LU91140I2 - Duloxètine et ses sels d'addition acides pharmaceutiquement acceptables et particulièrement chlorhydrate de duloxétine (ARICLAIM). - Google Patents

Duloxètine et ses sels d'addition acides pharmaceutiquement acceptables et particulièrement chlorhydrate de duloxétine (ARICLAIM).

Info

Publication number: LU91140I2
Authority: LU; Luxembourg
Prior art keywords: duloxetine; ariclaim; pharmaceutically acceptable; acid addition; addition salts
Prior art date: 1993-11-24

Application number

LU91140C

Other languages

English (en)

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-24

Filing date

2005-02-04

Publication date

2005-04-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22566762&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91140(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-02-04 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2005-04-04 Publication of LU91140I2 publication Critical patent/LU91140I2/fr

Links

ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title 1
BFFSMCNJSOPUAY-LMOVPXPDSA-N (S)-duloxetine hydrochloride Chemical compound Cl.C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 BFFSMCNJSOPUAY-LMOVPXPDSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
229960002866 duloxetine Drugs 0.000 title 1
229960002496 duloxetine hydrochloride Drugs 0.000 title 1
JFTURWWGPMTABQ-UHFFFAOYSA-N n,n-dimethyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCN(C)C)C1=CC=CS1 JFTURWWGPMTABQ-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
-1 aryloxy propanamines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 abstract 1
229960004688 venlafaxine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
External Artificial Organs (AREA)

LU91140C 1993-11-24 2005-02-04 Duloxètine et ses sels d'addition acides pharmaceutiquement acceptables et particulièrement chlorhydrate de duloxétine (ARICLAIM). LU91140I2 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15812193A	1993-11-24	1993-11-24

Publications (1)

Publication Number	Publication Date
LU91140I2 true LU91140I2 (fr)	2005-04-04

Family

ID=22566762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU91140C LU91140I2 (fr)	1993-11-24	2005-02-04	Duloxètine et ses sels d'addition acides pharmaceutiquement acceptables et particulièrement chlorhydrate de duloxétine (ARICLAIM).

Country Status (27)

Country	Link
US (1)	US5744474A (fr)
EP (1)	EP0654264B1 (fr)
JP (1)	JP3681009B2 (fr)
KR (1)	KR100347277B1 (fr)
CN (1)	CN1099284C (fr)
AT (1)	ATE201594T1 (fr)
AU (1)	AU679269B2 (fr)
CA (1)	CA2136120C (fr)
CY (2)	CY2245B1 (fr)
CZ (1)	CZ289069B6 (fr)
DE (2)	DE122005000005I2 (fr)
DK (1)	DK0654264T3 (fr)
ES (1)	ES2157958T3 (fr)
GE (1)	GEP20064000B (fr)
GR (1)	GR3036446T3 (fr)
HU (1)	HU218920B (fr)
IL (1)	IL111705A (fr)
LU (1)	LU91140I2 (fr)
NL (1)	NL300174I2 (fr)
NO (2)	NO313535B1 (fr)
PH (1)	PH30741A (fr)
PT (1)	PT654264E (fr)
RU (1)	RU2152786C2 (fr)
SI (1)	SI0654264T1 (fr)
TW (1)	TW344661B (fr)
UA (1)	UA32429C2 (fr)
ZA (1)	ZA949190B (fr)

Families Citing this family (45)

