LU88722I2 - Sels de ranitidine et d'un complexe bismuth/acide carboxylique et solvates y compris le citrate de ranitidine-bismuth - Google Patents

Sels de ranitidine et d'un complexe bismuth/acide carboxylique et solvates y compris le citrate de ranitidine-bismuth

Info

Publication number: LU88722I2
Authority: LU; Luxembourg
Prior art keywords: ranitidine; bismuth; carboxylic acid; acid salts; solvates including
Prior art date: 1988-07-18

Application number

LU88722C

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-18

Filing date

1989-07-17

Publication date

1996-08-23

1988-07-18 Priority claimed from GB888817098A external-priority patent/GB8817098D0/en

1989-03-01 Priority claimed from GB898904686A external-priority patent/GB8904686D0/en

1989-07-17 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1996-08-23 Publication of LU88722I2 publication Critical patent/LU88722I2/fr

Links

229910052797 bismuth Inorganic materials 0.000 title 1
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title 1
XAUTYMZTJWXZHZ-IGUOPLJTSA-K bismuth;(e)-1-n'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-n-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 XAUTYMZTJWXZHZ-IGUOPLJTSA-K 0.000 title 1
150000001734 carboxylic acid salts Chemical class 0.000 title 1
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 title 1
229960000620 ranitidine Drugs 0.000 title 1
229960004696 ranitidine bismuth citrate Drugs 0.000 title 1
239000012453 solvate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

LU88722C 1988-07-18 1989-07-17 Sels de ranitidine et d'un complexe bismuth/acide carboxylique et solvates y compris le citrate de ranitidine-bismuth LU88722I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB888817098A GB8817098D0 (en)	1988-07-18	1988-07-18	Chemical compounds
GB898904686A GB8904686D0 (en)	1989-03-01	1989-03-01	Chemical compounds

Publications (1)

Publication Number	Publication Date
LU88722I2 true LU88722I2 (fr)	1996-08-23

Family

ID=26294175

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU87557A LU87557A1 (fr)	1988-07-18	1989-07-17	Derives de furanne
LU88722C LU88722I2 (fr)	1988-07-18	1989-07-17	Sels de ranitidine et d'un complexe bismuth/acide carboxylique et solvates y compris le citrate de ranitidine-bismuth

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LU87557A LU87557A1 (fr)	1988-07-18	1989-07-17	Derives de furanne

Country Status (35)

