JPS6419082A - Cephalosporine derivative and its production - Google Patents

Cephalosporine derivative and its production

Info

Publication number
JPS6419082A
JPS6419082A JP62336812A JP33681287A JPS6419082A JP S6419082 A JPS6419082 A JP S6419082A JP 62336812 A JP62336812 A JP 62336812A JP 33681287 A JP33681287 A JP 33681287A JP S6419082 A JPS6419082 A JP S6419082A
Authority
JP
Japan
Prior art keywords
production
cephalosporine derivative
cephalosporine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62336812A
Other languages
English (en)
Other versions
JPH0670068B2 (ja
Inventor
Ratoreru Rudorufu
Biidobirudo Manfuretsudo
Deyurukuhaimaa Warutaa
Buramubatsuha Yurugen
Shiigaa Kaaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPS6419082A publication Critical patent/JPS6419082A/ja
Publication of JPH0670068B2 publication Critical patent/JPH0670068B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP62336812A 1981-05-12 1987-12-28 セファロスポリン誘導体 Expired - Lifetime JPH0670068B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813118732 DE3118732A1 (de) 1981-05-12 1981-05-12 Cephalosporinderivate und verfahren zu ihrer herstellung
DE3118732.3 1981-05-12

Publications (2)

Publication Number Publication Date
JPS6419082A true JPS6419082A (en) 1989-01-23
JPH0670068B2 JPH0670068B2 (ja) 1994-09-07

Family

ID=6132055

Family Applications (2)

Application Number Title Priority Date Filing Date
JP57078063A Granted JPS57192394A (en) 1981-05-12 1982-05-10 Cephalosporin derivatives and manufacture
JP62336812A Expired - Lifetime JPH0670068B2 (ja) 1981-05-12 1987-12-28 セファロスポリン誘導体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP57078063A Granted JPS57192394A (en) 1981-05-12 1982-05-10 Cephalosporin derivatives and manufacture

Country Status (36)

Country Link
US (1) US5071979A (ja)
EP (1) EP0064740B1 (ja)
JP (2) JPS57192394A (ja)
KR (1) KR880001541B1 (ja)
AR (1) AR241186A1 (ja)
AT (2) ATE19085T1 (ja)
AU (1) AU559727B2 (ja)
BE (1) BE893163A (ja)
BG (1) BG60838B2 (ja)
CA (1) CA1228850A (ja)
CH (1) CH654312A5 (ja)
CS (2) CS248025B2 (ja)
DD (1) DD202720A5 (ja)
DE (2) DE3118732A1 (ja)
DK (1) DK166500B1 (ja)
DZ (1) DZ418A1 (ja)
ES (1) ES8304143A1 (ja)
FI (1) FI70715C (ja)
FR (2) FR2511682B1 (ja)
GB (2) GB2098216B (ja)
GR (1) GR75506B (ja)
HU (1) HU186019B (ja)
IE (1) IE53296B1 (ja)
IL (1) IL65737A (ja)
IT (1) IT1157275B (ja)
LU (1) LU88736I2 (ja)
MA (1) MA19474A1 (ja)
MT (1) MTP909B (ja)
NL (3) NL8201913A (ja)
NO (2) NO162022C (ja)
NZ (1) NZ200567A (ja)
PH (1) PH20243A (ja)
PT (1) PT74877B (ja)
SE (1) SE8202961L (ja)
YU (1) YU44346B (ja)
ZA (1) ZA823226B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006348961A (ja) * 2005-06-13 2006-12-28 Kawasaki Shipbuilding Corp 壁掛機器用防振支持構造

