JPS6411616B2 - - Google Patents

Info

Publication number: JPS6411616B2
Authority: JP; Japan
Prior art keywords: lemongrass oil; aggregation; lemongrass; aspirin; oil
Prior art date: 1985-02-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP60035486A

Other languages

English (en)

Japanese (ja)

Other versions

JPS61194017A (ja

Inventor

Susumu Ooshiba

Terumi Tamada

Hiroshi Matsuta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

REMON GURASU FUUDO KK

Original Assignee

REMON GURASU FUUDO KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-25

Filing date

1985-02-25

Publication date

1989-02-27

1985-02-25 Application filed by REMON GURASU FUUDO KK filed Critical REMON GURASU FUUDO KK

1985-02-25 Priority to JP60035486A priority Critical patent/JPS61194017A/ja

1986-08-28 Publication of JPS61194017A publication Critical patent/JPS61194017A/ja

1989-02-27 Publication of JPS6411616B2 publication Critical patent/JPS6411616B2/ja

Status Granted legal-status Critical Current

Links

239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 claims description 58
GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 24
239000004480 active ingredient Substances 0.000 claims description 23
239000003146 anticoagulant agent Substances 0.000 claims description 12
QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 claims description 12
WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims description 10
229960004676 antithrombotic agent Drugs 0.000 claims description 9
WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims description 8
229940043350 citral Drugs 0.000 claims description 8
QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 claims description 6
GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 6
239000005792 Geraniol Substances 0.000 claims description 6
GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 claims description 6
JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 claims description 6
235000000484 citronellol Nutrition 0.000 claims description 6
229940113087 geraniol Drugs 0.000 claims description 6
WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 claims description 5
OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 claims description 5
229940088601 alpha-terpineol Drugs 0.000 claims description 5
229940087305 limonene Drugs 0.000 claims description 2
150000003505 terpenes Chemical class 0.000 claims description 2
235000007586 terpenes Nutrition 0.000 claims description 2
XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
235000001510 limonene Nutrition 0.000 claims 1
230000002776 aggregation Effects 0.000 description 33
238000004220 aggregation Methods 0.000 description 33
230000000694 effects Effects 0.000 description 23
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 20
229960001138 acetylsalicylic acid Drugs 0.000 description 20
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 18
241000283973 Oryctolagus cuniculus Species 0.000 description 15
210000004623 platelet-rich plasma Anatomy 0.000 description 14
240000004784 Cymbopogon citratus Species 0.000 description 13
235000017897 Cymbopogon citratus Nutrition 0.000 description 13
102000008186 Collagen Human genes 0.000 description 11
108010035532 Collagen Proteins 0.000 description 11
229920001436 collagen Polymers 0.000 description 11
230000002401 inhibitory effect Effects 0.000 description 11
XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 10
238000010494 dissociation reaction Methods 0.000 description 10
230000005593 dissociations Effects 0.000 description 10
239000004615 ingredient Substances 0.000 description 10
XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 9
XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 9
229940114079 arachidonic acid Drugs 0.000 description 9
235000021342 arachidonic acid Nutrition 0.000 description 9
238000012360 testing method Methods 0.000 description 9
230000005764 inhibitory process Effects 0.000 description 7
238000000034 method Methods 0.000 description 7
208000010110 spontaneous platelet aggregation Diseases 0.000 description 7
230000001737 promoting effect Effects 0.000 description 6
239000000126 substance Substances 0.000 description 6
238000002834 transmittance Methods 0.000 description 6
241000196324 Embryophyta Species 0.000 description 5
229940127218 antiplatelet drug Drugs 0.000 description 5
239000000106 platelet aggregation inhibitor Substances 0.000 description 5
201000010099 disease Diseases 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
239000003814 drug Substances 0.000 description 4
241000699670 Mus sp. Species 0.000 description 3
206010050661 Platelet aggregation inhibition Diseases 0.000 description 3
231100000673 dose–response relationship Toxicity 0.000 description 3
229940079593 drug Drugs 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
239000003921 oil Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
231100000216 vascular lesion Toxicity 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 description 2
101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 description 2
208000002249 Diabetes Complications Diseases 0.000 description 2
206010012655 Diabetic complications Diseases 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
230000009471 action Effects 0.000 description 2
231100000403 acute toxicity Toxicity 0.000 description 2
230000007059 acute toxicity Effects 0.000 description 2
150000001299 aldehydes Chemical class 0.000 description 2
230000002785 anti-thrombosis Effects 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229930003658 monoterpene Natural products 0.000 description 2
150000002773 monoterpene derivatives Chemical class 0.000 description 2
235000002577 monoterpenes Nutrition 0.000 description 2
WTEVQBCEXWBHNA-YFHOEESVSA-N neral Chemical compound CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
230000003449 preventive effect Effects 0.000 description 2
230000008569 process Effects 0.000 description 2
239000007901 soft capsule Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
244000215068 Acacia senegal Species 0.000 description 1
206010003210 Arteriosclerosis Diseases 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
240000007711 Peperomia pellucida Species 0.000 description 1
208000013544 Platelet disease Diseases 0.000 description 1
241000209504 Poaceae Species 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
238000011047 acute toxicity test Methods 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000000702 anti-platelet effect Effects 0.000 description 1
229940127217 antithrombotic drug Drugs 0.000 description 1
208000011775 arteriosclerosis disease Diseases 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
238000009835 boiling Methods 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000008859 change Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
238000004817 gas chromatography Methods 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
239000002075 main ingredient Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
239000010446 mirabilite Substances 0.000 description 1
230000001151 other effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
235000013599 spices Nutrition 0.000 description 1
238000001256 steam distillation Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229940116411 terpineol Drugs 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Landscapes

Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP60035486A 1985-02-25 1985-02-25 抗血栓剤 Granted JPS61194017A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP60035486A JPS61194017A (ja)	1985-02-25	1985-02-25	抗血栓剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP60035486A JPS61194017A (ja)	1985-02-25	1985-02-25	抗血栓剤

Publications (2)

Publication Number	Publication Date
JPS61194017A JPS61194017A (ja)	1986-08-28
JPS6411616B2 true JPS6411616B2 (de)	1989-02-27

Family

ID=12443076

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP60035486A Granted JPS61194017A (ja)	1985-02-25	1985-02-25	抗血栓剤

Country Status (1)

Country	Link
JP (1)	JPS61194017A (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2012051906A (ja) *	2011-10-05	2012-03-15	Ichimaru Pharcos Co Ltd	トリプシン阻害剤

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2613714B2 (ja) *	1992-03-04	1997-05-28	義秀萩原	ヒト血小板凝集阻害剤
JP2001278802A (ja) *	2000-03-30	2001-10-10	Hiroyuki Sumi	血栓予防剤
JP5452975B2 (ja) *	2008-05-21	2014-03-26	株式会社ロッテ	内服用虫よけ剤
CN118987008B (zh) *	2024-08-09	2025-06-24	皖西学院	调节血小板聚集的组合物、以血小板衍生生长因子受体α为靶点的筛选方法及应用

1985
- 1985-02-25 JP JP60035486A patent/JPS61194017A/ja active Granted

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2012051906A (ja) *	2011-10-05	2012-03-15	Ichimaru Pharcos Co Ltd	トリプシン阻害剤

Also Published As

Publication number	Publication date
JPS61194017A (ja)	1986-08-28

Publication	Publication Date	Title
SU1442068A3 (ru)	1988-11-30	Способ получени производных хинона
AU2002348802A1 (en)	2003-06-30	Compositions containeing curcuma extracts for the treatment of neurocerebrovascular disorders
JPH06197735A (ja)	1994-07-19	食品組成物
JPH0283320A (ja)	1990-03-23	腫瘍予防剤
JP4907750B2 (ja)	2012-04-04	サトウキビ・ワックスから得られる第一級脂肪酸の混合物
JP2000239297A (ja)	2000-09-05	薬効を有する梅抽出物およびそれを含有する組成物
AU2021204271A1 (en)	2021-07-22	Synergistic composition for osteoarthritis
JPS6411616B2 (de)	1989-02-27
DD299153A5 (de)	1992-04-02	Kombinationspraeparat mit antithrombotischer wirkung
JP4169245B2 (ja)	2008-10-22	カフェー酸誘導体を有効成分とする抗アレルギー剤
Guedes et al.	2024	Anti-hemostatic, antithrombotic, and chemical profiles of a curly-leaf variety of Petroselinum crispum (Apiaceae), a food and medicinal aromatic herb
JPH03251514A (ja)	1991-11-11	メラニン分解物質
JP2005350432A (ja)	2005-12-22	プロスタサイクリン生成促進剤
JPS6323819A (ja)	1988-02-01	血小板凝集抑制剤
JP2004315391A (ja)	2004-11-11	オリーブ果実抽出物およびその製造方法
JP7339698B2 (ja)	2023-09-06	野せり抽出物および抗血栓剤を含む抗血栓用組成物
JPH04178324A (ja)	1992-06-25	カルシウム拮抗剤
KR100491439B1 (ko)	2005-05-24	혈소판 응집 억제활성이 우수한 필발 나무 추출물 및 이의용도
JPS61291525A (ja)	1986-12-22	レンギヨウ及び／又はこの近縁種を原料とするアレルギ−及び成人病予防食品
JP2022020257A (ja)	2022-02-01	抗カンジダ活性を有する組成物
Konno et al.	1979	Accumulation of Phosvel in adipose tissue of hens
KR100543180B1 (ko)	2006-01-20	혈소판 응집 억제활성이 우수한 알카로이드계 화합물
JP4541635B2 (ja)	2010-09-08	トロンボキサンａ２合成酵素阻害剤
JPS5978118A (ja)	1984-05-04	血栓症治療および予防剤
JPH0319210B2 (de)	1991-03-14

JPS6411616B2 - - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=12443076

Family Applications (1)

Country Status (1)

Cited By (1)

Families Citing this family (4)

Cited By (1)

Also Published As

Similar Documents