Country	Link
US (1)	US5008256A (fr)
JP (1)	JP2523185B2 (fr)
KR (1)	KR0122598B1 (fr)
CN (1)	CN1022626C (fr)
AT (1)	AT398200B (fr)
AU (1)	AU632052B2 (fr)
BE (1)	BE1003254A5 (fr)
CA (1)	CA1332610C (fr)
CH (1)	CH679582A5 (fr)
CY (1)	CY1650A (fr)
DE (1)	DE3923638C2 (fr)
DK (1)	DK168381B1 (fr)
EG (1)	EG19368A (fr)
ES (1)	ES2014175A6 (fr)
FI (1)	FI90538C (fr)
FR (1)	FR2634122B1 (fr)
GB (1)	GB2220937B (fr)
GR (1)	GR1000431B (fr)
HK (1)	HK61392A (fr)
HU (2)	HU206104B (fr)
IE (1)	IE61076B1 (fr)
IL (1)	IL91005A (fr)
IT (1)	IT1231481B (fr)
LU (2)	LU87557A1 (fr)
MX (1)	MX174145B (fr)
MY (1)	MY104055A (fr)
NL (2)	NL192604C (fr)
NO (2)	NO176319C (fr)
NZ (1)	NZ229958A (fr)
PL (1)	PL162391B1 (fr)
PT (1)	PT91188B (fr)
SE (1)	SE468715B (fr)
SG (1)	SG51992G (fr)
YU (1)	YU47021B (fr)
ZW (1)	ZW8689A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE81011T1 (de) *	1987-03-09	1992-10-15	Procter & Gamble	Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen.
IL85472A (en) *	1987-03-09	1991-06-30	Procter & Gamble	Pharmaceutical compositions for treating gastrointestinal disorders
AU641903B2 (en) *	1988-10-26	1993-10-07	Glaxo Group Limited	Carboxylic acid derivatives
GB9004328D0 (en) *	1990-02-27	1990-04-25	Glaxo Group Ltd	Chemical compounds
GB9009240D0 (en) *	1990-04-25	1990-06-20	Glaxo Group Ltd	Chemical compounds
GB9009437D0 (en) *	1990-04-26	1990-06-20	Glaxo Group Ltd	Chemical compounds
DE69117955T2 (de) *	1990-07-20	1996-09-19	Tillotts Pharma Ag, Ziefen	Produkte und verfahren zur behandlung des verdauungskanals
GB9019875D0 (en) *	1990-09-11	1990-10-24	Glaxo Group Ltd	Pharmaceutical compositions
US5128140A (en) *	1991-01-14	1992-07-07	The Procter & Gamble Company	Swallowable pharmaceutical compositions
US5192752A (en) *	1991-01-14	1993-03-09	The Procter & Gamble Company	Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate
GB9120131D0 (en) *	1991-09-20	1991-11-06	Glaxo Group Ltd	Medicaments
DK0550083T3 (da) *	1991-12-06	1999-10-11	Glaxo Group Ltd	Lægemidler til behandling af inflammatoriske tilstande eller til analgesi og indeholdende et NSAID og ranitidinbismuthcitra
WO1994010164A1 (fr) *	1992-10-27	1994-05-11	Janssen Pharmaceutica N.V.	Derives de la 4-quinoleinyle a activite anti-helicobacter
WO1996019232A1 (fr) *	1994-12-19	1996-06-27	Lauteral Limited	Combinaisons d'hydrochlorure de ranitidine de forme 1 et de composes du bismuth
JPH10512877A (ja) *	1995-01-26	1998-12-08	ニコムドイメージングエイ／エス	ビスマス化合物
GB9501560D0 (en) *	1995-01-26	1995-03-15	Nycomed Imaging As	Contrast agents
RU2131264C1 (ru) *	1996-06-04	1999-06-10	Московское производственное химико-фармацевтическое объединение им.Н.А.Семашко	Противоязвенное средство в виде таблеток и способ его получения
EP1035192A1 (fr) *	1999-01-26	2000-09-13	Stefan Graichen	Additif pur un réfrigérant lubrifiant
CN1102585C (zh) *	1999-04-28	2003-03-05	常州兰陵制药有限公司	雷尼替丁枸橼酸铋盐的制备方法
US20060100271A1 (en) *	2004-11-08	2006-05-11	Keith Whitehead	Stabilized aqueous ranitidine compositions
CN100402514C (zh) *	2006-08-01	2008-07-16	丽珠医药集团股份有限公司	一种制备枸橼酸铋雷尼替丁的方法
CN101484132A (zh) *	2007-07-09	2009-07-15	柏树制药公司	具有合意口味的雷尼替丁制剂
CN102408398B (zh) *	2011-09-20	2012-12-05	江苏汉斯通药业有限公司	枸橼酸铋雷尼替丁的制备方法
US9731999B2 (en)	2011-09-23	2017-08-15	Iqbal Gill	Chemical admixtures for hydraulic cements
ES2426539B1 (es) *	2012-04-18	2014-09-09	Dr Healthcare España, S. L.	Uso de la diaminooxidasa para el tratamiento o la prevención del trastorno por deficit de atencion con hiperactividad (adhd)
CN103896888B (zh) *	2014-03-28	2015-11-18	常州兰陵制药有限公司	枸橼酸铋雷尼替丁的制备方法
EP2929884A1 (fr)	2014-04-11	2015-10-14	Sanovel Ilac Sanayi ve Ticaret A.S.	Combinaisons pharmaceutiques de dabigatran et antagonistes du récepteur de h2
EP2942058A1 (fr)	2014-05-09	2015-11-11	Sanovel Ilac Sanayi ve Ticaret A.S.	Combinaisons pharmaceutiques de rivaroxaban et des antagonistes du récepteur d'histamine H2
CN107382921B (zh) *	2017-07-28	2025-04-18	常州兰陵制药有限公司	制备枸橼酸铋雷尼替丁的方法
US20230349922A1 (en)	2020-08-11	2023-11-02	Université De Strasbourg	H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1565966A (en) *	1976-08-04	1980-04-23	Allen & Hanburys Ltd	Aminoalkyl furan derivatives
FR2531706A1 (fr) *	1982-08-13	1984-02-17	Sanofi Sa	Benzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
BE905235A (fr) *	1986-08-05	1986-12-01	Hasunor Ag	Ascorbates antagonistes des recepteurs h2 et leur procede de preparation.
IT1215325B (it) *	1987-01-07	1990-02-08	Barisintex Sa	Composti antagonisti di recettori -h2 e procedimento per la loro preparazione.
IL85472A (en) *	1987-03-09	1991-06-30	Procter & Gamble	Pharmaceutical compositions for treating gastrointestinal disorders
ATE81011T1 (de) *	1987-03-09	1992-10-15	Procter & Gamble	Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen.
DE3710462A1 (de) *	1987-03-30	1988-10-13	Heumann Pharma Gmbh & Co	Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes
GB9004328D0 (en) *	1990-02-27	1990-04-25	Glaxo Group Ltd	Chemical compounds
GB9009437D0 (en) *	1990-04-26	1990-06-20	Glaxo Group Ltd	Chemical compounds

