KR930019829A - 엡스타인 바르 비루스(Epstein Barr Virus)와 관련된 펩티드 및 핵산 서열 - Google Patents

엡스타인 바르 비루스(Epstein Barr Virus)와 관련된 펩티드 및 핵산 서열 Download PDF

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KR930019829A
KR930019829A KR1019930003940A KR930003940A KR930019829A KR 930019829 A KR930019829 A KR 930019829A KR 1019930003940 A KR1019930003940 A KR 1019930003940A KR 930003940 A KR930003940 A KR 930003940A KR 930019829 A KR930019829 A KR 930019829A
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마이클 미델도르프 재프
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에프. 쥐. 엠. 헤르만스, 에이. 쥐. 제이. 베르미어렌
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Abstract

본 발명은 EBA 오픈 리딩 프레임(open reading frame)DLS BFRF 3과 BdRF1 내에서 각각 암호된 VCA-p18이나 VCA-p40 단백질을 적어도 일부분 또는 그것의 작용성 변이체를 포함하고 있고, 엡스타인-바르 비루스(Epstein Barr virus)에 대한 항체와 면역화학적으로 반응적인 펩티드에 관한 것이다. 또한 본 발명은 이들 펩티드를 암호하는 핵산 서열, 이들 펩티드에 대하여 생성된 단일클론 항체, 이 단일클론 항체를 생성할 수 있는 세포주 및 항-유전인자형 항체에 관한 것이다.
본 발명은 또한 본 발명의 핵산 서열을 포함하는 제조합 벡터의 분자 및 이 벡터 분사로 형질전환되거나 형질감염된 숙주세포에 관한 것이다. 본 발명은 또한 EBV 또는 항-EBV 항체를 검측하기 위한 방법 및 면역학적 시약 그리고 엡스타인 바르 비루스 핵산을 증폭시키고 검측하는 방법에 관한 것이다.

Description

엡스타인 바르 비루스(Epstein Barr Virus)와 관련된 펩티드 및 핵산 서열.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 : VCA-p40 및 VCA-p18 단백질을 암호화하는 EBV-암호화된 유전자를 동정하기 위한 시도의 요약.
제2도 : a) EA 및 VCA의 발현을 위해 유도된 비루스-생산 세포주 HH514의 핵의 항원 추출물의 웨스턴 블로트, b) BFRF3-β-갈락토시다제 융합 단백질을 발현시키는 이. 콜리의 전체 세포 분해질의 웨스턴 블로드, c) BdRF1-β-갈락토시다제 융합 단백질을 발현시키는 이. 콜리의 전체 세포 분해질의 웨스턴 블로드. d) β-갈락토시다제만을 발현시키는 이. 콜리의 전체 세포 분해질의 웨스턴 블로트.

Claims (25)

