LT3722435T - Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema - Google Patents

Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema

Info

Publication number
LT3722435T
LT3722435T LTEP20176019.6T LT20176019T LT3722435T LT 3722435 T LT3722435 T LT 3722435T LT 20176019 T LT20176019 T LT 20176019T LT 3722435 T LT3722435 T LT 3722435T
Authority
LT
Lithuania
Prior art keywords
constant
fixed
flow pump
tubing system
bed bioreactor
Prior art date
Application number
LTEP20176019.6T
Other languages
English (en)
Inventor
Hanna LESCH
Eva RÄSÄNEN
Piia VALONEN
Tarja TUUNANEN
Milla Jonna KARNAATTU
Achim Müller
Minna Karhinen
Seppo Yla-Herttuala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/025681 external-priority patent/WO2017180341A2/en
Publication of LT3722435T publication Critical patent/LT3722435T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • C12M25/18—Fixed or packed bed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Clinical Laboratory Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
LTEP20176019.6T 2016-04-14 2017-04-03 Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema LT3722435T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662322651P 2016-04-14 2016-04-14
PCT/US2017/025681 WO2017180341A2 (en) 2016-04-14 2017-04-03 Fixed-bed bioreactor with constant-flow pump/ tubing system

Publications (1)

Publication Number Publication Date
LT3722435T true LT3722435T (lt) 2025-10-10

Family

ID=66522911

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP20176020.4T LT3722436T (lt) 2016-04-14 2017-04-03 Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema
LTEP20176019.6T LT3722435T (lt) 2016-04-14 2017-04-03 Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP20176020.4T LT3722436T (lt) 2016-04-14 2017-04-03 Fiksuoto lovio bioreaktorius su nuolatinio srauto siurbliu / vamzdžių sistema

Country Status (15)

Country Link
US (5) US11261416B2 (lt)
EP (1) EP3497224B1 (lt)
KR (3) KR102718795B1 (lt)
CN (2) CN116144500A (lt)
ES (3) ES3053142T3 (lt)
FI (2) FI3722435T3 (lt)
HR (2) HRP20251357T1 (lt)
HU (1) HUE073497T2 (lt)
LT (2) LT3722436T (lt)
PL (2) PL3722436T3 (lt)
PT (1) PT3722436T (lt)
RS (2) RS67444B1 (lt)
SG (2) SG10202110989QA (lt)
SI (2) SI3722436T1 (lt)
WO (1) WO2018007873A1 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3604547A1 (en) 2016-04-14 2020-02-05 Trizell Ltd. Fixed-bed bioreactor with constant-flow pump/tubing system
CN116144500A (zh) 2016-04-14 2023-05-23 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
HUE055862T2 (hu) 2016-04-20 2021-12-28 Centro De Investig Energeticas Készítmények és eljárások PKLR fokozott génexpressziójára
SG11202002263TA (en) 2017-10-16 2020-04-29 Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas Lentiviral vectors for delivery of pklr to treat pyruvate kinase deficiency
BE1026108B1 (fr) * 2018-03-16 2019-10-14 Univercells S.A. Échantillonneur à lit fixe et procédés associés
WO2019200167A1 (en) 2018-04-11 2019-10-17 Rocket Pharmaceuticals, Ltd. Compositions and methods for stem cell transplant
US12152281B2 (en) * 2019-05-30 2024-11-26 Trizell Ltd. Gene therapy vector contamination assay
KR102383015B1 (ko) * 2020-03-23 2022-04-05 프레스티지바이오로직스 주식회사 항체 의약품 제조 공정을 위한 하이브리드 무균 연결 시스템 및 무균 연결 방법
US20230272418A1 (en) * 2020-05-04 2023-08-31 Agc Biologics S.P.A. Lentiviral vector manufacturing process in packed bed bioreactor
CN112779226A (zh) * 2021-02-03 2021-05-11 苏州博腾生物制药有限公司 慢病毒贴壁细胞培养工艺
EP4294457A4 (en) * 2021-02-16 2025-06-18 The Johns Hopkins University Composition of storage-stable plasmid DNA/polyethylene imine particles with defined sizes for the production of viral vectors and production method
JP2024506394A (ja) * 2021-02-16 2024-02-13 ザ・ジョンズ・ホプキンス・ユニバーシティ 細胞トランスフェクションのための規定サイズの保存安定性があるプラスミドｄｎａ／ポリカチオン粒子の調製方法
US20230146372A1 (en) * 2021-11-07 2023-05-11 Univercells Technologies S.A. Sampling apparatus for cell culture bed and related methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63313576A (ja) 1987-06-13 1988-12-21 Rikagaku Kenkyusho チユ−ブラ−バイオリアクタ−
US5622857A (en) 1995-08-08 1997-04-22 Genespan Corporation High performance cell culture bioreactor and method
WO1998022588A2 (en) 1996-11-20 1998-05-28 Introgen Therapeutics, Inc. An improved method for the production and purification of adenoviral vectors
ZA200406921B (en) 2002-03-12 2006-10-25 Ark Therapeutics Ltd Engineered baculoviruses and their use
CA2557046A1 (en) 2004-03-05 2005-10-13 John Crowley Process for cell culturing by continuous perfusion and alternating tangential flow
US20110189764A1 (en) * 2011-03-27 2011-08-04 Nathan Starbard Single use device incorporating a container and scaffold
US20140315294A1 (en) 2011-11-24 2014-10-23 Genethon Scalable lentiviral vector production system compatible with industrial pharmaceutical applications
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
US10465157B2 (en) * 2014-08-19 2019-11-05 General Electric Company Systems and methods for aseptic sampling
JP5892216B1 (ja) * 2014-09-17 2016-03-23 東洋製罐グループホールディングス株式会社 細胞培養システムにおける送液方法、及び細胞培養システム
GB201417042D0 (en) * 2014-09-29 2014-11-12 Fkd Therapies Oy Method
US20160257972A1 (en) * 2015-03-04 2016-09-08 Children's Hospital Medical Center Foamy viral vector compositions and methods for the manufacture of same
CN116144500A (zh) 2016-04-14 2023-05-23 崔泽尔有限公司 具有恒流泵/管道系统的固定床生物反应器
EP3604547A1 (en) 2016-04-14 2020-02-05 Trizell Ltd. Fixed-bed bioreactor with constant-flow pump/tubing system

