LT4661B - Medikamentai prieš nevaisingumą ir vaisingumo skatinimui - Google Patents

Medikamentai prieš nevaisingumą ir vaisingumo skatinimui Download PDF

Info

Publication number: LT4661B
Authority: LT; Lithuania
Prior art keywords: sperm; lidocaine; endometriosis; peritoneal fluid; pharmaceutical composition
Prior art date: 1997-02-15

Application number

LT99-101A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT99101A (en

Inventor

Greta Edelstam

Original Assignee

Edelstam Inc

Greta Edelstam

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-15

Filing date

1999-08-12

Publication date

2000-05-25

1999-08-12 Application filed by Edelstam Inc, Greta Edelstam filed Critical Edelstam Inc

2000-03-27 Publication of LT99101A publication Critical patent/LT99101A/xx

2000-05-25 Publication of LT4661B publication Critical patent/LT4661B/lt

Links

208000000509 infertility Diseases 0.000 title claims abstract description 21
230000036512 infertility Effects 0.000 title claims abstract description 21
231100000535 infertility Toxicity 0.000 title claims abstract description 21
239000003814 drug Substances 0.000 title claims abstract description 6
230000035558 fertility Effects 0.000 claims abstract description 15
239000003589 local anesthetic agent Substances 0.000 claims abstract description 14
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
238000004519 manufacturing process Methods 0.000 claims abstract description 4
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 62
229960004194 lidocaine Drugs 0.000 claims description 59
238000011282 treatment Methods 0.000 claims description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims description 8
229920002674 hyaluronan Polymers 0.000 claims description 8
229940099552 hyaluronan Drugs 0.000 claims description 8
239000011780 sodium chloride Substances 0.000 claims description 7
239000000203 mixture Substances 0.000 claims description 6
ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 4
LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 4
INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims description 4
MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 4
230000001737 promoting effect Effects 0.000 claims description 4
210000000683 abdominal cavity Anatomy 0.000 claims description 3
229960003150 bupivacaine Drugs 0.000 claims description 3
229960002409 mepivacaine Drugs 0.000 claims description 3
229960001807 prilocaine Drugs 0.000 claims description 3
229960001549 ropivacaine Drugs 0.000 claims description 3
238000000034 method Methods 0.000 abstract description 12
238000011835 investigation Methods 0.000 abstract description 2
230000008569 process Effects 0.000 abstract description 2
210000003567 ascitic fluid Anatomy 0.000 description 50
201000009273 Endometriosis Diseases 0.000 description 30
238000011534 incubation Methods 0.000 description 29
210000004027 cell Anatomy 0.000 description 22
210000000265 leukocyte Anatomy 0.000 description 20
206010057249 Phagocytosis Diseases 0.000 description 14
239000002609 medium Substances 0.000 description 14
230000008782 phagocytosis Effects 0.000 description 14
230000016087 ovulation Effects 0.000 description 10
235000002639 sodium chloride Nutrition 0.000 description 10
230000000694 effects Effects 0.000 description 9
230000004083 survival effect Effects 0.000 description 9
230000000750 progressive effect Effects 0.000 description 8
230000004720 fertilization Effects 0.000 description 7
238000000338 in vitro Methods 0.000 description 7
238000003744 In vitro fertilisation Methods 0.000 description 6
230000004054 inflammatory process Effects 0.000 description 6
206010061218 Inflammation Diseases 0.000 description 5
239000004809 Teflon Substances 0.000 description 5
229920006362 Teflon® Polymers 0.000 description 5
239000004480 active ingredient Substances 0.000 description 5
238000003745 diagnosis Methods 0.000 description 5
230000004899 motility Effects 0.000 description 5
210000003024 peritoneal macrophage Anatomy 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
238000012360 testing method Methods 0.000 description 5
230000002939 deleterious effect Effects 0.000 description 4
210000002540 macrophage Anatomy 0.000 description 4
210000000287 oocyte Anatomy 0.000 description 4
239000000126 substance Substances 0.000 description 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000001464 adherent effect Effects 0.000 description 3
230000003444 anaesthetic effect Effects 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
230000001627 detrimental effect Effects 0.000 description 3
230000002357 endometrial effect Effects 0.000 description 3
231100000502 fertility decrease Toxicity 0.000 description 3
239000011521 glass Substances 0.000 description 3
239000003102 growth factor Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
230000027758 ovulation cycle Effects 0.000 description 3
230000035935 pregnancy Effects 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
230000035899 viability Effects 0.000 description 3
208000004998 Abdominal Pain Diseases 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
102000002322 Egg Proteins Human genes 0.000 description 2