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US5506270A (en) *	1995-01-30	1996-04-09	American Home Products Corporation	Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women
PL328959A1 (en) *	1996-03-11	1999-03-01	Lilly Co Eli	Method of treating or preventing interstitial cystitis
EP1331003B1 (fr) *	1996-03-25	2015-08-26	Wyeth LLC	Composition de venlafaxine à libération prolongée
PE57198A1 (es) *	1996-03-25	1998-10-10	American Home Prod	Formula de liberacion prolongada
US6274171B1 (en)	1996-03-25	2001-08-14	American Home Products Corporation	Extended release formulation of venlafaxine hydrochloride
US6150396A (en) *	1997-03-07	2000-11-21	Eli Lilly And Company	Methods of treating or preventing interstitial cystitis
US6579899B1 (en)	1998-07-16	2003-06-17	Massachusetts Institute Of Technology	Composition for treatment of stress
CA2337507A1 (fr) *	1998-07-16	2000-01-27	Massachusetts Institute Of Technology	Composition pour le traitement du stress
CA2311755C (fr) *	1998-08-27	2010-03-23	Pharmacia & Upjohn Ab	Formulation de tolterodine therapeutique a liberation controlee
US6046242A (en) *	1998-11-27	2000-04-04	Basf Aktiengesellschaft	Use of aryl-substituted cyclobutylalkylamines for treating urinary incontinence
US6197828B1 (en)	1998-12-01	2001-03-06	Sepracor, Inc.	Derivatives of (+)-venlafaxine and methods of preparing and using the same
US6342533B1 (en)	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
PL350924A1 (en) *	1999-04-06	2003-02-10	Sepracor Inc	Derivatives of venlafaxine and methods of preparing and using the same
DE60035232T2 (de) *	1999-07-01	2008-02-14	Pharmacia & Upjohn Co. Llc, Kalamazoo	(S,S)-Reboxetin zur Behandlung von chronischem Müdigkeits-Syndrom
US7291646B2 (en)	1999-11-24	2007-11-06	Wyeth	Ethers of O-desmethyl venlafaxine
US6572890B2 (en) *	2000-01-13	2003-06-03	Osmotica Corp.	Osmotic device containing venlafaxine and an anti-psychotic agent
DE10027290C2 (de)	2000-06-02	2002-07-11	Basf Coatings Ag	Pulverklarlackdispersionen (Pulverslurry-Klarlacke) und ihre Verwendung
DE10059412A1 (de) *	2000-11-30	2002-06-13	Gruenenthal Gmbh	Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz
DE60221642T3 (de) *	2001-02-12	2017-10-26	Wyeth LLC (n.d.Ges.d. Staates Delaware)	O-desmethyl-venlafaxine succinat salz
US6602911B2 (en)	2001-11-05	2003-08-05	Cypress Bioscience, Inc.	Methods of treating fibromyalgia
IL146462A (en) *	2001-11-13	2015-02-26	Lycored Bio Ltd	Prolonged-release preparations containing as an active compound and analapaxin hydrochloride
US7030164B2 (en) *	2001-12-05	2006-04-18	Wyeth	Crystalline polymorph of venlafaxine hydrochloride and methods for the preparation thereof
UA77234C2 (en) *	2001-12-05	2006-11-15	Wyeth Corp	Monohydrate of venlafaxine hydrochloride and methods for its preparation (variants)
GB0202265D0 (en) *	2002-01-31	2002-03-20	Arachnova Therapeutics Ltd	New therapeutic use
AU2003226751A1 (en) *	2002-03-28	2003-10-13	Synthon B.V.	Low water-soluble venlafaxine salts
WO2003090743A1 (fr) *	2002-04-24	2003-11-06	Cypress Bioscience, Inc.	Prevention et traitement de troubles somatiques fonctionnels, y-compris les troubles lies au stress
DE10224107A1 (de) *	2002-05-29	2003-12-11	Gruenenthal Gmbh	Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz
WO2004019892A2 (fr) *	2002-08-30	2004-03-11	Watson Pharmaceuticals, Inc.	Systeme ameliore de delivrance de medicaments pour le traitement de l'incontinence urinaire
GB0221438D0 (en) *	2002-09-16	2002-10-23	Avecia Ltd	Processes and compounds
EP1424079A1 (fr) *	2002-11-27	2004-06-02	Boehringer Ingelheim International GmbH	Combinaison d'un agoniste du beta-3-récepteur et d'un inhibiteur de recaptage de sérotonine et/ou norépinéphrine
US20070077301A1 (en) *	2002-12-23	2007-04-05	Meyer Glenn A	Venlafaxine osmotic device formulation
EP1539181B1 (fr) *	2003-04-04	2007-06-27	Dynogen Pharmaceuticals Inc.	Methode de traitement de troubles des voies urinaires inferieures
AP2006003771A0 (en) *	2004-04-30	2006-10-31	Warner Lambert Co	Substituted morpholine compounds for the treatmentof central nervous system disorders
US8685924B2 (en) *	2004-08-25	2014-04-01	Takeda Pharmaceutical Company Limited	Preventives/remedies for stress urinary incontinence and method of screening the same
WO2006071868A2 (fr) *	2004-12-23	2006-07-06	Teva Pharmaceutical Industries Ltd.	Processus de preparation de sels de duloxetine repondant aux normes pharmaceutiques et d'intermediaires de ceux-ci
EP1858859A1 (fr)	2005-03-14	2007-11-28	Teva Pharmaceutical Industries Ltd.	Procede de preparation du compose optiquement actif (s)-(+)-n,n-dimethyl-3-(1-naphtalenyloxy)-3-(2-thienyl)propanamine
US7842717B2 (en)	2005-09-22	2010-11-30	Teva Pharmaceutical Industries Ltd.	DNT-maleate and methods of preparation thereof
US7994220B2 (en) *	2005-09-28	2011-08-09	Cypress Bioscience, Inc.	Milnacipran for the long-term treatment of fibromyalgia syndrome
WO2007064697A1 (fr)	2005-12-01	2007-06-07	Auspex Pharmaceuticals, Inc.	Phénétylamines substituées à l’activité sérotoninergique et/ou norépinephrinergique
US7759500B2 (en)	2005-12-05	2010-07-20	Teva Pharmaceutical Industries Ltd.	2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
WO2007067501A1 (fr)	2005-12-05	2007-06-14	Wyeth	Procede pour la synthese selective d'enantiomeres de 1-(2-amino-1-phenyl-ethyl)-cyclohexanols substitues
EP1826204A1 (fr)	2006-02-28	2007-08-29	Laboratorios Del Dr. Esteve, S.A.	Procédé pour la préparation des précurseurs de duloxetine
US20080081067A1 (en) *	2006-10-03	2008-04-03	Gupta Manishkumar	Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
AU2008251773A1 (en)	2007-03-15	2008-11-20	Auspex Pharmaceuticals, Inc.	Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity
AU2019301128B2 (en)	2018-07-11	2024-07-25	Dignify Therapeutics, Llc	Method of treating voiding dysfunction

