LT3303564T - Vidurinių smegenų dopamininių (mda) neuronų diferenciacijos in vitro būdai - Google Patents

Vidurinių smegenų dopamininių (mda) neuronų diferenciacijos in vitro būdai

Info

Publication number
LT3303564T
LT3303564T LTEPPCT/US2016/035312T LT16035312T LT3303564T LT 3303564 T LT3303564 T LT 3303564T LT 16035312 T LT16035312 T LT 16035312T LT 3303564 T LT3303564 T LT 3303564T
Authority
LT
Lithuania
Prior art keywords
dopamin
mda
neurons
vitro differentiation
differentiation methods
Prior art date
Application number
LTEPPCT/US2016/035312T
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja KRIKS
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of LT3303564T publication Critical patent/LT3303564T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
LTEPPCT/US2016/035312T 2015-06-01 2016-06-01 Vidurinių smegenų dopamininių (mda) neuronų diferenciacijos in vitro būdai LT3303564T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562169444P 2015-06-01 2015-06-01
US201562169379P 2015-06-01 2015-06-01
PCT/US2016/035312 WO2016196661A1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons

Publications (1)

Publication Number Publication Date
LT3303564T true LT3303564T (lt) 2022-05-10

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2016/035312T LT3303564T (lt) 2015-06-01 2016-06-01 Vidurinių smegenų dopamininių (mda) neuronų diferenciacijos in vitro būdai

Country Status (18)

Country Link
US (3) US10858625B2 (lt)
EP (3) EP4070803B1 (lt)
JP (5) JP6974180B2 (lt)
KR (4) KR102358878B1 (lt)
AU (3) AU2016270793B2 (lt)
CY (1) CY1125423T1 (lt)
DK (2) DK3303564T3 (lt)
ES (2) ES2910032T3 (lt)
HR (1) HRP20220482T1 (lt)
HU (1) HUE058258T2 (lt)
IL (4) IL313799B2 (lt)
LT (1) LT3303564T (lt)
PL (1) PL3303564T3 (lt)
PT (2) PT4070803T (lt)
RS (1) RS63157B1 (lt)
SI (1) SI3303564T1 (lt)
SM (1) SMT202200263T1 (lt)
WO (1) WO2016196661A1 (lt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107438669B (zh) * 2015-04-09 2022-09-27 拜奥拉米那公司 用于治疗神经退行性疾病的干细胞衍生多巴胺能细胞的生产方法和组合物
DK3303564T3 (da) * 2015-06-01 2022-04-04 Memorial Sloan Kettering Cancer Center Fremgangsmåder til in vitro-differentiering af midthjerne-dopamin-(mda)-neuroner
JP7523885B2 (ja) 2016-02-05 2024-07-29 メモリアル スローン ケタリング キャンサー センター 幹細胞由来外胚葉系統前駆体を分化する方法
WO2018035214A1 (en) 2016-08-16 2018-02-22 Cellular Dynamics International., Inc. Methods for differentiating pluripotent cells
CN110868853A (zh) * 2017-04-26 2020-03-06 纪念斯隆-凯特琳癌症中心 即用型冷冻保存细胞
CN111213057A (zh) * 2017-07-17 2020-05-29 美天施生物科技有限两合公司 用于底板中脑多巴胺能祖细胞的单细胞蛋白质表达谱分析的方法
WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
MX2021007121A (es) 2018-12-19 2021-08-11 Univ Minnesota Metodos para generar y usar organoides y los tejidos en estos.
WO2020237104A1 (en) 2019-05-23 2020-11-26 The Mclean Hospital Corporation Autologous cell replacement therapy for parkinson's disease
JP7810357B2 (ja) 2019-07-25 2026-02-03 ザ スクリプス リサーチ インスティテュート ドーパミン作動性ニューロン及び前駆細胞を特定する方法
WO2021042027A1 (en) * 2019-08-29 2021-03-04 Memorial Sloan-Kettering Cancer Center Methods of generating and isolating midbrain dopamine neurons
JP2022549224A (ja) * 2019-09-20 2022-11-24 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー ダイレクトリプログラミングを用いる、誘導型ドーパミン作動性神経前駆細胞の製造方法
MX2022011831A (es) 2020-03-25 2023-01-04 Sana Biotechnology Inc Células neurales hipoinmunogénicas para el tratamiento de trastornos y afecciones neurológicas.
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
WO2021216623A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
CA3183958A1 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
CN114292814A (zh) * 2020-09-22 2022-04-08 上海跃赛生物科技有限公司 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法
CA3213988A1 (en) * 2021-04-07 2022-10-13 Christopher MCMAHON Dopaminergic precursor cells and methods of use
US20250082686A1 (en) 2021-07-21 2025-03-13 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
WO2023004366A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
EP4413119A1 (en) 2021-11-12 2024-08-14 Axent Biosciences Inc. Methods for production of functional neurons
EP4508645A1 (en) 2022-04-15 2025-02-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
EP4728055A2 (en) * 2023-06-13 2026-04-22 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
CN117448271B (zh) * 2023-12-22 2024-07-16 上海元戊医学技术有限公司 一种诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法
WO2025166063A1 (en) 2024-01-31 2025-08-07 Bluerock Therapeutics Lp Igfbp2 in cell culture
WO2025252180A1 (zh) * 2024-06-05 2025-12-11 中国科学院脑科学与智能技术卓越创新中心 中脑多巴胺能祖细胞群的体外制备方法
WO2026006245A1 (en) 2024-06-25 2026-01-02 Bluerock Therapeutics Lp Three-dimensional culturing of pluripotent stem cells for improved differentiability

