KR910000748A - 결정성 세펨산 부가염 및 이의 제조 방법 - Google Patents

결정성 세펨산 부가염 및 이의 제조 방법 Download PDF

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KR910000748A
KR910000748A KR1019900008498A KR900008498A KR910000748A KR 910000748 A KR910000748 A KR 910000748A KR 1019900008498 A KR1019900008498 A KR 1019900008498A KR 900008498 A KR900008498 A KR 900008498A KR 910000748 A KR910000748 A KR 910000748A
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South Korea
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addition salt
acid addition
cefeic
crystalline
formula
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KR1019900008498A
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KR0158883B1 (ko
Inventor
아담 프리드헬름
뒤르크하이머 발터
멘케 부르크하르트
이제르트 디이터
Original Assignee
베른하르트 벡크, 하인리히 벡커
훽스트 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

결정성 세펨산 부가염 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(Ⅱ)의 결정성 세펨산 부가염.
    상기식에서 R은 수소 또는 C1-C4-알킬이고, 그룹 =N-OH는 syn-위치에 존재한다.
  2. 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카르복실레이트 벤젠설포네이트인 결정성 세펨산 부가염.
  3. 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카르복실레이트 톨루엔설포네이트인 결정성 세펨산 부가염.
  4. 제1항에 있어서, α-(2, 2-디메틸프로파노일옥시)에틸7-〔2-(2-아미노티아졸-4-일)-2-(Z)-하이드록시이미노-아세트아미도〕-3-메톡시메틸-3-세펨--카복실레이트p-에틸벤젠셀포네이트인 결정성 세펨산 부가염.
  5. 일반식(Ⅰ)의 비결정성 세펨을 유기 용매중에서 일반식(Ⅲ)의 산과 반응시킨 다음 생성된 산 부가염을 직접 또는 다른 유기용매 또는 물을 첨가하여 결정화시킴을 특징으로 하여, 일반식(Ⅱ)의 결정성 세펨산 부가염을 제조하는 방법.
    상기식에서 R은 수소 또는 C1-C4-알킬이고, 그룹 =N-OH는 syn-위치에 존재한다.
  6. 일반식(Ⅱ)의 세펨산 부가염을 함유하는, 세균감염에 대해 효과적인 약제.
  7. 통상적인 약제학적 부형제 또는 희석제를 사용하여 일반식(Ⅱ)의 세펨산 부가염을 약제학적 투여에 적합한 형태로 하여, 세균 감염에 효과적인 약제를 제조하는 방법.
  8. 세균감염을 억제하기 위한 일반식(Ⅱ)의 세펨산 부가염의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900008498A 1989-06-13 1990-06-11 결정성 세펨산 부가염 및 이의 제조방법 Expired - Lifetime KR0158883B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3919259A DE3919259A1 (de) 1989-06-13 1989-06-13 Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3919259.8 1989-06-13

Publications (2)

Publication Number Publication Date
KR910000748A true KR910000748A (ko) 1991-01-30
KR0158883B1 KR0158883B1 (ko) 1998-12-01

Family

ID=6382651

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KR1019900008498A Expired - Lifetime KR0158883B1 (ko) 1989-06-13 1990-06-11 결정성 세펨산 부가염 및 이의 제조방법

Country Status (19)

Country Link
US (1) US5409918A (ko)
EP (1) EP0402806B1 (ko)
JP (1) JPH0730085B2 (ko)
KR (1) KR0158883B1 (ko)
CN (1) CN1043043C (ko)
AT (1) ATE95185T1 (ko)
AU (1) AU645254B2 (ko)
CA (1) CA2018794C (ko)
DE (2) DE3919259A1 (ko)
DK (1) DK0402806T3 (ko)
ES (1) ES2045653T3 (ko)
FI (1) FI96424C (ko)
HU (1) HU207087B (ko)
IE (1) IE64076B1 (ko)
IL (1) IL94701A (ko)
NO (1) NO174258C (ko)
NZ (1) NZ234004A (ko)
PT (1) PT94347B (ko)
ZA (1) ZA904526B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
US5589593A (en) * 1991-11-11 1996-12-31 Biochimica Opos Spa Crystalline form of a cephalosporin antibiotic
TW212181B (ko) * 1992-02-14 1993-09-01 Hoechst Ag
DK0570849T3 (da) * 1992-05-21 1998-09-28 Hoechst Ag Fremgangsmåde til spaltning af cephalosporin-prodrugestere til dannelse af 7-amino-3-methoxymethyl-ceph-3-em-4-carboxylsyre
LT3871B (en) 1993-11-30 1996-04-25 Hoechst Ag Additive crystalline salts of pure diastereomers of 1-cefem-4-carboxylic acid 1-(2,2-dimethyl-propionyloxy)ethyl esters, process for the preparation thereof, pharmaceutical compositions and process for the preparation thereof
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
AT408226B (de) * 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
JP4749194B2 (ja) * 2006-03-28 2011-08-17 ジャパンパイル株式会社 オーガー削孔装置における土質試料採取具

