LT2361936T - Antigeną rišanti molekulė ir jos panaudojimas - Google Patents

Antigeną rišanti molekulė ir jos panaudojimas

Info

Publication number: LT2361936T
Authority: LT; Lithuania
Prior art keywords: antigen; binding molecule; molecule; binding
Prior art date: 2010-02-25

Application number

LTEP10154751.1T

Other languages

English (en)

Inventor

Melvyn Little

Fabrice Le Gall

Original Assignee

Affimed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-02-25

Filing date

2010-02-25

Publication date

2016-09-12

2010-02-25 Application filed by Affimed Gmbh filed Critical Affimed Gmbh

2016-09-12 Publication of LT2361936T publication Critical patent/LT2361936T/lt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

LTEP10154751.1T 2010-02-25 2010-02-25 Antigeną rišanti molekulė ir jos panaudojimas LT2361936T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP10154751.1A EP2361936B1 (en)	2010-02-25	2010-02-25	Antigen-binding molecule and uses thereof

Publications (1)

Publication Number	Publication Date
LT2361936T true LT2361936T (lt)	2016-09-12

Family

ID=42232726

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP10154751.1T LT2361936T (lt)	2010-02-25	2010-02-25	Antigeną rišanti molekulė ir jos panaudojimas
LTEP11156113.0T LT2371866T (lt)	2010-02-25	2011-02-25	Daugiavalentė antigeną rišanti fv molekulė

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTEP11156113.0T LT2371866T (lt)	2010-02-25	2011-02-25	Daugiavalentė antigeną rišanti fv molekulė

Country Status (12)

Country	Link
EP (2)	EP2361936B1 (lt)
DK (1)	DK2371866T3 (lt)
ES (2)	ES2582001T3 (lt)
HR (1)	HRP20190288T1 (lt)
HU (1)	HUE041615T2 (lt)
LT (2)	LT2361936T (lt)
PL (2)	PL2361936T3 (lt)
PT (2)	PT2361936T (lt)
RS (1)	RS58352B1 (lt)
SI (1)	SI2371866T1 (lt)
SM (1)	SMT201900115T1 (lt)
TR (1)	TR201902400T4 (lt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2013013700A1 (en) *	2011-07-22	2013-01-31	Affimed Therapeutics Ag	Multivalent antigen-binding fv molecule
PL2970449T3 (pl) *	2013-03-15	2020-04-30	Amgen Research (Munich) Gmbh	Jednołańcuchowe cząsteczki wiążące zawierające N-końcowy ABP
EA035419B9 (ru)	2014-05-29	2020-08-07	Мэкроудженикс, Инк.	Триспецифичные связывающие молекулы и способы их применения
WO2016001810A1 (en)	2014-07-01	2016-01-07	Pfizer Inc.	Bispecific heterodimeric diabodies and uses thereof
CA2970924A1 (en) *	2014-10-31	2016-05-06	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Tetravalent tlr9 bispecific antibody
RU2017129236A (ru)	2015-01-26	2019-03-07	Макродженикс, Инк.	Мультивалентные молекулы, содержащие dr5-связывающие домены
PL3298033T5 (pl)	2015-05-18	2023-10-30	TCR2 Therapeutics Inc.	Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
TWI773646B (zh)	2015-06-08	2022-08-11	美商宏觀基因股份有限公司	結合lag-3的分子和其使用方法
HUE068868T2 (hu)	2015-07-30	2025-02-28	Macrogenics Inc	PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások
IL260021B (en)	2015-12-14	2022-09-01	Macrogenics Inc	Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them
WO2017142928A1 (en)	2016-02-17	2017-08-24	Macrogenics, Inc.	Ror1-binding molecules, and methods of use thereof
GEP20227398B (en)	2016-04-15	2022-07-25	Macrogenics Inc	Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof
CA3032498A1 (en)	2016-08-02	2018-02-08	TCR2 Therapeutics Inc.	Compositions and methods for tcr reprogramming using fusion proteins
WO2018067993A1 (en)	2016-10-07	2018-04-12	TCR2 Therapeutics Inc.	Compositions and methods for t-cell receptors reprogramming using fusion proteins
JP7291396B2 (ja)	2016-11-22	2023-06-15	ティーシーアール２セラピューティクスインク．	融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
CA3048211A1 (en)	2016-12-23	2018-06-28	Macrogenics, Inc.	Adam9-binding molecules, and methods of use thereof
AU2018226526B2 (en) *	2017-02-28	2025-03-13	Affimed Gmbh	Combination of an anti-CD16A antibody with a cytokine
WO2018158349A1 (en)	2017-02-28	2018-09-07	Affimed Gmbh	Tandem diabody for cd16a-directed nk-cell engagement
KR20200098590A (ko)	2017-12-12	2020-08-20	마크로제닉스, 인크.	이중특이적 cd16-결합 분자 및 질환 치료에서의 그것의 용도
JP7337079B2 (ja)	2018-02-15	2023-09-01	マクロジェニクス，インコーポレーテッド	変異型ｃｄ３結合ドメイン、及び疾患の治療のための併用療法におけるその使用
CA3095373A1 (en) *	2018-04-13	2019-10-17	Affimed Gmbh	Nk cell engaging antibody fusion constructs
JP7489407B2 (ja)	2019-05-21	2024-05-23	ノバルティスアーゲー	Ｃｄ１９結合分子及びその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2156149T3 (es)	1992-12-04	2001-06-16	Medical Res Council	Proteinas de union multivalente y multiespecificas, su fabricacion y su uso.
DE19819846B4 (de)	1998-05-05	2016-11-24	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Multivalente Antikörper-Konstrukte
DE10060140A1 (de) *	2000-12-04	2002-06-06	Vectron Therapeutics Ag Imt	Multimerer mehrfach-antigenbindender einzelkettiger Antikörper
WO2003087163A1 (en) *	2002-04-15	2003-10-23	Chugai Seiyaku Kabushiki Kaisha	METHOD OF CONSTRUCTING scDb LIBRARY
EP1400534B1 (en)	2002-09-10	2015-10-28	Affimed GmbH	Human CD3-specific antibody with immunosuppressive properties
GB0510790D0 (en)	2005-05-26	2005-06-29	Syngenta Crop Protection Ag	Anti-CD16 binding molecules

