PL3303564T3 - Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) - Google Patents

Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

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Publication number
PL3303564T3
PL3303564T3 PL16804350T PL16804350T PL3303564T3 PL 3303564 T3 PL3303564 T3 PL 3303564T3 PL 16804350 T PL16804350 T PL 16804350T PL 16804350 T PL16804350 T PL 16804350T PL 3303564 T3 PL3303564 T3 PL 3303564T3
Authority
PL
Poland
Prior art keywords
mda
methods
central brain
vitro differential
dopamine neurones
Prior art date
Application number
PL16804350T
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja KRIKS
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of PL3303564T3 publication Critical patent/PL3303564T3/pl

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL16804350T 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda) PL3303564T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562169444P 2015-06-01 2015-06-01
US201562169379P 2015-06-01 2015-06-01
EP16804350.3A EP3303564B1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons
PCT/US2016/035312 WO2016196661A1 (en) 2015-06-01 2016-06-01 Methods of in vitro differentiation of midbrain dopamine (mda) neurons

Publications (1)

Publication Number Publication Date
PL3303564T3 true PL3303564T3 (pl) 2022-05-09

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16804350T PL3303564T3 (pl) 2015-06-01 2016-06-01 Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Country Status (18)

Country Link
US (3) US10858625B2 (pl)
EP (3) EP3303564B1 (pl)
JP (5) JP6974180B2 (pl)
KR (4) KR20250118858A (pl)
AU (3) AU2016270793B2 (pl)
CY (1) CY1125423T1 (pl)
DK (2) DK3303564T3 (pl)
ES (2) ES2910032T3 (pl)
HR (1) HRP20220482T1 (pl)
HU (1) HUE058258T2 (pl)
IL (4) IL320440A (pl)
LT (1) LT3303564T (pl)
PL (1) PL3303564T3 (pl)
PT (2) PT4070803T (pl)
RS (1) RS63157B1 (pl)
SI (1) SI3303564T1 (pl)
SM (1) SMT202200263T1 (pl)
WO (1) WO2016196661A1 (pl)

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PL3303564T3 (pl) * 2015-06-01 2022-05-09 Memorial Sloan Kettering Cancer Center Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)
KR20180105236A (ko) * 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
KR102487142B1 (ko) 2016-08-16 2023-01-12 후지필름 셀룰러 다이내믹스, 인코포레이티드 만능 세포를 분화시키는 방법
EP3614837A4 (en) * 2017-04-26 2020-12-30 Memorial Sloan-Kettering Cancer Center READY-TO-USE CRYOPRESERVED CELLS
ES2988722T3 (es) * 2017-07-17 2024-11-21 Miltenyi Biotec Bv & Co Kg Un método para el perfilado de la expresión de proteínas de una sola célula de células progenitoras dopaminérgicas mesencefálicas de la placa del suelo
WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
EP3898944A1 (en) 2018-12-19 2021-10-27 Regents of the University of Minnesota Methods for generating and using organoids and tissue therein
JP7790973B2 (ja) * 2019-05-23 2025-12-23 ザ マクリーン ホスピタル コーポレーション パーキンソン病のための自家細胞置換療法
EP4038181A1 (en) 2019-07-25 2022-08-10 The Scripps Research Institute Methods of identifying dopaminergic neurons and progenitor cells
AU2020336221A1 (en) * 2019-08-29 2022-04-07 Memorial Sloan-Kettering Cancer Center Methods of generating and isolating midbrain dopamine neurons
EP4032974A4 (en) * 2019-09-20 2023-12-06 Korea Research Institute of Bioscience and Biotechnology Production method for induced dopaminergic neuronal progenitors, using direct reprogramming
US20230293593A1 (en) 2020-03-25 2023-09-21 Sana Biotechnology, Inc. Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions
US20230165909A1 (en) 2020-04-21 2023-06-01 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
CA3183958A1 (en) * 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
CN114292814A (zh) * 2020-09-22 2022-04-08 上海跃赛生物科技有限公司 一种多能干细胞分化为中脑黒质多巴胺能神经细胞的方法
AU2022256048A1 (en) * 2021-04-07 2023-10-05 FUJIFILM Cellular Dynamics, Inc. Dopaminergic precursor cells and methods of use
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US20250082686A1 (en) 2021-07-21 2025-03-13 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
AU2022387671B2 (en) 2021-11-12 2024-11-07 Axent Biosciences Inc. Methods for production of functional neurons
IL316055A (en) 2022-04-15 2024-11-01 Aspen Neuroscience Inc Methods of classifying the differentiation state of cells and related compositions of differentiated cells
WO2024259119A2 (en) * 2023-06-13 2024-12-19 Aspen Neuroscience, Inc. Methods for differentiating dopaminergic neurons from stem cells
CN117448271B (zh) * 2023-12-22 2024-07-16 上海元戊医学技术有限公司 一种诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法
WO2025166063A1 (en) 2024-01-31 2025-08-07 Bluerock Therapeutics Lp Igfbp2 in cell culture
WO2025252180A1 (zh) * 2024-06-05 2025-12-11 中国科学院脑科学与智能技术卓越创新中心 中脑多巴胺能祖细胞群的体外制备方法
WO2026006245A1 (en) 2024-06-25 2026-01-02 Bluerock Therapeutics Lp Three-dimensional culturing of pluripotent stem cells for improved differentiability

