JPS643169A - Production of heterocyclic compound - Google Patents
Production of heterocyclic compoundInfo
- Publication number
- JPS643169A JPS643169A JP15630287A JP15630287A JPS643169A JP S643169 A JPS643169 A JP S643169A JP 15630287 A JP15630287 A JP 15630287A JP 15630287 A JP15630287 A JP 15630287A JP S643169 A JPS643169 A JP S643169A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pyridyl
- grignard reagent
- heterocyclic group
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000007818 Grignard reagent Substances 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000004795 grignard reagents Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- -1 pyridyl Grignard reagent Chemical class 0.000 abstract 2
- 150000003462 sulfoxides Chemical class 0.000 abstract 2
- RTLUPHDWSUGAOS-UHFFFAOYSA-N 4-iodopyridine Chemical compound IC1=CC=NC=C1 RTLUPHDWSUGAOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound for a variety of intermediates by forming a pyridyl Grignard reagent from a pyridine derivative and a Grignard reagent, and allowing the reagent with a variety of heterocyclic group-containing sulfoxide to effect coupling of the pyridyl group with the heterocyclic group.
CONSTITUTION: 2-, 3-, or 4-Pyridyl Grignard reagent is obtained by allowing 2-, 3-, 4-iodopyridine with a Grignard reagent of the formula: RMgX (R is alkyl, alkenyl; X is halogen) and then allowed to react with a heterocyclic group- containing sulfoxide of the formula (R1 is 2-, 3-, or 4-pyridyl which may be substituted, 2-, 3-, 4-, 5-. 6-, 7-, or 8-quinoline which may be substituted; R2 is alkyl) to give bipyridines which may substituted, pyridylquinolines which may be substituted by pyridylisoquinolines which may be substituted. These products are used an intermediate of medicines and agrochemicals.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62156302A JP2583062B2 (en) | 1987-06-23 | 1987-06-23 | Method for producing heterocyclic compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62156302A JP2583062B2 (en) | 1987-06-23 | 1987-06-23 | Method for producing heterocyclic compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPS643169A true JPS643169A (en) | 1989-01-06 |
| JPH013169A JPH013169A (en) | 1989-01-06 |
| JP2583062B2 JP2583062B2 (en) | 1997-02-19 |
Family
ID=15624839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62156302A Expired - Lifetime JP2583062B2 (en) | 1987-06-23 | 1987-06-23 | Method for producing heterocyclic compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2583062B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076975A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| WO2000076976A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| JP2001139549A (en) * | 1999-11-15 | 2001-05-22 | Sankio Chemical Co Ltd | New dipyridyl derivative |
| WO2001040186A1 (en) * | 1999-11-30 | 2001-06-07 | Sankio Chemical Co., Ltd. | Process for the production of pyridine derivatives |
-
1987
- 1987-06-23 JP JP62156302A patent/JP2583062B2/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076975A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| WO2000076976A1 (en) * | 1999-06-14 | 2000-12-21 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| US6489483B1 (en) | 1999-06-14 | 2002-12-03 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| US6504032B1 (en) | 1999-06-14 | 2003-01-07 | Sankio Chemical Co., Ltd. | Process for the production of 2-pyridylpyridine derivatives |
| JP2001139549A (en) * | 1999-11-15 | 2001-05-22 | Sankio Chemical Co Ltd | New dipyridyl derivative |
| WO2001036387A1 (en) * | 1999-11-15 | 2001-05-25 | Sankio Chemical Co., Ltd. | Novel bipyridyl derivatives |
| WO2001040186A1 (en) * | 1999-11-30 | 2001-06-07 | Sankio Chemical Co., Ltd. | Process for the production of pyridine derivatives |
| JP2001158773A (en) * | 1999-11-30 | 2001-06-12 | Sankio Chemical Co Ltd | Method for producing pyridine derivative |
| US6509469B1 (en) | 1999-11-30 | 2003-01-21 | Sankio Chemical Co., Ltd. | Process for the production of pyridine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2583062B2 (en) | 1997-02-19 |
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