1989
- 1989-07-14 CH CH2647/89A patent/CH679582A5/fr not_active IP Right Cessation
- 1989-07-17 US US07/380,378 patent/US5008256A/en not_active Expired - Lifetime
- 1989-07-17 NL NL8901840A patent/NL192604C/nl not_active IP Right Cessation
- 1989-07-17 NO NO892936A patent/NO176319C/no not_active IP Right Cessation
- 1989-07-17 ZW ZW86/89A patent/ZW8689A1/xx unknown
- 1989-07-17 YU YU142789A patent/YU47021B/sh unknown
- 1989-07-17 MY MYPI89000969A patent/MY104055A/en unknown
- 1989-07-17 HU HU893595A patent/HU206104B/hu unknown
- 1989-07-17 AT AT0172889A patent/AT398200B/de not_active IP Right Cessation
- 1989-07-17 EG EG34289A patent/EG19368A/xx active
- 1989-07-17 AU AU38178/89A patent/AU632052B2/en not_active Ceased
- 1989-07-17 SE SE8902550A patent/SE468715B/sv not_active IP Right Cessation
- 1989-07-17 DK DK351789A patent/DK168381B1/da not_active IP Right Cessation
- 1989-07-17 FI FI893448A patent/FI90538C/fi not_active IP Right Cessation
- 1989-07-17 LU LU87557A patent/LU87557A1/fr active Protection Beyond IP Right Term
- 1989-07-17 LU LU88722C patent/LU88722I2/fr unknown
- 1989-07-17 NZ NZ229958A patent/NZ229958A/xx unknown
- 1989-07-17 GR GR890100454A patent/GR1000431B/el not_active IP Right Cessation
- 1989-07-17 PL PL28062889A patent/PL162391B1/pl unknown
- 1989-07-17 IE IE230989A patent/IE61076B1/en not_active IP Right Cessation
- 1989-07-17 CA CA000605843A patent/CA1332610C/fr not_active Expired - Fee Related
- 1989-07-17 FR FR8909575A patent/FR2634122B1/fr not_active Expired - Fee Related
- 1989-07-17 PT PT91188A patent/PT91188B/pt not_active IP Right Cessation
- 1989-07-17 ES ES8902517A patent/ES2014175A6/es not_active Expired - Fee Related
- 1989-07-17 IT IT8948196A patent/IT1231481B/it active Protection Beyond IP Right Term
- 1989-07-17 MX MX1682989A patent/MX174145B/es unknown
- 1989-07-17 CN CN89104959A patent/CN1022626C/zh not_active Expired - Fee Related
- 1989-07-17 BE BE8900773A patent/BE1003254A5/fr not_active IP Right Cessation
- 1989-07-17 GB GB8916288A patent/GB2220937B/en not_active Expired - Lifetime
- 1989-07-17 JP JP1184402A patent/JP2523185B2/ja not_active Expired - Lifetime
- 1989-07-17 DE DE3923638A patent/DE3923638C2/de not_active Expired - Fee Related
- 1989-07-17 IL IL9100589A patent/IL91005A/en not_active IP Right Cessation
- 1989-07-18 KR KR1019890010213A patent/KR0122598B1/ko not_active Expired - Fee Related
1992
- 1992-05-09 SG SG519/92A patent/SG51992G/en unknown
- 1992-08-13 HK HK613/92A patent/HK61392A/xx not_active IP Right Cessation
- 1992-12-11 CY CY1650A patent/CY1650A/en unknown
1995
- 1995-06-12 HU HU95P/P00186P patent/HU211173A9/hu unknown
1997
- 1997-12-18 NL NL970046C patent/NL970046I2/nl unknown
1998
- 1998-02-05 NO NO1998007C patent/NO1998007I1/no unknown