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR76701B (ja) * 1981-09-08 1984-08-29 Lilly Co Eli
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
DE3374410D1 (en) * 1982-06-28 1987-12-17 Bristol Myers Co Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
DE3247613A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
ZA847926B (en) * 1983-10-17 1986-05-28 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
JPS6094984A (ja) * 1983-10-28 1985-05-28 Dai Ichi Seiyaku Co Ltd セフエム誘導体
GB8401093D0 (en) * 1984-01-16 1984-02-15 Fujisawa Pharmaceutical Co Cephem compounds
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
JPS60222490A (ja) * 1984-04-17 1985-11-07 Dai Ichi Seiyaku Co Ltd セフアロスポリン誘導体およびその塩
IL74822A (en) * 1984-04-17 1989-06-30 Daiichi Seiyaku Co Cephalosporin derivatives and salts thereof and their preparation
JPS60226884A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd セフアロスポリン誘導体
EP0160546A3 (en) * 1984-04-26 1986-12-17 Yamanouchi Pharmaceutical Co. Ltd. Cephalosporin compounds, and their production, and medicaments containing them
WO1985005106A1 (fr) * 1984-05-09 1985-11-21 Takeda Chemical Industries, Ltd. Composes cephem
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
JPH0613530B2 (ja) * 1984-06-08 1994-02-23 武田薬品工業株式会社 セフエム化合物
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
DE3775798D1 (de) 1986-03-19 1992-02-20 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
JPH0242086A (ja) * 1988-08-02 1990-02-13 Banyu Pharmaceut Co Ltd （３‐ヒドロキシ‐４‐ピリドン‐１‐イル）メチル基を有する新規セファロスポリン誘導体
JPH02117679A (ja) * 1989-09-22 1990-05-02 Sankyo Co Ltd チアゾリオメチル置換基を有するセファロスポリン誘導体
US5594129A (en) * 1991-09-10 1997-01-14 Bristol-Myers Squibb Company Process for the preparation of a cephalosporin antibiotic
US5698703A (en) * 1991-09-10 1997-12-16 Bristol-Myers Squibb Company Syn-isomer of thiazolyl intermediate and process for the preparation thereof
EP0554004A3 (en) * 1992-01-27 1993-11-24 Katayama Seisakusho Cephem compounds and antibacterial agents
JPH0741485A (ja) * 1993-07-30 1995-02-10 Katayama Seiyakushiyo:Kk セフェム誘導体およびそれを含有する抗菌剤
CN1150429A (zh) * 1994-05-23 1997-05-21 韩国科学技术研究院 头孢菌素化合物及其制备方法
DE4440141A1 (de) 1994-11-10 1996-05-15 Hoechst Ag Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤
US6214818B1 (en) * 1996-04-04 2001-04-10 Shionogi & Co., Ltd. Cephem compounds and pharmaceutical compositions containing the same
US5929086A (en) * 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
KR100293728B1 (ko) * 1998-05-22 2001-09-17 손 경 식 결정성세피롬황산염의제조방법
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
DE602004024393D1 (de) * 2003-05-23 2010-01-14 Theravance Inc Quervernetzte glycopeptid-cephalosporin-antibiotika
SI3616695T1 (sl) 2011-09-09 2025-01-31 Merck Sharp & Dohme Llc Ceftolozan/tazobaktam za zdravljenje intrapulmonalnih okužb
CN102584856A (zh) * 2011-12-27 2012-07-18 开封豫港制药有限公司 硫酸头孢匹罗的制备方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
UA121298C2 (uk) 2013-03-15 2020-05-12 Мерк Шарп І Доум Корп. Антибіотична композиція на основі цефтолозану і тазобактаму
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
AU2014233637A1 (en) 2013-09-09 2015-03-26 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
KR20180066264A (ko) * 2015-12-10 2018-06-18 나에자-알지엠 파마슈티칼스 유엘씨 세펨 화합물, 그의 제조 및 용도
CN105646543B (zh) * 2016-03-17 2018-03-27 天津大学 一种头孢喹肟晶体及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192394A (en) * 1981-05-12 1982-11-26 Hoechst Ag Cephalosporin derivatives and manufacture

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082962A (en) * 1963-05-28 1967-09-13 Glaxo Lab Ltd Derivatives of 7-aminocephalosporanic acid
GB1052068A (ja) * 1963-11-04
GB1310642A (en) * 1970-11-09 1973-03-21 Pfizer Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4200746A (en) * 1974-12-20 1980-04-29 Glaxo Laboratories, Ltd. Cephalosporins
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
US4336353A (en) * 1979-09-11 1982-06-22 Ciba-Geigy Corporation Salts of 3-methyl-2-(2',4'-dimethyl-phenylimino)-4-thiazoline with polymers containing sulfonic acid groups
DE3069364D1 (en) * 1979-10-12 1984-11-08 Fujisawa Pharmaceutical Co Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR75644B (ja) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
US4367228A (en) * 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
US4427677A (en) * 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192394A (en) * 1981-05-12 1982-11-26 Hoechst Ag Cephalosporin derivatives and manufacture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006348961A (ja) * 2005-06-13 2006-12-28 Kawasaki Shipbuilding Corp 壁掛機器用防振支持構造

