LU86396A1 - Compositions pour le traitement de la calvitie et des alopecies - Google Patents

Compositions pour le traitement de la calvitie et des alopecies Download PDF

Info

Publication number: LU86396A1
Authority: LU; Luxembourg
Prior art keywords: diazoxide; phenytoin; derivatives; alopecia; baldness
Prior art date: 1986-04-18

Application number

LU86396A

Other languages

English (en)

French (fr)

Inventor

Pierre-Yves Venencie

Rene Levayer

Original Assignee

Pharma Roche Posay Lab

Venenice Pierre Yves

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-18

Filing date

1986-04-18

Publication date

1986-09-02

1986-04-18 Application filed by Pharma Roche Posay Lab, Venenice Pierre Yves filed Critical Pharma Roche Posay Lab

1986-04-18 Priority to LU86396A priority Critical patent/LU86396A1/fr

1986-09-02 Publication of LU86396A1 publication Critical patent/LU86396A1/fr

1987-04-15 Priority to EP87400868A priority patent/EP0243248A1/fr

1987-04-16 Priority to PT84697A priority patent/PT84697B/pt

1987-04-18 Priority to JP62094329A priority patent/JPH01230518A/ja

Links

239000000203 mixture Substances 0.000 title claims description 31
201000004384 Alopecia Diseases 0.000 title claims description 26
230000003676 hair loss Effects 0.000 title claims description 13
231100000360 alopecia Toxicity 0.000 title claims description 11
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims description 22
229960002036 phenytoin Drugs 0.000 claims description 22
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims description 21
229960004042 diazoxide Drugs 0.000 claims description 21
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
239000000047 product Substances 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 11
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239000013543 active substance Substances 0.000 claims description 8
239000000499 gel Substances 0.000 claims description 8
239000000839 emulsion Substances 0.000 claims description 7
239000006210 lotion Substances 0.000 claims description 7
239000002253 acid Substances 0.000 claims description 6
KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 claims description 6
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 6
230000000699 topical effect Effects 0.000 claims description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 4
239000002537 cosmetic Substances 0.000 claims description 4
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 4
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FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 4
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 3
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108010035532 Collagen Proteins 0.000 claims description 3
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 claims description 3
239000005844 Thymol Substances 0.000 claims description 3
229950004580 benzyl nicotinate Drugs 0.000 claims description 3
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229920001436 collagen Polymers 0.000 claims description 3
238000009109 curative therapy Methods 0.000 claims description 3
230000000694 effects Effects 0.000 claims description 3
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235000019161 pantothenic acid Nutrition 0.000 claims description 3
239000011713 pantothenic acid Substances 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 3
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PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
229930003427 Vitamin E Natural products 0.000 claims description 2
230000010933 acylation Effects 0.000 claims description 2
238000005917 acylation reaction Methods 0.000 claims description 2
239000002671 adjuvant Substances 0.000 claims description 2
150000001412 amines Chemical group 0.000 claims description 2
YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 claims description 2
239000007859 condensation product Substances 0.000 claims description 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
238000000034 method Methods 0.000 claims description 2
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239000011709 vitamin E Substances 0.000 claims description 2
239000002050 international nonproprietary name Substances 0.000 claims 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
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GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
229910018134 Al-Mg Inorganic materials 0.000 description 2
229910018467 Al—Mg Inorganic materials 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
239000004166 Lanolin Substances 0.000 description 2
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PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical class CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
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IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth

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LU86396A 1986-04-18 1986-04-18 Compositions pour le traitement de la calvitie et des alopecies LU86396A1 (fr)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
LU86396A LU86396A1 (fr)	1986-04-18	1986-04-18	Compositions pour le traitement de la calvitie et des alopecies
EP87400868A EP0243248A1 (fr)	1986-04-18	1987-04-15	Compositions pour le traitement de la calvitie et des alopécies
PT84697A PT84697B (pt)	1986-04-18	1987-04-16	Processo para a preparacao de composicoes para o tratamento da calvicie e das alopecias contendo fenitoina e dizaoxida
JP62094329A JPH01230518A (ja)	1986-04-18	1987-04-18	禿および脱毛症の予防または治療用調合剤

