JPS643189A - Novel damavaricin fc carbamate derivative - Google Patents
Novel damavaricin fc carbamate derivativeInfo
- Publication number
- JPS643189A JPS643189A JP62158559A JP15855987A JPS643189A JP S643189 A JPS643189 A JP S643189A JP 62158559 A JP62158559 A JP 62158559A JP 15855987 A JP15855987 A JP 15855987A JP S643189 A JPS643189 A JP S643189A
- Authority
- JP
- Japan
- Prior art keywords
- damavaricin
- novel
- carbamate derivative
- expressed
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930186463 Damavaricin Natural products 0.000 title abstract 2
- AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 title 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- JZCUPRBTPVMOJI-UHFFFAOYSA-N 4,5-dihydroimidazole-1-carboxamide Chemical compound NC(=O)N1CCN=C1 JZCUPRBTPVMOJI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I [A is expressed by formula II (B is methylene, O or S; l is 0 or 1; m and n are 0W6; R1 and R2 are methyl or ethyl; R3 is 1W5C alkyl; R4 is H, methyl or ethyl)].
EXAMPLE: 19-O-Trimethylsilylmethylaminocarbonyldamavaricin Fc.
USE: An antimicrobial and antiviral agent.
PREPARATION: For example, an amine, expressed by formula III and corresponding to the group A is reacted in a solvent, such as DMF, at 0W80°C to provide imidazolinecarbonylamine, which is then reacted with damavaricin Fc under condition similar to that described above.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-158559A JPH013189A (en) | 1987-06-25 | Novel damavaricin Fc carbamate derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-158559A JPH013189A (en) | 1987-06-25 | Novel damavaricin Fc carbamate derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS643189A true JPS643189A (en) | 1989-01-06 |
| JPH013189A JPH013189A (en) | 1989-01-06 |
Family
ID=
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