LT2767539T - Pseudopolimorfinės živ proteazės inhibitorių formos - Google Patents

Pseudopolimorfinės živ proteazės inhibitorių formos

Info

Publication number: LT2767539T
Authority: LT; Lithuania
Prior art keywords: protease inhibitor; hiv protease; pseudopolymorphic forms; pseudopolymorphic; forms
Prior art date: 2002-05-16

Application number

LTEP14168686.5T

Other languages

English (en)

Inventor

Hans Wim Pieter Vermeersch

Daniel Joseph Christiaan Thone

Luc Donné Marie-Louise Janssens

Piet Bert Paul Wigerinck

Original Assignee

Janssen Sciences Ireland Uc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-16

Filing date

2003-05-16

Publication date

2017-09-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29724454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2767539(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-05-16 Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc

2017-09-25 Publication of LT2767539T publication Critical patent/LT2767539T/lt

Links

229940122440 HIV protease inhibitor Drugs 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

LTEP14168686.5T 2002-05-16 2003-05-16 Pseudopolimorfinės živ proteazės inhibitorių formos LT2767539T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076929		2002-05-16

Publications (1)

Publication Number	Publication Date
LT2767539T true LT2767539T (lt)	2017-09-25

Family

ID=29724454

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP14168686.5T LT2767539T (lt)	2002-05-16	2003-05-16	Pseudopolimorfinės živ proteazės inhibitorių formos

Country Status (25)

Country	Link
US (8)	US7700645B2 (lt)
EP (4)	EP2314591B2 (lt)
JP (1)	JP4864320B2 (lt)
KR (2)	KR20100119906A (lt)
CN (1)	CN100475819C (lt)
AP (1)	AP2052A (lt)
AU (2)	AU2003271740B2 (lt)
BR (1)	BRPI0311176B8 (lt)
CA (1)	CA2485834C (lt)
CY (3)	CY1117928T1 (lt)
DK (3)	DK2767539T3 (lt)
EA (1)	EA007120B8 (lt)
ES (4)	ES2503551T5 (lt)
HR (1)	HRP20041061B1 (lt)
HU (1)	HUE034389T2 (lt)
IL (1)	IL165140A0 (lt)
LT (1)	LT2767539T (lt)
MX (1)	MXPA04011427A (lt)
NO (1)	NO331477B1 (lt)
NZ (1)	NZ536497A (lt)
PL (1)	PL215151B1 (lt)
PT (3)	PT2314591E (lt)
SI (3)	SI1567529T2 (lt)
WO (1)	WO2003106461A2 (lt)
ZA (1)	ZA200410154B (lt)

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JP4776775B2 (ja)	1998-06-23	2011-09-21	アメリカ合衆国	Ｈｉｖ感染哺乳動物を治療するための医薬組成物
ES2503551T5 (es)	2002-05-16	2021-10-28	Janssen Sciences Ireland Unlimited Co	Formas pseudopolimórficas de un inhibidor de la proteasa de VIH
HRP20020614A2 (en) *	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
RS51073B (sr)	2003-12-23	2010-10-31	Tibotec Pharmaceuticals Ltd.	Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
AU2006217922B2 (en)	2005-02-25	2012-04-05	Janssen Sciences Ireland Uc	Protease inhibitor precursor synthesis
ES2359949T3 (es) *	2006-11-09	2011-05-30	Tibotec Pharmaceuticals	Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en)	2009-01-29	2014-12-30	Mapi Pharma Ltd.	Polymorphs of darunavir
US20120035142A1 (en) *	2009-01-29	2012-02-09	Mapi Pharma Limited	Polymorphs of darunavir
WO2011048604A2 (en) *	2009-09-17	2011-04-28	Matrix Laboratories Limited	An improved process for the preparation of darunavir
WO2011051978A2 (en)	2009-10-30	2011-05-05	Lupin Limited	A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
ES2546866T3 (es) *	2009-12-16	2015-09-29	Hetero Research Foundation	Polimorfos de darunavir
AU2010340799B2 (en) *	2010-01-05	2015-06-11	Cipla Limited	Darunavir polymorph and process for preparation thereof
EP2528923B1 (en)	2010-01-28	2014-07-30	Mapi Pharma Limited	Process for the preparation of darunavir and darunavir intermediates
EP2571355B1 (en)	2010-05-20	2016-09-07	Hetero Research Foundation	Crystalline hydrochloride salt of darunavir
WO2012107889A1 (en)	2011-02-10	2012-08-16	Ranbaxy Laboratories Limited	Process for the preparation of amorphous darunavir
SI2729130T1 (en)	2011-07-07	2018-03-30	Janssen Sciences Ireland Uc	Combined formulations of darunavir
WO2013114382A1 (en)	2011-12-05	2013-08-08	Mylan Laboratories Ltd	Crystalline darunavir
WO2013108105A2 (en) *	2012-01-18	2013-07-25	Aurobindo Pharma Limited	Novel solvates of darunavir
CN103509031B (zh) *	2012-06-20	2016-04-27	上海迪赛诺药业有限公司	制备达芦那韦无定形物的方法
ES2848216T3 (es) *	2012-07-24	2021-08-05	Laurus Labs Ltd	Un proceso para la preparación de Darunavir
WO2014068265A1 (en)	2012-10-29	2014-05-08	Cipla Limited	Antiviral phosphonate analogues and process for preparation thereof
US9346820B2 (en) *	2013-09-11	2016-05-24	Purdue Research Foundation	HIV-1 protease inhibitors having gem-di-fluoro bicyclic P2-ligands
WO2016092525A1 (en) *	2014-12-12	2016-06-16	Lupin Limited	Darunavir n-propanol solvate and process for preparation thereof
WO2016092527A1 (en) *	2014-12-12	2016-06-16	Sun Pharmaceutical Industries Limited	A process for the preparation of dolutegravir
PL3271347T3 (pl) *	2015-03-19	2022-11-21	Mycovia Pharmaceuticals, Inc.	Związki przeciwgrzybicze i sposoby wytwarzania
US20190175511A1 (en)	2016-08-08	2019-06-13	Hetero Labs Limited	A Multi-Class Anti-Retroviral Composition
US11045423B2 (en)	2016-08-08	2021-06-29	Hetero Labs Limited	Anti-retroviral compositions
US10407438B2 (en)	2016-10-27	2019-09-10	Gilead Sciences, Inc.	Crystalline forms of darunavir
CN108727401A (zh) *	2017-04-20	2018-11-02	盐城迪赛诺制药有限公司	达鲁那韦新晶型及其制备方法和应用
CN109053753A (zh) *	2018-08-05	2018-12-21	浙江大学	一种制备达卢那韦二水合物晶型的方法