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU86396A LU86396A1 (fr)	1986-04-18	1986-04-18	Compositions pour le traitement de la calvitie et des alopecies
LU86396		1986-04-18

Publications (1)

Publication Number	Publication Date
LU86396A1 true LU86396A1 (fr)	1986-09-02

Family

ID=19730685

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86396A LU86396A1 (fr)	1986-04-18	1986-04-18	Compositions pour le traitement de la calvitie et des alopecies

Country Status (4)

Country	Link
EP (1)	EP0243248A1 (pt)
JP (1)	JPH01230518A (pt)
LU (1)	LU86396A1 (pt)
PT (1)	PT84697B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU8276987A (en) *	1986-12-12	1988-06-30	Upjohn Company, The	Use of nicorandil to treat alopecia
JP2566792B2 (ja) *	1987-09-30	1996-12-25	株式会社資生堂	発毛、養毛促進剤
WO1998032443A1 (de) *	1997-01-24	1998-07-30	Marigen S.A.	Ultramikroemulsionen aus spontan dispergierbaren konzentraten enthaltend antitumoral, antiviral und antiparasitär wirksame ester von pentacyclischen triterpenen
US6350848B1 (en)	1997-11-28	2002-02-26	Hitachi, Ltd.	Process and apparatus for producing polycarbonate
JPH11158262A (ja)	1997-11-28	1999-06-15	Hitachi Ltd	ポリカーボネートの製造方法
GB2341317A (en) *	1998-09-14	2000-03-15	Brian Terence Biddle	A topical preparation for the promotion of hair growth or regrowth containing an absorption promoting agent and/or a blood thining agent
WO2000048559A2 (en) *	1999-02-19	2000-08-24	Jones Marcus R	Composition for promoting hair growth comprising derivatives of vitamins and dmso
KR20020050135A (ko) *	2000-12-20	2002-06-26	조명재	피부 주름 예방 및 완화를 목적으로 하는 피부 외용 조성물
US6399739B1 (en)	2001-08-22	2002-06-04	General Electric Company	Preparation of polycarbonate having a predetermined molecular weight and level of endcapping
MX2019009482A (es) *	2019-08-08	2021-02-09	Proyectos Atso S A P I De C V	FORMAS FARMACEUTICAS DEL ACIDO 18ß-GLICIRRETINICO.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2942666A1 (de) *	1979-10-23	1981-05-07	Wella Ag, 6100 Darmstadt	Kosmetisches mittel zur behandlung der haare und der kopfhaut
LU84800A1 (fr) *	1983-05-11	1985-03-21	Oreal	Composition cosmetique pour le traitement des cheveux et de la peau,contenant des oxathiazinones
JPH0629165B2 (ja) *	1985-11-15	1994-04-20	株式会社資生堂	〔ベンゾ−１，２，４−チアジアジン〕−１−ジオキシド誘導体溶解組成物
JPS62135409A (ja) *	1985-12-10	1987-06-18	Lion Corp	養毛化粧料

1986
- 1986-04-18 LU LU86396A patent/LU86396A1/fr unknown
1987
- 1987-04-15 EP EP87400868A patent/EP0243248A1/fr not_active Withdrawn
- 1987-04-16 PT PT84697A patent/PT84697B/pt not_active IP Right Cessation
- 1987-04-18 JP JP62094329A patent/JPH01230518A/ja active Pending

Also Published As

Publication number	Publication date
PT84697B (pt)	1989-11-30
PT84697A (fr)	1987-05-01
EP0243248A1 (fr)	1987-10-28
JPH01230518A (ja)	1989-09-14

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