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US4314081A (en) *	1974-01-10	1982-02-02	Eli Lilly And Company	Arloxyphenylpropylamines
FI77018C (fi) *	1980-11-14	1989-01-10	Lilly Co Eli	Analogifoerfarande foer framstaellning av antidepressivt aktiv (-)-enantiomer av n-metyl-n-/3-(2-metylfenoxi) -3-fenylpropyl/amin och dess farmaceutiskt godtagbara salt.
IE56324B1 (en) *	1982-12-13	1991-06-19	American Home Prod	Phenethylamine derivatives and intermediates therefor
US4761501A (en) *	1983-10-26	1988-08-02	American Home Products Corporation	Substituted phenylacetamides
KR880007433A (ko) *	1986-12-22	1988-08-27	메리 앤 터커	3-아릴옥시-3-치환된 프로판아민
US4956388A (en) *	1986-12-22	1990-09-11	Eli Lilly And Company	3-aryloxy-3-substituted propanamines
CA1329937C (fr) *	1987-04-09	1994-05-31	Dennis Charles Thompson	1-phenyl-3-naphtalenyloxpropanamines
SE8804003D0 (sv) *	1988-11-04	1988-11-04	Pharmacia Ab	Compounds for the treatment of urinary incontinence
US5236956A (en) *	1988-11-04	1993-08-17	Kabi Pharmacia Aktiebolag	Compounds for the treatment of urinary incontinence
US5250571A (en) *	1988-11-14	1993-10-05	Eli Lilly And Company	(S)-norfluoxetine in method of inhibiting serotonin uptake
DE3912232A1 (de) *	1989-04-11	1989-11-30	Klosa Josef	Mittel gegen harninkontinenz
AU642582B2 (en) *	1991-02-25	1993-10-21	Eli Lilly And Company	Treatment of lower urinary tract disorders
US5281624A (en) *	1991-09-27	1994-01-25	Eli Lilly And Company	N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof
DK0537915T3 (da) *	1991-09-27	1995-11-27	Lilly Co Eli	N-alkyl-3-phenyl-3-(2-alkylthiophenoxy)propylaminer som inhibitorer for epinephrin
DK0617620T3 (da) *	1991-12-21	1999-06-07	Smithkline Beecham Plc	Anvendelse af 5-HT4-modulatorer til fremstilling af et lægemiddel til behandling af blærelidelser
US5192751A (en) *	1992-07-24	1993-03-09	Eli Lilly And Company	Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence

