LT5416B - Antikūnai, nukreipti prieš monocito chemotaksio baltymą -1, ir jų panaudojimas - Google Patents

Antikūnai, nukreipti prieš monocito chemotaksio baltymą -1, ir jų panaudojimas Download PDF

Info

Publication number
LT5416B
LT5416B LT2005099A LT2005099A LT5416B LT 5416 B LT5416 B LT 5416B LT 2005099 A LT2005099 A LT 2005099A LT 2005099 A LT2005099 A LT 2005099A LT 5416 B LT5416 B LT 5416B
Authority
LT
Lithuania
Prior art keywords
amino acid
seq
sequence
acid comprises
chain amino
Prior art date
Application number
LT2005099A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT2005099A (en
Inventor
Jean M. Gudas
Mary Haak-Frendscho
Orit Foord
Meina L. Liang
Kiran Ahluwalia
Sunil Bhakta
Original Assignee
Abgenix, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31888391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT5416(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abgenix, Inc. filed Critical Abgenix, Inc.
Publication of LT2005099A publication Critical patent/LT2005099A/xx
Publication of LT5416B publication Critical patent/LT5416B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LT2005099A 2002-08-19 2005-11-08 Antikūnai, nukreipti prieš monocito chemotaksio baltymą -1, ir jų panaudojimas LT5416B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40480202P 2002-08-19 2002-08-19

Publications (2)

Publication Number Publication Date
LT2005099A LT2005099A (en) 2006-11-27
LT5416B true LT5416B (lt) 2007-04-25

Family

ID=31888391

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2005099A LT5416B (lt) 2002-08-19 2005-11-08 Antikūnai, nukreipti prieš monocito chemotaksio baltymą -1, ir jų panaudojimas

Country Status (17)

