LT4123B - The active ingredient of pharmaceutical composition for treating constipation - Google Patents

The active ingredient of pharmaceutical composition for treating constipation Download PDF

Info

Publication number: LT4123B
Authority: LT; Lithuania
Prior art keywords: constipation; dimethylpolysiloxane; active ingredient; pharmaceutical composition; treatment
Prior art date: 1993-12-02

Application number

LT96-094A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT96094A (en

Inventor

Alfred Schmidt

Hans-Juergen Upmeyer

Original Assignee

Alfred Schmidt

Upmeyer Hans Juergen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-02

Filing date

1996-07-01

Publication date

1997-03-25

1996-07-01 Application filed by Alfred Schmidt, Upmeyer Hans Juergen filed Critical Alfred Schmidt

1996-12-27 Publication of LT96094A publication Critical patent/LT96094A/xx

1997-03-25 Publication of LT4123B publication Critical patent/LT4123B/lt

Links

206010010774 Constipation Diseases 0.000 title claims abstract description 17
239000004480 active ingredient Substances 0.000 title claims 3
239000008194 pharmaceutical composition Substances 0.000 title claims 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 17
239000004205 dimethyl polysiloxane Substances 0.000 claims description 16
235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 16
239000000203 mixture Substances 0.000 claims description 13
238000011282 treatment Methods 0.000 claims description 10
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 3
239000000377 silicon dioxide Substances 0.000 claims description 3
239000006185 dispersion Substances 0.000 claims description 2
239000003995 emulsifying agent Substances 0.000 claims 2
229960001275 dimeticone Drugs 0.000 abstract 1
CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 abstract 1
239000000839 emulsion Substances 0.000 description 5
239000008141 laxative Substances 0.000 description 5
230000000694 effects Effects 0.000 description 4
229940125722 laxative agent Drugs 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
239000003826 tablet Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
239000002775 capsule Substances 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
206010000060 Abdominal distension Diseases 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
208000024330 bloating Diseases 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
235000015872 dietary supplement Nutrition 0.000 description 2
239000008103 glucose Substances 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
239000008101 lactose Substances 0.000 description 2
230000002475 laxative effect Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
230000011514 reflex Effects 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
230000008961 swelling Effects 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
239000001828 Gelatine Substances 0.000 description 1
206010020571 Hyperaldosteronism Diseases 0.000 description 1
208000019025 Hypokalemia Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
210000003489 abdominal muscle Anatomy 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000004067 bulking agent Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229940097217 cardiac glycoside Drugs 0.000 description 1
239000002368 cardiac glycoside Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000011970 concomitant therapy Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
230000007547 defect Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000000378 dietary effect Effects 0.000 description 1
229940008099 dimethicone Drugs 0.000 description 1
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000003736 gastrointestinal content Anatomy 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
231100001261 hazardous Toxicity 0.000 description 1
230000003862 health status Effects 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
208000003243 intestinal obstruction Diseases 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
238000012153 long-term therapy Methods 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
238000000034 method Methods 0.000 description 1
210000000653 nervous system Anatomy 0.000 description 1
FWRBVROZVUCLNY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O FWRBVROZVUCLNY-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
201000009395 primary hyperaldosteronism Diseases 0.000 description 1
230000003578 releasing effect Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
229940083037 simethicone Drugs 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
229930002534 steroid glycoside Natural products 0.000 description 1
150000008143 steroidal glycosides Chemical class 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
206010043827 tibia fracture Diseases 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Optical Recording Or Reproduction (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

LT96-094A 1993-12-02 1996-07-01 The active ingredient of pharmaceutical composition for treating constipation LT4123B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4341165A DE4341165C1 (de)	1993-12-02	1993-12-02	Verwendung von Dimeticon zur Behandlung von Obstipation

Publications (2)

Publication Number	Publication Date
LT96094A LT96094A (en)	1996-12-27
LT4123B true LT4123B (en)	1997-03-25

Family

ID=6504057

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT96-094A LT4123B (en)	1993-12-02	1996-07-01	The active ingredient of pharmaceutical composition for treating constipation

Country Status (21)