Family Cites Families (16)

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US5413999A (en) *	1991-11-08	1995-05-09	Merck & Co., Inc.	HIV protease inhibitors useful for the treatment of AIDS
JPH05230044A (ja)	1992-02-21	1993-09-07	Hoechst Japan Ltd	ピレタニドの新規な結晶多形
US5968942A (en) *	1992-08-25	1999-10-19	G. D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
AU7669794A (en) *	1993-08-24	1995-03-21	G.D. Searle & Co.	Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
CN1072215C (zh) *	1995-02-22	2001-10-03	赫彻斯特药品和化学品公司	无定形吡咯他尼、吡咯他尼多晶型物,其制备方法和用途
CO4940492A1 (es) *	1997-05-29	2000-07-24	Merck & Co Inc	Inhibidor de proteasa de vih
GB9712253D0 (en)	1997-06-13	1997-08-13	Glaxo Group Ltd	Antiviral compound
US6287693B1 (en) *	1998-02-25	2001-09-11	John Claude Savoir	Stable shaped particles of crystalline organic compounds
GB9805898D0 (en) *	1998-03-20	1998-05-13	Glaxo Group Ltd	Process for the sythesis of hiv protease inhibitors
GB9807354D0 (en)	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
JP4776775B2 (ja)	1998-06-23	2011-09-21	アメリカ合衆国	Ｈｉｖ感染哺乳動物を治療するための医薬組成物
WO1999067254A2 (en) *	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
WO2000029390A1 (en)	1998-11-19	2000-05-25	Du Pont Pharmaceuticals Company	Crystalline (-)-6- chloro-4- cyclopropylethynyl- 4-trifluoromethyl- 3,4-dihydro- 2(1h)-quinazolinone
EP1159278B1 (en)	1999-02-12	2005-11-30	Vertex Pharmaceuticals Incorporated	Inhibitors of aspartyl protease
ES2503551T5 (es)	2002-05-16	2021-10-28	Janssen Sciences Ireland Unlimited Co	Formas pseudopolimórficas de un inhibidor de la proteasa de VIH
AU2010340799B2 (en) *	2010-01-05	2015-06-11	Cipla Limited	Darunavir polymorph and process for preparation thereof

