PT88253B - Processo para a preparacao de composicoes farmaceuticas contendo um composto com um anel imidazole substituido com alquilo inferior - Google Patents

Processo para a preparacao de composicoes farmaceuticas contendo um composto com um anel imidazole substituido com alquilo inferior Download PDF

Info

Publication number: PT88253B
Authority: PT; Portugal
Prior art keywords: acid; compound; formula; miconazole; combination
Prior art date: 1987-08-15

Application number

PT88253A

Other languages

English (en)

Portuguese (pt)

Other versions

PT88253A (pt

Inventor

Alain Li Wan Po

Eileen Margaret Scott

Beat W Muller

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-12

Publication date

1995-03-31

1988-08-12 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1989-06-30 Publication of PT88253A publication Critical patent/PT88253A/pt

1995-03-31 Publication of PT88253B publication Critical patent/PT88253B/pt

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 32
238000000034 method Methods 0.000 title claims description 24
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title claims description 18
239000008194 pharmaceutical composition Substances 0.000 title claims description 12
235000010233 benzoic acid Nutrition 0.000 claims abstract description 64
230000000845 anti-microbial effect Effects 0.000 claims abstract description 25
239000002253 acid Substances 0.000 claims abstract description 22
150000001559 benzoic acids Chemical class 0.000 claims abstract description 20
238000002360 preparation method Methods 0.000 claims abstract description 16
150000003839 salts Chemical class 0.000 claims abstract description 14
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 7
125000005843 halogen group Chemical group 0.000 claims abstract description 5
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 97
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 92
239000000203 mixture Substances 0.000 claims description 56
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 52
229960004889 salicylic acid Drugs 0.000 claims description 49
239000005711 Benzoic acid Substances 0.000 claims description 46
BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical class ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 45
229960002509 miconazole Drugs 0.000 claims description 38
MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims description 30
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-1 for example Chemical class 0.000 claims description 27
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125000000217 alkyl group Chemical group 0.000 claims description 9
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VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 9
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CUBCNYWQJHBXIY-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O CUBCNYWQJHBXIY-UHFFFAOYSA-N 0.000 description 4
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LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 2
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125000000623 heterocyclic group Chemical group 0.000 description 1
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VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
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239000001525 mentha piperita l. herb oil Substances 0.000 description 1
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PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
238000000424 optical density measurement Methods 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
239000006072 paste Substances 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
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229940066842 petrolatum Drugs 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
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229920002451 polyvinyl alcohol Polymers 0.000 description 1
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239000003380 propellant Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
206010040882 skin lesion Diseases 0.000 description 1
231100000444 skin lesion Toxicity 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940057429 sorbitan isostearate Drugs 0.000 description 1
229950004959 sorbitan oleate Drugs 0.000 description 1
230000003330 sporicidal effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000007480 spreading Effects 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000010998 test method Methods 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
210000002268 wool Anatomy 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)

PT88253A 1987-08-15 1988-08-12 Processo para a preparacao de composicoes farmaceuticas contendo um composto com um anel imidazole substituido com alquilo inferior PT88253B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8719375A GB2208598A (en)	1987-08-15	1987-08-15	Antimicrobial preparations for external use

Publications (2)

Publication Number	Publication Date
PT88253A PT88253A (pt)	1989-06-30
PT88253B true PT88253B (pt)	1995-03-31

Family

ID=10622371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88253A PT88253B (pt)	1987-08-15	1988-08-12	Processo para a preparacao de composicoes farmaceuticas contendo um composto com um anel imidazole substituido com alquilo inferior

Country Status (17)