Also Published As

Publication number Publication date
AU8358982A (en) 1982-11-18
US5071979A (en) 1991-12-10
NO162022B (no) 1989-07-17
FR2515654B1 (fr) 1986-11-14
MTP909B (en) 1985-02-28
DD202720A5 (de) 1983-09-28
IE53296B1 (en) 1988-10-12
NL940003I2 (nl) 1997-02-03
FI821644L (fi) 1982-11-13
ES511955A0 (es) 1983-02-16
PT74877B (de) 1984-11-26
FR2515654A1 (fr) 1983-05-06
IT1157275B (it) 1987-02-11
NZ200567A (en) 1985-01-31
GB2098216B (en) 1985-08-14
NO1999008I1 (no) 1999-05-27
DK211382A (da) 1982-11-13
ATE19085T1 (de) 1986-04-15
GB2144424B (en) 1986-02-12
NL940003I1 (nl) 1994-04-05
GR75506B (ja) 1984-07-24
EP0064740A3 (en) 1983-11-23
CS248025B2 (en) 1987-01-15
HU186019B (en) 1985-05-28
GB8423511D0 (en) 1984-10-24
SE8202961D0 (sv) 1982-05-11
MA19474A1 (fr) 1982-12-31
JPH0670068B2 (ja) 1994-09-07
ZA823226B (en) 1983-03-30
FR2511682B1 (fr) 1985-06-28
CS415891A3 (en) 1992-04-15
BG60838B2 (bg) 1996-04-30
AT381945B (de) 1986-12-10
FI70715C (fi) 1986-10-06
ATA184382A (de) 1986-05-15
IE821129L (en) 1982-11-12
DE3270360D1 (en) 1986-05-15
CH654312A5 (de) 1986-02-14
SE8202961L (sv) 1982-11-13
DZ418A1 (fr) 2004-09-13
YU98382A (en) 1985-08-31
NL950013I2 (nl) 1997-02-03
PT74877A (de) 1982-06-01
IL65737A (en) 1986-11-30
JPH0144190B2 (ja) 1989-09-26
PH20243A (en) 1986-11-10
DE3118732A1 (de) 1982-12-02
NO821562L (no) 1982-11-15
IT8221182A0 (it) 1982-05-10
AU559727B2 (en) 1987-03-19
LU88736I2 (fr) 1996-08-23
IL65737A0 (en) 1982-08-31
EP0064740B1 (de) 1986-04-09
GB2098216A (en) 1982-11-17
KR830010121A (ko) 1983-12-26
YU44346B (en) 1990-06-30
AR241186A1 (es) 1992-01-31
FR2511682A1 (fr) 1983-02-25
JPS57192394A (en) 1982-11-26
CA1228850A (en) 1987-11-03
FI821644A0 (fi) 1982-05-10
NO162022C (no) 1989-10-25
EP0064740A2 (de) 1982-11-17
KR880001541B1 (ko) 1988-08-20
ES8304143A1 (es) 1983-02-16
NL8201913A (nl) 1982-12-01
GB2144424A (en) 1985-03-06
NL950013I1 (nl) 1997-02-03
FI70715B (fi) 1986-06-26
BE893163A (fr) 1982-11-12
DK166500B1 (da) 1993-06-01

Similar Documents

Publication Publication Date Title
JPS6419082A (en) Cephalosporine derivative and its production
GB2103121B (en) Production lines
MY8800090A (en) Tetrahydropthalimide compounds and their production and use
DE3271334D1 (en) Production of 3-trichloromethyl- and 3-trifluoromethyl-pyridines
JPS57158759A (en) Benzoisourea derivative
IL66531A (en) Production of 2-chloropyridines
GB2087394B (en) 2-oxazetidine derivatives and production thereof
GB2101986B (en) Thiazolinoazetidinone derivatives
GB2111521B (en) Polysaccharide production
GB2099424B (en) Isoprenylamine derivatives
GB2099419B (en) Imidazothizole derivatives
IL67451A0 (en) 4-cyano-2-azetidinones and production thereof
DE3265658D1 (en) 4-cyclopentenones and their production
GB2098613B (en) Polyisoprenylamine derivatives
GB2094297B (en) Apovincaminol derivatives
GB2099423B (en) Isopyrenylamine derivatives
JPS57175135A (en) 4-halogenostilbene derivative and manufacture
ZA823934B (en) Novel bis-triazole derivative
GB2103602B (en) Pthalide derivative
ZA826821B (en) Penicillin derivative
ZA824536B (en) New benzoyl-phenyl-piperidine derivatives
DE3261765D1 (en) Aminonaphthacene derivatives and their production
PT76355A (en) Isoxazolopyrimidine derivatives and production thereof
JPS57123191A (en) Novel cephalosporin derivatives
JPS57188582A (en) Novel 13-thia-prostacycline derivative and manufacture