  1. EBV 오픈 리딩 프레임(open reading frame)DLS BFRF 3과 BdRF1 내에서 각각 암호된 VCA-p18이나 VCA-p40 단백질을 적어도 일부분 또는 그것의 작용성 변이체를 포함하고 있고, 엡스타인-바르 비루스(Epstein Barr virus)에 대한 항체와 면역화학적으로 반응적인 펩티드.
  2. 제1항에 있어서, 서열 동정 번호 2에 나타낸 아미노산 서열의 적어도 일부분 또는 그것의 작용성 변이체를 포함하고 있는 펩티드.
  3. 제1항에 있어서, 서열 동정 번호 4에 나타낸 아미노산 서열의 적어도 일부분 또는 그것의 작용성 변이체를 포함하고 있는 펩티드.
  4. 제2항에 있어서, 서열 동정 번호 5와 6에 나타낸 아미노산 서열 중에서 선책된 아미노산 서열을 적어도 하나 포함하는 펩티드.
  5. 제4항에 있어서, 서열 동정 번호 6에 나타낸 아미노산 서열에 연결된 서열 동정 번호 5에 나타낸 아미노산 서열을 포함하는 펩티드.
  6. 제1항 내지 제5항 중 어느 한 항의 펩티드를 암호하는 핵산 서열.
  7. 서열 동정 번호 1에 나타낸 핵산 서열을 적어도 일부분 포함하는 핵산 서열.
  8. 서열 동정 번호 3에 나타낸 핵산 서열을 적어도 일부분 포함하는 핵산 서열.
  9. 제6항 내지 제8항 중 어느 한 항의 핵산 서열을 포함하는 재조합 벡터분자.
  10. 제9항의 재조합 벡터 분자로 형질전환되거나 형질감염된 숙주세포.
  11. 제1항 내지 제5항 중 어느 한 항의 펩티드에 대하여 생성된 항체.
  12. 제11항에 있어서, 상기 항체는 단일 클론 항체인 것을 특징으로 하는 항체.
  13. 유럽 동물 세포 배양 수집소(ECACC, 영국 포톤 다운에 소재)에 기탁 번호 제93020413호 및 제 93020412호로 각각 기탁되어 있는 래트-마우스 하이브리도마 세포주가 생성하는 단일클론 항체 EBV.OT15E 또는 EBV.OT15Ⅰ로서, VCA-p18과 동일한 반응성을 가진 단일클론 항체.
  14. 유럽 동물 세포 배양 수집소(ECACC, 영국 포톤 다운에 소재)에 기탁 번호 제93020414호로 기탁되어 있는 마우스-마우스 하이브리도마 세포주가 생성하는 단일 클론 항체 EBV.OT41A로서, VCA-p40과 동일한 반응성을 가진 단일클론 항체.
  15. 제13항이나 제14항의 단일클론 항체를 생성할 수 있는 영구적인 세포주.
  16. 제15항에 있어서, 유럽 동물 세포 배양 수집소(ECACC, 영국 포톤 다운에 소재)에 기탁 번호 제93020413호, 제 93020412호 또는 제93020414호로 기탁되어 있는 영 구적인 세포주.
  17. 제11항의 항체와 반응적인 항-유전인자형 항체.
  18. 제11항 내지 제5항 중 어느 한 항의 펩티드(들)을 하나 이상 포함하는 면역화학 시약.
  19. 제11항 내지 제14항 중 어느 한 항의 항체들을 하나 이상 포함하는 면역화학 시약.
  20. 제11항 내지 제14항 중 어느 한 항의 항체를 샘플과 접촉시킨 후 형성된 면역 복합체의 상기 샘플 중의 엡스타인-바르 비루스 존재의 척도로서 검측하는 것을 특징으로 하는 샘플내에 엡스타인-바르 비루스를 검측하는 방법.
  21. 제14항의 면역화학 시약을 샘플과 접촉시킨 후 그 샘플내의 펩티드와 항체 사이에 형성된 면역 복합체의 존재를 상기 샘플 중의 엡스타인-바르 비루스에 대한 항체 존재이 척도로서 검측하는 것을 특징으로 하는 샘플내에 엡스타인-바르 비루스에 대하여 생성되는 항체의 검측 방법.
  22. 제1항 내지 제5항 중 어느 한 항의 하나 이상의 펩티드를 샘플 및 엡스타인 바르 비루스에 대하여 생성된 항체와 접촉시킨 후, 형성된 면역 복합체의 존재를 검측하고 이로부터 상기 샘플내의 엡스타인 바르 비루스의 존재가 층정됨을 특징으로 하는 상기 샘플내에 엡스타인-바르 비루스를 검측하는 방법.
  23. 엡스타인-바르 비루스 핵산 서열을 증폭시키고 증폭된 서열을 검측하기 위하여 프라이머(들)로서 제6항 내지 제8항의 핵산 서열이나 그것의 단편 중 적어도 하나를 사용하여 샘플내에 상기 엡스타인-바르 비루스 핵산 서열을 증폭시키고 검측하는 방법.
  24. 제20항 내지 제22항 중 어느 한 항의 방법을 실시하기 위한 실험 킷트.
  25. 제23항의 증폭 방법을 시하기 위한 시험 증폭 킷트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930003940A 1992-03-13 1993-03-13 엡스타인 바르 바이러스와 관련된 펩티드 및 핵산 서열 Expired - Lifetime KR100291247B1 (ko)

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