LU87312A1 - Pharmazeutische praeparate fuer die topische anwendung - Google Patents

Pharmazeutische praeparate fuer die topische anwendung Download PDF

Info

Publication number: LU87312A1
Authority: LU; Luxembourg
Prior art keywords: acid; formula; topical use; pharmaceutical preparations; miconazole
Prior art date: 1987-08-15

Application number

LU87312A

Other languages

German (de)

English (en)

Inventor

Alain Li Wan Po

Eileen Margaret Scott

Beat W Mueller

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-10

Publication date

1989-09-20

1988-08-10 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1989-09-20 Publication of LU87312A1 publication Critical patent/LU87312A1/de

Links

239000000825 pharmaceutical preparation Substances 0.000 title claims description 28
230000000699 topical effect Effects 0.000 title claims description 23
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 114
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 99
235000010233 benzoic acid Nutrition 0.000 claims description 61
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 59
229960004889 salicylic acid Drugs 0.000 claims description 56
239000005711 Benzoic acid Substances 0.000 claims description 49
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 49
229960002509 miconazole Drugs 0.000 claims description 43
239000006071 cream Substances 0.000 claims description 32
-1 tincture Substances 0.000 claims description 30
230000000845 anti-microbial effect Effects 0.000 claims description 29
MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims description 27
229960005040 miconazole nitrate Drugs 0.000 claims description 26
150000001875 compounds Chemical class 0.000 claims description 18
239000004480 active ingredient Substances 0.000 claims description 17
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 17
239000000243 solution Substances 0.000 claims description 15
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 14
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MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 claims description 3
LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims description 3
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239000012297 crystallization seed Substances 0.000 description 1
WPYMKLBDIGXBTP-DYCDLGHISA-N deuterio benzoate Chemical compound [2H]OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-DYCDLGHISA-N 0.000 description 1
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
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229920001249 ethyl cellulose Polymers 0.000 description 1
238000011049 filling Methods 0.000 description 1
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235000011852 gelatine desserts Nutrition 0.000 description 1
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150000002334 glycols Chemical class 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
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150000002367 halogens Chemical class 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000010512 hydrogenated peanut oil Substances 0.000 description 1
150000002440 hydroxy compounds Chemical class 0.000 description 1
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150000002460 imidazoles Chemical class 0.000 description 1
238000011534 incubation Methods 0.000 description 1
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VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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150000002823 nitrates Chemical class 0.000 description 1
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
230000004526 pharmaceutical effect Effects 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
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150000004760 silicates Chemical class 0.000 description 1
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206010040872 skin infection Diseases 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
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229940080236 sodium cetyl sulfate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940057429 sorbitan isostearate Drugs 0.000 description 1
229950004959 sorbitan oleate Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000010998 test method Methods 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
230000035899 viability Effects 0.000 description 1
NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)

LU87312A 1987-08-15 1988-08-10 Pharmazeutische praeparate fuer die topische anwendung LU87312A1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8719375A GB2208598A (en)	1987-08-15	1987-08-15	Antimicrobial preparations for external use
GB8719375		1987-08-15

Publications (1)

Publication Number	Publication Date
LU87312A1 true LU87312A1 (de)	1989-09-20

Family

ID=10622371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU87312A LU87312A1 (de)	1987-08-15	1988-08-10	Pharmazeutische praeparate fuer die topische anwendung

Country Status (17)

Country	Link
JP (1)	JPS6466121A (da)
AU (1)	AU2065588A (da)
BE (1)	BE1003229A3 (da)
DE (1)	DE3827515A1 (da)
DK (1)	DK453688A (da)
ES (1)	ES2020012A6 (da)
FI (1)	FI883747A7 (da)
FR (1)	FR2619311A1 (da)
GB (1)	GB2208598A (da)
GR (1)	GR880100526A (da)
IT (1)	IT1224701B (da)
LU (1)	LU87312A1 (da)
NL (1)	NL8802008A (da)
NO (1)	NO883609L (da)
PT (1)	PT88253B (da)
SE (1)	SE8802814L (da)
ZA (1)	ZA885969B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5100908A (en) *	1990-03-06	1992-03-31	Ss Pharmaceutical Co., Ltd.	Antimycotic external imidazole preparations
CA2121123C (en) *	1991-10-15	2002-02-05	Kenneth Vincent Mason	Anti-seborrhoeic formulation
ATE205393T1 (de) *	1995-06-07	2001-09-15	Taisho Pharmaceutical Co Ltd	Fungizid
TW200501959A (en) *	2003-02-20	2005-01-16	Taisho Pharmaceutical Co Ltd	Antifungal agents
EP2679225A1 (de) *	2012-06-26	2014-01-01	Universitätsklinikum Freiburg	Pharmazeutische Zusammensetzung mit synergistischer Wirkung von direkten Katalaseinhibitoren und zur Katalasezerstörung führenden Modulatoren des NO-Stoffwechsels oder der extrazellulären Superoxidanionenproduktion
EP3581566A3 (en) *	2016-11-28	2020-01-22	Cellix Bio Private Limited	Compositions and methods for the treatment of fungal infections
US11981953B2 (en) *	2018-03-29	2024-05-14	Wisconsin Alumni Research Foundation	Method to screen compounds for antifungal activity and pharmaceutical compositions and methods to treat fungal diseases by inhibiting spore germination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56115817A (en) *	1980-02-14	1981-09-11	Nissan Motor Co Ltd	Combustion chamber for spark igniting engine
JPS5815909A (ja) *	1981-07-22	1983-01-29	Toko Yakuhin Kogyo Kk	抗真菌外用剤

