KR970700202A - 다공성 입자 응집체 및 이의 제조방법(porous particle aggregate and method therefor) - Google Patents

다공성 입자 응집체 및 이의 제조방법(porous particle aggregate and method therefor)

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KR970700202A
KR970700202A KR1019960703783A KR19960703783A KR970700202A KR 970700202 A KR970700202 A KR 970700202A KR 1019960703783 A KR1019960703783 A KR 1019960703783A KR 19960703783 A KR19960703783 A KR 19960703783A KR 970700202 A KR970700202 A KR 970700202A
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aggregate
composition
particles
porous
binder
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엘. 휘슬러 로이
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리차드 디. 스미트
푸이즈 테크놀로지즈 리미티드
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Abstract

기능성 물질을 방출할 수 있도록 보류하는 높은 응집체내 망상 용적을 가지는 다공성 응집체가 설명된다. 다공성 응집체는 응집체내에서 적어도 접점에서 서로 결합된 구별된 입자, 바람직하게는 전분 과립을 포함한다. 구별된 입자의 표면들은 서로 합력하여 응집체내 망상 용적을 한정한다. 본 발명의 다공성 응집체 조성물은 기능성 물질의 고 효능 운반체로서의 용도를 가지고 있으며, 여기서 기능성 물질이 기계적 압력/해체의 영향하에서, 결합제 및/또는 입자 성분의 분해 또는 용해에 의해서, 또는 다공성 표면으로부터의 확산에 의해서 응집체 조성물로부터 방출된다.

Description

다공성 입자 응집체 및 이의 제조방법(POROUS PARTICLE AGGREGATE AND METHOD THEREFOR)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (30)