Also Published As

Publication number	Publication date
GB2220937A (en)	1990-01-24
NL970046I1 (nl)	1998-03-02
BE1003254A5 (fr)	1992-02-11
HUT52082A (en)	1990-06-28
NL970046I2 (nl)	1998-04-01
CA1332610C (fr)	1994-10-18
GR1000431B (el)	1992-07-30
IT8948196A0 (it)	1989-07-17
YU47021B (sh)	1994-11-15
AT398200B (de)	1994-10-25
JPH02117684A (ja)	1990-05-02
FI893448A0 (fi)	1989-07-17
IL91005A (en)	1994-10-07
GR890100454A (en)	1990-06-27
DK351789D0 (da)	1989-07-17
SG51992G (en)	1992-07-24
NO1998007I1 (no)	1998-02-05
PT91188A (pt)	1990-02-08
PT91188B (pt)	1995-03-01
CN1022626C (zh)	1993-11-03
DK351789A (da)	1990-01-19
ZW8689A1 (en)	1990-02-21
FI90538C (fi)	1994-02-25
DE3923638A1 (de)	1990-03-01
CN1039419A (zh)	1990-02-07
NO892936D0 (no)	1989-07-17
AU3817889A (en)	1990-01-18
KR910002826A (ko)	1991-02-26
IE61076B1 (en)	1994-09-21
NO892936L (no)	1990-01-19
LU87557A1 (fr)	1990-07-24
CH679582A5 (fr)	1992-03-13
AU632052B2 (en)	1992-12-17
NL192604B (nl)	1997-07-01
PL162391B1 (pl)	1993-10-30
KR0122598B1 (ko)	1997-11-13
HU211173A9 (en)	1995-11-28
ES2014175A6 (es)	1990-06-16
FI893448L (fi)	1990-01-19
FI90538B (fi)	1993-11-15
GB2220937B (en)	1991-11-27
HK61392A (en)	1992-08-21
US5008256A (en)	1991-04-16
SE8902550L (sv)	1990-01-19
IT1231481B (it)	1991-12-07
HU206104B (en)	1992-08-28
ATA172889A (de)	1994-02-15
GB8916288D0 (en)	1989-08-31
NO176319B (no)	1994-12-05
DK168381B1 (da)	1994-03-21
DE3923638C2 (de)	1995-11-23
NL8901840A (nl)	1990-02-16
MX16829A (es)	1993-10-01
FR2634122B1 (fr)	1993-11-19
MX174145B (es)	1994-04-25
NO176319C (no)	1995-03-15
YU142789A (en)	1991-04-30
IE892309L (en)	1990-01-18
SE8902550D0 (sv)	1989-07-17
EG19368A (en)	1995-02-28
FR2634122A1 (fr)	1990-01-19
SE468715B (sv)	1993-03-08
NZ229958A (en)	1991-09-25
IL91005A0 (en)	1990-02-09
MY104055A (en)	1993-10-30
NL192604C (nl)	1997-11-04
CY1650A (en)	1992-12-11
JP2523185B2 (ja)	1996-08-07

Publication	Publication Date	Title
LU88722I2 (fr)	1996-08-23	Sels de ranitidine et d'un complexe bismuth/acide carboxylique et solvates y compris le citrate de ranitidine-bismuth
LU90218I2 (fr)	1998-04-27	Sertindole ainsi que ses sels d'addition d'acide (serdolect)
FI900463A7 (fi)	1990-08-01	Karboksyylihappo- ja sulfonihappoamideja
FR2609638B1 (fr)	1989-08-25	Plancher d'entrainement
KR890009418A (ko)	1989-08-01	농축안정화된 미세기포형 초음파촬영제
KR900016727U (ko)	1990-10-05	멀티 플레이어식 비디오 게임장치
IT1245849B (it)	1994-10-25	Procedimento per rivelare la concentrazione di un ingrediente attivo in un sistema acquoso
LU90240I2 (fr)	1998-07-06	Tilmicosine et les sels d'addition d'acide de celle-ci (micotil r)
DK131087D0 (da)	1987-03-13	1,2,3,4-tetrahydro-6-substitueret-4-aryl-(eller -heterocyclo-)-3-substitueret-2-thioxo-/eller -oxo)-5-pyrimidincarboxylsyrer og estere
FI904403A7 (fi)	1991-03-08	Rasvahappohoito
FR2640263B1 (fr)	1991-06-14	Preparation d'acide levulinique
FR2632428B1 (fr)	1995-08-11	Processeur d'image
BE891914A (fr)	1982-05-17	Sels d'acide (1-benzyl-1h-indazol-3-yl)oxy acetique avec la lysine, leur preparation et leur utilisation
IT214905Z2 (it)	1990-07-04	Accoppiamento sferico smontabile
FI904335A7 (fi)	1991-03-14	Laivan käyttölaite
IT8805209A0 (it)	1988-09-09	Dispositivo per l'accoppiamento rapido di due elementi d'albero
FR2603284B1 (fr)	1990-11-16	Derives d'acide 7-oxabicyclo(2.2.1.)heptane hydroxamique a action therapeutique
DE59010296D1 (de)	1996-05-30	Polyethercarbonsäureester und ihre Herstellung
KR900017945U (ko)	1990-10-05	모니터의 주사선수 변환장치
DK349687A (da)	1988-01-09	7beta-(substituerede)-amino-3-substituerede cephalosporansyrer og estere deraf
FI905550A7 (fi)	1990-11-09	G-amino-B-fenyylivoihappo-orotaatti
IT1223180B (it)	1990-09-19	Procedimento per ottenere calcestruzzi leggeri e calcestruzzi cosi' ottenuto
IT1220217B (it)	1990-06-06	Gioco di abilita'
FR2622597B1 (fr)	1990-02-16	Dispositif de mesure de l'activite cellulaire
KR840006498U (ko)	1984-12-12	경운기 츄레라의 승강장치