1987
- 1987-08-15 GB GB8719375A patent/GB2208598A/en not_active Withdrawn
1988
- 1988-08-03 SE SE8802814A patent/SE8802814L/xx not_active Application Discontinuation
- 1988-08-08 IT IT8848276A patent/IT1224701B/it active
- 1988-08-10 LU LU87312A patent/LU87312A1/de unknown
- 1988-08-12 JP JP63200243A patent/JPS6466121A/ja active Pending
- 1988-08-12 DE DE3827515A patent/DE3827515A1/de not_active Withdrawn
- 1988-08-12 AU AU20655/88A patent/AU2065588A/en not_active Abandoned
- 1988-08-12 ES ES8802542A patent/ES2020012A6/es not_active Expired - Lifetime
- 1988-08-12 NO NO88883609A patent/NO883609L/no unknown
- 1988-08-12 NL NL8802008A patent/NL8802008A/nl not_active Application Discontinuation
- 1988-08-12 DK DK453688A patent/DK453688A/da not_active Application Discontinuation
- 1988-08-12 FR FR8810868A patent/FR2619311A1/fr active Pending
- 1988-08-12 GR GR880100526A patent/GR880100526A/el unknown
- 1988-08-12 FI FI883747A patent/FI883747A7/fi not_active IP Right Cessation
- 1988-08-12 ZA ZA885969A patent/ZA885969B/xx unknown
- 1988-08-12 PT PT88253A patent/PT88253B/pt not_active IP Right Cessation
- 1988-08-12 BE BE8800923A patent/BE1003229A3/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8719375D0 (en)	1987-09-23
FI883747A0 (fi)	1988-08-12
BE1003229A3 (fr)	1992-02-04
NO883609D0 (no)	1988-08-12
SE8802814L (sv)	1989-02-16
GR880100526A (el)	1989-05-25
NO883609L (no)	1989-02-16
GB2208598A (en)	1989-04-12
IT8848276A0 (it)	1988-08-08
PT88253A (pt)	1989-06-30
PT88253B (pt)	1995-03-31
DK453688D0 (da)	1988-08-12
DK453688A (da)	1989-02-16
FR2619311A1 (fr)	1989-02-17
SE8802814D0 (sv)	1988-08-03
JPS6466121A (en)	1989-03-13
ZA885969B (en)	1989-03-29
FI883747A7 (fi)	1989-02-16
NL8802008A (nl)	1989-03-01
DE3827515A1 (de)	1989-03-02
IT1224701B (it)	1990-10-18
AU2065588A (en)	1989-02-16
ES2020012A6 (es)	1991-07-16

Publication	Publication Date	Title
DE69615184T2 (de)	2002-06-13	Fungizid
DE69432190T2 (de)	2003-11-27	Papamycinderivate
EP0242328B1 (de)	1991-07-24	Arzneimittel zur Behandlung von Entzündungen im Auge
DE3120460C2 (da)	1990-12-13
DE19681478B4 (de)	2006-09-21	R-(-)-(E)-[4-(2,4-Dichlorphenyl)-1,3-dithiolan-2-yliden]-1-imidazolylacetonitril,Verfahren zu seiner Herstellung und seine Verwendung
DE69534120T2 (de)	2006-01-26	Topisch anzuwendende ketoconazol enthaltende emulsionen
DE3780091T2 (de)	1993-02-11	Behandlung von pilzinfektionen.
DE69933890T2 (de)	2007-03-15	Antimykotische wirkung von dikationischen molekülen
EP0060553A1 (de)	1982-09-22	Präparat zur Behandlung von Wunden der Hautoberfläche und Verfahren zur Herstellung des Präparats
DE102005045145A1 (de)	2007-03-29	Verwendung von Octenidindihydrochlorid in halbfesten Zubereitungen
EP0055396B1 (de)	1985-01-23	Antimykotische Mittel mit hoher Wirkstoff-Freisetzung in Form von elastischen Flüssig-Pflastern
DE69500511T2 (de)	1998-01-02	Phosphatdiester zur Behandlung von proliferativen Erkrankungen der Epidermis
DE2739661C3 (de)	1982-02-04	Jodderivat von Benzalkoniumchlorid und dieses enthaltendes Arzneimittel
DE69612540T2 (de)	2001-08-30	Verwendung von Hydantoin-Derivaten zur Herstellung eines Medikaments zur Behandlung von Krankheiten in Zusammenhang mit aktivem Sauestoff und freien Radikalen
DE3827515A1 (de)	1989-03-02	Pharmazeutische praeparate fuer die topische anwendung
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CH646057A5 (de)	1984-11-15	Mittel zur behandlung von glaucoma.
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