1994
- 1994-05-12 TW TW083104298A patent/TW344661B/zh not_active IP Right Cessation
- 1994-11-18 CA CA002136120A patent/CA2136120C/fr not_active Expired - Lifetime
- 1994-11-18 ZA ZA949190A patent/ZA949190B/xx unknown
- 1994-11-21 IL IL11170594A patent/IL111705A/en not_active IP Right Cessation
- 1994-11-21 PH PH49414A patent/PH30741A/en unknown
- 1994-11-21 UA UA94119056A patent/UA32429C2/uk unknown
- 1994-11-21 NO NO19944456A patent/NO313535B1/no not_active IP Right Cessation
- 1994-11-22 JP JP28811994A patent/JP3681009B2/ja not_active Expired - Lifetime
- 1994-11-22 DE DE1994627337 patent/DE122005000005I2/de active Active
- 1994-11-22 SI SI9430379T patent/SI0654264T1/xx unknown
- 1994-11-22 PT PT94308604T patent/PT654264E/pt unknown
- 1994-11-22 ES ES94308604T patent/ES2157958T3/es not_active Expired - Lifetime
- 1994-11-22 EP EP94308604A patent/EP0654264B1/fr not_active Expired - Lifetime
- 1994-11-22 AT AT94308604T patent/ATE201594T1/de active
- 1994-11-22 AU AU78968/94A patent/AU679269B2/en not_active Expired
- 1994-11-22 DK DK94308604T patent/DK0654264T3/da active
- 1994-11-22 DE DE69427337T patent/DE69427337T2/de not_active Expired - Lifetime
- 1994-11-22 KR KR1019940030696A patent/KR100347277B1/ko not_active Expired - Lifetime
- 1994-11-23 RU RU94041950/14A patent/RU2152786C2/ru active
- 1994-11-23 HU HU9403369A patent/HU218920B/hu unknown
- 1994-11-23 CZ CZ19942893A patent/CZ289069B6/cs not_active IP Right Cessation
- 1994-11-23 CN CN94118993A patent/CN1099284C/zh not_active Expired - Lifetime
1995
- 1995-04-20 US US08/425,703 patent/US5744474A/en not_active Expired - Lifetime
2001
- 2001-08-27 GR GR20010401296T patent/GR3036446T3/el unknown
- 2001-11-14 CY CY0100037A patent/CY2245B1/xx unknown
2005
- 2005-02-04 LU LU91140C patent/LU91140I2/fr unknown
- 2005-02-09 NO NO2005004C patent/NO2005004I1/no unknown
- 2005-02-10 CY CY2005002C patent/CY2005002I1/el unknown
- 2005-02-10 NL NL300174C patent/NL300174I2/nl unknown
2006
- 2006-05-23 GE GEAP20069411A patent/GEP20064000B/en unknown

