LT3013855T - Mutavusio viii faktoriaus kompozicijos ir metodai - Google Patents

Mutavusio viii faktoriaus kompozicijos ir metodai

Info

Publication number
LT3013855T
LT3013855T LTEP14817835.3T LT14817835T LT3013855T LT 3013855 T LT3013855 T LT 3013855T LT 14817835 T LT14817835 T LT 14817835T LT 3013855 T LT3013855 T LT 3013855T
Authority
LT
Lithuania
Prior art keywords
mututus
compositions
methods
factor viii
viii
Prior art date
Application number
LTEP14817835.3T
Other languages
English (en)
Inventor
Wenjing Cao
Biao DONG
Original Assignee
Xiao, Weidong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xiao, Weidong filed Critical Xiao, Weidong
Publication of LT3013855T publication Critical patent/LT3013855T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LTEP14817835.3T 2013-06-24 2014-06-24 Mutavusio viii faktoriaus kompozicijos ir metodai LT3013855T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361838867P 2013-06-24 2013-06-24
PCT/US2014/043777 WO2014209942A1 (en) 2013-06-24 2014-06-24 Mutant factor viii compositions and methods

Publications (1)

Publication Number Publication Date
LT3013855T true LT3013855T (lt) 2021-01-25

Family

ID=52142603

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14817835.3T LT3013855T (lt) 2013-06-24 2014-06-24 Mutavusio viii faktoriaus kompozicijos ir metodai

Country Status (14)

Country Link
US (3) US20160102133A1 (lt)
EP (2) EP3013855B1 (lt)
CN (1) CN105431451B (lt)
CY (1) CY1124110T1 (lt)
DK (1) DK3013855T3 (lt)
ES (1) ES2837475T3 (lt)
HR (1) HRP20210031T1 (lt)
HU (1) HUE052074T2 (lt)
LT (1) LT3013855T (lt)
PL (1) PL3013855T3 (lt)
PT (1) PT3013855T (lt)
RS (1) RS61305B1 (lt)
SI (1) SI3013855T1 (lt)
WO (1) WO2014209942A1 (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127057A1 (en) * 2015-02-06 2016-08-11 The University Of North Carolina At Chapel Hill Optimized human clotting factor viii gene expression cassettes and their use
CN116479001A (zh) 2015-11-13 2023-07-25 武田药品工业株式会社 用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体
WO2019210270A2 (en) * 2018-04-27 2019-10-31 Seattle Children's Hospital D/B/A Seattle Children's Research Institute In vivo gene therapy using delivery of a lentiviral gene construct
KR20210034013A (ko) 2018-07-16 2021-03-29 박스알타 인코퍼레이티드 발현이 증가된 재조합 fviii 변이체들을 인코딩하는 바이러스 벡터를 이용한 혈우병의 유전적 치료법
US11795207B2 (en) 2021-03-30 2023-10-24 AAVnerGene Inc. Modified plasma clotting factor VIII and method of use thereof
EP4314041A1 (en) * 2021-03-30 2024-02-07 Aavnergene Inc. Modified plasma clotting factor viii and method of use thereof
JP2024544499A (ja) * 2021-11-25 2024-12-03 四川至善唯新生物科技有限公司 遺伝子工学的改変により得られた、分泌能と凝固活性を向上させた組換えヒト第ｖｉｉｉ因子
WO2025180508A1 (en) * 2024-02-29 2025-09-04 Shanghai Vitalgen Biopharma Co., Ltd. Human factor viii variant expression cassettes and uses thereof for treating hemophilia a

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
US5859204A (en) 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
US5364771A (en) 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US20040092442A1 (en) 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
US6759216B1 (en) 1998-11-06 2004-07-06 Emory University Glycosylated, low antigenicity low immunogenicity factor VIII
ATE454445T1 (de) 1998-11-10 2010-01-15 Univ North Carolina Virusvektoren und verfahren für ihre herstellung und verabreichung.
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
ATE318923T1 (de) 2000-06-01 2006-03-15 Univ North Carolina Doppelsträngige parvovirus-vektoren
EP1319016A4 (en) 2000-09-19 2006-05-10 Univ Emory MODIFIED FACTOR VIII
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
ATE417618T1 (de) 2001-10-05 2009-01-15 Expression Therapeutics Llc Faktor-viii-polypeptide auf hohem expressionsniveau codierende nukleinsäure- und aminosäuresequenzen und verwendungsverfahren
EP1424344A1 (en) 2002-11-29 2004-06-02 Aventis Behring Gesellschaft mit beschränkter Haftung Modified cDNA factor VIII and its derivates
US7211559B2 (en) * 2003-10-31 2007-05-01 University Of Maryland, Baltimore Factor VIII compositions and methods
ATE463572T1 (de) * 2003-12-03 2010-04-15 Univ Rochester Rekombinanter faktor viii mit erhöhter spezifischer aktivität
AU2009256093A1 (en) * 2008-06-04 2009-12-10 Bayer Healthcare Llc FVIII muteins for treatment of von Willebrand disease
US20130183280A1 (en) 2010-07-15 2013-07-18 Novo Nordisk A/S Stabilized factor viii variants
US8637448B2 (en) * 2010-09-14 2014-01-28 University Of Rochester Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface

Also Published As

Publication number Publication date
DK3013855T3 (da) 2021-01-11
PL3013855T3 (pl) 2021-04-19
WO2014209942A1 (en) 2014-12-31
EP3904376A1 (en) 2021-11-03
CN105431451B (zh) 2024-08-23
US20220144919A1 (en) 2022-05-12
SI3013855T1 (sl) 2021-06-30
RS61305B1 (sr) 2021-02-26
EP3013855A1 (en) 2016-05-04
US20160102133A1 (en) 2016-04-14
HRP20210031T1 (hr) 2021-05-14
US11261234B2 (en) 2022-03-01
HUE052074T2 (hu) 2021-04-28
CY1124110T1 (el) 2022-05-27
ES2837475T3 (es) 2021-06-30
EP3013855A4 (en) 2017-12-13
CN105431451A (zh) 2016-03-23
PT3013855T (pt) 2021-01-13
EP3904376B1 (en) 2024-11-13
US20190177399A1 (en) 2019-06-13
EP3013855B1 (en) 2020-10-14

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