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PL3303564T3 (pl) * 2015-06-01 2022-05-09 Memorial Sloan Kettering Cancer Center Metody in vitro różnicowania neuronów dopaminowych śródmózgowia (mda)

Also Published As

Publication number Publication date
IL320440A (en) 2025-06-01
ES3057638T3 (en) 2026-03-03
EP3303564A4 (en) 2018-10-31
JP2026015509A (ja) 2026-01-29
IL313799B1 (en) 2025-05-01
IL313799A (en) 2024-08-01
HRP20220482T1 (hr) 2022-07-08
JP2018522538A (ja) 2018-08-16
US20240400987A1 (en) 2024-12-05
JP7737787B2 (ja) 2025-09-11
IL291532B2 (en) 2024-12-01
JP6974180B2 (ja) 2021-12-01
SMT202200263T1 (it) 2022-07-21
WO2016196661A1 (en) 2016-12-08
AU2022228216B2 (en) 2026-02-19
SI3303564T1 (sl) 2022-07-29
IL291532B1 (en) 2024-08-01
LT3303564T (lt) 2022-05-10
RS63157B1 (sr) 2022-05-31
CY1125423T1 (el) 2024-12-13
AU2022228216A1 (en) 2022-10-06
EP3303564B1 (en) 2022-02-23
EP4070803A1 (en) 2022-10-12
HUE058258T2 (hu) 2022-07-28
KR20250118858A (ko) 2025-08-06
DK4070803T3 (da) 2026-01-12
CA2987617A1 (en) 2016-12-08
AU2016270793A1 (en) 2017-12-14
US20180094242A1 (en) 2018-04-05
EP3303564A1 (en) 2018-04-11
KR102679619B1 (ko) 2024-07-01
EP4079314B1 (en) 2025-10-29
KR20240101884A (ko) 2024-07-02
EP4079314A1 (en) 2022-10-26
AU2026200680A1 (en) 2026-02-19
PT3303564T (pt) 2022-06-02
KR102358878B1 (ko) 2022-02-08
JP2020146060A (ja) 2020-09-17
US10858625B2 (en) 2020-12-08
IL291532A (en) 2022-05-01
JP2023181494A (ja) 2023-12-21
ES2910032T3 (es) 2022-05-11
PT4070803T (pt) 2026-01-08
US20210123018A1 (en) 2021-04-29
US12084679B2 (en) 2024-09-10
KR102841407B1 (ko) 2025-08-01
IL255992B (en) 2022-04-01
IL313799B2 (en) 2025-09-01
DK3303564T3 (da) 2022-04-04
IL255992A (en) 2018-01-31
KR20220020416A (ko) 2022-02-18
KR20180014743A (ko) 2018-02-09
EP4070803B1 (en) 2025-10-08
AU2016270793B2 (en) 2022-06-09
JP2022031961A (ja) 2022-02-22

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