LT4161927T - Spiro junginiai kaip melanokortino receptoriaus antagonistai ir jų panaudojimas - Google Patents

Spiro junginiai kaip melanokortino receptoriaus antagonistai ir jų panaudojimas

Info

Publication number: LT4161927T
Authority: LT; Lithuania
Prior art keywords: melanocortin; receptor antagonists; spiro compounds; spiro; compounds
Prior art date: 2020-06-09

Application number

LTEPPCT/IB2021/054970T

Other languages

English (en)

Inventor

Christopher Ryan BUTLER

Michelle Renee GARNSEY

Kevin Alexander OGILVIE

Jana Polivkova

Matthew Forrest Sammons

Aaron Christopher Smith

Qingyi YANG

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-06-09

Filing date

2021-06-07

Publication date

2024-09-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=76422026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4161927(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2021-06-07 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2024-09-25 Publication of LT4161927T publication Critical patent/LT4161927T/lt

Links

102000001796 Melanocortin 4 receptors Human genes 0.000 title 1
108010021436 Type 4 Melanocortin Receptor Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
150000003413 spiro compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Neurology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

LTEPPCT/IB2021/054970T 2020-06-09 2021-06-07 Spiro junginiai kaip melanokortino receptoriaus antagonistai ir jų panaudojimas LT4161927T (lt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US202063036798P	2020-06-09	2020-06-09
US202163167271P	2021-03-29	2021-03-29
PCT/IB2021/054970 WO2021250541A1 (en)	2020-06-09	2021-06-07	Spiro compounds as melanocortin 4 receptor antagonists and uses thereof

Publications (1)

Publication Number	Publication Date
LT4161927T true LT4161927T (lt)	2024-09-25

Family

ID=76422026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEPPCT/IB2021/054970T LT4161927T (lt)	2020-06-09	2021-06-07	Spiro junginiai kaip melanokortino receptoriaus antagonistai ir jų panaudojimas

Country Status (34)

Country	Link
US (3)	US11643412B2 (lt)
EP (1)	EP4161927B9 (lt)
JP (1)	JP7288554B1 (lt)
KR (1)	KR102838870B1 (lt)
CN (1)	CN116113635B (lt)
AU (1)	AU2021289169B2 (lt)
BR (1)	BR112022024527A2 (lt)
CA (1)	CA3186348A1 (lt)
CL (1)	CL2022003503A1 (lt)
CO (1)	CO2022017790A2 (lt)
CR (1)	CR20220632A (lt)
DK (1)	DK4161927T3 (lt)
DO (1)	DOP2022000281A (lt)
EC (1)	ECSP22093794A (lt)
ES (1)	ES2994968T3 (lt)
FI (1)	FI4161927T3 (lt)
HR (1)	HRP20241177T1 (lt)
HU (1)	HUE068344T2 (lt)
IL (1)	IL298891B2 (lt)
LT (1)	LT4161927T (lt)
MA (1)	MA59895B1 (lt)
MD (1)	MD4161927T3 (lt)
MX (1)	MX2022015706A (lt)
PE (1)	PE20231215A1 (lt)
PH (1)	PH12022553296A1 (lt)
PL (1)	PL4161927T3 (lt)
PT (1)	PT4161927T (lt)
PY (1)	PY2146664A (lt)
RS (1)	RS65929B9 (lt)
SI (1)	SI4161927T1 (lt)
TW (1)	TWI843949B (lt)
UY (1)	UY39260A (lt)
WO (1)	WO2021250541A1 (lt)
ZA (1)	ZA202213427B (lt)

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WO2024104452A1 (zh)	2022-11-17	2024-05-23	长春金赛药业有限责任公司	Mc4r拮抗剂化合物、药物组合物及其在医药上的应用
WO2024173905A1 (en) *	2023-02-17	2024-08-22	Endevica Bio, Inc.	Methods of preventing and/or treating side effects associated with anti-cancer agents using non-naturally occurring melanocortin analogs with anti-gdf-15 antibodies
WO2024255412A1 (zh) *	2023-06-14	2024-12-19	广州必贝特医药股份有限公司	螺杂环化合物及其应用
AU2024312554A1 (en)	2023-06-19	2025-12-18	F. Hoffmann-La Roche Ag	Process for the preparation of a chiral pyrrolo triazole alcohol