2003
- 2003-05-16 ES ES10180831T patent/ES2503551T5/es not_active Expired - Lifetime
- 2003-05-16 DK DK14168686.5T patent/DK2767539T3/en active
- 2003-05-16 AP AP2004003191A patent/AP2052A/xx active
- 2003-05-16 AU AU2003271740A patent/AU2003271740B2/en not_active Revoked
- 2003-05-16 LT LTEP14168686.5T patent/LT2767539T/lt unknown
- 2003-05-16 ES ES03753571T patent/ES2498370T5/es not_active Expired - Lifetime
- 2003-05-16 EP EP10180831.9A patent/EP2314591B2/en not_active Expired - Lifetime
- 2003-05-16 WO PCT/EP2003/050176 patent/WO2003106461A2/en not_active Ceased
- 2003-05-16 PT PT101808319T patent/PT2314591E/pt unknown
- 2003-05-16 EA EA200401503A patent/EA007120B8/ru unknown
- 2003-05-16 CN CNB038164590A patent/CN100475819C/zh not_active Expired - Lifetime
- 2003-05-16 CA CA002485834A patent/CA2485834C/en not_active Expired - Lifetime
- 2003-05-16 KR KR1020107024106A patent/KR20100119906A/ko not_active Ceased
- 2003-05-16 SI SI200332389T patent/SI1567529T2/sl unknown
- 2003-05-16 BR BRPI0311176A patent/BRPI0311176B8/pt active IP Right Grant
- 2003-05-16 DK DK03753571.3T patent/DK1567529T4/da active
- 2003-05-16 DK DK10180831.9T patent/DK2314591T4/da active
- 2003-05-16 PT PT37535713T patent/PT1567529E/pt unknown
- 2003-05-16 MX MXPA04011427A patent/MXPA04011427A/es active IP Right Grant
- 2003-05-16 ES ES14168686.5T patent/ES2638412T3/es not_active Expired - Lifetime
- 2003-05-16 SI SI200332383T patent/SI2314591T2/sl unknown
- 2003-05-16 ES ES16158480T patent/ES2728735T3/es not_active Expired - Lifetime
- 2003-05-16 EP EP16158480.0A patent/EP3045460B1/en not_active Expired - Lifetime
- 2003-05-16 EP EP14168686.5A patent/EP2767539B1/en not_active Expired - Lifetime
- 2003-05-16 EP EP03753571.3A patent/EP1567529B2/en not_active Expired - Lifetime
- 2003-05-16 NZ NZ536497A patent/NZ536497A/en not_active IP Right Cessation
- 2003-05-16 HR HRP20041061AA patent/HRP20041061B1/hr not_active IP Right Cessation
- 2003-05-16 PL PL374321A patent/PL215151B1/pl unknown
- 2003-05-16 SI SI200332545T patent/SI2767539T1/sl unknown
- 2003-05-16 JP JP2004513292A patent/JP4864320B2/ja not_active Expired - Lifetime
- 2003-05-16 US US10/514,352 patent/US7700645B2/en active Active
- 2003-05-16 HU HUE14168686A patent/HUE034389T2/en unknown
- 2003-05-16 KR KR1020047018426A patent/KR101128370B1/ko not_active Expired - Lifetime
- 2003-05-16 PT PT141686865T patent/PT2767539T/pt unknown
2004
- 2004-11-10 IL IL16514004A patent/IL165140A0/xx unknown
- 2004-12-10 NO NO20045409A patent/NO331477B1/no not_active IP Right Cessation
- 2004-12-15 ZA ZA2004/10154A patent/ZA200410154B/en unknown
2009
- 2009-08-06 US US12/536,807 patent/US8518987B2/en not_active Expired - Fee Related
2012
- 2012-07-03 AU AU2012205289A patent/AU2012205289A1/en active Pending
2013
- 2013-07-11 US US13/939,494 patent/US20130303790A1/en not_active Abandoned
2014
- 2014-02-19 US US14/183,712 patent/US20140171499A1/en not_active Abandoned
- 2014-09-17 CY CY20141100756T patent/CY1117928T1/el unknown
- 2014-09-17 CY CY20141100755T patent/CY1115665T1/el unknown
2015
- 2015-08-04 US US14/817,827 patent/US20150336980A1/en not_active Abandoned
2017
- 2017-05-22 US US15/600,932 patent/US10000504B2/en not_active Expired - Lifetime
- 2017-08-23 CY CY20171100896T patent/CY1119311T1/el unknown
2018
- 2018-05-16 US US15/980,993 patent/US10858369B2/en not_active Expired - Lifetime
2020
- 2020-10-30 US US17/085,096 patent/US20210179631A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO331477B1 (no)	2012-01-16
HUE034389T2 (en)	2018-02-28
NO20045409L (no)	2004-12-10
AP2052A (en)	2009-10-05
EP3045460A1 (en)	2016-07-20
EA200401503A1 (ru)	2005-06-30
CA2485834A1 (en)	2003-12-24
SI2314591T2 (sl)	2021-08-31
US20050250845A1 (en)	2005-11-10
US10858369B2 (en)	2020-12-08
US8518987B2 (en)	2013-08-27
CY1115665T1 (el)	2017-01-25
AU2003271740B2 (en)	2010-05-13
KR20100119906A (ko)	2010-11-11
EA007120B1 (ru)	2006-06-30
SI1567529T1 (sl)	2014-11-28
AP2004003191A0 (en)	2004-12-31
IL165140A0 (en)	2005-12-18
EP2767539A1 (en)	2014-08-20
WO2003106461A3 (en)	2004-05-13
EP2314591B1 (en)	2014-06-18
PT2767539T (pt)	2017-08-28
ES2498370T5 (es)	2021-11-24
CY1117928T1 (el)	2017-05-17
EP1567529B2 (en)	2021-02-24
EP1567529B1 (en)	2014-06-18
ES2498370T3 (es)	2014-09-24
HK1081969A1 (en)	2006-05-26
PT2314591E (pt)	2014-09-19
US20100204316A1 (en)	2010-08-12
AU2012205289A1 (en)	2012-08-09
HRP20041061A2 (en)	2006-07-31
BR0311176A (pt)	2005-03-15
CA2485834C (en)	2007-07-17
US20130303790A1 (en)	2013-11-14
SI2314591T1 (sl)	2014-11-28
DK1567529T4 (da)	2021-05-10
EP3045460B1 (en)	2019-04-17
DK1567529T3 (da)	2014-09-15
PL215151B1 (pl)	2013-10-31
EP1567529A2 (en)	2005-08-31
KR101128370B1 (ko)	2012-04-23
WO2003106461A2 (en)	2003-12-24
BRPI0311176B8 (pt)	2021-05-25
PL374321A1 (en)	2005-10-17
NZ536497A (en)	2006-08-31
EP2314591A1 (en)	2011-04-27
KR20050008715A (ko)	2005-01-21
DK2314591T4 (da)	2021-05-10
BRPI0311176B1 (pt)	2019-08-20
DK2767539T3 (en)	2017-09-11
EP2314591B2 (en)	2021-02-24
ES2503551T5 (es)	2021-10-28
EA007120B8 (ru)	2012-03-30
US20150336980A1 (en)	2015-11-26
US10000504B2 (en)	2018-06-19
US20210179631A1 (en)	2021-06-17
ES2638412T3 (es)	2017-10-20
DK2314591T3 (da)	2014-09-22
US7700645B2 (en)	2010-04-20
CN1668623A (zh)	2005-09-14
PT1567529E (pt)	2014-09-09
CY1119311T1 (el)	2018-02-14
JP4864320B2 (ja)	2012-02-01
HRP20041061B1 (hr)	2015-02-27
US20180312517A1 (en)	2018-11-01
AU2003271740A1 (en)	2003-12-31
EP2767539B1 (en)	2017-07-12
SI2767539T1 (sl)	2017-10-30
US20140171499A1 (en)	2014-06-19
ZA200410154B (en)	2005-12-28
ES2728735T3 (es)	2019-10-28
SI1567529T2 (sl)	2021-08-31
CN100475819C (zh)	2009-04-08
US20170260196A1 (en)	2017-09-14
JP2005533068A (ja)	2005-11-04
ES2503551T3 (es)	2014-10-07
MXPA04011427A (es)	2005-02-17