Country Link
US (3) US7202343B2 (fr)
EP (1) EP1542724A4 (fr)
JP (1) JP4468172B2 (fr)
AU (1) AU2003265575B2 (fr)
CA (1) CA2496419A1 (fr)
CO (1) CO6220978A2 (fr)
HR (1) HRP20050986A2 (fr)
IL (1) IL171674A0 (fr)
IS (1) IS8115A (fr)
LT (1) LT5416B (fr)
ME (1) MEP18108A (fr)
NZ (1) NZ542784A (fr)
RS (1) RS20050834A (fr)
RU (1) RU2339647C2 (fr)
UA (1) UA87979C2 (fr)
WO (1) WO2004016769A2 (fr)
ZA (1) ZA200508994B (fr)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
KR101317045B1 (ko) 2002-09-06 2013-10-16 암젠 인코포레이티드 치료학적 인체 항-ｉｌ-1ｒ1 모노클로날 항체
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US8017113B2 (en) 2003-03-12 2011-09-13 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
WO2004080273A2 (fr) 2003-03-12 2004-09-23 Rappaport Family Institute For Research In The Medical Sciences Compositions et procedes pour le diagnostic et le traitement du cancer de la prostate
WO2005044200A2 (fr) * 2003-11-05 2005-05-19 Centocor, Inc. Procedes et compositions pour traiter des pathologies associees a la mcp-1
US7674884B2 (en) * 2003-12-10 2010-03-09 Novimmune S.A. Neutralizing antibodies and methods of use thereof
US8481035B2 (en) * 2004-04-27 2013-07-09 Northwestern University Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A
WO2005113814A2 (fr) * 2004-04-27 2005-12-01 Northwestern University Biomarqueurs du syndrome de la douleur pelvienne chronique
CA2575402A1 (fr) * 2004-08-05 2006-02-09 Genentech, Inc. Antagonistes anti-cmet humanises
US8114964B2 (en) * 2005-05-19 2012-02-14 Centocor, Inc. Anti-MCP-1 antibodies, compositions, methods and uses
PE20061444A1 (es) * 2005-05-19 2007-01-15 Centocor Inc Anticuerpo anti-mcp-1, composiciones, metodos y usos
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
WO2007021807A1 (fr) * 2005-08-12 2007-02-22 Schering Corporation Fusions de mcp1
CA2644594A1 (fr) * 2006-03-01 2007-09-07 The Regents Of The University Of Michigan Diagnostic et traitement du cancer de la prostate
JP2009538436A (ja) * 2006-05-26 2009-11-05 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 逆相プロテインアレイ、タンパク質活性化及び発現のサイン並びに関連する方法
EP2041568A4 (fr) * 2006-06-15 2009-08-12 Antagonistes de ccr2 destine au traitement d'un rejet chronique de transplantation d'organe
ES2434039T3 (es) * 2006-07-24 2013-12-13 Yeda Research And Development Co. Ltd. Composiciones farmacéuticas que comprenden ccl2 para su uso en el tratamiento de la inflamación
WO2008077945A2 (fr) * 2006-12-22 2008-07-03 Ablynx N.V. Séquences d'acides aminés dirigées contre des chimiokines et polypeptides comprenant celles-ci pour le traitement de maladies et de troubles liés aux chimiokines
EP1958647A1 (fr) * 2007-02-15 2008-08-20 Helmholtz-Zentrum für Infektionsforschung GmbH Composition pharmaceutique avec des bactéries pour le traitement de tumeurs
CN101827610A (zh) * 2007-06-29 2010-09-08 森托科尔奥索生物科技公司 抗mcp-1抗体、组合物、方法和用途
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
AU2008274978A1 (en) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods of identifying modulators of ion channels
US8309088B2 (en) 2007-08-10 2012-11-13 Regeneron Pharmaceuticals, Inc. Method of treating osteoarthritis with an antibody to NGF
MX2010001395A (es) * 2007-08-10 2010-03-10 Regeneron Pharma Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano.
CN103223165B (zh) * 2007-08-24 2015-02-11 学校法人庆应义塾 肿瘤细胞所导致的免疫抑制的解除剂及使用该解除剂的抗肿瘤剂
JP2011509156A (ja) 2008-01-08 2011-03-24 イェール ユニバーシティ 血管移植片の開存性を促進するための組成物および方法
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
SG190572A1 (en) * 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US20100260668A1 (en) * 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
TW201006485A (en) * 2008-06-03 2010-02-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
CA2726087A1 (fr) * 2008-06-03 2009-12-10 Tariq Ghayur Immunoglobulines a deux domaines variables et leurs utilisations
CN102149825B (zh) * 2008-07-08 2015-07-22 Abbvie公司 前列腺素e2双重可变结构域免疫球蛋白及其用途
RU2547595C2 (ru) 2008-08-18 2015-04-10 Пфайзер Инк Антитела против ccr2
EP2328930B1 (fr) 2008-08-20 2014-12-24 Probiodrug AG Anticorps dirigés contre une protéine-1 chimiotactique des monocytes a terminal pyroglutamate (mcp-1 n1pe)
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
PL2350128T3 (pl) * 2008-10-22 2015-03-31 Inst Res Biomedicine Sposoby wytwarzania przeciwciał z komórek plazmatycznych
US8298533B2 (en) 2008-11-07 2012-10-30 Medimmune Limited Antibodies to IL-1R1
RU2393216C1 (ru) * 2009-02-06 2010-06-27 Александр Валентинович Шишкин Способ комбинированного иммунологического исследования клеток с помощью биочипа
CN103382222B (zh) * 2009-03-20 2016-12-28 安姆根有限公司 α-4-β-7异二聚体特异性拮抗剂抗体
UY32808A (es) * 2009-07-29 2011-02-28 Abbott Lab Inmunoglobulinas como dominio variable dual y usos de las mismas
EP2470671B1 (fr) 2009-08-28 2014-12-24 Regeneron Pharmaceuticals, Inc. Anticorps antikines se liant à plusieurs chimiokines cc
WO2011028811A2 (fr) * 2009-09-01 2011-03-10 Abbott Laboratories Immunoglobulines à double domaine variable et leurs utilisations
BR112012008833A2 (pt) * 2009-10-15 2015-09-08 Abbott Lab imunoglobulinas de dominio variavel duplo e usos das mesmas
UY32979A (es) * 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
WO2011101433A1 (fr) * 2010-02-18 2011-08-25 Probiodrug Ag Procédés de diagnostic de maladies inflammatoires par détermination de mcp-1 modifié par le pyroglutamate et procédés de criblage pour des inhibiteurs de glutaminyl-cyclase
US8524217B2 (en) 2010-05-11 2013-09-03 Merck Sharp & Dohme Corp. MCP1-Ig fusion variants