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4703300A (en) 1999-05-06 2000-11-21 Mount Sinai School Of Medicine Of The City University Of New York, The Dna-based steganography
JP5943533B2 (ja) 2000-05-17 2016-07-06 アステリアス バイオセラピューティクス インコーポレイテッド 神経前駆細胞の集団
WO2006024947A2 (en) * 2004-09-02 2006-03-09 Neuro Therapeutics Ab Methods and materials relating to enhanced production of dopamine neurons
EP1835924B1 (en) * 2004-12-23 2013-08-21 Ethicon, Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
EP2422802A3 (en) 2006-03-07 2013-03-06 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
US8535719B2 (en) 2006-07-07 2013-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
US9453198B2 (en) 2010-05-25 2016-09-27 Memorial Sloan Kettering Cancer Center Method of nociceptor differentiation of human embryonic stem cells and uses thereof
US20110296542A1 (en) 2010-05-28 2011-12-01 Kevin Ka-Wang Wang Exogenous matrix-supported topical application of stem cells to organ surface
PT2773748T (pt) * 2011-11-04 2020-03-26 Memorial Sloan Kettering Cancer Center Neurónios dopaminérgicos (da) do mesencéfalo para enxerto
WO2013188744A1 (en) 2012-06-15 2013-12-19 Baylor College Of Medicine Perineurium derived adult stem cells and methods of use
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
KR101696874B1 (ko) 2013-07-31 2017-01-16 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법
WO2015020234A1 (ja) * 2013-08-06 2015-02-12 武田薬品工業株式会社 ドパミン神経細胞の製造方法
AU2014316100B2 (en) * 2013-09-05 2020-11-05 Eisai R&D Management Co., Ltd. New method for inducing dopamine-producing neural precursor cells
JP6723918B2 (ja) 2013-11-21 2020-07-15 メモリアル スローン ケタリング キャンサー センター ヒト多能性幹細胞からの機能的頭蓋プラコード派生体の特定
WO2015143342A1 (en) * 2014-03-21 2015-09-24 Cellular Dynamics International, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
DK3303564T3 (da) * 2015-06-01 2022-04-04 Memorial Sloan Kettering Cancer Center Fremgangsmåder til in vitro-differentiering af midthjerne-dopamin-(mda)-neuroner

