JPS643188A - Damavaricin fc carbamate derivative - Google Patents
Damavaricin fc carbamate derivativeInfo
- Publication number
- JPS643188A JPS643188A JP62158558A JP15855887A JPS643188A JP S643188 A JPS643188 A JP S643188A JP 62158558 A JP62158558 A JP 62158558A JP 15855887 A JP15855887 A JP 15855887A JP S643188 A JPS643188 A JP S643188A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- damavaricin
- expressed
- reacted
- carbamate derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930186463 Damavaricin Natural products 0.000 title abstract 2
- AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 title 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 2
- NMIZONYLXCOHEF-UHFFFAOYSA-N 1h-imidazole-2-carboxamide Chemical compound NC(=O)C1=NC=CN1 NMIZONYLXCOHEF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I {A is amino expressed by formula II [R1 and R2 are H or (substituted) aliphatic hydrocarbon or R1 and R2 represent bifunctional organic group which, together with N to which they are linked cyclic tertiary amino]}.
EXAMPLE: 19-O-(Hexylamino)carbonyldamavaricin Fc.
USE: An antimicrobial and antiviral agent.
PREPARATION: The corresponding amine expressed by the formula (R1)(R2)NH is reacted with N,N'-carbonyldiimidazole in a solvent, such as DMF, at 0W80°C to afford imidazolylcarbonylamine, which is then reacted with damavaricin Fc under condition similar to that described above.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-158558A JPH013188A (en) | 1987-06-25 | Damavaricin Fc carbamate derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-158558A JPH013188A (en) | 1987-06-25 | Damavaricin Fc carbamate derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS643188A true JPS643188A (en) | 1989-01-06 |
| JPH013188A JPH013188A (en) | 1989-01-06 |
Family
ID=
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003516187A (en) * | 1999-12-10 | 2003-05-13 | バイオドーム | Method for manufacturing a device for connecting a container and a container, a corresponding connecting device and a ready-to-use assembly comprising a device of this type |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003516187A (en) * | 1999-12-10 | 2003-05-13 | バイオドーム | Method for manufacturing a device for connecting a container and a container, a corresponding connecting device and a ready-to-use assembly comprising a device of this type |
| US7632260B2 (en) | 1999-12-10 | 2009-12-15 | Biodome | Method for producing a device for connecting a receptacle and a container, corresponding connecting device and ready-for-use assembly comprising a device of this type |
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