LT3218351T - Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas - Google Patents

Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas

Info

Publication number
LT3218351T
LT3218351T LTEP15808087.9T LT15808087T LT3218351T LT 3218351 T LT3218351 T LT 3218351T LT 15808087 T LT15808087 T LT 15808087T LT 3218351 T LT3218351 T LT 3218351T
Authority
LT
Lithuania
Prior art keywords
ahu
isolation
purification
preparation
pharmaceutically applicable
Prior art date
Application number
LTEP15808087.9T
Other languages
English (en)
Inventor
Ales Halama
Pavel ZVATORA
Ondrej Dammer
Jan Stach
Michal Zapadlo
Lukas KREJCIK
Michal Voslar
Original Assignee
Zentiva K.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ2014-792A external-priority patent/CZ2014792A3/cs
Priority claimed from CZ2015-758A external-priority patent/CZ2015758A3/cs
Application filed by Zentiva K.S. filed Critical Zentiva K.S.
Publication of LT3218351T publication Critical patent/LT3218351T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/06—Monoamines containing only n- or iso-propyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/07—Monoamines containing one, two or three alkyl groups, each having the same number of carbon atoms in excess of three
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LTEP15808087.9T 2014-11-14 2015-11-11 Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas LT3218351T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ2014-792A CZ2014792A3 (cs) 2014-11-14 2014-11-14 Způsob přípravy, izolace a čištění farmaceuticky využitelných forem AHU-377
CZ2015-758A CZ2015758A3 (cs) 2015-10-27 2015-10-27 Pevné formy vápenaté soli ethyl esteru (2R, 4S)-5-(bifenyl-4-yl)-4-[(3-karboxypropionyl)amino]-2-methylpentanové kyseliny, způsob jejich přípravy a použití
PCT/CZ2015/000136 WO2016074651A1 (en) 2014-11-14 2015-11-11 A method for the preparation, isolation and purification of pharmaceutically applicable forms of ahu-377

Publications (1)

Publication Number Publication Date
LT3218351T true LT3218351T (lt) 2019-09-25

Family

ID=54848362

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15808087.9T LT3218351T (lt) 2014-11-14 2015-11-11 Ahu-377 farmaciniu požiūriu priimtinų formų gavimo, atskyrimo ir gryninimo būdas

Country Status (8)

Country Link
EP (1) EP3218351B1 (lt)
DK (1) DK3218351T3 (lt)
ES (1) ES2745157T3 (lt)
HU (1) HUE046278T2 (lt)
LT (1) LT3218351T (lt)
PL (1) PL3218351T3 (lt)
PT (1) PT3218351T (lt)
WO (1) WO2016074651A1 (lt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3317248T1 (sl) 2015-07-02 2021-01-29 Novartis Ag Sakubitril kalcijeve soli
EP3386945A1 (en) * 2015-12-11 2018-10-17 Zentiva, K.S. Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method
CN109641856B (zh) * 2016-09-02 2022-09-30 南京诺瑞特医药科技有限公司 缬沙坦二钠盐的晶型
US10683260B2 (en) 2016-09-07 2020-06-16 Nanjing Noratech Pharmaceuticals Co., Ltd. Crystalline form of sacubitril sodium salt
CN106496055A (zh) * 2016-10-09 2017-03-15 杭州科巢生物科技有限公司 一种抗心衰新药的关键组分沙库比曲的新合成方法
WO2018069833A1 (en) * 2016-10-10 2018-04-19 Laurus Labs Limited Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof
WO2018078592A1 (en) * 2016-10-28 2018-05-03 Biocon Limited Amorphous trisodium sacubitril valsartan and process for its preparation
CN107188817A (zh) * 2017-05-22 2017-09-22 杭州瑞法康科技有限公司 一种高纯度沙库比曲半钙盐一水合物的新晶型及其制备方法
CN107602410A (zh) * 2017-09-13 2018-01-19 浙江三门恒康制药有限公司 沙库比曲钠盐的晶型ii及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
DK1467728T3 (da) 2002-01-17 2007-12-27 Novartis Ag Farmaceutiske sammensætninger indeholdende valsartan og NEP-inhibitorer
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP1903027A1 (en) 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
KR101580067B1 (ko) 2007-01-12 2015-12-23 노파르티스 아게 5-바이페닐-4-아미노-2-메틸 펜탄산의 제조 방법
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
KR101463670B1 (ko) 2010-01-22 2014-11-19 노파르티스 아게 중성 엔도펩티다제 억제제의 중간체 및 그의 제조 방법
MX2013002149A (es) 2010-08-23 2013-04-03 Novartis Ag Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep.
RU2588572C2 (ru) 2010-08-23 2016-07-10 Новартис Аг Способ получения промежуточных соединений для получения ингибиторов nep
AR092278A1 (es) 2012-08-31 2015-04-08 Novartis Ag Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法

Also Published As

Publication number Publication date
HUE046278T2 (hu) 2020-02-28
WO2016074651A1 (en) 2016-05-19
ES2745157T3 (es) 2020-02-27
PL3218351T3 (pl) 2019-12-31
DK3218351T3 (da) 2019-09-16
EP3218351B1 (en) 2019-06-19
EP3218351A1 (en) 2017-09-20
PT3218351T (pt) 2019-09-26

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