Also Published As

Publication number Publication date
US20240400987A1 (en) 2024-12-05
IL291532B2 (en) 2024-12-01
EP3303564A1 (en) 2018-04-11
JP2023181494A (ja) 2023-12-21
WO2016196661A1 (en) 2016-12-08
ES3057638T3 (en) 2026-03-03
IL255992B (en) 2022-04-01
SMT202200263T1 (it) 2022-07-21
JP2022031961A (ja) 2022-02-22
JP2018522538A (ja) 2018-08-16
JP2020146060A (ja) 2020-09-17
KR102841407B1 (ko) 2025-08-01
KR20250118858A (ko) 2025-08-06
IL291532B1 (en) 2024-08-01
RS63157B1 (sr) 2022-05-31
IL313799B2 (en) 2025-09-01
IL313799A (en) 2024-08-01
ES2910032T3 (es) 2022-05-11
PT3303564T (pt) 2022-06-02
US10858625B2 (en) 2020-12-08
EP4070803A1 (en) 2022-10-12
PL3303564T3 (pl) 2022-05-09
US12084679B2 (en) 2024-09-10
AU2026200680A1 (en) 2026-02-19
IL255992A (en) 2018-01-31
KR102679619B1 (ko) 2024-07-01
US20180094242A1 (en) 2018-04-05
SI3303564T1 (sl) 2022-07-29
HUE058258T2 (hu) 2022-07-28
DK4070803T3 (da) 2026-01-12
JP7737787B2 (ja) 2025-09-11
EP3303564A4 (en) 2018-10-31
EP3303564B1 (en) 2022-02-23
AU2016270793B2 (en) 2022-06-09
KR20220020416A (ko) 2022-02-18
EP4070803B1 (en) 2025-10-08
KR20180014743A (ko) 2018-02-09
PT4070803T (pt) 2026-01-08
CY1125423T1 (el) 2024-12-13
CA2987617A1 (en) 2016-12-08
DK3303564T3 (da) 2022-04-04
JP2026015509A (ja) 2026-01-29
KR102358878B1 (ko) 2022-02-08
AU2016270793A1 (en) 2017-12-14
EP4079314B1 (en) 2025-10-29
JP6974180B2 (ja) 2021-12-01
AU2022228216A1 (en) 2022-10-06
US20210123018A1 (en) 2021-04-29
IL313799B1 (en) 2025-05-01
HRP20220482T1 (hr) 2022-07-08
IL291532A (en) 2022-05-01
EP4079314A1 (en) 2022-10-26
KR20240101884A (ko) 2024-07-02
AU2022228216B2 (en) 2026-02-19
IL320440A (en) 2025-06-01

Similar Documents

Publication Publication Date Title
LT3303564T (lt) Vidurinių smegenų dopamininių (mda) neuronų diferenciacijos in vitro būdai
IL283561B (en) Methods for treating ocular diseases
IL280743B (en) Methods for enriching or producing immune cell populations for adoptive therapy
IL285433A (en) Converted tricycles and method of use
IL256482A (en) Manufacturing device and process for personalized delivery vector-based immunotherapy
HUE051488T2 (hu) Készítmények és eljárások központi idegrendszeri rendellenességek kezelésére
HUE053857T2 (hu) Anti-GITR antitestek és eljárások azok elõállítására
HUE043310T2 (hu) COT modulátorok és eljárások alkalmazásukra
HUE071447T2 (hu) Genetikailag módosított baktériumok és eljárások baktériumok genetikai módosítására
IL259861A (en) Methods and compositions for the treatment of seizure-related disorders
HUE054092T2 (hu) Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások
HUE050095T2 (hu) Anyagcsere-rendellenességek kezelése lófélékben
EP3551036A4 (en) STIMULUS AND EYE TRACKING SYSTEM
PL3289672T3 (pl) Sposoby i urządzenia do tworzenia przeplatanych zespołów falistych cewek
DK3393579T3 (da) Øjenbehandlingssystem
EP3564253A4 (en) ANTIDEPRESSANT COMPOUND, AND ITS PREPARATION METHOD AND APPLICATION
HUE046306T2 (hu) Katekollal funkcionalizált mágneses nanorészecskék, elõállításuk és alkalmazásuk
DK3848028T3 (da) Fremgangsmåder til behandling af øjenlidelser
HRP20190086T1 (hr) Sustav za vuču i suspenziju
BR112016028653A2 (pt) métodos de tratamento de doenças e distúrbios neurodesenvolvimentais
SG11201704578RA (en) Methods and apparatus for manufacture of ophthalmic lenses
TH1601001781A (th) ออปติคัลอิเลเม้นต์และวิธีการผลิตนั้น
TH1501005968A (th) สารองค์ประกอบโปรตีนและวิธีผลิต
TH1501002005A (th) วิธีการสำหรับการผลิตตัวต่อและตัวต่อ
GB201406623D0 (en) Treatment of optical aberration/s