Also Published As

Publication number Publication date
CN109072252A (zh) 2018-12-21
PL3722436T3 (pl) 2026-03-23
HUE073497T2 (hu) 2026-01-28
RS67367B1 (sr) 2025-11-28
FI3497224T3 (fi) 2023-08-17
RS67444B1 (sr) 2025-12-31
SI3722435T1 (sl) 2026-03-31
LT3722436T (lt) 2025-11-10
WO2018007873A4 (en) 2018-03-01
PL3722435T3 (pl) 2026-03-09
KR20240025689A (ko) 2024-02-27
US12116559B2 (en) 2024-10-15
ES3054035T3 (en) 2026-01-28
US11242504B2 (en) 2022-02-08
EP3497224A1 (en) 2019-06-19
US20240247218A1 (en) 2024-07-25
SI3722436T1 (sl) 2026-03-31
PT3722436T (pt) 2025-10-16
WO2018007873A1 (en) 2018-01-11
SG11201808700QA (en) 2018-11-29
US11261416B2 (en) 2022-03-01
KR20230022177A (ko) 2023-02-14
US20220364036A1 (en) 2022-11-17
ES3053142T3 (en) 2026-01-19
KR20190039021A (ko) 2019-04-10
ES2951678T3 (es) 2023-10-24
FI3722435T3 (fi) 2025-12-05
KR102718795B1 (ko) 2024-10-16
SG10202110989QA (en) 2021-11-29
EP3497224B1 (en) 2023-06-07
CA3021045A1 (en) 2018-01-11
US20190031998A1 (en) 2019-01-31
CN116144500A (zh) 2023-05-23
US20240425792A1 (en) 2024-12-26
HRP20251357T1 (hr) 2025-12-19
HRP20251455T1 (hr) 2026-01-02
US20190218495A1 (en) 2019-07-18

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