JPS6455192A - Production of acidic amino acid oligopeptide - Google Patents

Production of acidic amino acid oligopeptide

Info

Publication number
JPS6455192A
JPS6455192A JP21389787A JP21389787A JPS6455192A JP S6455192 A JPS6455192 A JP S6455192A JP 21389787 A JP21389787 A JP 21389787A JP 21389787 A JP21389787 A JP 21389787A JP S6455192 A JPS6455192 A JP S6455192A
Authority
JP
Japan
Prior art keywords
amino acid
oligopeptide
acidic amino
acid ester
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP21389787A
Other languages
Japanese (ja)
Inventor
Keiichi Aso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP21389787A priority Critical patent/JPS6455192A/en
Publication of JPS6455192A publication Critical patent/JPS6455192A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE:To control molecular weight and readily and industrially obtain the titled oligopeptide in high yield, by adding a proteolytic enzyme to a solution of an L-acidic amino acid ester and polymerizing the above-mentioned amino acid ester. CONSTITUTION:(B) A proteolytic enzyme (e.g. papain or trypsin) capable of producing in oligopeptide in an amount of preferably 1-1,000muM is added to (A) a solution of an L-acidic amino acid ester (e.g. alpha,gamma-dimethyl L-glutamate), preferably in 10-100mM concentration and polymerization in carried out at, e.g. pH6-11 and 10-70 deg.C reaction temperature, to provide a reaction solution having preferably 2-5 polymerization degree. The resultant reaction solution is subjected to, e.g. centrifugation, to afford the aimed oligopeptide.
JP21389787A 1987-08-27 1987-08-27 Production of acidic amino acid oligopeptide Pending JPS6455192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21389787A JPS6455192A (en) 1987-08-27 1987-08-27 Production of acidic amino acid oligopeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21389787A JPS6455192A (en) 1987-08-27 1987-08-27 Production of acidic amino acid oligopeptide

Publications (1)

Publication Number Publication Date
JPS6455192A true JPS6455192A (en) 1989-03-02

Family

ID=16646824

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21389787A Pending JPS6455192A (en) 1987-08-27 1987-08-27 Production of acidic amino acid oligopeptide

Country Status (1)

Country Link
JP (1) JPS6455192A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03183495A (en) * 1989-09-26 1991-08-09 Chisso Corp Method for enzymically synthesizing amino acid oligomer having single molecular weight
US6221423B1 (en) 1998-04-13 2001-04-24 Protein Technologies Int'l Inc. Short-chained peptide material

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03183495A (en) * 1989-09-26 1991-08-09 Chisso Corp Method for enzymically synthesizing amino acid oligomer having single molecular weight
US6221423B1 (en) 1998-04-13 2001-04-24 Protein Technologies Int'l Inc. Short-chained peptide material

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