JPS6411618B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a therapeutic agent for athlete's foot. In Japan, temperatures rise from spring to summer, and the climate becomes hot and humid, especially during the rainy season.
This creates the most suitable environment for the growth of ringworm. Furthermore, as lifestyles change, people increasingly wear shoes for long periods of time, and synthetic fibers with low hygroscopic properties are increasingly being used for socks, leading to an increasing number of people suffering from athlete's foot. What is generally referred to as athlete's foot is caused by the parasitism of the tinea fungus on the skin. When infected with athlete's foot, various symptoms such as itching, pain, rash, and blisters appear on the skin, and in severe cases. Even the nails are affected. After contracting athlete's foot once, the unique symptoms of athlete's foot recur every summer, and many people are troubled by it. In other words, when conventional medicines are used to treat athlete's foot, the hyphae of Trichophyton disappear, but only the spores remain and the condition appears to have been cured, but the spores survive by hiding in the sweat glands and pores, so if appropriate When the temperature and humidity increase, the ringworm fungus becomes active again and symptoms of athlete's foot appear. Many drugs have been invented to treat athlete's foot, but nothing groundbreaking has yet been developed. Although it is known that lower and intermediate fatty acids have a bactericidal effect against Trichophyton, they have the drawback of being extremely uncomfortable to use due to their unpleasant odor and skin irritation. In addition, although drugs such as antibiotics and organic mercury agents have been invented to completely cure athlete's foot, they are highly toxic and often cause the affected area to swell and have side effects. As a result of intensive research, the present inventors have invented a therapeutic agent for athlete's foot that does not have such drawbacks. The present invention is a therapeutic agent for athlete's foot characterized by containing a glycerin ester of a carboxylic acid having 2 to 14 carbon atoms as an active ingredient. Suitable carboxylic acids serving as raw materials for the glycerin ester used in the present invention have 2 to 14 carbon atoms, such as acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid, pelargonic acid, and capric acid. , undecanoic acid, lauric acid, tridecanoic acid, myristic acid, isobutyric acid, 2
-Ethylhexanoic acid, 3.5.5-trimethylhexanoic acid, pivalic acid, and commercially available versatic acid, neoacid, etc., and these may be used alone or in combination of two or more. Those using carboxylic acids outside the above range have a small bactericidal effect. The glycerin ester used in the present invention is synthesized by the usual esterification reaction of carboxylic acid and glycerin, and then purified through removal of unreacted carboxylic acid, decolorization, deodorization, etc., or it is produced by refining natural oils and fats. It is something. As the athlete's foot treatment agent in the present invention, all of the monoglycerides, diglycerides, and triglycerides of the above-mentioned carboxylic acids can be used;
Species or mixtures of two or more species can be used. Examples of carboxylic acid glycerin esters used in the present invention include acetic acid mono, di, triglyceride; propionic acid mono, di, triglyceride; butyric acid mono, di, triglyceride; valeric acid mono, di, triglyceride; caproic acid mono, di, triglyceride. : Enanthate mono, di, triglyceride; caprylic acid mono, di, triglyceride; pelargonic acid mono, di, triglyceride; capric acid mono, di, triglyceride;
G, triglyceride; undecanoic acid mono, G, triglyceride; lauric acid mono, G,
Triglyceride; tridecanoic acid mono, di, triglyceride; myristic acid mono, di, triglyceride; 2-ethylhexanoic acid mono, di, triglyceride; monocaproic acid dicaprylic acid triglyceride; monocaprylic acid dicaprylic acid triglyceride; monolauric acid dicaprylic acid triglyceride; monomyristin Examples include acid dicaprylic acid triglyceride; acetin fat; coconut oil, palm oil and mono- or diglycerides derived therefrom. The glycerin ester of carboxylic acid used in the present invention is a liquid or semi-solid compound at room temperature, is colorless and odorless, and is not only non-irritating to the skin, but also has a skin protective effect. It has a strong ability to penetrate the skin, and has a strong bactericidal effect against ringworm and other molds as well as athlete's foot. Furthermore, the athlete's foot treatment agent of the present invention has excellent performance as a solvent and dissolves well in conventionally used sterilizing and disinfecting drugs, solvents, or ointment bases, so it can be used in combination with these. It is. Examples of the above drugs include salicylic acid, mether salicylate, benzalkonium chloride, boric acid, N
Examples of solvents or ointment bases include water, ethanol, glycerin, ethylene glycol, propylene glycol, mineral oil, vaseline, paraffin, fats and waxes. By applying the athlete's foot treatment agent of the present invention to the affected area, those with mild symptoms will be cured in 10 to 15 days, and those with severe symptoms will rapidly recover in about one week and be cured in three to four weeks. Next, the present invention will be explained with reference to examples. Example: Apply the athlete's foot treatment agent of the present invention to the affected area of an athlete's foot patient once every morning.
The condition of the affected area and the progress of treatment were observed every day. The results are shown in Table 1.

【table】

[Table] As is clear from Table 1, the therapeutic agent for athlete's foot of the present invention has an extremely excellent therapeutic effect. It also had no odor or skin irritation, and had good affinity with the skin.

Claims (1)

[Claims] 1. A therapeutic agent for athlete's foot, characterized by containing a glycerin ester of a carboxylic acid having 2 to 14 carbon atoms as an active ingredient.