Country	Link
EP (1)	EP0731705B1 (de)
JP (1)	JP4047376B2 (de)
CN (1)	CN1138296A (de)
AT (1)	ATE208202T1 (de)
AU (1)	AU1242095A (de)
BG (1)	BG100686A (de)
CZ (1)	CZ286371B6 (de)
DE (2)	DE4341165C1 (de)
HU (1)	HU216837B (de)
IL (1)	IL111804A (de)
LT (1)	LT4123B (de)
LV (1)	LV11593B (de)
MD (1)	MD1484F2 (de)
NO (1)	NO962221L (de)
NZ (1)	NZ277255A (de)
PL (1)	PL314799A1 (de)
RU (1)	RU2143907C1 (de)
SI (1)	SI9420073A (de)
SK (1)	SK70296A3 (de)
WO (1)	WO1995015170A1 (de)
ZA (1)	ZA949564B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY138097A (en) *	2000-03-22	2009-04-30	Du Pont	Insecticidal anthranilamides
KR100442174B1 (ko) *	2001-09-25	2004-07-30	(주)다산메디켐	이산화규소, 폴리소르베이트류 및디메칠폴리실록산(디메치콘, 시메치콘)을 함유하는소화기장애에 사용되는 고형의 신규의약조성물
RU2253359C1 (ru) *	2003-12-17	2005-06-10	Лазебник Леонид Борисович	Способ дифференциальной диагностики дискинезии толстой кишки и синдрома раздраженного кишечника
JP2008503445A (ja) *	2004-04-13	2008-02-07	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	便秘患者におけるシメチコンの使用
DE102006001199A1 (de) *	2006-01-10	2007-07-12	Medicoforum Gmbh	Fixe Kombination von Substanzen unter Beigabe von Entschäumern zum Einsatz als Darmspüllösung und/oder Laxans
DE102012024434A1 (de)	2012-12-14	2014-06-18	Regalismons S.A.	Verstärkung der entschäumenden Wirkung von Polysiloxanen, zugehöriger Zusammensetzungen und Lösungen
IT202000001831A1 (it) *	2020-01-30	2021-07-30	Caprika Srl	Composizione per applicazione rettale a base di sale di acido butirrico per il trattamento delle patologie proctologiche

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3807712A1 (de)	1987-07-25	1989-02-02	Nordend Apotheke Angela Hein	Arzneimittel-trockenpraeparat zur bereitung einer laxativ wirkenden trinkloesung sowie ein verfahren zur herstellung dieses praeparates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR5549M (de) *	1966-04-14	1967-11-20
FR2438431A1 (fr) *	1978-10-09	1980-05-09	Grimberg Georges	Produits speciaux et compositions pharmaceutiques a base de son pour dispersions
AU637570B2 (en) *	1989-01-19	1993-06-03	Alfred Schmidt	Use of dimethylpolysiloxane for treating disorders of the gastrointestinal tract

1993
- 1993-12-02 DE DE4341165A patent/DE4341165C1/de not_active Expired - Fee Related
1994
- 1994-11-29 IL IL11180494A patent/IL111804A/en not_active IP Right Cessation
- 1994-12-01 ZA ZA949564A patent/ZA949564B/xx unknown
- 1994-12-02 DE DE69429013T patent/DE69429013D1/de not_active Expired - Lifetime
- 1994-12-02 SI SI9420073A patent/SI9420073A/sl unknown
- 1994-12-02 WO PCT/EP1994/004024 patent/WO1995015170A1/en not_active Ceased
- 1994-12-02 RU RU96115138A patent/RU2143907C1/ru active
- 1994-12-02 PL PL94314799A patent/PL314799A1/xx unknown
- 1994-12-02 CZ CZ19961579A patent/CZ286371B6/cs not_active IP Right Cessation
- 1994-12-02 EP EP95903316A patent/EP0731705B1/de not_active Expired - Lifetime
- 1994-12-02 CN CN94194564A patent/CN1138296A/zh active Pending
- 1994-12-02 HU HU9601498A patent/HU216837B/hu not_active IP Right Cessation
- 1994-12-02 JP JP51540995A patent/JP4047376B2/ja not_active Expired - Fee Related
- 1994-12-02 MD MD96-0221A patent/MD1484F2/ro unknown
- 1994-12-02 SK SK702-96A patent/SK70296A3/sk unknown
- 1994-12-02 AU AU12420/95A patent/AU1242095A/en not_active Abandoned
- 1994-12-02 NZ NZ277255A patent/NZ277255A/en unknown
- 1994-12-02 AT AT95903316T patent/ATE208202T1/de not_active IP Right Cessation
1996
- 1996-05-30 NO NO962221A patent/NO962221L/no not_active Application Discontinuation
- 1996-06-28 LV LVP-96-205A patent/LV11593B/en unknown
- 1996-07-01 BG BG100686A patent/BG100686A/xx unknown
- 1996-07-01 LT LT96-094A patent/LT4123B/lt not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3807712A1 (de)	1987-07-25	1989-02-02	Nordend Apotheke Angela Hein	Arzneimittel-trockenpraeparat zur bereitung einer laxativ wirkenden trinkloesung sowie ein verfahren zur herstellung dieses praeparates

