JPS6469A - Novel prolinal derivative, production thereof and drug for alleviating amnesia containing said derivative - Google Patents
Novel prolinal derivative, production thereof and drug for alleviating amnesia containing said derivativeInfo
- Publication number
- JPS6469A JPS6469A JP63022814A JP2281488A JPS6469A JP S6469 A JPS6469 A JP S6469A JP 63022814 A JP63022814 A JP 63022814A JP 2281488 A JP2281488 A JP 2281488A JP S6469 A JPS6469 A JP S6469A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- formula
- amnesia
- alleviating
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000000044 Amnesia Diseases 0.000 title abstract 2
- 208000031091 Amnestic disease Diseases 0.000 title abstract 2
- 230000006986 amnesia Effects 0.000 title abstract 2
- AGRIQBHIKABLPJ-UHFFFAOYSA-N 1-Pyrrolidinecarboxaldehyde Chemical class O=CN1CCCC1 AGRIQBHIKABLPJ-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- HVVNJUAVDAZWCB-YFKPBYRVSA-N [(2s)-pyrrolidin-2-yl]methanol Chemical class OC[C@@H]1CCCN1 HVVNJUAVDAZWCB-YFKPBYRVSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by formula I [A is 1W4C alkylene or 3W7C saturated hydrocarbon ring; n is 2W4; D is carbon ring or heterocyclic ring which may contain 1W3 substituent groups (halogen, 1W4C alkyl, 1W4C alkoxy, CF3 or NO2)].
EXAMPLE: N-[trans-2-(3-Phenylpropanoyl)cyclopentanecarbonyl]-L-prolinal.
USE: Having inhibitory action on prolyl endopeptidase and useful for preventing and/or treating amnesia.
PREPARATION: A prolinol derivative shown by formula II or formula III is oxidized under a mild condition (e.g. inert organic solvent with an oxidizing agent at 0W50°C) to give a compound shown by formula I.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63022814A JP2528343B2 (en) | 1987-02-04 | 1988-02-04 | Novel proline derivative |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-22407 | 1987-02-04 | ||
| JP2240787 | 1987-02-04 | ||
| JP63022814A JP2528343B2 (en) | 1987-02-04 | 1988-02-04 | Novel proline derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPS6469A true JPS6469A (en) | 1989-01-05 |
| JPH0169A JPH0169A (en) | 1989-01-05 |
| JP2528343B2 JP2528343B2 (en) | 1996-08-28 |
Family
ID=26359622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63022814A Expired - Lifetime JP2528343B2 (en) | 1987-02-04 | 1988-02-04 | Novel proline derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2528343B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| EP2481408A2 (en) | 2007-03-01 | 2012-08-01 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
-
1988
- 1988-02-04 JP JP63022814A patent/JP2528343B2/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
| EP2481408A2 (en) | 2007-03-01 | 2012-08-01 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2528343B2 (en) | 1996-08-28 |
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