  1. 전분 과립의 실질적인 구형 응집체들의 이 응집체들의 최소한 접점에서 결합체와 결합되어 있고, 상기 응집된 전분 과립들의 표면이 기능성 물질을 방출할 수 있도록 보유하는 응집체내 망상 용적을 한정하며, 상기 전분 과립 응집체는 약 5 내지 약 250 미크론의 평균 직경을 가지는, 상기 다공성 응집체를 포함하는 물질의 조성물.
  2. 제1항에 있어서, 결합제는 전분 과립에 내재적인 것이 아닌 수용성 폴리머를 포함하는 전분 과립 응집체 조성물.
  3. 제1항에 있어서, 상기 응집체의 표면에 적용된 코팅 조성물을 더 포함하는 전분 과립 응집체.
  4. 제1항에 있어서, 결합제 과립은 부분적으로 가수분해된 미세 다공성 전분 과립을 포함하는 전분 과립 응집체 조성물.
  5. 제1항에 있어서, 상기 결합제는 상기 전분 과립에 내재적이 아닌 다당류, 단백질 및 폴리에스테르로 구성되는 군으로부터 선택된 생분해성 또는 생부식성 중합체인 전분 과립 응집체.
  6. 제1항에 있어서, 상기 다공성 응집체의 망상 용적에 기능성 물질을 더 포함하는 전분 과립 응집체.
  7. 제6항에 있어서, 상기 기능성 물질은 치료 약물 물질을 포함하는 전분 과립 응집체.
  8. 제6항에 있어서, 상기 응집체의 표면에 적용된 코팅 조성물을 더 포함하는 전분 과립 응집체.
  9. 제1항에 있어서, 상기 조성물은 제조된 식품인 전분 과립 응집체.
  10. 제9항에 있어서, 상기 제조된 식품은 추잉껌인 전분 과립 응집체.
  11. 최대 크기로 약 1 내지 약 100 미크론의 평균 입자 크기를 가지는 구별된 입자들의 다공성 응집체들이 상기 다공성 응집체 내의 입자들의 적어도 접점에서 상기 구별된 입자들에 내재적인 것이 아닌 결합제와 결합되어 있는 그러한 다공성 응집체들을 제조하는 방법에 있어서, 상기 입자들을 상기 결합제의 용액에 현탁시키고 및 상기 현탁액을 스프레이 건조시키는 단계를 포함하는 방법.
  12. 제11항에 있어서, 코팅 조성물을 상기 다공성 응집체의 표면에 적용시키는 단계를 더 포함하는 방법.
  13. 제11항에 있어서, 상기 결합제는 수용성 중합체인 방법.
  14. 제11항에 있어서, 기능성 물질을 상기 다공성 응집체의 망상 용적에 유입하는 단계를 포함하는 방법.
  15. 제14항에 있어서, 상기 기능성 물질은 치료 약물 물질인 방법.
  16. 제14항에 있어서, 중합체 용액을 적용하여 상기 다공성 응집체의 표면을 코팅하는 방법.
  17. 제11항에 있어서, 상기 구별된 입자는 전분 과립인 방법.
  18. 제12항에 있어서, 상기 구별된 입자는 전분 과립인 방법.
  19. 제14항에 있어서, 상기 구별된 입자는 전분 과립인 방법.
  20. 제16항에 있어서, 상기 구별된 입자는 전분 과립인 방법.
  21. 최대 크기로 약 1 내지 약 100 미크론의 평균 입자 크기를 가지는 구별된 입자들의 다공성 응집체들이 상기 다공성 응집체 내의 입자들의 적어도 접점에서 상기 구별된 입자들에 내재적인 것이 아닌 결합제와 결합되어 있고, 상기 응집된 입자의 표면이 기능성 물질을 방출할 수 있도록 보유하는 응집체내 망상 용적을 한정하는 상기 구별된 입자들의 응집체를 포함하는 조성물.
  22. 제21항에 있어서, 상기 구별된 입자는 전분 과립을 포함하는 입자 응집체 조성물.
  23. 제21항에 있어서, 상기 입자들은 미세화된 셀룰로스성 펄프를 포함하는 입자 응집체 조성물.
  24. 제21항에 있어서, 상기 입자들은 합성 중합체 입자들을 포함하는 입자 응집체 조성물.
  25. 제21항에 있어서, 망상 용적에 기능성 물질을 포함하는 입자 응집체 조성물.
  26. 제25항에 있어서, 상기 기능성 물질은 치료 약물을 포함하는 입자 응집체 조성물.
  27. 제25항에 있어서, 상기 응집체의 표면에 적용된 코팅 조성물을 더 포함하는 입자 응집체 조성물.
  28. 제27항에 있어서, 상기 코팅 조성물은 다당류, 폴리비닐 알콜, 폴리-N-비닐-2-피롤리돈, 폴리아크릴아미드, 및 아크릴성 중합체 또는 공중합체로 구성되는 군으로부터 선택되는 입자 응집체 조성물.
  29. 제21항에 있어서, 상기 결합제는 생분해성 중합체인 입자 응집체 조성물.
  30. 제29항에 있어서, 상기 중합체는 다당류, 단백질 및 폴리에스테르류로부터 구성되는 군으로부터 선택되는 입자 응집체 조성물.
KR1019960703783A 1994-01-14 1995-01-17 다공성 입자 응집체 및 이의 제조방법(porous particle aggregate and method therefor) Ceased KR970700202A (ko)

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US08/182,442 US5486507A (en) 1994-01-14 1994-01-14 Porous particle aggregate and method therefor
US08/182,442 1994-01-14
PCT/US1995/000707 WO1995019376A1 (en) 1994-01-14 1995-01-17 Porous particle aggregate and method therefor

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US5670490A (en) 1997-09-23
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WO1995019376A1 (en) 1995-07-20
JPH09511531A (ja) 1997-11-18
CN1146773A (zh) 1997-04-02
CA2180856C (en) 2008-03-11
US5726161A (en) 1998-03-10
US5486507A (en) 1996-01-23
CA2180856A1 (en) 1995-07-20

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