LT3377511T - Azitromicino dariniai su epitelinio barjero sustiprinimo savybėmis - Google Patents

Azitromicino dariniai su epitelinio barjero sustiprinimo savybėmis

Info

Publication number
LT3377511T
LT3377511T LTEP16804720.7T LT16804720T LT3377511T LT 3377511 T LT3377511 T LT 3377511T LT 16804720 T LT16804720 T LT 16804720T LT 3377511 T LT3377511 T LT 3377511T
Authority
LT
Lithuania
Prior art keywords
epitelic
azitromycin
derivatives
strengthening properties
barrier strengthening
Prior art date
Application number
LTEP16804720.7T
Other languages
English (en)
Inventor
Fridrik Runar GARDARSSON
Fredrik Lehmann
Peter Teodorovic
Original Assignee
Epiendo Pharmaceuticals Ehf.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55133040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3377511(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Epiendo Pharmaceuticals Ehf. filed Critical Epiendo Pharmaceuticals Ehf.
Publication of LT3377511T publication Critical patent/LT3377511T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
LTEP16804720.7T 2015-11-19 2016-11-21 Azitromicino dariniai su epitelinio barjero sustiprinimo savybėmis LT3377511T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1520419.1A GB201520419D0 (en) 2015-11-19 2015-11-19 Compounds
PCT/EP2016/078360 WO2017085329A1 (en) 2015-11-19 2016-11-21 Azithromycin derivatives with epithelial barrier enhancement properties

Publications (1)

Publication Number Publication Date
LT3377511T true LT3377511T (lt) 2020-09-25

Family

ID=55133040

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP16804720.7T LT3377511T (lt) 2015-11-19 2016-11-21 Azitromicino dariniai su epitelinio barjero sustiprinimo savybėmis

Country Status (19)

Country Link
US (3) US10723752B2 (lt)
EP (2) EP3708573A1 (lt)
JP (2) JP6849896B2 (lt)
KR (2) KR20240157138A (lt)
CN (2) CN114933620B (lt)
CA (1) CA3005088A1 (lt)
CY (1) CY1123418T1 (lt)
DK (1) DK3377511T3 (lt)
ES (1) ES2810703T3 (lt)
GB (1) GB201520419D0 (lt)
HR (1) HRP20201246T1 (lt)
HU (1) HUE050307T2 (lt)
LT (1) LT3377511T (lt)
PL (1) PL3377511T3 (lt)
PT (1) PT3377511T (lt)
RS (1) RS60698B1 (lt)
SI (1) SI3377511T1 (lt)
SM (1) SMT202000426T1 (lt)
WO (1) WO2017085329A1 (lt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
EP4118092B1 (en) * 2020-03-12 2025-07-16 Zoetis Services LLC Immunomodulating o-het-aryl azalides
MX2024002892A (es) * 2021-09-07 2024-04-05 Zoetis Services Llc Azalidos inmunomoduladores.
JP2026512285A (ja) 2023-03-22 2026-04-15 エピエンド ファーマシューティカルズ イーエッチエフ． 好酸球関連疾患の治療における使用のためのアジスロマイシン誘導体
GB202404587D0 (en) 2024-03-28 2024-05-15 Epiendo Pharmaceuticals Ehf Chemical forms
GB202412461D0 (en) 2024-08-23 2024-10-09 Epiendo Pharmaceuticals Ehf Medial use

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
HRP20010018A2 (en) * 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003255851B2 (en) * 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
ITMI20022292A1 (it) 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
GB0310984D0 (en) * 2003-05-13 2003-06-18 Glaxo Group Ltd Novel compounds
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
KR20070105993A (ko) * 2005-01-13 2007-10-31 글락소스미쓰클라인 이스트라지바치키 센타 자그레브 디.오.오. 소염 활성을 갖는 마크로라이드
WO2006077501A2 (en) * 2005-01-13 2006-07-27 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Decladinosyl-macrolides with anti-inflammatory activity
CN1837225A (zh) 2005-08-23 2006-09-27 济南思创生物技术有限公司 阿奇霉素衍生物及其制法和药物应用
EP2077271A4 (en) 2006-05-01 2010-09-15 Taisho Pharmaceutical Co Ltd Macrolide derivative
CN101074251B (zh) * 2007-06-22 2011-06-15 山东大学 阿奇霉素4＂-氨甲酸酯衍生物、制备方法及其药物组合物
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
CA2814333A1 (en) 2010-10-10 2012-04-19 Synovo Gmbh Anti-inflammatory macrolides
GB201105633D0 (en) * 2011-04-01 2011-05-18 Norbrook Lab Ltd Antibotic compounds
WO2013148874A1 (en) * 2012-03-27 2013-10-03 Burnet Michael W Anti-inflammatory macrolides
CA2908620A1 (en) * 2013-04-10 2014-10-16 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201520419D0 (en) 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds

Also Published As

Publication number Publication date
CN114933620A (zh) 2022-08-23
US11236120B2 (en) 2022-02-01
US20220106349A1 (en) 2022-04-07
JP7256558B2 (ja) 2023-04-12
JP2018534324A (ja) 2018-11-22
RS60698B1 (sr) 2020-09-30
KR20240157138A (ko) 2024-10-31
EP3377511A1 (en) 2018-09-26
SI3377511T1 (sl) 2020-10-30
CY1123418T1 (el) 2021-12-31
JP2021073303A (ja) 2021-05-13
JP6849896B2 (ja) 2021-03-31
CA3005088A1 (en) 2017-05-26
WO2017085329A1 (en) 2017-05-26
SMT202000426T1 (it) 2020-09-10
US20200317710A1 (en) 2020-10-08
PT3377511T (pt) 2020-08-21
HUE050307T2 (hu) 2020-11-30
KR102724114B1 (ko) 2024-10-29
CN108290919B (zh) 2022-06-17
CN114933620B (zh) 2026-03-31
DK3377511T3 (da) 2020-08-17
EP3377511B1 (en) 2020-05-13
US10723752B2 (en) 2020-07-28
US20180354981A1 (en) 2018-12-13
GB201520419D0 (en) 2016-01-06
CN108290919A (zh) 2018-07-17
HK1255270A1 (en) 2019-08-09
ES2810703T3 (es) 2021-03-09
PL3377511T3 (pl) 2020-11-16
KR20180077282A (ko) 2018-07-06
US12049477B2 (en) 2024-07-30
EP3708573A1 (en) 2020-09-16
HRP20201246T1 (hr) 2020-11-13

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