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2021
- 2021-06-07 LT LTEPPCT/IB2021/054970T patent/LT4161927T/lt unknown
- 2021-06-07 KR KR1020227042755A patent/KR102838870B1/ko active Active
- 2021-06-07 PT PT217321264T patent/PT4161927T/pt unknown
- 2021-06-07 SI SI202130198T patent/SI4161927T1/sl unknown
- 2021-06-07 JP JP2022575378A patent/JP7288554B1/ja active Active
- 2021-06-07 MA MA59895A patent/MA59895B1/fr unknown
- 2021-06-07 HR HRP20241177TT patent/HRP20241177T1/hr unknown
- 2021-06-07 WO PCT/IB2021/054970 patent/WO2021250541A1/en not_active Ceased
- 2021-06-07 PE PE2022002902A patent/PE20231215A1/es unknown
- 2021-06-07 BR BR112022024527A patent/BR112022024527A2/pt unknown
- 2021-06-07 ES ES21732126T patent/ES2994968T3/es active Active
- 2021-06-07 RS RS20240965A patent/RS65929B9/sr unknown
- 2021-06-07 AU AU2021289169A patent/AU2021289169B2/en active Active
- 2021-06-07 MX MX2022015706A patent/MX2022015706A/es unknown
- 2021-06-07 HU HUE21732126A patent/HUE068344T2/hu unknown
- 2021-06-07 PH PH1/2022/553296A patent/PH12022553296A1/en unknown
- 2021-06-07 MD MDE20230408T patent/MD4161927T3/ro unknown
- 2021-06-07 CR CR20220632A patent/CR20220632A/es unknown
- 2021-06-07 PL PL21732126.4T patent/PL4161927T3/pl unknown
- 2021-06-07 FI FIEP21732126.4T patent/FI4161927T3/fi active
- 2021-06-07 CA CA3186348A patent/CA3186348A1/en active Pending
- 2021-06-07 DK DK21732126.4T patent/DK4161927T3/da active
- 2021-06-07 CN CN202180056466.1A patent/CN116113635B/zh active Active
- 2021-06-07 EP EP21732126.4A patent/EP4161927B9/en active Active
- 2021-06-08 UY UY0001039260A patent/UY39260A/es not_active Application Discontinuation
- 2021-06-08 TW TW110120795A patent/TWI843949B/zh active
- 2021-06-08 US US17/341,877 patent/US11643412B2/en active Active
- 2021-06-09 PY PY202102146664A patent/PY2146664A/es unknown
2022
- 2022-12-06 IL IL298891A patent/IL298891B2/en unknown
- 2022-12-07 CO CONC2022/0017790A patent/CO2022017790A2/es unknown
- 2022-12-08 DO DO2022000281A patent/DOP2022000281A/es unknown
- 2022-12-09 CL CL2022003503A patent/CL2022003503A1/es unknown
- 2022-12-09 EC ECSENADI202293794A patent/ECSP22093794A/es unknown
- 2022-12-12 ZA ZA2022/13427A patent/ZA202213427B/en unknown
2023
- 2023-01-31 US US18/162,052 patent/US12187727B2/en active Active
2024
- 2024-11-21 US US18/954,736 patent/US20250084084A1/en active Pending

Also Published As

Publication number	Publication date
MD4161927T2 (ro)	2024-11-30
DK4161927T3 (da)	2024-08-26
CL2022003503A1 (es)	2023-09-01
WO2021250541A1 (en)	2021-12-16
TW202204357A (zh)	2022-02-01
JP7288554B1 (ja)	2023-06-07
ES2994968T3 (en)	2025-02-04
MX2022015706A (es)	2023-01-24
PY2146664A (es)	2022-10-12
US12187727B2 (en)	2025-01-07
DOP2022000281A (es)	2023-01-15
JP2023525394A (ja)	2023-06-15
ZA202213427B (en)	2023-07-26
US20230174532A1 (en)	2023-06-08
MA59895B1 (fr)	2024-10-31
KR20230011968A (ko)	2023-01-25
SI4161927T1 (sl)	2024-11-29
EP4161927A1 (en)	2023-04-12
IL298891B2 (en)	2026-07-01
CN116113635A (zh)	2023-05-12
UY39260A (es)	2022-01-31
HUE068344T2 (hu)	2024-12-28
CR20220632A (es)	2023-01-23
US20230019853A1 (en)	2023-01-19
EP4161927B9 (en)	2024-11-06
MD4161927T3 (ro)	2025-02-28
ECSP22093794A (es)	2023-01-31
CA3186348A1 (en)	2021-12-16
RS65929B9 (sr)	2025-02-28
PL4161927T3 (pl)	2024-11-18
EP4161927B1 (en)	2024-08-07
FI4161927T3 (fi)	2024-10-03
AU2021289169B2 (en)	2024-01-04
US20250084084A1 (en)	2025-03-13
AU2021289169A1 (en)	2023-01-19
IL298891A (en)	2023-02-01
HRP20241177T1 (hr)	2024-11-22
US11643412B2 (en)	2023-05-09
BR112022024527A2 (pt)	2022-12-27
CN116113635B (zh)	2025-03-18
CO2022017790A2 (es)	2022-12-20
PE20231215A1 (es)	2023-08-17
RS65929B1 (sr)	2024-10-31
IL298891B1 (en)	2026-03-01
TWI843949B (zh)	2024-06-01
PH12022553296A1 (en)	2024-06-24
PT4161927T (pt)	2024-10-08
KR102838870B1 (ko)	2025-07-24

Publication	Publication Date	Title
ZA202213427B (en)	2023-07-26	Spiro compounds as melanocortin 4 receptor antagonists and uses thereof
IL273924A (en)	2020-05-31	Muscarinic acetylcholine M4 receptor antagonists
IL279152A (en)	2021-01-31	Melanocortin subtype-2 receptor antagonists and uses thereof
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