Publication	Publication Date	Title
IL165140A0 (en)	2005-12-18	Pseudopolymorphic forms of a hiv protease inhibitor
PL375486A1 (en)	2005-11-28	Potent inhibitor of hcv serine protease
AU2003213776A1 (en)	2003-09-29	Carbamates as hiv protease inhibitors
EP1483254A4 (en)	2005-06-08	INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
AU2003269984A8 (en)	2004-03-11	Protease inhibitors
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
AU2003263738A8 (en)	2003-12-02	Protease inhibitors
AU2001280634A1 (en)	2002-02-13	Salt forms of an hiv protease inhibitor
GB0123467D0 (en)	2001-11-21	Carbocyclic HIV Protease inhibitors
AU2002305720A1 (en)	2002-12-09	Piperazine pentanamide hiv protease inhibitors
AU2003304496A8 (en)	2005-04-27	Protease inhibitors
AU2003233642A8 (en)	2003-12-12	Protease inhibitors
AU2003252417A1 (en)	2004-03-03	Protease inhibitor
IL160626A0 (en)	2004-07-25	Antiviral protease inhibitors
EP1546333A4 (en)	2005-12-21	INHIBITOR OF ASPARTYL PROTEASE IN PLACE OF NEMATODE ALLERGENE
AU153048S (en)	2003-09-25	A set of jewellery
ZA200500560B (en)	2006-07-26	Potent inhibitor of HCV serine protease
AU2002255485A8 (en)	2008-01-10	Hiv/fiv protease inhibitors
AU2003269878A8 (en)	2003-12-22	Protease inhibitors
AU2003265240A8 (en)	2003-12-22	Protease inhibitors
GB0206465D0 (en)	2002-05-01	A set of parts
GB0125884D0 (en)	2001-12-19	A piece of jewellery
GB0229288D0 (en)	2003-01-22	A modification of chess
AU151187S (en)	2003-03-24	A pair of jeans
AU153862S (en)	2003-11-25	A set of jewellery