LT3573948T - Citotoksinių benzodiazepino darinių paruošimo būdai - Google Patents
Citotoksinių benzodiazepino darinių paruošimo būdaiInfo
- Publication number
- LT3573948T LT3573948T LTEPPCT/US2018/014956T LT18014956T LT3573948T LT 3573948 T LT3573948 T LT 3573948T LT 18014956 T LT18014956 T LT 18014956T LT 3573948 T LT3573948 T LT 3573948T
- Authority
- LT
- Lithuania
- Prior art keywords
- cytotoxic
- preparation
- methods
- benzodiazepin
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450270P | 2017-01-25 | 2017-01-25 | |
| PCT/US2018/014956 WO2018140435A1 (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3573948T true LT3573948T (lt) | 2023-02-10 |
Family
ID=61189535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2018/014956T LT3573948T (lt) | 2017-01-25 | 2018-01-24 | Citotoksinių benzodiazepino darinių paruošimo būdai |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10385071B2 (lt) |
| EP (2) | EP4148044A1 (lt) |
| JP (3) | JP7066725B2 (lt) |
| KR (2) | KR102480594B1 (lt) |
| CN (3) | CN116102615A (lt) |
| AU (3) | AU2018213202B2 (lt) |
| CA (1) | CA3050262A1 (lt) |
| CY (1) | CY1125759T1 (lt) |
| DK (1) | DK3573948T3 (lt) |
| ES (1) | ES2935346T3 (lt) |
| FI (1) | FI3573948T3 (lt) |
| HR (1) | HRP20230002T1 (lt) |
| HU (1) | HUE060746T2 (lt) |
| IL (3) | IL287405B (lt) |
| LT (1) | LT3573948T (lt) |
| PL (1) | PL3573948T3 (lt) |
| PT (1) | PT3573948T (lt) |
| RS (1) | RS63871B1 (lt) |
| RU (2) | RU2762891C2 (lt) |
| SG (1) | SG11201906666QA (lt) |
| SI (1) | SI3573948T1 (lt) |
| SM (1) | SMT202300001T1 (lt) |
| TW (3) | TWI763771B (lt) |
| WO (1) | WO2018140435A1 (lt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4148044A1 (en) | 2017-01-25 | 2023-03-15 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN113166053A (zh) | 2018-11-12 | 2021-07-23 | 伊缪诺金公司 | 制备细胞毒性苯二氮䓬衍生物的方法 |
| MA54228A (fr) | 2018-11-12 | 2021-09-22 | Immunogen Inc | Procédés de préparation de dérivés de benzodiazépine cytotoxiques |
| CN113661172A (zh) * | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| CN103282367B (zh) | 2010-12-21 | 2015-07-29 | 詹森药业有限公司 | 二环苯衍生物取代的5,6-二氢-4h-吡咯并[1,2-a][1,4]苯并二氮杂*和6h-吡咯并[1,2-a][1,4]苯并二氮杂*新抗真菌剂 |
| JP5826863B2 (ja) * | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| MX2017009145A (es) | 2015-01-14 | 2017-11-22 | Bristol Myers Squibb Co | Dimeros de benzodiazepina, conjugados de estos, y sus metodos de preparacion y uso. |
| AU2016285552B2 (en) * | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| EP3325482B1 (en) | 2015-07-21 | 2020-06-24 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EP4148044A1 (en) | 2017-01-25 | 2023-03-15 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
-
2018
- 2018-01-24 EP EP22199432.0A patent/EP4148044A1/en not_active Withdrawn
- 2018-01-24 HR HRP20230002TT patent/HRP20230002T1/hr unknown
- 2018-01-24 RU RU2019125133A patent/RU2762891C2/ru active
- 2018-01-24 ES ES18704352T patent/ES2935346T3/es active Active
- 2018-01-24 CN CN202310124604.6A patent/CN116102615A/zh active Pending
- 2018-01-24 JP JP2019540404A patent/JP7066725B2/ja not_active Expired - Fee Related
- 2018-01-24 US US15/878,991 patent/US10385071B2/en active Active
- 2018-01-24 RU RU2021138005A patent/RU2021138005A/ru unknown
- 2018-01-24 AU AU2018213202A patent/AU2018213202B2/en not_active Ceased
- 2018-01-24 HU HUE18704352A patent/HUE060746T2/hu unknown
- 2018-01-24 IL IL287405A patent/IL287405B/en unknown
- 2018-01-24 DK DK18704352.6T patent/DK3573948T3/da active
- 2018-01-24 KR KR1020197024738A patent/KR102480594B1/ko active Active
- 2018-01-24 IL IL293645A patent/IL293645A/en unknown
- 2018-01-24 KR KR1020227044421A patent/KR20230005410A/ko not_active Abandoned
- 2018-01-24 SM SM20230001T patent/SMT202300001T1/it unknown
- 2018-01-24 FI FIEP18704352.6T patent/FI3573948T3/fi active
- 2018-01-24 RS RS20221193A patent/RS63871B1/sr unknown
- 2018-01-24 TW TW107102506A patent/TWI763771B/zh not_active IP Right Cessation
- 2018-01-24 SG SG11201906666QA patent/SG11201906666QA/en unknown
- 2018-01-24 PL PL18704352.6T patent/PL3573948T3/pl unknown
- 2018-01-24 LT LTEPPCT/US2018/014956T patent/LT3573948T/lt unknown
- 2018-01-24 TW TW111114178A patent/TWI805325B/zh not_active IP Right Cessation
- 2018-01-24 CN CN202310124650.6A patent/CN116554262A/zh active Pending
- 2018-01-24 PT PT187043526T patent/PT3573948T/pt unknown
- 2018-01-24 CA CA3050262A patent/CA3050262A1/en active Pending
- 2018-01-24 WO PCT/US2018/014956 patent/WO2018140435A1/en not_active Ceased
- 2018-01-24 CN CN201880008141.4A patent/CN110225904B/zh not_active Expired - Fee Related
- 2018-01-24 TW TW112117953A patent/TW202400551A/zh unknown
- 2018-01-24 SI SI201830832T patent/SI3573948T1/sl unknown
- 2018-01-24 EP EP18704352.6A patent/EP3573948B1/en active Active
-
2019
- 2019-06-17 US US16/442,718 patent/US10844078B2/en active Active
- 2019-07-22 IL IL268213A patent/IL268213B/en unknown
-
2020
- 2020-10-22 US US17/077,688 patent/US11390633B2/en active Active
-
2022
- 2022-03-07 AU AU2022201572A patent/AU2022201572B2/en not_active Ceased
- 2022-04-27 JP JP2022072946A patent/JP7400005B2/ja active Active
- 2022-06-15 US US17/841,026 patent/US11981687B2/en active Active
-
2023
- 2023-01-04 CY CY20231100006T patent/CY1125759T1/el unknown
- 2023-12-06 JP JP2023205788A patent/JP2024028860A/ja not_active Withdrawn
-
2024
- 2024-02-21 AU AU2024201119A patent/AU2024201119A1/en not_active Abandoned
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