JPS6425718A - Oral solid drug for treating syndrome of epilepsy or spasm - Google Patents
Oral solid drug for treating syndrome of epilepsy or spasmInfo
- Publication number
- JPS6425718A JPS6425718A JP15246688A JP15246688A JPS6425718A JP S6425718 A JPS6425718 A JP S6425718A JP 15246688 A JP15246688 A JP 15246688A JP 15246688 A JP15246688 A JP 15246688A JP S6425718 A JPS6425718 A JP S6425718A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical preparations
- pharmaceutical
- treating
- syndrome
- spasmodic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007787 solid Substances 0.000 title abstract 5
- 206010015037 epilepsy Diseases 0.000 title abstract 3
- 208000011580 syndromic disease Diseases 0.000 title abstract 3
- 208000005392 Spasm Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 206010010904 Convulsion Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 abstract 2
- 208000028329 epileptic seizure Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 abstract 2
- 229940084026 sodium valproate Drugs 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000009969 flowable effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: To prepare a orally administered solid pharmaceutical for treating an epileptic seizure or spasmodic syndrome that enables easy production of solid pharmaceutical preparations having reduced hygroscopicity and improved stability while retaining an efficacy equivalent to or more than that of conventional pharmaceutical preparations by using crystalline single compound consisting of valpronic acid and sodium valproate at a specific mol ratio as the main active component. CONSTITUTION: This orally administered solid pharmaceutical effective for treating an epileptic seizure or spasmodic syndrome comprises a crystalline single compound consisting of valpronic acid and sodium valproate at a mol ratio of (1:1), and one or more excipients or diluents which are permitted for pharmaceutical preparations, thereby enabling production of pharmaceutical preparations in the solid form without special precautions and use of absorbents because its non-hygroscopicity and very high stability while exhibiting its efficacy of the same degree as that of the liquid valpronic acid and its sodium salt, which is hygroscopic and unstable. A specific amount of this pharmaceutical is mixed with starch and/or other binders to make a flowable powdery mixture, and the powdery mixture is granulated and then pelletized through a pelletizer, to provide the excellent pellets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15246688A JPS6425718A (en) | 1988-06-22 | 1988-06-22 | Oral solid drug for treating syndrome of epilepsy or spasm |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15246688A JPS6425718A (en) | 1988-06-22 | 1988-06-22 | Oral solid drug for treating syndrome of epilepsy or spasm |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6425718A true JPS6425718A (en) | 1989-01-27 |
| JPH0160452B2 JPH0160452B2 (en) | 1989-12-22 |
Family
ID=15541128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15246688A Granted JPS6425718A (en) | 1988-06-22 | 1988-06-22 | Oral solid drug for treating syndrome of epilepsy or spasm |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6425718A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1479291A1 (en) | 2003-05-19 | 2004-11-24 | Shotaro Mochizuki | Discharged waste processing materials for animals |
-
1988
- 1988-06-22 JP JP15246688A patent/JPS6425718A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1479291A1 (en) | 2003-05-19 | 2004-11-24 | Shotaro Mochizuki | Discharged waste processing materials for animals |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0160452B2 (en) | 1989-12-22 |
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