108010000912 Egg Proteins Proteins 0.000 description 2
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
208000007514 Herpes zoster Diseases 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
210000001109 blastomere Anatomy 0.000 description 2
238000009534 blood test Methods 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
239000000969 carrier Substances 0.000 description 2
230000021164 cell adhesion Effects 0.000 description 2
210000000170 cell membrane Anatomy 0.000 description 2
229940079593 drug Drugs 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
229920000669 heparin Polymers 0.000 description 2
229960002897 heparin Drugs 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
239000007943 implant Substances 0.000 description 2
208000021267 infertility disease Diseases 0.000 description 2
210000004681 ovum Anatomy 0.000 description 2
230000009467 reduction Effects 0.000 description 2
210000000582 semen Anatomy 0.000 description 2
238000000926 separation method Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
206010013554 Diverticulum Diseases 0.000 description 1
208000007984 Female Infertility Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
206010021928 Infertility female Diseases 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
102000003896 Myeloperoxidases Human genes 0.000 description 1
108090000235 Myeloperoxidases Proteins 0.000 description 1
229920002274 Nalgene Polymers 0.000 description 1
241000337007 Oceania Species 0.000 description 1
206010034238 Pelvic adhesions Diseases 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical class [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000004075 alteration Effects 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
239000003146 anticoagulant agent Substances 0.000 description 1
229940127219 anticoagulant drug Drugs 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000000337 buffer salt Substances 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000007541 cellular toxicity Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 1
229960003608 clomifene Drugs 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000001514 detection method Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000013020 embryo development Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
210000004696 endometrium Anatomy 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000001733 follicular fluid Anatomy 0.000 description 1
210000004392 genitalia Anatomy 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
230000012447 hatching Effects 0.000 description 1
210000003494 hepatocyte Anatomy 0.000 description 1
229940088592 immunologic factor Drugs 0.000 description 1
239000000367 immunologic factor Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000011221 initial treatment Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
229940079322 interferon Drugs 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000002357 laparoscopic surgery Methods 0.000 description 1
230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
238000002690 local anesthesia Methods 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
230000029849 luteinization Effects 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
210000001161 mammalian embryo Anatomy 0.000 description 1
IWYDHOAUDWTVEP-UHFFFAOYSA-N mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
239000003550 marker Substances 0.000 description 1
230000035800 maturation Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
208000004296 neuralgia Diseases 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229940052264 other local anesthetics in atc Drugs 0.000 description 1
230000002611 ovarian Effects 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
230000000624 ovulatory effect Effects 0.000 description 1
239000006174 pH buffer Substances 0.000 description 1
230000007170 pathology Effects 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
230000004526 pharmaceutical effect Effects 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
-1 polypropylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000000047 product Substances 0.000 description 1
230000007425 progressive decline Effects 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000003307 reticuloendothelial effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000019100 sperm motility Effects 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100001265 toxicological assessment Toxicity 0.000 description 1
238000012546 transfer Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)

LT99-101A 1997-02-15 1999-08-12 Medikamentai prieš nevaisingumą ir vaisingumo skatinimui LT4661B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/800,737 US5977143A (en)	1997-02-15	1997-02-15	Medicament against infertility which reduces phagocytosis of spermatozoa in women

Publications (2)

Publication Number	Publication Date
LT99101A LT99101A (en)	2000-03-27
LT4661B true LT4661B (lt)	2000-05-25

Family

ID=25179227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT99-101A LT4661B (lt)	1997-02-15	1999-08-12	Medikamentai prieš nevaisingumą ir vaisingumo skatinimui

Country Status (23)

