JPS646271A - Carbostyril derivative - Google Patents

Carbostyril derivative

Info

Publication number
JPS646271A
JPS646271A JP62060770A JP6077087A JPS646271A JP S646271 A JPS646271 A JP S646271A JP 62060770 A JP62060770 A JP 62060770A JP 6077087 A JP6077087 A JP 6077087A JP S646271 A JPS646271 A JP S646271A
Authority
JP
Japan
Prior art keywords
formula
compound
formulas
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62060770A
Other languages
Japanese (ja)
Other versions
JPH0681752B2 (en
Inventor
Takao Nishi
Tetsuyuki Uno
Yasuo Koga
Yoshio Shu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP62060770A priority Critical patent/JPH0681752B2/en
Priority to DK167187A priority patent/DK167187A/en
Priority to DE3750913T priority patent/DE3750913T2/en
Priority to ES87104873T priority patent/ES2068807T3/en
Priority to KR1019870003141A priority patent/KR940000785B1/en
Priority to EP87104873A priority patent/EP0240015B1/en
Priority to US07/232,524 priority patent/US5008274A/en
Publication of JPS646271A publication Critical patent/JPS646271A/en
Priority to US07/958,489 priority patent/US5434164A/en
Publication of JPH0681752B2 publication Critical patent/JPH0681752B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formulas I-III (R is residue of unsaturated heterocyclic ring bearing 1-4 heteroatoms (O, N), which may be substituted; R<1> is H, alkyl, phenylalkyl; R<2> is H, halogen, alkylsulfonyloxy, alkoxy, hydroxyl; Z is O, S, CO, formula IV, formula V (R<3> is H, alkyl), NH; A is alkylene; X is O, S, SO, SO2; Z' is Z except O] or its salt. EXAMPLE:6-[2-(1-Phenyl-2-imidazolyl)thioacetyl-3,4-dihydrocarbostyril. USE:It has action to inhibit blood platelets from adhering and is useful as a remedy or prophylactic for arteriosclerosis, ischemic cardiopathy, acute or chromic nephritis. PREPARATION:For example, the reaction of a compound of formula VI (Za is O, S, NH) with another compound of formula VII (X<1> is halogen, alkanesulfonyl; n is 0, 1) gives a corresponding compound of formulas I through III.
JP62060770A 1986-04-02 1987-03-16 Carbostyril derivative Expired - Lifetime JPH0681752B2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP62060770A JPH0681752B2 (en) 1986-04-02 1987-03-16 Carbostyril derivative
DK167187A DK167187A (en) 1986-04-02 1987-04-01 CARBOSTYRIC DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS AND MEDICINAL CONTAINING THESE
EP87104873A EP0240015B1 (en) 1986-04-02 1987-04-02 Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
ES87104873T ES2068807T3 (en) 1986-04-02 1987-04-02 CARBOESTIRILE DERIVATIVES, PROCEDURE TO PREPARE THEM, PHARMACEUTICAL COMPOSITION, AND USE.
KR1019870003141A KR940000785B1 (en) 1986-04-02 1987-04-02 Method for preparing carbostyryl derivatives and salts thereof
DE3750913T DE3750913T2 (en) 1986-04-02 1987-04-02 Carbostyril derivatives, processes for their preparation, pharmaceutical compositions containing them and their use.
US07/232,524 US5008274A (en) 1986-04-02 1988-08-16 Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes
US07/958,489 US5434164A (en) 1986-04-02 1992-10-08 Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7608986 1986-04-02
JP61-76089 1986-04-02
JP4345887 1987-02-25
JP62-43458 1987-02-25
JP62060770A JPH0681752B2 (en) 1986-04-02 1987-03-16 Carbostyril derivative

Publications (2)

Publication Number Publication Date
JPS646271A true JPS646271A (en) 1989-01-10
JPH0681752B2 JPH0681752B2 (en) 1994-10-19

Family

ID=27291551

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62060770A Expired - Lifetime JPH0681752B2 (en) 1986-04-02 1987-03-16 Carbostyril derivative

Country Status (1)

Country Link
JP (1) JPH0681752B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0733765A (en) * 1993-05-19 1995-02-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
US5892190A (en) * 1988-01-29 1999-04-06 Hitachi, Ltd. Method and system of controlling elevators and method and apparatus of inputting requests to the control system
JP2006501243A (en) * 2002-08-23 2006-01-12 カイロン コーポレイション A pyrrole-based inhibitor of glycogen synthase kinase 3

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50142576A (en) * 1974-04-25 1975-11-17
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5649378A (en) * 1979-08-25 1981-05-02 Otsuka Pharmaceut Co Ltd Tetrazolylalkoxycarbostyril derivative
JPS579780A (en) * 1980-06-21 1982-01-19 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57159778A (en) * 1981-03-27 1982-10-01 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57183761A (en) * 1981-04-30 1982-11-12 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50142576A (en) * 1974-04-25 1975-11-17
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative
JPS5535019A (en) * 1978-09-01 1980-03-11 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS5649378A (en) * 1979-08-25 1981-05-02 Otsuka Pharmaceut Co Ltd Tetrazolylalkoxycarbostyril derivative
JPS579780A (en) * 1980-06-21 1982-01-19 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57159778A (en) * 1981-03-27 1982-10-01 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57183761A (en) * 1981-04-30 1982-11-12 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892190A (en) * 1988-01-29 1999-04-06 Hitachi, Ltd. Method and system of controlling elevators and method and apparatus of inputting requests to the control system
JPH0733765A (en) * 1993-05-19 1995-02-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JP2006501243A (en) * 2002-08-23 2006-01-12 カイロン コーポレイション A pyrrole-based inhibitor of glycogen synthase kinase 3

Also Published As

Publication number Publication date
JPH0681752B2 (en) 1994-10-19

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