LT4780B - Živ proteazės inhibitoriaus rūgštusis sulfatas - Google Patents

Živ proteazės inhibitoriaus rūgštusis sulfatas Download PDF

Info

Publication number: LT4780B
Authority: LT; Lithuania
Prior art keywords: free base; solubility; acid; sulfate; compound
Prior art date: 1998-01-20

Application number

LT2000067A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT2000067A (en

Inventor

Janak Singh

Madhusudhan Pudipeddi

Mark D. Lindrud

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-20

Filing date

2000-07-14

Publication date

2001-04-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22104737&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4780(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-07-14 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2000-11-27 Publication of LT2000067A publication Critical patent/LT2000067A/xx

2001-04-25 Publication of LT4780B publication Critical patent/LT4780B/lt

Links

QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical class S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 title abstract description 13
239000004030 hiv protease inhibitor Substances 0.000 title abstract description 5
229940122440 HIV protease inhibitor Drugs 0.000 title abstract description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 29
239000002253 acid Substances 0.000 claims description 25
239000002552 dosage form Substances 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims 1
239000012458 free base Substances 0.000 abstract description 29
150000001875 compounds Chemical class 0.000 abstract description 15
238000004090 dissolution Methods 0.000 abstract description 3
150000003839 salts Chemical class 0.000 description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 13
239000007787 solid Substances 0.000 description 12
239000000725 suspension Substances 0.000 description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 11
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 10
239000000463 material Substances 0.000 description 9
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
239000007790 solid phase Substances 0.000 description 8
239000002775 capsule Substances 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 6
239000013078 crystal Substances 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
238000002425 crystallisation Methods 0.000 description 5
230000008025 crystallization Effects 0.000 description 5
239000000203 mixture Substances 0.000 description 5
229910021653 sulphate ion Inorganic materials 0.000 description 5
239000007903 gelatin capsule Substances 0.000 description 4
239000006186 oral dosage form Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
-1 2-pyridinyl Chemical group 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
230000002378 acidificating effect Effects 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
238000000921 elemental analysis Methods 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 2
241000725303 Human immunodeficiency virus Species 0.000 description 2
239000007900 aqueous suspension Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000000113 differential scanning calorimetry Methods 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000000034 method Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
238000002076 thermal analysis method Methods 0.000 description 2
230000009466 transformation Effects 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
241000700605 Viruses Species 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000002585 base Substances 0.000 description 1
230000008901 benefit Effects 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
229940077388 benzenesulfonate Drugs 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
229960000913 crospovidone Drugs 0.000 description 1
239000002178 crystalline material Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
230000006872 improvement Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
102220168432 rs750420022 Human genes 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000000844 transformation Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LT2000067A 1998-01-20 2000-07-14 Živ proteazės inhibitoriaus rūgštusis sulfatas LT4780B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7196898P	1998-01-20	1998-01-20

Publications (2)

Publication Number	Publication Date
LT2000067A LT2000067A (en)	2000-11-27
LT4780B true LT4780B (lt)	2001-04-25

Family

ID=22104737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT2000067A LT4780B (lt)	1998-01-20	2000-07-14	Živ proteazės inhibitoriaus rūgštusis sulfatas

Country Status (38)

Country	Link
US (1)	US6087383A (de)
EP (1)	EP1056722B1 (de)
JP (2)	JP4860037B2 (de)
KR (1)	KR100559283B1 (de)
CN (1)	CN1116282C (de)
AR (1)	AR014417A1 (de)
AT (1)	ATE219057T1 (de)
AU (1)	AU735875B2 (de)
BG (1)	BG64774B1 (de)
BR (1)	BR9814736A (de)
CA (1)	CA2317736C (de)
CO (1)	CO4970820A1 (de)
CZ (1)	CZ293507B6 (de)
DE (1)	DE69806067T2 (de)
DK (1)	DK1056722T3 (de)
EE (1)	EE04434B1 (de)
EG (1)	EG23936A (de)
ES (1)	ES2178300T3 (de)
GE (1)	GEP20033026B (de)
HU (1)	HU227196B1 (de)
IL (2)	IL137384A0 (de)
LT (1)	LT4780B (de)
LV (1)	LV12522B (de)
MY (1)	MY114838A (de)
NO (1)	NO315605B1 (de)
NZ (1)	NZ504417A (de)
PE (1)	PE20000185A1 (de)
PL (1)	PL190744B1 (de)
PT (1)	PT1056722E (de)
RO (1)	RO118869B1 (de)
RU (1)	RU2186070C2 (de)
SK (1)	SK283975B6 (de)
TR (1)	TR200001876T2 (de)
TW (1)	TW531531B (de)
UA (1)	UA59432C2 (de)
UY (1)	UY25345A1 (de)
WO (1)	WO1999036404A1 (de)
ZA (1)	ZA9956B (de)