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668783A (en) * 1974-12-19 1987-05-26 Takeda Chemical Industries, Ltd. Thiazolylacetamido cephalosporin compounds
US4203899A (en) * 1974-12-19 1980-05-20 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
JPS5760345B2 (ko) * 1974-12-19 1982-12-18 Takeda Chemical Industries Ltd
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
JPS523091A (en) * 1975-06-23 1977-01-11 Takeda Chem Ind Ltd A prcess for preparing cephalosporins
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
IT1101437B (it) * 1978-11-28 1985-09-28 Proter Spa Procedimento per il recupero di cefaloridina da soluzione acquosa nella quale e'stata prodotta
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5759894A (en) * 1980-09-30 1982-04-10 Sankyo Co Ltd Cephalosporin for oral administration
US4486425A (en) * 1980-09-30 1984-12-04 Sankyo Company Limited 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates
FR2532315A1 (fr) * 1982-08-27 1984-03-02 Rhone Poulenc Sante Formes cristallisees de sels d'addition avec des acides, de l'((amino-2-thiazolyl-4)-2 methoxyimino-2 acetamido)-7 carboxy-2 (dioxo-5,6 formylmethyl-4 tetrahydro-1,4,5,6 triazine-1,2,4 yl-3) thio-2 vinyl)-3 oxo-8 thia-5 aza-1 bicyclo(4.2.0) octene-2 isomere syn, forme e et leur preparation
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
DE3809561A1 (de) * 1988-03-22 1989-10-05 Hoechst Ag Ester der 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroxyiminoacetamido)-3-methoxymethyl-3-cephem-4-carbonsaeure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil

Also Published As

Publication number Publication date
CN1048042A (zh) 1990-12-26
AU5697690A (en) 1990-12-20
NO902607D0 (no) 1990-06-12
IL94701A (en) 1994-11-28
DK0402806T3 (da) 1994-01-17
FI96424B (fi) 1996-03-15
NO174258C (no) 1994-04-06
PT94347A (pt) 1991-02-08
IE902115A1 (en) 1991-01-02
EP0402806A1 (de) 1990-12-19
NZ234004A (en) 1992-07-28
HUT56375A (en) 1991-08-28
JPH0324086A (ja) 1991-02-01
FI902900A0 (fi) 1990-06-11
CA2018794C (en) 2000-05-16
US5409918A (en) 1995-04-25
CA2018794A1 (en) 1990-12-13
DE59002880D1 (de) 1993-11-04
CN1043043C (zh) 1999-04-21
IE902115L (en) 1990-12-13
AU645254B2 (en) 1994-01-13
IL94701A0 (en) 1991-04-15
KR0158883B1 (ko) 1998-12-01
ES2045653T3 (es) 1994-01-16
NO902607L (no) 1990-12-14
IE64076B1 (en) 1995-07-12
HU207087B (en) 1993-03-01
FI96424C (fi) 1996-06-25
HU903828D0 (en) 1990-11-28
PT94347B (pt) 1997-01-31
NO174258B (no) 1993-12-27
EP0402806B1 (de) 1993-09-29
ATE95185T1 (de) 1993-10-15
ZA904526B (en) 1991-03-27
DE3919259A1 (de) 1990-12-20
JPH0730085B2 (ja) 1995-04-05

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