LT3368555T - Dvejopos funkcijos baltymai ir juos apimanti farmacinė kompozicija - Google Patents
Dvejopos funkcijos baltymai ir juos apimanti farmacinė kompozicijaInfo
- Publication number
- LT3368555T LT3368555T LTEPPCT/KR2016/012300T LTKR2016012300T LT3368555T LT 3368555 T LT3368555 T LT 3368555T LT KR2016012300 T LTKR2016012300 T LT KR2016012300T LT 3368555 T LT3368555 T LT 3368555T
- Authority
- LT
- Lithuania
- Prior art keywords
- same
- pharmaceutical composition
- dual function
- function proteins
- proteins
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150150576A KR102670157B1 (ko) | 2015-10-28 | 2015-10-28 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| PCT/KR2016/012300 WO2017074123A1 (en) | 2015-10-28 | 2016-10-28 | Dual function proteins and pharmaceutical composition comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3368555T true LT3368555T (lt) | 2025-04-10 |
Family
ID=58630627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/KR2016/012300T LT3368555T (lt) | 2015-10-28 | 2016-10-28 | Dvejopos funkcijos baltymai ir juos apimanti farmacinė kompozicija |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11136364B2 (lt) |
| EP (2) | EP4527403A3 (lt) |
| JP (3) | JP7575862B2 (lt) |
| KR (2) | KR102670157B1 (lt) |
| CN (4) | CN115925979A (lt) |
| AU (1) | AU2016346870B2 (lt) |
| CA (1) | CA3003115C (lt) |
| DK (1) | DK3368555T3 (lt) |
| ES (1) | ES3013110T3 (lt) |
| FI (1) | FI3368555T3 (lt) |
| HR (1) | HRP20250309T1 (lt) |
| HU (1) | HUE071444T2 (lt) |
| LT (1) | LT3368555T (lt) |
| MX (1) | MX2018005193A (lt) |
| PL (1) | PL3368555T3 (lt) |
| PT (1) | PT3368555T (lt) |
| RS (1) | RS66648B1 (lt) |
| RU (1) | RU2741345C2 (lt) |
| SI (1) | SI3368555T1 (lt) |
| WO (1) | WO2017074123A1 (lt) |
| ZA (1) | ZA201802003B (lt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) * | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| CN107759696A (zh) | 2016-08-19 | 2018-03-06 | 安源医药科技(上海)有限公司 | 人白介素7融合蛋白及其制备方法 |
| WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| KR102692516B1 (ko) * | 2016-11-10 | 2024-08-08 | 주식회사유한양행 | 융합 단백질을 포함하는 간염증, 간섬유화 및 간경화 예방 또는 치료용 약학적 조성물 |
| ES3014984T3 (en) | 2017-03-14 | 2025-04-28 | Sunshine Lake Pharma Co Ltd | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| MX2019012331A (es) * | 2017-04-21 | 2020-01-23 | Yuhan Corp | Metodo para producir proteinas de doble funcion y sus derivados. |
| CN109836503B (zh) * | 2017-11-24 | 2022-09-16 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的多重活性蛋白 |
| CN113603794B (zh) * | 2018-01-11 | 2024-01-16 | 安源医药科技(上海)有限公司 | 用于调节血糖和脂质的增效型双功能蛋白 |
| US11679143B2 (en) | 2018-02-08 | 2023-06-20 | Sunshine Lake Pharma Co., Ltd. | FGF21 variant, fusion protein and application thereof |
| US20210275643A1 (en) * | 2018-06-21 | 2021-09-09 | Sanofi | Fgf21 compound / glp-1r agonist combinations with optimized activity ratio |
| US20210338779A1 (en) * | 2018-10-04 | 2021-11-04 | Hanmi Pharm. Co., Ltd | Therapeutic use of glucagon and combination including the same |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
| EP3935075A4 (en) | 2019-03-05 | 2023-01-18 | Sunshine Lake Pharma Co., Ltd. | POLYPEPTIDE MOLECULE AND APPLICATION THEREOF |
| CN114853908B (zh) * | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| US11639383B2 (en) * | 2019-11-27 | 2023-05-02 | Gi Innovation, Inc. | Pharmaceutical composition for treatment of cancer, comprising an immune checkpoint inhibitor antibody and a fusion protein comprising an IL-2 mutant and a CD80 extracellular domain |
| CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| TW202140525A (zh) * | 2020-01-08 | 2021-11-01 | 大陸商上海翰森生物醫藥科技有限公司 | Fgf21突變體蛋白及其融合蛋白 |
| WO2021139744A1 (en) * | 2020-01-11 | 2021-07-15 | Beijing Ql Biopharmaceutical Co., Ltd. | Conjugates of fusion proteins of glp-1 and fgf21 |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| KR20230034356A (ko) * | 2020-07-02 | 2023-03-09 | 사노피 | 활성이 감소된 glp-1r 효능제 펩티드 |
| JP2023540663A (ja) * | 2020-07-02 | 2023-09-26 | サノフイ | Glp-1rアゴニスト/fgf21融合タンパク質 |
| EP4308610A4 (en) * | 2021-03-19 | 2025-07-16 | Sunshine Lake Pharma Co Ltd | USES OF FGF21 POLYPEPTIDES AND FUSION POLYPEPTIDES THEREOF |
| CN113265007B (zh) * | 2021-06-10 | 2022-02-15 | 江南大学 | 一种治疗代谢疾病的融合蛋白及其制备方法和应用 |
| KR20240034235A (ko) | 2021-07-14 | 2024-03-13 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 대사 장애를 위한 융합 폴리펩타이드 |
| CN117510646A (zh) * | 2022-08-03 | 2024-02-06 | 无锡市华盛康肽生物技术有限公司 | 一种双功能融合蛋白及其用途 |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
| EP4659888A1 (en) | 2023-01-30 | 2025-12-10 | Nippon Steel Corporation | Tailored blank, press-molded article, method for producing tailored blank, and method for producing press-molded article |
