JPS646263A - Novel thiazolidine derivative, its production and antiamnestic agent containing same - Google Patents
Novel thiazolidine derivative, its production and antiamnestic agent containing sameInfo
- Publication number
- JPS646263A JPS646263A JP63038675A JP3867588A JPS646263A JP S646263 A JPS646263 A JP S646263A JP 63038675 A JP63038675 A JP 63038675A JP 3867588 A JP3867588 A JP 3867588A JP S646263 A JPS646263 A JP S646263A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- antiamnestic
- single bond
- production
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003496 anti-amnesic effect Effects 0.000 title abstract 2
- 150000003548 thiazolidines Chemical class 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The thiazolidine derivative of formula I [R is G-E-D-B-A-; A and B are single bond or 1-6C alkylene, A may be 2-6C alkenylene or group of formula II-III; Y is 1-4C alkylene or 2-4C alkenylene; D is single bond, O, CO or group of formula IV-V; R<1> is H, 1-4C alkyl, phenyl or benzyl; E is single bond or 1-8C alkylene which may have substituent (phenyl or ben zyl); G is carbon ring or heterocyclic group which may have 1-3 substituents (1-6C alkyl, halogen, CF3 or NO2); A and B are not single bond at the same time]. EXAMPLE:4(R)-3-[3-[N-(4-methylbenzyl)carbamoyl]propionyl]thiazolidin-4 -al. USE:A prolylendopeptitase inhibitor useful as an antiamnestic agent. PREPARATION:The compound of formula I can be produced by oxidizing a compound of formula VI [R<h> is G-E-D<h>-B-A-; D<h> is D or CH(OH)] under mild condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63038675A JP2526084B2 (en) | 1987-02-23 | 1988-02-23 | Novel thiazolidine derivative |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-37844 | 1987-02-23 | ||
| JP3784487 | 1987-02-23 | ||
| JP63038675A JP2526084B2 (en) | 1987-02-23 | 1988-02-23 | Novel thiazolidine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS646263A true JPS646263A (en) | 1989-01-10 |
| JP2526084B2 JP2526084B2 (en) | 1996-08-21 |
Family
ID=26376995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63038675A Expired - Lifetime JP2526084B2 (en) | 1987-02-23 | 1988-02-23 | Novel thiazolidine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2526084B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01226880A (en) * | 1988-03-07 | 1989-09-11 | Kissei Pharmaceut Co Ltd | Thiazolidine derivative |
| WO1990006919A1 (en) * | 1988-12-14 | 1990-06-28 | Kabushiki Kaisha Yakult Honsha | New thioproline derivative |
| WO1990012005A1 (en) * | 1989-04-13 | 1990-10-18 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
| WO1991018877A1 (en) * | 1990-06-07 | 1991-12-12 | Zeria Pharmaceutical Co., Ltd. | Novel arylalkanoylamine derivative and drug containing the same |
| JPH05506442A (en) * | 1990-06-04 | 1993-09-22 | ファイザー・インコーポレーテッド | Aromatic pyrrolidine and thiazolidine amides |
| WO1994012474A1 (en) | 1992-11-20 | 1994-06-09 | Japan Tobacco Inc. | Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof |
| WO1995019356A1 (en) * | 1994-01-18 | 1995-07-20 | Santen Pharmaceutical Co., Ltd. | Endopeptidase 24.15 inhibitor |
-
1988
- 1988-02-23 JP JP63038675A patent/JP2526084B2/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01226880A (en) * | 1988-03-07 | 1989-09-11 | Kissei Pharmaceut Co Ltd | Thiazolidine derivative |
| WO1990006919A1 (en) * | 1988-12-14 | 1990-06-28 | Kabushiki Kaisha Yakult Honsha | New thioproline derivative |
| WO1990012005A1 (en) * | 1989-04-13 | 1990-10-18 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
| JPH05506442A (en) * | 1990-06-04 | 1993-09-22 | ファイザー・インコーポレーテッド | Aromatic pyrrolidine and thiazolidine amides |
| WO1991018877A1 (en) * | 1990-06-07 | 1991-12-12 | Zeria Pharmaceutical Co., Ltd. | Novel arylalkanoylamine derivative and drug containing the same |
| US5407950A (en) * | 1990-06-07 | 1995-04-18 | Zeria Pharmaceutical Co., Ltd. | Arylalkanoylamine derivative and drug containing the same |
| EP0536399B1 (en) * | 1990-06-07 | 1996-01-24 | Zeria Pharmaceutical Co., Ltd. | Novel arylalkanoylamine derivative and drug containing the same |
| WO1994012474A1 (en) | 1992-11-20 | 1994-06-09 | Japan Tobacco Inc. | Compound with prolyl endopeptidase inhibitor activity and pharmaceutical use thereof |
| WO1995019356A1 (en) * | 1994-01-18 | 1995-07-20 | Santen Pharmaceutical Co., Ltd. | Endopeptidase 24.15 inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2526084B2 (en) | 1996-08-21 |
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