JPS646265A - Production of thiazepine derivative - Google Patents
Production of thiazepine derivativeInfo
- Publication number
- JPS646265A JPS646265A JP63032381A JP3238188A JPS646265A JP S646265 A JPS646265 A JP S646265A JP 63032381 A JP63032381 A JP 63032381A JP 3238188 A JP3238188 A JP 3238188A JP S646265 A JPS646265 A JP S646265A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- formula
- protective group
- formula iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000004912 thiazepines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 abstract 1
- IXZDIALLLMRYOU-UHFFFAOYSA-N tert-butyl hypochlorite Chemical compound CC(C)(C)OCl IXZDIALLLMRYOU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE:To obtain a perhydro compound, by reducing alpha-[5-oxo-4,5,6,7- tetrahydro-2-(2-thienyl)-6(R)-triphenylme-thylamino-1,4-thiazepin-4-yl ]acetic acid t-butyl ester, etc. CONSTITUTION:The objective compound can be produced by reacting a compound of formula I (R<1> is aryl or heterocyclic group; R<2> is protective group for carboxyl group; R<4> is protective group for amino group) with an oxidizing agent (e.g. t-butyl hypochlorite) in a proper solvent at -80-+100 deg.C for 30min-a whole day and night, reducing the obtained compound of formula II with Mg preferably in methanol at 20-30 deg.C and, as necessary, eliminating the protective group of the amino group from the resultant compound of formula III. The objective compound such as the compound of formula III is useful as an intermediate for hypotensive agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63032381A JP2628876B2 (en) | 1987-02-17 | 1988-02-15 | Method for producing thiazepine derivatives |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3419687 | 1987-02-17 | ||
| JP62-34196 | 1987-02-17 | ||
| JP63032381A JP2628876B2 (en) | 1987-02-17 | 1988-02-15 | Method for producing thiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS646265A true JPS646265A (en) | 1989-01-10 |
| JP2628876B2 JP2628876B2 (en) | 1997-07-09 |
Family
ID=26370943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63032381A Expired - Lifetime JP2628876B2 (en) | 1987-02-17 | 1988-02-15 | Method for producing thiazepine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2628876B2 (en) |
-
1988
- 1988-02-15 JP JP63032381A patent/JP2628876B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2628876B2 (en) | 1997-07-09 |
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