| WO2024162363A1 (ja) | 2023-01-30 | 2024-08-08 | 日本製鉄株式会社 | テーラードブランク、プレス成形品、テーラードブランクの製造方法、及びプレス成形品の製造方法 |
| CN117143242B (zh) * | 2023-10-30 | 2024-03-29 | 南京佰抗生物科技有限公司 | 抗Galectin-3蛋白的单克隆抗体组合物及应用 |
| CN117942425B (zh) * | 2024-03-27 | 2024-10-22 | 杭州惠康医疗器械有限公司 | 一种促进伤口愈合的水凝胶敷料及其制备方法 |
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| JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
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| US5851800A (en) | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
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| WO2005091944A2 (en) | 2004-03-17 | 2005-10-06 | Eli Lilly And Company | Glycol linked fgf-21 compounds |
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| WO2011089170A2 (en) | 2010-01-22 | 2011-07-28 | Novo Nordisk A/S | Process for preparing fgf-21 with low degree of o-glycosylation |
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| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| US9574002B2 (en) | 2011-06-06 | 2017-02-21 | Amgen Inc. | Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor |
| EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
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| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| CN102558358A (zh) * | 2011-12-30 | 2012-07-11 | 张海涛 | 人成纤维细胞生长因子21融合蛋白及其突变体的制备与应用 |
| WO2013131091A1 (en) * | 2012-03-02 | 2013-09-06 | New York University | Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
| AR092076A1 (es) * | 2012-08-22 | 2015-03-18 | Lilly Co Eli | Proteinas homodimericas |
| CA2880929A1 (en) * | 2012-09-07 | 2014-03-13 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| WO2014130659A1 (en) | 2013-02-22 | 2014-08-28 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| AU2014318579A1 (en) * | 2013-09-13 | 2016-04-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| BR112017008157A2 (pt) | 2014-10-24 | 2017-12-19 | Bristol Myers Squibb Co | polipeptídeos de fgf-21 modificados e usos dos mesmos |
| KR102668200B1 (ko) | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) * | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| CN105288592A (zh) | 2015-11-02 | 2016-02-03 | 哈尔滨博翱生物医药技术开发有限公司 | 成纤维细胞生长因子-21成熟肽在制备肝纤维化治疗药物中的应用 |
| ES3014984T3 (en) | 2017-03-14 | 2025-04-28 | Sunshine Lake Pharma Co Ltd | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| MX2019012331A (es) | 2017-04-21 | 2020-01-23 | Yuhan Corp | Metodo para producir proteinas de doble funcion y sus derivados. |
-
2015
- 2015-10-28 KR KR1020150150576A patent/KR102670157B1/ko active Active
-
2016
- 2016-10-28 CN CN202210973282.8A patent/CN115925979A/zh active Pending
- 2016-10-28 EP EP25151368.5A patent/EP4527403A3/en active Pending
- 2016-10-28 CN CN202210972247.4A patent/CN115925978A/zh active Pending
- 2016-10-28 AU AU2016346870A patent/AU2016346870B2/en active Active
- 2016-10-28 ES ES16860306T patent/ES3013110T3/es active Active
- 2016-10-28 HU HUE16860306A patent/HUE071444T2/hu unknown
- 2016-10-28 CN CN201680062638.5A patent/CN108350054B/zh active Active
- 2016-10-28 SI SI201631894T patent/SI3368555T1/sl unknown
- 2016-10-28 PT PT168603066T patent/PT3368555T/pt unknown
- 2016-10-28 PL PL16860306.6T patent/PL3368555T3/pl unknown
- 2016-10-28 LT LTEPPCT/KR2016/012300T patent/LT3368555T/lt unknown
- 2016-10-28 RS RS20250290A patent/RS66648B1/sr unknown
- 2016-10-28 US US15/768,865 patent/US11136364B2/en active Active
- 2016-10-28 CN CN202210973281.3A patent/CN116333160A/zh active Pending
- 2016-10-28 MX MX2018005193A patent/MX2018005193A/es unknown
- 2016-10-28 WO PCT/KR2016/012300 patent/WO2017074123A1/en not_active Ceased
- 2016-10-28 JP JP2018522147A patent/JP7575862B2/ja active Active
- 2016-10-28 DK DK16860306.6T patent/DK3368555T3/da active
- 2016-10-28 CA CA3003115A patent/CA3003115C/en active Active
- 2016-10-28 RU RU2018118025A patent/RU2741345C2/ru active
- 2016-10-28 FI FIEP16860306.6T patent/FI3368555T3/fi active
- 2016-10-28 EP EP16860306.6A patent/EP3368555B1/en active Active
- 2016-10-28 HR HRP20250309TT patent/HRP20250309T1/hr unknown
-
2018
- 2018-03-26 ZA ZA2018/02003A patent/ZA201802003B/en unknown
-
2021
- 2021-09-17 US US17/478,628 patent/US20220002368A1/en not_active Abandoned
-
2022
- 2022-10-12 JP JP2022164154A patent/JP2023011644A/ja active Pending
-
2024
- 2024-05-20 KR KR1020240065441A patent/KR102927838B1/ko active Active
- 2024-10-18 US US18/919,743 patent/US20250270269A1/en active Pending
-
2025
- 2025-05-27 JP JP2025087649A patent/JP2025128179A/ja active Pending
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