JPS6429313A - Enzyme inhibitor - Google Patents

Enzyme inhibitor

Info

Publication number
JPS6429313A
JPS6429313A JP18536587A JP18536587A JPS6429313A JP S6429313 A JPS6429313 A JP S6429313A JP 18536587 A JP18536587 A JP 18536587A JP 18536587 A JP18536587 A JP 18536587A JP S6429313 A JPS6429313 A JP S6429313A
Authority
JP
Japan
Prior art keywords
aralkyl
alkenyl
aryl
active ingredient
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18536587A
Other languages
Japanese (ja)
Inventor
Yuji Narutomi
Manabu Katsumata
Yasuko Osawa
Saburo Uchikuga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sogo Pharmaceutical Co Ltd
Original Assignee
Sogo Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sogo Pharmaceutical Co Ltd filed Critical Sogo Pharmaceutical Co Ltd
Priority to JP18536587A priority Critical patent/JPS6429313A/en
Priority to CA000543814A priority patent/CA1302275C/en
Priority to EP19870111397 priority patent/EP0262345A3/en
Priority to US07/299,024 priority patent/US4898870A/en
Publication of JPS6429313A publication Critical patent/JPS6429313A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To obtain an inhibitor against aldose reductase, glyoxalase I and reverse transcriptase, useful for diabetic complication and cancers, capable of being administered for a long period of time, having high safety, containing pyrroloquinolinequinone or a derivative thereof as an active ingredient. CONSTITUTION:A compound shown by the formula [R is H, replaceable alkyl, alkenyl, aryl or aralkyl; X is OR', NR''R'' (R' and R'' are H, replaceable alkyl, alkenyl, aryl or aralkyl)] as an active ingredient is blended with a conventional drug carrier or excipient and pharmaceutically manufactured by a conventional procedure to give the aimed preparation. The aimed substance can be prepared into a dosage form such as capsule, tablet, granule, powder, dust, injection, solution or suppository. A dose is preferably 0.2-200mg/kg/day and administered dividedly once-twice.
JP18536587A 1986-08-07 1987-07-27 Enzyme inhibitor Pending JPS6429313A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP18536587A JPS6429313A (en) 1987-07-27 1987-07-27 Enzyme inhibitor
CA000543814A CA1302275C (en) 1986-08-07 1987-08-05 Enzyme inhibitor
EP19870111397 EP0262345A3 (en) 1986-08-07 1987-08-06 Pyrroloquinoline quinones as enzyme inhibitors
US07/299,024 US4898870A (en) 1986-08-07 1989-01-19 Pyrroloquinoline quinone compounds useful as an enzyme inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18536587A JPS6429313A (en) 1987-07-27 1987-07-27 Enzyme inhibitor

Publications (1)

Publication Number Publication Date
JPS6429313A true JPS6429313A (en) 1989-01-31

Family

ID=16169526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18536587A Pending JPS6429313A (en) 1986-08-07 1987-07-27 Enzyme inhibitor

Country Status (1)

Country Link
JP (1) JPS6429313A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429333A1 (en) 1989-11-13 1991-05-29 Mitsubishi Gas Chemical Company, Inc. Process for producing oxazopyrroloquinolines, novel oxazopyrroloquinolines, and use of oxazopyrroloquinolines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429333A1 (en) 1989-11-13 1991-05-29 Mitsubishi Gas Chemical Company, Inc. Process for producing oxazopyrroloquinolines, novel oxazopyrroloquinolines, and use of oxazopyrroloquinolines

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