Country	Link
US (1)	US5977143A (no)
EP (1)	EP1001771B1 (no)
JP (1)	JP3497513B2 (no)
KR (1)	KR20000071053A (no)
CN (1)	CN1248915A (no)
AT (1)	ATE295169T1 (no)
AU (1)	AU743346B2 (no)
BR (1)	BR9807370A (no)
CA (1)	CA2280685C (no)
DE (1)	DE69830176T2 (no)
EE (1)	EE9900346A (no)
ES (1)	ES2245022T3 (no)
HU (1)	HUP0001342A3 (no)
IL (1)	IL131267A0 (no)
IS (1)	IS5152A (no)
LT (1)	LT4661B (no)
LV (1)	LV12450B (no)
NO (1)	NO321663B1 (no)
NZ (1)	NZ337504A (no)
PL (1)	PL335419A1 (no)
SK (1)	SK110599A3 (no)
TR (1)	TR199901958T2 (no)
WO (1)	WO1998035676A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2249250T3 (es) *	1997-02-15	2006-04-01	Edelstam Inc.	Medicamento contra la dismenorrea y el sindrome premenstrual que comprende lidocaina.
US8425892B2 (en)	2001-10-29	2013-04-23	Columbia Laboratories, Inc.	Extended, controlled-release pharmaceutical compositions using charged polymers
US20030114394A1 (en) *	2001-10-29	2003-06-19	Levine Howard L.	Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US9849102B2 (en)	2010-05-19	2017-12-26	Isifer Ab	Treatment for reducing inflammation
AU2016340769B2 (en) *	2015-10-23	2018-07-12	Isifer Ab	Composition for treatment of infertility in a female subject
KR101802090B1 (ko) *	2016-09-26	2017-11-27	서울대학교산학협력단	탈락막 자궁내막 세포를 포함하는 자궁내막 손상의 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0507160A1 (en)	1991-03-30	1992-10-07	Teikoku Seiyaku Kabushiki Kaisha	External preparation for application to the skin containing lidocaine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2704147B1 (fr)	1993-04-22	1995-07-21	Leguern Jacques	Composition régénératrice des cellules et son application en milieu médical, vétérinaire et agricole.

1997
- 1997-02-15 US US08/800,737 patent/US5977143A/en not_active Expired - Lifetime
1998
- 1998-02-09 AT AT98904958T patent/ATE295169T1/de not_active IP Right Cessation
- 1998-02-09 WO PCT/US1998/002267 patent/WO1998035676A1/en not_active Ceased
- 1998-02-09 AU AU62703/98A patent/AU743346B2/en not_active Expired
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1999
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Also Published As

Publication number	Publication date
ES2245022T3 (es)	2005-12-16
NZ337504A (en)	2001-01-26
AU743346B2 (en)	2002-01-24
DE69830176D1 (de)	2005-06-16
HUP0001342A2 (hu)	2000-09-28
CN1248915A (zh)	2000-03-29
EP1001771A1 (en)	2000-05-24
IS5152A (is)	1999-08-11
IL131267A0 (en)	2001-01-28
AU6270398A (en)	1998-09-08
NO321663B1 (no)	2006-06-19
EP1001771B1 (en)	2005-05-11
ATE295169T1 (de)	2005-05-15
EE9900346A (et)	2000-02-15
EP1001771A4 (en)	2000-09-27
US5977143A (en)	1999-11-02
HUP0001342A3 (en)	2000-10-30
KR20000071053A (ko)	2000-11-25
LV12450B (en)	2000-10-20
LT99101A (en)	2000-03-27
CA2280685A1 (en)	1998-08-20
JP3497513B2 (ja)	2004-02-16
CA2280685C (en)	2004-06-29
PL335419A1 (en)	2000-04-25
SK110599A3 (en)	2000-11-07
DE69830176T2 (de)	2006-01-26
BR9807370A (pt)	2000-03-14
NO993921D0 (no)	1999-08-13
NO993921L (no)	1999-08-13
TR199901958T2 (xx)	1999-12-21
LV12450A (lv)	2000-04-20
WO1998035676A1 (en)	1998-08-20
JP2000513737A (ja)	2000-10-17

Legal Events

Date	Code	Title	Description
2002-09-25	MM9A	Lapsed patents	Effective date: 20020209

Publication	Publication Date	Title
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