JPS643126A - Androgen acceptor bonding inhibitor - Google Patents

Androgen acceptor bonding inhibitor

Info

Publication number
JPS643126A
JPS643126A JP62157605A JP15760587A JPS643126A JP S643126 A JPS643126 A JP S643126A JP 62157605 A JP62157605 A JP 62157605A JP 15760587 A JP15760587 A JP 15760587A JP S643126 A JPS643126 A JP S643126A
Authority
JP
Japan
Prior art keywords
radix
androgen
extract
semen
schtellariae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62157605A
Other languages
Japanese (ja)
Other versions
JPH013126A (en
JP2655646B2 (en
Inventor
Masatsune Kurono
Hideshi Yamakawa
Takuya Koshizaka
Hidekazu Kato
Takashi Iida
Shigeko Oishi
Kunio Yagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BITAMIN KENKYUSHO KK
Original Assignee
BITAMIN KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BITAMIN KENKYUSHO KK filed Critical BITAMIN KENKYUSHO KK
Priority to JP62157605A priority Critical patent/JP2655646B2/en
Priority to CA000570091A priority patent/CA1308661C/en
Priority to US07/210,489 priority patent/US4987150A/en
Priority to EP88110140A priority patent/EP0296625A3/en
Publication of JPH013126A publication Critical patent/JPH013126A/en
Publication of JPS643126A publication Critical patent/JPS643126A/en
Application granted granted Critical
Publication of JP2655646B2 publication Critical patent/JP2655646B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE:To obtain androgen acceptor bonding inhibitor containing extract of crude drugs such as Swertiae Herba, S. Pseudochinensis Hara, Schtellariae Radix or Glycyrrhizae Radix, useful in prevention of androgen dependent disease and advantageous in acquisition of raw material and cost. CONSTITUTION:Extract of crude drug obtained from Swertiae Herba, S. Pseudochinensis Hara, Schtellariae Radix, Glycyrrhizae Radix, Rhei Rhizonma, San-chi ginseng, Phyllostachysis Folium, Citri Leiocarpae Exocarpium, Arecae Semen, Caryophylli Flos, Bupleuri Radix, Coicis Semen, Cnidii Rhizome, Chinese peony, Gambir, Polygalae Radix, Plantaginis Semen, etc. are contained as active ingredients. The extraction is carried out by immersing dried product, finely cut product or ground product of whole glass of crude drugs in a solvent such as pentane or hexane and subjecting the extract to filtration and centrifugal separation. The inhibitor is used in prevention and remedy for androgen- dependent disease, for example, hirsutism, spasm, android baldness, prostatic hypertrophy, prostatic ulcer, early maturation, etc.
JP62157605A 1987-06-26 1987-06-26 Androgen receptor binding inhibitor Expired - Lifetime JP2655646B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP62157605A JP2655646B2 (en) 1987-06-26 1987-06-26 Androgen receptor binding inhibitor
CA000570091A CA1308661C (en) 1987-06-26 1988-06-22 AGENT FOR INHIBITING BINDING OF 5.alpha.-DIHYDRO-TESTOSTERONE WITH ANDROGEN RECEPTOR AS WELL AS PROCESS FOR OBTAINING SAME
US07/210,489 US4987150A (en) 1987-06-26 1988-06-23 Agent for inhibiting binding of 5-dihydro-testosterone with androgen receptor as well as process for obtaining same
EP88110140A EP0296625A3 (en) 1987-06-26 1988-06-24 Agent for inhibiting binding of 5 alpha -dihydrotestosterone with androgen receptor as well as process for obtaining same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62157605A JP2655646B2 (en) 1987-06-26 1987-06-26 Androgen receptor binding inhibitor

Publications (3)

Publication Number Publication Date
JPH013126A JPH013126A (en) 1989-01-06
JPS643126A true JPS643126A (en) 1989-01-06
JP2655646B2 JP2655646B2 (en) 1997-09-24

Family

ID=15653378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62157605A Expired - Lifetime JP2655646B2 (en) 1987-06-26 1987-06-26 Androgen receptor binding inhibitor

Country Status (1)