Also Published As

Publication number	Publication date
NZ277255A (en)	1999-09-29
HUT75529A (en)	1997-05-28
HU9601498D0 (en)	1996-07-29
ATE208202T1 (de)	2001-11-15
IL111804A0 (en)	1995-01-24
EP0731705B1 (de)	2001-11-07
SK70296A3 (en)	1997-06-04
DE4341165C1 (de)	1995-04-20
JPH09505824A (ja)	1997-06-10
CZ157996A3 (en)	1997-01-15
LV11593A (lv)	1996-12-20
LT96094A (en)	1996-12-27
AU1242095A (en)	1995-06-19
BG100686A (en)	1997-01-31
EP0731705A1 (de)	1996-09-18
CZ286371B6 (cs)	2000-03-15
NO962221D0 (no)	1996-05-30
LV11593B (en)	1997-04-20
SI9420073A (en)	1997-02-28
IL111804A (en)	2001-06-14
MD1484F2 (ro)	2000-06-30
WO1995015170A1 (en)	1995-06-08
HU216837B (hu)	1999-09-28
JP4047376B2 (ja)	2008-02-13
DE69429013D1 (de)	2001-12-13
ZA949564B (en)	1995-08-16
PL314799A1 (en)	1996-09-30
CN1138296A (zh)	1996-12-18
RU2143907C1 (ru)	2000-01-10
NO962221L (no)	1996-06-14

Legal Events

Date	Code	Title	Description
2001-08-27	MM9A	Lapsed patents	Effective date: 20001202

Publication	Publication Date	Title
Nimmo	1976	Drugs, diseases and altered gastric emptying
US6162464A (en)	2000-12-19	Non-aqueous colonic purgative formulations
CA2478135C (en)	2017-10-24	Electrolyte purgative
JP3850891B2 (ja)	2006-11-29	緩下効果を有する組成物
ES2213838T3 (es)	2004-09-01	Uso de composiciones para el suministro postgastrectomico de minerales.
IL96020A (en)	1995-03-30	Preparations containing L-monosaccharide sugar that provide volume in the feces and laxity in the intestines of mammals
US5348744A (en)	1994-09-20	Antidiarrheal compositions containing loperamide hydrochloride and a saccharide
Steffen et al.	2007	The eating disorders medicine cabinet revisited: a clinician's guide to ipecac and laxatives
LT4123B (en)	1997-03-25	The active ingredient of pharmaceutical composition for treating constipation
US5418220A (en)	1995-05-23	Method for treating constipation using dimethicone
Glazer et al.	1953	Volvulus of the colon: a complication of sprue
US10617761B2 (en)	2020-04-14	Compositions and solutions for colon cleansing
JP4601091B2 (ja)	2010-12-22	環状オリゴ糖
CN114144189B (zh)	2024-05-28	包含二甲基硅油和蔗糖酯的组合物及其作为消泡剂的用途
CA2177955C (en)	2006-03-21	Use of dimeticone for treating constipation
WO2003000299A1 (en)	2003-01-03	Laxative preparation
Gordon et al.	1968	Studies of malabsorption and calcium excretion induced by neomycin sulfate: effect of intestinal site, bile salt, and pancreatic enzymes
AU2002312652B2 (en)	2006-11-30	Laxative preparation
AU2003205450C1 (en)	2009-04-23	Electrolyte purgative
SWARTZ	1992	Drug Formus: NuLYTELY (PEG 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution)
Stebbins et al.	1978	Clinical use of cholestyramine resin in diarrheas of various etiology
AU2002312652A1 (en)	2003-06-19	Laxative preparation
BAUMGARTNER et al.	1924	Clifton Medical Bulletin
JPH0219329A (ja)	1990-01-23	Ｘ線造影用バリウム塩製剤