EP3252072A3 (fr) * 2010-08-03 2018-03-14 AbbVie Inc. Immunoglobuline à double domaine variable et ses utilisations
JP2013539364A (ja) 2010-08-26 2013-10-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
US8628773B2 (en) * 2011-04-07 2014-01-14 Amgen Inc. Antigen binding proteins
AR086823A1 (es) 2011-06-30 2014-01-22 Genentech Inc Formulaciones de anticuerpo anti-c-met, metodos
TW201333035A (zh) 2011-12-30 2013-08-16 Abbvie Inc 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白
AR091069A1 (es) * 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
RU2501017C1 (ru) * 2012-10-18 2013-12-10 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский институт акушерства и педиатрии" Министерства здравоохранения и социального развития Российской Федерации Способ прогнозирования невынашивания беременности в ранние сроки
TW202037609A (zh) 2012-11-01 2020-10-16 美商艾伯維有限公司 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US9708375B2 (en) 2013-03-15 2017-07-18 Amgen Inc. Inhibitory polypeptides specific to WNT inhibitors
WO2014144280A2 (fr) 2013-03-15 2014-09-18 Abbvie Inc. Protéines de liaison spécifiques à domaines variables doubles dirigées contre il -1β et/ou il -17
JPWO2015020040A1 (ja) * 2013-08-06 2017-03-02 国立大学法人九州大学 有機酸重合体を有効成分とする癌細胞の生着予防又は生着抑制のための医薬
EP3041863A4 (fr) 2013-09-05 2017-08-16 Amgen Inc. Molécules contenant des fc et présentant des profils de glycoforme prévisibles, uniformes et reproductibles
RU2016141385A (ru) 2014-03-24 2018-04-28 Дженентек, Инк. Лечение рака антагонистами с-мет и их корреляция с экспрессией hgf
US10156562B2 (en) 2014-05-16 2018-12-18 Amgen Inc. Assay for detecting Th1 and Th2 cell populations
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
WO2017100782A1 (fr) 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systèmes et procédés pour greffons vasculaires de génie tissulaire optimisés spécifiques à un patient
US20200306283A1 (en) 2016-06-22 2020-10-01 William Warren HARLESS Cancer treatment and metastasis inhibition using an anti-cancer stem cell agent in combination with a neu1 sialidase inhibitor or a cytokine inhibitor after primary cancer treatment
WO2018106945A1 (fr) 2016-12-07 2018-06-14 Progenity Inc. Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal
EP3554541B1 (fr) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Traitement d'une maladie du tractus gastro-intestinal avec une chimoikine/un inhibiteur du récepteur de chimiokine
AU2018219887B2 (en) 2017-02-08 2024-08-15 Dragonfly Therapeutics, LLC Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
WO2018148447A1 (fr) * 2017-02-08 2018-08-16 Adimab, Llc Domaines variables de chaînes lourdes d'anticorps ciblant le récepteur nkg2d
CN110944661A (zh) 2017-02-20 2020-03-31 蜻蜓疗法股份有限公司 结合her2、nkg2d和cd16的蛋白质
CA3056011A1 (fr) 2017-03-14 2018-09-20 Amgen Inc. Controle des glycoformes afucosylees totales d'anticorps produits en culture cellulaire
CN108048408B (zh) * 2018-01-26 2020-02-07 扬州大学 牛单核细胞趋化蛋白-1杂交瘤细胞株、其分泌的单克隆抗体及应用
CA3237846A1 (fr) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Domaines variables d'anticorps ciblant le recepteur nkg2d
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
WO2019164930A1 (fr) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Protéines de liaison multi-spécifiques qui se lient à cd33, nkg2d et cd16, et procédés d'utilisation
US12325737B2 (en) 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
EP3833392A4 (fr) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. Protéines de liaison multi-spécifiques se liant à bcma, nkg2d et cd16, et méthodes d'utilisation
EP3883635A1 (fr) 2018-11-19 2021-09-29 Progenity, Inc. Méthodes et dispositifs pour traiter une maladie au moyen d'une biothérapie
AU2020268684C1 (en) * 2019-05-09 2026-04-02 Merus B.V. Variant domains for multimerizing proteins and separation thereof
BR112022005583A2 (pt) 2019-09-26 2022-09-20 Amgen Inc Métodos para a produção de composições de anticorpos
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
JP7512394B2 (ja) 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
US20230273126A1 (en) 2020-06-04 2023-08-31 Amgen Inc. Assessment of cleaning procedures of a biotherapeutic manufacturing process
KR20230087539A (ko) 2020-10-15 2023-06-16 암젠 인크 항체 생산 방법에서의 상대적인 비결합 글리칸
EP4301774A4 (fr) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc Méthodes de traitement du cancer à l'aide de protéines de liaison multi-spécifiques qui se lient à nkg2d, à cd16 et à un antigène associé à une tumeur
EP4352094A1 (fr) 2021-06-07 2024-04-17 Amgen Inc. Utilisation de fucosidase pour contrôler le taux d'afucosylation de protéines glycosylées
AU2022295067A1 (en) * 2021-06-18 2023-12-21 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
US20250076309A1 (en) 2021-10-05 2025-03-06 Amgen Inc. Fc-gamma receptor ii binding and glycan content
WO2023122211A2 (fr) * 2021-12-21 2023-06-29 Duke University Anticorps du coronavirus et leurs utilisations
WO2023215725A1 (fr) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions et méthodes pour l'immunothérapie cellulaire
WO2023213400A1 (fr) * 2022-05-05 2023-11-09 Institute For Research In Biomedicine Anticorps dirigés contre des chimiokines, procédé d'identification desdits anticorps et leurs utilisations
AU2024256160A1 (en) 2023-04-20 2025-10-02 Amgen Inc. Methods of determining relative unpaired glycan content
WO2025038600A1 (fr) 2023-08-14 2025-02-20 Amgen Inc. Procédés de réduction de couleur jaune
WO2025101820A1 (fr) 2023-11-08 2025-05-15 Fred Hutchinson Cancer Center Compositions et méthodes pour l'immunothérapie cellulaire