2010
- 2010-02-25 EP EP10154751.1A patent/EP2361936B1/en active Active
- 2010-02-25 ES ES10154751.1T patent/ES2582001T3/es active Active
- 2010-02-25 PT PT101547511T patent/PT2361936T/pt unknown
- 2010-02-25 PL PL10154751.1T patent/PL2361936T3/pl unknown
- 2010-02-25 LT LTEP10154751.1T patent/LT2361936T/lt unknown
2011
- 2011-02-25 PL PL11156113T patent/PL2371866T3/pl unknown
- 2011-02-25 PT PT11156113T patent/PT2371866T/pt unknown
- 2011-02-25 RS RS20190201A patent/RS58352B1/sr unknown
- 2011-02-25 ES ES11156113T patent/ES2711377T3/es active Active
- 2011-02-25 DK DK11156113.0T patent/DK2371866T3/en active
- 2011-02-25 TR TR2019/02400T patent/TR201902400T4/tr unknown
- 2011-02-25 SI SI201131675T patent/SI2371866T1/sl unknown
- 2011-02-25 LT LTEP11156113.0T patent/LT2371866T/lt unknown
- 2011-02-25 HU HUE11156113A patent/HUE041615T2/hu unknown
- 2011-02-25 EP EP11156113.0A patent/EP2371866B1/en active Active
- 2011-02-25 SM SM20190115T patent/SMT201900115T1/it unknown
2019
- 2019-02-13 HR HRP20190288TT patent/HRP20190288T1/hr unknown

Also Published As

Publication number	Publication date
EP2371866B1 (en)	2018-11-21
EP2371866A3 (en)	2013-06-26
PT2371866T (pt)	2019-02-27
TR201902400T4 (tr)	2019-03-21
HRP20190288T1 (hr)	2019-04-05
LT2371866T (lt)	2019-03-12
EP2361936B1 (en)	2016-04-20
ES2711377T3 (es)	2019-05-03
EP2371866A2 (en)	2011-10-05
SMT201900115T1 (it)	2019-02-28
ES2582001T3 (es)	2016-09-08
PL2361936T3 (pl)	2016-10-31
HUE041615T2 (hu)	2019-05-28
DK2371866T3 (en)	2019-03-18
SI2371866T1 (sl)	2019-04-30
PL2371866T3 (pl)	2019-05-31
RS58352B1 (sr)	2019-03-29
EP2361936A1 (en)	2011-08-31
PT2361936T (pt)	2016-07-15

Publication	Publication Date	Title
PL2361936T3 (pl)	2016-10-31	Cząsteczka wiążąca antygen i jej zastosowania
DK2729170T3 (en)	2022-03-21	Antibody variants and uses thereof
IL232399A0 (en)	2014-06-30	Anti-2fgfr antibodies and their use
ZA201308879B (en)	2014-07-30	Anti-angptl3 antibodies and uses thereof
PT2581113T (pt)	2018-07-04	Anticorpo anti-tim-3
HRP20180952T1 (hr)	2018-07-27	Anti-dll3 antitijelo
SI2946791T1 (sl)	2022-02-28	Protitelesa proti CD277 in uporabe le-teh
PL2616489T3 (pl)	2017-07-31	Przeciwciało anty-huTNFR1
SG11201401411TA (en)	2014-08-28	Meditopes and meditope-binding antibodies and uses thereof
GB201000467D0 (en)	2010-02-24	Antibodies
EP2569012A4 (en)	2013-10-30	ANTI-FGFR2 ANTIBODY
SI2531518T1 (sl)	2016-09-30	Oligopeptidne spojine in njihova uporaba
GB201002238D0 (en)	2010-03-31	Antibodies
GB201106357D0 (en)	2011-06-01	Composition and uses thereof
EP2716359A4 (en)	2014-04-23	COMPLEX AND USES THEREOF
GB201111775D0 (en)	2011-08-24	Compounds and uses thereof
GB201007957D0 (en)	2010-06-30	Antibody
AU4935P (en)	2014-10-21	FerrupenGL Pimelea ferruginea
GB201014319D0 (en)	2010-10-13	Compounds and uses thereof
GB201115285D0 (en)	2011-10-19	Biosensor and uses thereof
GB201017780D0 (en)	2010-12-01	Antibody
GB201013665D0 (en)	2010-09-29	Molecules
GB201121726D0 (en)	2012-02-01	Compounds and uses thereof
GB201121551D0 (en)	2012-01-25	Compounds and uses thereof
GB201019361D0 (en)	2010-12-29	Biosensor and uses thereof