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EA015145B1 (ru) *	2003-01-14	2011-06-30	Джилид Сайэнс, Инк.	Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
TW200534879A (en) *	2004-03-25	2005-11-01	Bristol Myers Squibb Co	Coated tablet formulation and method
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TWI415635B (zh)	2004-05-28	2013-11-21	必治妥施貴寶公司	加衣錠片調製物及製備彼之方法
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ES2359770T3 (es) *	2007-06-22	2011-05-26	Bristol-Myers Squibb Company	Composiciones en comprimidos que contienen atazanavir.
JP2010530889A (ja) *	2007-06-22	2010-09-16	ブリストル−マイヤーズスクイブカンパニー	アタザナビルを含む錠剤組成物
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JP2010530892A (ja) *	2007-06-22	2010-09-16	ブリストル−マイヤーズスクイブカンパニー	アタザナビルを含む錠剤組成物
BRPI0813955A2 (pt) *	2007-06-29	2017-05-09	Gilead Sciences Inc	composições terapêuticas e o uso das mesmas
NZ582086A (en) *	2007-06-29	2012-07-27	Gilead Sciences Inc	Therapeutic compositions and the use thereof
WO2009136365A1 (en) *	2008-05-08	2009-11-12	Ranbaxy Laboratories Limited	Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
WO2010070611A1 (en)	2008-12-18	2010-06-24	Ranbaxy Laboratories Limited	Atazanavir formulations
WO2010079497A2 (en) *	2009-01-12	2010-07-15	Hetero Research Foundation	Novel polymorph of atazanavir sulfate
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EP2272830A1 (de)	2009-06-18	2011-01-12	Esteve Química, S.A.	Herstellungsverfahren für ein antivirales heterozyklisches Azahexan-Derivat
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ES2898348T3 (es)	2009-10-26	2022-03-07	Merck Sharp & Dohme	Composiciones farmacéuticas sólidas que contienen un inhibidor de la integrasa
WO2011080562A1 (en)	2009-12-29	2011-07-07	Hetero Research Foundation	Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals
UA105556C2 (uk)	2010-01-27	2014-05-26	Віів Гелскер Компані	Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
US20130005780A1 (en)	2010-03-01	2013-01-03	Lupin Limited	Controlled release pharmaceutical compositions of tapentadol
JP6158702B2 (ja)	2010-04-09	2017-07-05	ブリストル−マイヤーズ・スクイブ・ホールディングス・アイルランドＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＨｏｌｄｉｎｇｓＩｒｅｌａｎｄ	ｐＨの影響を改善したアタザナビル硫酸塩製剤
CA2849546A1 (en)	2010-09-28	2012-04-05	Ratiopharm Gmbh	Dry processing of atazanavir
WO2013014633A1 (en)	2011-07-27	2013-01-31	Ranbaxy Laboratories Limited	Process for preparation of atazanavir or its bisulfate salt
US8461347B2 (en)	2011-08-05	2013-06-11	Scinopharm Taiwan, Ltd.	Process for preparing form A of atazanavir sulfate
EP2771332B1 (de)	2011-10-26	2016-06-29	Merck Canada Inc.	Thiophen- und Thiazol-Sulfonamid-Derivate als HIV Protease Inhibitoren zur Behandlung von AIDS
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1998
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Also Published As

Publication number	Publication date
SK283975B6 (sk)	2004-06-08
EE200000798A (et)	2002-06-17
ZA9956B (en)	2000-07-05
EP1056722A4 (de)	2001-01-10
JP2002509136A (ja)	2002-03-26
BG104618A (en)	2001-02-28
DE69806067T2 (de)	2003-01-23
EP1056722B1 (de)	2002-06-12
PL342019A1 (en)	2001-05-07
EE04434B1 (et)	2005-02-15
TR200001876T2 (tr)	2000-11-21
SK10622000A3 (sk)	2001-02-12
PL190744B1 (pl)	2006-01-31
GEP20033026B (en)	2003-07-25
RU2186070C2 (ru)	2002-07-27
WO1999036404A1 (en)	1999-07-22
CZ20002564A3 (cs)	2000-10-11
LV12522A (en)	2000-08-20
JP2009102357A (ja)	2009-05-14
UA59432C2 (uk)	2003-09-15
CN1116282C (zh)	2003-07-30
AU735875B2 (en)	2001-07-19
CN1283188A (zh)	2001-02-07
KR100559283B1 (ko)	2006-03-15
IL137384A (en)	2006-08-01
JP4860037B2 (ja)	2012-01-25
KR20010034221A (ko)	2001-04-25
CO4970820A1 (es)	2000-11-07
NO20003692L (no)	2000-07-19
EP1056722A1 (de)	2000-12-06
CA2317736C (en)	2004-11-02
PE20000185A1 (es)	2000-05-14
LT2000067A (en)	2000-11-27
BG64774B1 (bg)	2006-03-31
CZ293507B6 (cs)	2004-05-12
AR014417A1 (es)	2001-02-28
MY114838A (en)	2003-01-31
AU2010199A (en)	1999-08-02
CA2317736A1 (en)	1999-07-22
DE69806067D1 (de)	2002-07-18
HK1033667A1 (en)	2001-09-14
DK1056722T3 (da)	2002-09-30
HU227196B1 (en)	2010-10-28
ES2178300T3 (es)	2002-12-16
BR9814736A (pt)	2000-10-24
NZ504417A (en)	2001-09-28
TW531531B (en)	2003-05-11
RO118869B1 (ro)	2003-12-30
ATE219057T1 (de)	2002-06-15
HUP0101389A2 (hu)	2001-08-28
HK1033458A1 (en)	2001-08-31
EG23936A (en)	2008-01-14
US6087383A (en)	2000-07-11
NO20003692D0 (no)	2000-07-19
NO315605B1 (no)	2003-09-29
IL137384A0 (en)	2001-07-24
LV12522B (en)	2000-10-20
UY25345A1 (es)	2000-12-29
PT1056722E (pt)	2002-09-30
HUP0101389A3 (en)	2003-07-28

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2013-10-25

PC9A

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Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH

Effective date: 20130926