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5703057A (en) 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO2001089565A1 (fr) 2000-05-19 2001-11-29 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methodes de reduction de la croissance tumorale et de la metastase tumorale par inhibition de l'activite de la proteine chimioattractive monocytaire-1 (mcp-1)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0967399A (ja) * 1995-08-30 1997-03-11 Mitsui Toatsu Chem Inc 抗ｍｃｐ−１ヒトモノクローナル抗体
ES2233978T3 (es) * 1995-09-27 2005-06-16 SHIONOGI & CO., LTD. Proteina analoga a la quimiocina de tipo cc.
JPH1160502A (ja) * 1997-08-12 1999-03-02 Teijin Ltd 脳梗塞症治療薬もしくは予防薬
GB0016138D0 (en) 2000-06-30 2000-08-23 Novartis Ag Organic compounds

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683202B1 (fr) 1985-03-28 1990-11-27 Cetus Corp
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683195B1 (fr) 1986-01-30 1990-11-27 Cetus Corp
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5703057A (en) 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
WO2001089565A1 (fr) 2000-05-19 2001-11-29 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methodes de reduction de la croissance tumorale et de la metastase tumorale par inhibition de l'activite de la proteine chimioattractive monocytaire-1 (mcp-1)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOEDE V. ET AL.: "Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1", INTERNATIONAL JOURNAL OF CANCER, 1999, pages 765 - 770, XP001016221, DOI: doi:10.1002/(SICI)1097-0215(19990827)82:5<765::AID-IJC23>3.0.CO;2-F
ONO M. ET AL.: "Biological implications of macrophage infiltration in human tumor angiogenesis", CANCER CHEMOTHER PHARMACOL., 1999, pages 69 - 71

Also Published As

Publication number Publication date
US20050058639A1 (en) 2005-03-17
AU2003265575B2 (en) 2009-12-10
CO6220978A2 (es) 2010-11-19
US20070116708A1 (en) 2007-05-24
ZA200508994B (en) 2006-09-27
HRP20050986A2 (en) 2006-11-30
NZ542784A (en) 2008-07-31
US7202343B2 (en) 2007-04-10
IL171674A0 (en) 2009-02-11
CA2496419A1 (fr) 2004-02-26
US7687606B2 (en) 2010-03-30
EP1542724A2 (fr) 2005-06-22
JP4468172B2 (ja) 2010-05-26
WO2004016769A2 (fr) 2004-02-26
LT2005099A (en) 2006-11-27
UA87979C2 (ru) 2009-09-10
RU2005134354A (ru) 2006-06-10
JP2005536534A (ja) 2005-12-02
RU2339647C2 (ru) 2008-11-27
WO2004016769A3 (fr) 2004-10-14
MEP18108A (en) 2010-06-10
IS8115A (is) 2005-11-01
US20070128112A1 (en) 2007-06-07
RS20050834A (sr) 2007-12-31
EP1542724A4 (fr) 2005-10-19
AU2003265575A1 (en) 2004-03-03
US7482434B2 (en) 2009-01-27

Similar Documents

Publication Publication Date Title
LT5416B (lt) Antikūnai, nukreipti prieš monocito chemotaksio baltymą -1, ir jų panaudojimas
ES2321088T3 (es) Anticuerpos dirigidos frente a la hormona paratiroidea (pth) y usos de los mismos.
US8101178B2 (en) Antibodies directed to tumor necrosis factor and uses thereof
AU2006236417B2 (en) High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies
JP2006517188A (ja) ホスホリパーゼａ２に対する抗体及びその使用
US7318925B2 (en) Methods of use for antibodies against parathyroid hormone
US12138295B2 (en) Methods of treating Crohn&#39;s disease with anti-IL23 specific antibody
WO2018064436A1 (fr) Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique contre l&#39;il-23
JP2006511471A (ja) 抗ｐｄｇｆ−ｄｄ抗体を用いた腎炎の処置方法
KR20060054435A (ko) 부갑상선 호르몬(ｐｔｈ)에 대한 항체 및 그의 용도

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20100819