Country	Link
JP (1)	JPS6466121A (da)
AU (1)	AU2065588A (da)
BE (1)	BE1003229A3 (da)
DE (1)	DE3827515A1 (da)
DK (1)	DK453688A (da)
ES (1)	ES2020012A6 (da)
FI (1)	FI883747A7 (da)
FR (1)	FR2619311A1 (da)
GB (1)	GB2208598A (da)
GR (1)	GR880100526A (da)
IT (1)	IT1224701B (da)
LU (1)	LU87312A1 (da)
NL (1)	NL8802008A (da)
NO (1)	NO883609L (da)
PT (1)	PT88253B (da)
SE (1)	SE8802814L (da)
ZA (1)	ZA885969B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5100908A (en) *	1990-03-06	1992-03-31	Ss Pharmaceutical Co., Ltd.	Antimycotic external imidazole preparations
CA2121123C (en) *	1991-10-15	2002-02-05	Kenneth Vincent Mason	Anti-seborrhoeic formulation
ATE205393T1 (de) *	1995-06-07	2001-09-15	Taisho Pharmaceutical Co Ltd	Fungizid
TW200501959A (en) *	2003-02-20	2005-01-16	Taisho Pharmaceutical Co Ltd	Antifungal agents
EP2679225A1 (de) *	2012-06-26	2014-01-01	Universitätsklinikum Freiburg	Pharmazeutische Zusammensetzung mit synergistischer Wirkung von direkten Katalaseinhibitoren und zur Katalasezerstörung führenden Modulatoren des NO-Stoffwechsels oder der extrazellulären Superoxidanionenproduktion
EP3581566A3 (en) *	2016-11-28	2020-01-22	Cellix Bio Private Limited	Compositions and methods for the treatment of fungal infections
US11981953B2 (en) *	2018-03-29	2024-05-14	Wisconsin Alumni Research Foundation	Method to screen compounds for antifungal activity and pharmaceutical compositions and methods to treat fungal diseases by inhibiting spore germination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56115817A (en) *	1980-02-14	1981-09-11	Nissan Motor Co Ltd	Combustion chamber for spark igniting engine
JPS5815909A (ja) *	1981-07-22	1983-01-29	Toko Yakuhin Kogyo Kk	抗真菌外用剤

1987
- 1987-08-15 GB GB8719375A patent/GB2208598A/en not_active Withdrawn
1988
- 1988-08-03 SE SE8802814A patent/SE8802814L/xx not_active Application Discontinuation
- 1988-08-08 IT IT8848276A patent/IT1224701B/it active
- 1988-08-10 LU LU87312A patent/LU87312A1/de unknown
- 1988-08-12 JP JP63200243A patent/JPS6466121A/ja active Pending
- 1988-08-12 DE DE3827515A patent/DE3827515A1/de not_active Withdrawn
- 1988-08-12 AU AU20655/88A patent/AU2065588A/en not_active Abandoned
- 1988-08-12 ES ES8802542A patent/ES2020012A6/es not_active Expired - Lifetime
- 1988-08-12 NO NO88883609A patent/NO883609L/no unknown
- 1988-08-12 NL NL8802008A patent/NL8802008A/nl not_active Application Discontinuation
- 1988-08-12 DK DK453688A patent/DK453688A/da not_active Application Discontinuation
- 1988-08-12 FR FR8810868A patent/FR2619311A1/fr active Pending
- 1988-08-12 GR GR880100526A patent/GR880100526A/el unknown
- 1988-08-12 FI FI883747A patent/FI883747A7/fi not_active IP Right Cessation
- 1988-08-12 ZA ZA885969A patent/ZA885969B/xx unknown
- 1988-08-12 PT PT88253A patent/PT88253B/pt not_active IP Right Cessation
- 1988-08-12 BE BE8800923A patent/BE1003229A3/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8719375D0 (en)	1987-09-23
FI883747A0 (fi)	1988-08-12
BE1003229A3 (fr)	1992-02-04
NO883609D0 (no)	1988-08-12
SE8802814L (sv)	1989-02-16
GR880100526A (el)	1989-05-25
NO883609L (no)	1989-02-16
GB2208598A (en)	1989-04-12
IT8848276A0 (it)	1988-08-08
PT88253A (pt)	1989-06-30
DK453688D0 (da)	1988-08-12
DK453688A (da)	1989-02-16
FR2619311A1 (fr)	1989-02-17
SE8802814D0 (sv)	1988-08-03
JPS6466121A (en)	1989-03-13
ZA885969B (en)	1989-03-29
FI883747A7 (fi)	1989-02-16
LU87312A1 (de)	1989-09-20
NL8802008A (nl)	1989-03-01
DE3827515A1 (de)	1989-03-02
IT1224701B (it)	1990-10-18
AU2065588A (en)	1989-02-16
ES2020012A6 (es)	1991-07-16

Legal Events

Date

Code

Title

Description

1995-03-31

FG3A

Patent granted, date of granting

Effective date: 19940908

1996-07-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960331

Publication	Publication Date	Title
DE69615184T2 (de)	2002-06-13	Fungizid
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