JPS6442425A - Remedy for cachexia - Google Patents
Remedy for cachexiaInfo
- Publication number
- JPS6442425A JPS6442425A JP20036487A JP20036487A JPS6442425A JP S6442425 A JPS6442425 A JP S6442425A JP 20036487 A JP20036487 A JP 20036487A JP 20036487 A JP20036487 A JP 20036487A JP S6442425 A JPS6442425 A JP S6442425A
- Authority
- JP
- Japan
- Prior art keywords
- alanine
- beta
- remedy
- side effects
- cachexia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010006895 Cachexia Diseases 0.000 title abstract 3
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 10
- 229940000635 beta-alanine Drugs 0.000 abstract 5
- 239000002246 antineoplastic agent Substances 0.000 abstract 3
- 229940127089 cytotoxic agent Drugs 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000037396 body weight Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 206010001541 Akinesia Diseases 0.000 abstract 1
- 206010073306 Exposure to radiation Diseases 0.000 abstract 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 230000001612 cachectic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 229960002949 fluorouracil Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 201000002364 leukopenia Diseases 0.000 abstract 1
- 231100001022 leukopenia Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004857 mitomycin Drugs 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE:To obtain a remedy for cachexia, containing beta-alanine or a salt thereof as an active ingredient and having removing action on side effects of chemotherapeutic agent, anti-AIDS chemotherapeutic agent, exposure to radiation, etc. CONSTITUTION:The aimed substance obtained by using beta-alanine or a salt thereof present in animal and plant tissues as an active ingredient and preparing a pharmaceutical by a conventional method. The remedy can be prepared in a form, such as injection, powder, granule, tablet or capsule. The dose thereof is 50mg/kg/day beta-alanine and about 3g per day for adult of 60kg body weight for subcutaneous administration. The beta-alanine effectively acts on leukopenia which is one of side effects caused by mitomycin C and 5-fluorouracil having strong side effects of cachectic reaction, such as collapse, akinesia, emesis, nausea, anorexia, reduction of body weight, symptosis or deterioration in biophylaxis, represented by chemotherapeutic agents and the remedy is effective in treating cachexia. The beta-alanine can be synthesized by a well-known method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20036487A JPS6442425A (en) | 1987-08-11 | 1987-08-11 | Remedy for cachexia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20036487A JPS6442425A (en) | 1987-08-11 | 1987-08-11 | Remedy for cachexia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6442425A true JPS6442425A (en) | 1989-02-14 |
Family
ID=16423074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20036487A Pending JPS6442425A (en) | 1987-08-11 | 1987-08-11 | Remedy for cachexia |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6442425A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2659013A1 (en) * | 1990-03-01 | 1991-09-06 | Peoch Rene | Novel pharmaceutical composition acting on cell division |
| JP2006337207A (en) * | 2005-06-02 | 2006-12-14 | Shimadzu Corp | Electronic balance |
| US8129422B2 (en) | 1996-08-12 | 2012-03-06 | Natural Alternatives International, Inc. | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US8329207B2 (en) | 2005-05-23 | 2012-12-11 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
-
1987
- 1987-08-11 JP JP20036487A patent/JPS6442425A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| CHEM ABSTR=1982 * |
| CHEM ABSTR=1987 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2659013A1 (en) * | 1990-03-01 | 1991-09-06 | Peoch Rene | Novel pharmaceutical composition acting on cell division |
| US8129422B2 (en) | 1996-08-12 | 2012-03-06 | Natural Alternatives International, Inc. | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US10881629B2 (en) | 2003-04-10 | 2021-01-05 | Natural Alternatives International, Inc. | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US9907770B2 (en) | 2003-04-10 | 2018-03-06 | Natural Alternatives International, Inc. | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US9668994B2 (en) | 2003-04-10 | 2017-06-06 | Natural Alternatives International, Inc. | Methods and compositions for increasing the anaerobic working capacity in tissues |
| US8980307B2 (en) | 2005-05-23 | 2015-03-17 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US8496958B2 (en) | 2005-05-23 | 2013-07-30 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US9636315B2 (en) | 2005-05-23 | 2017-05-02 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US8394402B2 (en) | 2005-05-23 | 2013-03-12 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US9907769B2 (en) | 2005-05-23 | 2018-03-06 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of betaalanine |
| US8329207B2 (en) | 2005-05-23 | 2012-12-11 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US10828274B2 (en) | 2005-05-23 | 2020-11-10 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| US12036196B2 (en) | 2005-05-23 | 2024-07-16 | Natural Alternatives International, Inc. | Compositions and methods for the sustained release of beta-alanine |
| JP2006337207A (en) * | 2005-06-02 | 2006-12-14 | Shimadzu Corp | Electronic balance |
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