JPS63502928A - 自己免疫病の診断法及び診断試薬、自己免疫病の治療剤並びにこれに好適な抗パラタイプ抗体 - Google Patents

自己免疫病の診断法及び診断試薬、自己免疫病の治療剤並びにこれに好適な抗パラタイプ抗体

Info

Publication number
JPS63502928A
JPS63502928A JP62501823A JP50182387A JPS63502928A JP S63502928 A JPS63502928 A JP S63502928A JP 62501823 A JP62501823 A JP 62501823A JP 50182387 A JP50182387 A JP 50182387A JP S63502928 A JPS63502928 A JP S63502928A
Authority
JP
Japan
Prior art keywords
antibody
disease
paratype
thyroid
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62501823A
Other languages
English (en)
Japanese (ja)
Inventor
ウザデル，クラウス‐ヘニング
トイバー，ヨーゼフ　フオルカー
Original Assignee
ベーリンガー　マンハイム　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーリンガー　マンハイム　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング filed Critical ベーリンガー　マンハイム　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング
Publication of JPS63502928A publication Critical patent/JPS63502928A/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP62501823A 1986-03-19 1987-03-13 自己免疫病の診断法及び診断試薬、自己免疫病の治療剤並びにこれに好適な抗パラタイプ抗体 Pending JPS63502928A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3609271.1 1986-03-19
DE19863609271 DE3609271A1 (de) 1986-03-19 1986-03-19 Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper

Publications (1)

Publication Number Publication Date
JPS63502928A true JPS63502928A (ja) 1988-10-27

Family

ID=6296775

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62501823A Pending JPS63502928A (ja) 1986-03-19 1987-03-13 自己免疫病の診断法及び診断試薬、自己免疫病の治療剤並びにこれに好適な抗パラタイプ抗体

Country Status (5)

Country Link
EP (1) EP0263135A1 (de)
JP (1) JPS63502928A (de)
AU (1) AU7160887A (de)
DE (2) DE3609271A1 (de)
WO (1) WO1987005703A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341277C (en) * 1987-03-16 2001-07-31 Roland Keith Mcgready Anti-paratopic antibody and a method of its manufacture
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
EP0433509B1 (de) * 1989-12-14 1996-11-13 B.R.A.H.M.S Diagnostica GmbH Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
FR2657014A1 (fr) * 1990-01-15 1991-07-19 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur.
WO1991018628A1 (en) * 1990-06-08 1991-12-12 Symbicom Aktiebolag Therapy and prophylaxis of autoimmune diseases
US5691151A (en) * 1994-10-07 1997-11-25 Regents Of University Of California Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692416A (en) * 1982-12-03 1987-09-08 Yeshiva University Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus
EP0133540A1 (de) * 1983-08-03 1985-02-27 E.I. Du Pont De Nemours And Company Rezeptorbestimmungen unter Verwendung markierter, monoclonaler, anti-idiotypischer Antikörper
US4828981A (en) * 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
FR2568585B1 (fr) * 1984-08-06 1988-08-12 Centre Nat Rech Scient Nouvelles cellules hybrides secretant des anticorps anti-idiotypiques, nouveaux anticorps monoclonaux secretes par lesdites cellules hybrides, leur preparation et leur application
AU4777385A (en) * 1984-08-27 1986-03-24 Trustees Of Columbia University In The City Of New York, The Method of producing monoclonal anti-idiotypic antibodies 0
US4699880A (en) * 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody

Also Published As

Publication number Publication date
EP0263135A1 (de) 1988-04-13
DE3609271A1 (de) 1987-09-24
DE3790139D2 (en) 1988-08-25
WO1987005703A1 (fr) 1987-09-24
AU7160887A (en) 1987-10-09

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