Also Published As

Publication number	Publication date
NO2005004I1 (no)	2005-02-10
NO944456D0 (no)	1994-11-21
HU218920B (hu)	2000-12-28
HU9403369D0 (en)	1995-02-28
EP0654264A1 (fr)	1995-05-24
NL300174I2 (nl)	2005-05-02
CA2136120C (fr)	2008-01-29
KR100347277B1 (ko)	2003-03-06
ATE201594T1 (de)	2001-06-15
UA32429C2 (uk)	2000-12-15
CN1107699A (zh)	1995-09-06
NO313535B1 (no)	2002-10-21
HK1013799A1 (en)	1999-09-10
HUT72317A (en)	1996-04-29
PT654264E (pt)	2001-09-28
DE69427337T2 (de)	2001-10-31
DE122005000005I2 (de)	2006-06-08
EP0654264B1 (fr)	2001-05-30
CN1099284C (zh)	2003-01-22
CZ289069B6 (cs)	2001-10-17
IL111705A0 (en)	1995-01-24
NL300174I1 (nl)	2005-04-01
IL111705A (en)	2001-01-11
DE69427337D1 (de)	2001-07-05
CZ289394A3 (en)	1995-07-12
NO944456L (no)	1995-05-26
AU679269B2 (en)	1997-06-26
RU94041950A (ru)	1996-09-20
PH30741A (en)	1997-10-17
CY2005002I2 (el)	2010-07-28
DK0654264T3 (da)	2001-07-30
DE122005000005I1 (de)	2005-05-12
CY2005002I1 (el)	2010-07-28
JP3681009B2 (ja)	2005-08-10
ES2157958T3 (es)	2001-09-01
AU7896894A (en)	1995-06-01
CA2136120A1 (fr)	1995-05-25
CY2245B1 (en)	2003-07-04
ZA949190B (en)	1996-05-20
TW344661B (en)	1998-11-11
RU2152786C2 (ru)	2000-07-20
GEP20064000B (en)	2006-12-11
US5744474A (en)	1998-04-28
SI0654264T1 (en)	2001-10-31
GR3036446T3 (en)	2001-11-30
KR950013511A (ko)	1995-06-15
JPH07188003A (ja)	1995-07-25

Publication	Publication Date	Title
LU91140I2 (fr)	2005-04-04	Duloxètine et ses sels d'addition acides pharmaceutiquement acceptables et particulièrement chlorhydrate de duloxétine (ARICLAIM).
TW262468B (fr)	1995-11-11
EP0659416A3 (fr)	1995-09-06	Inhibition de séborrhée et de l'acné.
MY132056A (en)	2007-09-28	Methods of inhibiting physiological conditions associated with an excess of neuropeptide y.
DE69402173D1 (de)	1997-04-24	Hemmung von Thrombin
GR3033020T3 (en)	2000-08-31	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses.
NO943878L (no)	1995-04-18	Hemming av uterinfibrose
NO943875D0 (no)	1994-10-13	Hemming av angiogenese og angiogene sykdommer
MX9709475A (es)	1998-02-28	Derivados de pirrol y composicion medicinal.
NO943873D0 (no)	1994-10-13	Hemming av bruskdegradering
AU7578694A (en)	1995-05-04	Methods for treating resistant neoplasms
ATE101126T1 (de)	1994-02-15	Amide von cyclomethylen-1,2 bicarbonsaeure mit therapeutischer wirkung, verfahren zu deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen.
ES2157961T3 (es)	2001-09-01	Inhibicion del hirsutismo y la alopecia en mujeres.
CA2561293A1 (fr)	1995-05-25	Traitement de l'incontinence