Country Link
JP (1) JP2655646B2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6438011A (en) * 1987-07-31 1989-02-08 Pola Chem Ind Inc Promoter for hair restoration and hair growth
JPH0236125A (en) * 1988-07-26 1990-02-06 Ichimaru Pharcos Co Ltd Testosterone 5alpha-reductase inhibitor
JPH0248517A (en) * 1988-08-11 1990-02-19 Shiseido Co Ltd Hair tonic
JPH0393710A (en) * 1989-09-07 1991-04-18 Ichimaru Pharcos Co Ltd External preparation or cosmetic for skin or hair containing rearing inhibitor of propionibacterium acnes
JPH07285833A (en) * 1994-04-15 1995-10-31 Atsushi Nukada Hair tonic agent
JP2002179584A (en) * 2000-12-13 2002-06-26 Maruzen Pharmaceut Co Ltd Testosterone 5α-reductase inhibitor and androgen receptor binding inhibitor, hair preparation and skin cosmetic
JP2003026592A (en) * 2001-07-09 2003-01-29 Nippon Hypox Lab Inc Anti-androgenic agent comprising fermented licorice extract
JP2003089626A (en) * 2001-09-20 2003-03-28 Kao Corp Hair growth inhibitor
JP2007505151A (en) * 2003-05-25 2007-03-08 杭州浙大力夫生物科技有限公司 Application of bamboo leaf flavone in preventive and therapeutic drugs for prostate diseases and health foods
JP2008502712A (en) * 2004-06-11 2008-01-31 ユニジェン インク． Androgenic composition comprising bamboo or bamboo extract
JP2009001523A (en) * 2007-06-22 2009-01-08 Maruzen Pharmaceut Co Ltd Antiandrogenic agent, hair grower and hair cosmetic
JP2009114082A (en) * 2007-11-02 2009-05-28 Maruzen Pharmaceut Co Ltd Hair papilla cell growth promoter, fibroblast growth factor-7 (FGF-7) production promoter, vascular endothelial growth factor (VEGF) production promoter, antiandrogen, hair restorer and hair cosmetics

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4730985B2 (en) * 1997-09-10 2011-07-20 武田薬品工業株式会社 Stabilized pharmaceutical formulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5970605A (en) * 1982-10-13 1984-04-21 Hiroshi Doi Hair tonic
JPS60146829A (en) * 1984-01-05 1985-08-02 Rooto Seiyaku Kk Testosterone 5alpha-reductase inhibitor
JPS6147411A (en) * 1984-08-15 1986-03-07 Dai Ichi Seiyaku Co Ltd Promoter for hair growth

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5970605A (en) * 1982-10-13 1984-04-21 Hiroshi Doi Hair tonic
JPS60146829A (en) * 1984-01-05 1985-08-02 Rooto Seiyaku Kk Testosterone 5alpha-reductase inhibitor
JPS6147411A (en) * 1984-08-15 1986-03-07 Dai Ichi Seiyaku Co Ltd Promoter for hair growth

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6438011A (en) * 1987-07-31 1989-02-08 Pola Chem Ind Inc Promoter for hair restoration and hair growth
JPH0236125A (en) * 1988-07-26 1990-02-06 Ichimaru Pharcos Co Ltd Testosterone 5alpha-reductase inhibitor
JPH0248517A (en) * 1988-08-11 1990-02-19 Shiseido Co Ltd Hair tonic
JPH0393710A (en) * 1989-09-07 1991-04-18 Ichimaru Pharcos Co Ltd External preparation or cosmetic for skin or hair containing rearing inhibitor of propionibacterium acnes
JPH07285833A (en) * 1994-04-15 1995-10-31 Atsushi Nukada Hair tonic agent
JP2002179584A (en) * 2000-12-13 2002-06-26 Maruzen Pharmaceut Co Ltd Testosterone 5α-reductase inhibitor and androgen receptor binding inhibitor, hair preparation and skin cosmetic
JP2003026592A (en) * 2001-07-09 2003-01-29 Nippon Hypox Lab Inc Anti-androgenic agent comprising fermented licorice extract
JP2003089626A (en) * 2001-09-20 2003-03-28 Kao Corp Hair growth inhibitor
JP2007505151A (en) * 2003-05-25 2007-03-08 杭州浙大力夫生物科技有限公司 Application of bamboo leaf flavone in preventive and therapeutic drugs for prostate diseases and health foods
JP2008502712A (en) * 2004-06-11 2008-01-31 ユニジェン インク． Androgenic composition comprising bamboo or bamboo extract
JP2009001523A (en) * 2007-06-22 2009-01-08 Maruzen Pharmaceut Co Ltd Antiandrogenic agent, hair grower and hair cosmetic
JP2009114082A (en) * 2007-11-02 2009-05-28 Maruzen Pharmaceut Co Ltd Hair papilla cell growth promoter, fibroblast growth factor-7 (FGF-7) production promoter, vascular endothelial growth factor (VEGF) production promoter, antiandrogen, hair restorer and hair cosmetics

Also Published As

Publication number Publication date
JP2655646B2 (en) 1997-09-24

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