AU602868B2 (en)	1990-11-01	Sensor having ion-selective electrodes
Eggenstein et al.	1999	A disposable biosensor for urea determination in blood based on an ammonium-sensitive transducer
Solsky	2002	Ion-selective electrodes
JPS62116252A (ja)	1987-05-27	電気化学分析の方法及び装置
US5779867A (en)	1998-07-14	Dry chemistry glucose sensor
JP7618702B2 (ja)	2025-01-21	単回使用ディスポーザブル参照センサ
Solsky et al.	1981	Preparation and properties of an antibody-selective membrane electrode
EP1269174A2 (fr)	2003-01-02	Electrode a selectivite d'ions lithium pour applications cliniques
AU2001247614A1 (en)	2001-12-20	Lithium ion-selective electrode for clinical applications
US4708776A (en)	1987-11-24	Sodium ion selective electrode and method of use
US3896008A (en)	1975-07-22	Electrochemical potentiometric method for selectively determining alkaline phosphatase content in aqueous fluids
Campanella et al.	1990	Suitable potentiometric enzyme sensors for urea and creatinine
EP0228456A1 (fr)	1987-07-15	Ionophores et membranes selectives aux ions contenant lesdits ionophores
JPS6097250A (ja)	1985-05-31	特定の酵素／イオン発生団対を使用する診断用電極膜
US4399002A (en)	1983-08-16	Large organic cation-selective electrodes
JPH06507479A (ja)	1994-08-25	センサデバイス
JP4662615B2 (ja)	2011-03-30	乾式操作型イオン選択性電極及び液体中のイオンの存在又は量の決定法
EP0741796B1 (fr)	1998-06-10	Dispositif de detection
US20010051109A1 (en)	2001-12-13	Enzymatic analysis system
Chen et al.	2000	Optical urea biosensor based on ammonium ion selective membrane
Altikatoglu et al.	2013	Novel creatine biosensors based on all solid-state contact ammonium-selective membrane electrodes
Poklonnov et al.	2022	Voltammetric studies of glutathione transfer across arrays of liquid–liquid microinterfaces for sensing applications
Aidil et al.	2021	Electrochemical detection of tributyrin using gold nanoparticle functionalized screen-printed electrode
JPH0943191A (ja)	1997-02-14	塩素イオンセンサ