MA43214A - Détection d'aneuploïdies chromosomiques foetales à l'aide des régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte - Google Patents

Détection d'aneuploïdies chromosomiques foetales à l'aide des régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte

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Publication number
MA43214A
MA43214A MA043214A MA43214A MA43214A MA 43214 A MA43214 A MA 43214A MA 043214 A MA043214 A MA 043214A MA 43214 A MA43214 A MA 43214A MA 43214 A MA43214 A MA 43214A
Authority
MA
Morocco
Prior art keywords
anuploids
chromosomic
fetus
fetal
dna
Prior art date
Application number
MA043214A
Other languages
English (en)
Inventor
Wera Hofmann
Matthias Sachse
Steffi Werler
Original Assignee
Lifecodexx Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifecodexx Ag filed Critical Lifecodexx Ag
Publication of MA43214A publication Critical patent/MA43214A/fr

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/107—Reactions characterised by their quantitative nature the purpose being quantitative analysis with a competitive internal standard/control
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MA043214A 2015-11-10 2016-11-09 Détection d'aneuploïdies chromosomiques foetales à l'aide des régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte MA43214A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15193966.7A EP3168309B8 (fr) 2015-11-10 2015-11-10 Détection d'aneuploïdies chromosomiques foetales au moyen de régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte

Publications (1)

Publication Number Publication Date
MA43214A true MA43214A (fr) 2018-09-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA043214A MA43214A (fr) 2015-11-10 2016-11-09 Détection d'aneuploïdies chromosomiques foetales à l'aide des régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte

Country Status (15)

Country Link
US (1) US11753684B2 (fr)
EP (2) EP3168309B8 (fr)
JP (1) JP2018533953A (fr)
KR (1) KR20180093902A (fr)
CN (1) CN109689896A (fr)
AU (1) AU2016351889A1 (fr)
BR (1) BR112018008532A2 (fr)
CA (1) CA3042946A1 (fr)
DK (1) DK3168309T3 (fr)
ES (1) ES2965036T3 (fr)
HU (2) HUE050491T2 (fr)
IL (1) IL258796A (fr)
MA (1) MA43214A (fr)
SG (1) SG11201803190SA (fr)
WO (1) WO2017081047A1 (fr)

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CN111979309B (zh) * 2019-05-21 2022-08-26 北京达微生物科技有限公司 用于三体综合征检测的组合套装
CN110734968B (zh) * 2019-10-29 2022-05-31 华侨大学 一种用于鉴定方格星虫遗传性别的探针及方法
CN111154841B (zh) * 2020-02-06 2024-02-20 江苏圣极基因科技有限公司 基于数字pcr检测母体血浆中胎儿游离dna绝对拷贝数的方法及试剂盒
CN113249458B (zh) * 2020-02-10 2023-07-07 北京优乐复生科技有限责任公司 一种预测胎盘源性疾病的评估和预测的方法和试剂盒
CN112662763A (zh) * 2020-03-10 2021-04-16 博尔诚（北京）科技有限公司 一种检测常见两性癌症的探针组合物
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚（北京）科技有限公司 一种检测11种癌症的探针组合物
KR102332540B1 (ko) * 2020-07-02 2021-11-29 의료법인 성광의료재단 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법
CN112143790B (zh) * 2020-09-29 2021-08-24 时伟丽 基于NRIP1 mRNA的m6A甲基化修饰评估唐氏综合征风险的方法及其应用
RU2760701C1 (ru) * 2021-04-13 2021-11-29 Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" Способ выявления хромосомных аномалий у плодов беременных группы низкого риска по результатам комбинированного пренатального скрининга во втором и третьем триместре беременности
CN113046435B (zh) * 2021-05-14 2023-10-03 吉林大学第一医院 一种用于制备产前胎儿21-三体综合征检测的pcr反应体系的特异性引物
CN113643755B (zh) * 2021-08-11 2023-10-13 上海小海龟科技有限公司 一种nipt试剂盒阳性率校正方法、装置、计算机设备和介质
CN116779025B (zh) * 2022-03-08 2026-02-17 博尔诚（北京）科技有限公司 用于癌症筛查的系统
WO2024195263A1 (fr) * 2023-03-17 2024-09-26 国立大学法人山口大学 Procédé de mesure du niveau de méthylation de cpg du gène
CN121195078A (zh) * 2023-05-23 2025-12-23 国立大学法人山口大学 辅助肝细胞癌的诊断的方法
CN119351541B (zh) * 2024-10-28 2025-12-09 南京市妇幼保健院 一种子痫前期诊疗生物学标志物及其应用

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Publication number Publication date
KR20180093902A (ko) 2018-08-22
US20190249249A1 (en) 2019-08-15
EP3374519B1 (fr) 2023-10-04
EP3168309A1 (fr) 2017-05-17
BR112018008532A2 (pt) 2018-10-30
DK3168309T3 (da) 2020-06-22
HUE064507T2 (hu) 2024-03-28
AU2016351889A1 (en) 2018-06-28
IL258796A (en) 2018-06-28
CA3042946A1 (fr) 2017-05-18
HUE050491T2 (hu) 2020-12-28
EP3374519C0 (fr) 2023-10-04
ES2965036T3 (es) 2024-04-10
EP3168309B8 (fr) 2020-06-03
WO2017081047A1 (fr) 2017-05-18
EP3168309B1 (fr) 2020-04-08
SG11201803190SA (en) 2018-05-30
CN109689896A (zh) 2019-04-26
US11753684B2 (en) 2023-09-12
EP3374519A1 (fr) 2018-09-19
JP2018533953A (ja) 2018-11-22

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